Abstract：
PURPOSE:Heterocyclic amines (HCAs), which are found mainly in well-cooked meat, require metabolic activation to function as mutagens and animal carcinogens. Enzymes such as cytochrome P4501A2 (CYP1A2) and N-acetyltransferase (NAT2) perform this task and are subject to interindividual variation. The source of this variation may be genetic, as in the case of NAT2, or both genetic and environmental as with CYP1A2. The present study examined the effect of HCAs on the NAT2 and CYP1A2 phenotypes in 33 males and 33 females. METHODS:The subjects consumed a low HCA-containing diet for 1 week followed by a high HCA diet for the subsequent week. The subjects were phenotyped for CYP1A2 and NAT2 at the time of entry into the study (free-living), 1 week later (end of low-HCA or low-induction diet) and 2 weeks later (end of high-HCA or high-induction diet). RESULTS:Consistent with genetic sources of variability, NAT2 showed little effect of a high-HCA diet and exhibited high intraindividual correlation. CYP1A2, in contrast, was induced by a high-HCA diet and exhibited a more modest intraindividual correlation. CONCLUSIONS:Incorporating putative genetic susceptibility makers in population studies requires consideration of issues of induction and inhibition of metabolizing enzymes, and effects of covariates.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Sinha R,Caporaso Ndoi
10.1016/s1047-2797(97)00027-6subject
Has Abstractpub_date
1997-07-01 00:00:00pages
350-6issue
5eissn
1047-2797issn
1873-2585pii
S1047-2797(97)00027-6journal_volume
7pub_type
杂志文章abstract：PURPOSE:Asthma is a major complication of pregnancy, but there are currently no reliable national estimates for the United States of asthma prevalence in pregnancy or in the childbearing years. METHODS:The prevalence of asthma among pregnant women and all childbearing-aged women was estimated and examined by age group...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(03)00008-5
更新日期：2003-05-01 00:00:00
abstract：PURPOSE:To examine the association between folic acid (FA) supplementation obtained through either single FA tablets or multivitamins (MVs) and menstrual cycle characteristics among 5386 women aged 18-40 years, enrolled in an Internet-based study of Danish women attempting pregnancy during 2007-2011. METHODS:In a cros...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2015.05.008
更新日期：2015-10-01 00:00:00
abstract：PURPOSE:We sought to evaluate the association between childhood socioeconomic status (SES) at two time points and age at menarche in a multiracial sample of U.S. girls. METHODS:Our study population consisted of a cohort of female participants enrolled at birth at the New York site of the Collaborative Perinatal Projec...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2010.08.006
更新日期：2010-11-01 00:00:00
abstract：PURPOSE:Research examining the association between crime and health outcomes has been hampered by a lack of reliable small-area (e.g., census tract or census block group) crime data. Our objective is to assess the accuracy of synthetically estimated crime indices for use in health research by using preterm birth as a c...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2020.11.008
更新日期：2020-12-05 00:00:00
abstract：:PURPOSE: To assist in elucidating principles underlying the design of injury case-control studies.APPROACH: We begin by defining "event" as the sequence of circumstances that place a person at risk of injury (e.g. bicycle crash) and "injury given the event" as the resultant physical damage (e.g. head injury in bicycle...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(00)00134-4
更新日期：2000-10-01 00:00:00
abstract：PURPOSE:The purpose of the study was to evaluate overdose death rates in relation to socioeconomic characteristics and measures of socioeconomic residential segregation at substate geography. METHODS:County overdose deaths were linked to socioeconomic characteristics that are related to social vulnerability. Dissimila...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2019.04.009
更新日期：2019-07-01 00:00:00
abstract：PURPOSE:Estimates of mammography utilization vary considerably, depending on the data source. Among women aged 65 years and older, recent estimates of annual mammography derived from the 1992 National Health Interview Survey (NHIS) were 50% higher than estimates from Medicare claims. We investigated possible reasons fo...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(98)00010-6
更新日期：1998-10-01 00:00:00
abstract：:Data are presented contrasting racial and ethnic differences in the use of alcohol and other drugs, and in the morbidity and mortality consequent to substance abuse and dependence. In a review of recent studies, whites were found to have higher rates of use, abuse, and dependence than other racial and ethnic groups, d...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(93)90131-m
更新日期：1993-03-01 00:00:00
abstract：PURPOSE:A review of recent threats and challenges to epidemiology suggests that some represent an opportunity to advance the discipline while others are a major threat to conducting epidemiologic work. METHODS:Two issues are identified which should advance the publication and conduct of epidemiologic research. Three a...
journal_title：Annals of epidemiology
pub_type：
doi：10.1016/s1047-2797(97)00206-8
更新日期：1998-02-01 00:00:00
abstract：PURPOSE:We conducted this study to investigate birth seasonality in rural parts of Iran. METHODS:In this study, patterns of 5,536,262 live births in rural parts of Iran between 1992 and 2007 were studied. Information about birth numbers, environmental factors, and sociocultural status of participants was obtained from...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2016.09.009
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:To examine the mortality risk associated with diabetes in the Mexico City Diabetes Study (MCDS) and the San Antonio Heart Study (SAHS). METHODS:Prospective cohorts conducted 1990-2007 in MCDS and 1979-2000 in SAHS. Mortality risk was examined using Cox proportional hazard models in 1402 non-Hispanic whites (NH...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2011.07.003
更新日期：2011-12-01 00:00:00
abstract：PURPOSE:Preterm birth is associated with gastric acid-related disorders in infancy, but no investigators have examined this association beyond early childhood. We used antisecretory medication data to explore whether preterm birth is associated with gastric acid-related disorders in young adulthood. METHODS:We conduct...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2012.02.006
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:The health of infants that are HIV-exposed and -uninfected (HEU) is a major public health concern as HIV becomes a chronic condition. We investigate the interrelationship between maternal viral suppression, maternal weight status, breastfeeding, and infants that are HEU. METHODS:The Kabeho study followed 502 H...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2020.08.008
更新日期：2021-01-01 00:00:00
abstract：PURPOSE:This cohort study examined the relationship between maternal intake of individual fatty acids, meat, and fish during pregnancy and the risk of wheeze and eczema in children aged 23-29 months because epidemiologic evidence on this topic is inconclusive. METHODS:Subjects were 1354 Japanese mother-child pairs. Da...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2013.08.004
更新日期：2013-11-01 00:00:00
abstract：PURPOSE:To evaluate the factors associated with receiving cutaneous injection-related infection (CIRI) care among a representative cohort of supervised injecting facility (SIF) users. METHODS:Data were collected biannually as part of a prospective cohort, the Scientific Evaluation of Supervised Injection study. Kaplan...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2009.03.007
更新日期：2009-06-01 00:00:00
abstract：PURPOSE:Social and economic contextual factors may promote concurrent sexual partnerships, which can accelerate population HIV transmission and are more common among African Americans than U.S. Whites. We investigated the relationship between contextual factors and concurrency. METHODS:We analyzed past 12-month concur...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2013.08.002
更新日期：2013-11-01 00:00:00
abstract：PURPOSE:This paper examines the relationship between alcohol dependence according to the criteria found in the 4th edition of the Diagnostic and Statistical Manual (DSM-IV) of the American Psychiatric Association and drinking in the U.S. general population. METHODS:The data set under analysis is the 1988 National Heal...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(97)00114-2
更新日期：1997-11-01 00:00:00
abstract：PURPOSE:Depression is a risk factor for incident coronary heart disease (CHD), and predicts poor prognosis for patients post-myocardial infarction (MI). Few population-based, prospective studies have tested a gradient risk for depressive symptoms on CHD incidence. METHODS:The sample (n=1302) was derived from the Nova ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2004.08.006
更新日期：2005-04-01 00:00:00
abstract：PURPOSE:We sought to identify factors related to total mortality in older Japanese men in Japan and Hawaii. METHODS:Baseline data were collected from 1980 to 1982 in 1379 men in Hawaii and 954 men in Japan. Ages ranged from 61 to 81 years, with mortality follow-up during a 19-year period. RESULTS:Compared with Japan,...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2008.09.004
更新日期：2008-12-01 00:00:00
abstract：:The Physicians' Health Study is a randomized, double-blind, placebo-controlled prevention trial of 22,071 US physicians, using a factorial design to evaluate the role of aspirin in the prevention of cardiovascular mortality and beta carotene in the reduction of cancer incidence. After approximately 5 years of follow-u...
journal_title：Annals of epidemiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/1047-2797(91)90009-2
更新日期：1991-08-01 00:00:00
abstract：PURPOSE:Population-based cancer incidence rates of the corpus uteri, cervix uteri, and ovaries are underestimated if they fail to remove women not at risk for developing the cancers from the denominator in the race calculation. This study compares incidence rates among selected racial groups for these cancers before an...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2006.06.001
更新日期：2006-12-01 00:00:00
abstract：PURPOSE:The intestinal microbiome is critical for human health and preventing colonization by enteric pathogens. There are notable differences in the microbiota composition among individuals with and without enteric infections, though the impact that age and gender has on the composition and abundance of intestinal mic...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2016.03.007
更新日期：2016-05-01 00:00:00
abstract：PURPOSE:Serum concentrations of the adrenal androgen dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS), both of which decline with age more markedly than other sex hormone levels, have been alternately credited and discredited as "protective" correlates of heart disease. Baseline data from the Massachusetts M...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(97)00199-3
更新日期：1998-05-01 00:00:00
abstract：:PURPOSE: The most recent atlas of cancer mortality in the United States revealed elevated prostate cancer mortality rates among white males in the northwest, Rocky Mountain, northcentral, and southeast areas, as well as New England, especially during the 1970-94 period. We wanted to test whether this observed geograph...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(00)00094-6
更新日期：2000-10-01 00:00:00
abstract：PURPOSE:To estimate the annual incidence, cumulative probability of presumed urinary tract infection (UTI) by age, and the social costs. METHODS:Analysis of a random digit dialing survey of 2000 women in the United States. RESULTS:10.8 percent (95% CI: 9.4, 12.1%) of women aged 18 and older reported at least one pres...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(00)00072-7
更新日期：2000-11-01 00:00:00
abstract：PURPOSE:To examine prospectively the relationship between vegetable consumption and long-term survival. METHODS:In 1965, a total of 1536 Italian males from two Italian rural cohorts of the Seven Countries Study, aged 45-65 years, were examined. Information on lifestyle and food consumption collected at this visit, and...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(02)00457-x
更新日期：2003-07-01 00:00:00
abstract：PURPOSE:Few studies have examined methods of contraception, beyond oral contraceptives (OCs) and tubal ligation, in relation to ovarian cancer risk. METHODS:Nine hundred two cases with incident ovarian/peritoneal/tubal cancer were compared with 1800 population-based control subjects. Women self-reported all methods of...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2010.10.002
更新日期：2011-03-01 00:00:00
abstract：PURPOSE:The role of estrogen in cardiovascular health remains contested with discrepancies between findings from randomized controlled trials and observational studies. Mendelian randomization, which assesses the effect of lifelong endogenous exposure, may help elucidate these discrepancies. METHODS:We used separate s...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2016.01.005
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:There are limited data on vascular predictors of long-term disability in Hispanics. We hypothesized that (1) functional status declines over time and (2) vascular risk factors predict functional decline. METHODS:The Northern Manhattan Study contains a population-based study of 3298 stroke-free individuals aged...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2013.12.013
更新日期：2014-05-01 00:00:00
abstract：PURPOSE:Alcohol consumption has been implicated in the pathogenesis of cataract in some, but not all analytic studies. To date, no prospective analysis of the relationship between alcohol consumption and cataract has been conducted in women. METHODS:We examined the association between alcohol consumption and cataract ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(00)00054-5
更新日期：2000-08-01 00:00:00
