Abstract：
PURPOSE:The intestinal microbiome is critical for human health and preventing colonization by enteric pathogens. There are notable differences in the microbiota composition among individuals with and without enteric infections, though the impact that age and gender has on the composition and abundance of intestinal microbes is not known. METHODS:A comparative 16S rRNA gene sequencing study was performed on stool DNA from 200 patients with enteric infections and 75 healthy family members representing both sexes and multiple age groups. RESULTS:Microbial community profiles were affected by age and sex in patients with enteric infections and their healthy family members. Overall, we observed an increase in Bacteroides abundance and decrease in Escherichia abundance with age, though these differences were most apparent for patients with enteric infections. Genus Bacteroides was also higher in female communities while Escherichia predominated in males. CONCLUSIONS:Because Escherichia abundance was previously linked to symptom severity, children with enteric infections may be most susceptible to severe disease outcomes due to high and low abundance of Escherichia and Bacteroides, respectively. Future studies should focus on classifying specific differences in the microbiome using metagenomics and identifying novel methods aimed at shifting the intestinal microbiome to a healthy state.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Singh P,Manning SDdoi
10.1016/j.annepidem.2016.03.007subject
Has Abstractpub_date
2016-05-01 00:00:00pages
380-5issue
5eissn
1047-2797issn
1873-2585pii
S1047-2797(16)30077-1journal_volume
26pub_type
杂志文章abstract：PURPOSE:Socioeconomic disadvantage is often evaluated at single points in the adult life course in health research. Social mobility models suggest that socioeconomic patterns may also influence disease risk. This study examines cumulative socioeconomic disadvantage (CSD) in relation to cardiovascular disease mortality ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2014.11.018
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:We aimed to explore the relationship between physician characteristics and their prescribing behavior regarding category D and X drugs for pregnant women by using a population-based data set in Taiwan. METHODS:The sampled population for the study included 14,430 women. These women received a total of 198,420 p...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2012.11.007
更新日期：2013-02-01 00:00:00
abstract：PURPOSE:Develop and evaluate a food frequency questionnaire (FFQ) for assessing calcium intake in Chinese postmenopausal women. METHODS:An interviewer-conducted FFQ that asks respondents about their consumption of 110 calcium-containing foods over the previous week was developed and administered to 21 randomly selecte...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(99)00055-1
更新日期：2000-04-01 00:00:00
abstract：:This article proposes that the nation undertake a study of a cohort which will be followed from pregnancy to death- a research project that will require more than 100 years. The project would take advantage of the recent completion of the human genome study, the accelerating development of new non-invasive measurement...
journal_title：Annals of epidemiology
pub_type： 杂志文章,评审
doi：10.1016/s1047-2797(01)00314-3
更新日期：2002-10-01 00:00:00
abstract：PURPOSE:Studies indicate breakfast cereals may reduce the risk of overweight, cardiovascular diseases, and diabetes, but a limited number of longitudinal studies have explored these relationships, indicating the need for further assessment. METHODS:We used 45 and Up Study data to examine the longitudinal association b...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2019.07.004
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:To examine community differences in cardiovascular disease (CVD) risk factors among black and white young adults by combining data from two large epidemiologic studies. METHODS:Data are from participants aged 20-31 years in the Coronary Artery Risk Development In Young Adults (CARDIA) study (1987-1988; N = 412...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(97)00127-0
更新日期：1998-01-01 00:00:00
abstract：PURPOSE:Ultraviolet light from sunlight and other sources is the major environmental risk factor for melanoma of the skin. Humans also derive most of their vitamin D from exposure to sunlight. This article reviews current evidence that vitamin D might play a preventive role in the development of melanoma or affect tumo...
journal_title：Annals of epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.annepidem.2009.01.005
更新日期：2009-07-01 00:00:00
abstract：PURPOSE:Observational studies in Western settings show moderate alcohol use associated with better cognitive function, but they are vulnerable to contextual bias. Evidence from non-Western settings may be useful to verify causality. We examined such association in southern China where alcohol use is low. METHODS:We us...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2010.06.005
更新日期：2010-12-01 00:00:00
abstract：:The current study investigated the association between the use of recreational drugs at the time of sexual activity and high-risk sexual behavior in a Toronto cohort of 249 homosexual and bisexual men over a 5-year period commencing in 1984 to 1985 and concluding in 1989 to 1990. The main analysis was based on a total...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(93)90030-8
更新日期：1993-05-01 00:00:00
abstract：PURPOSE:This cross-sectional study sought to identify diabetes accurately in a study population of 3681 women age 75 and older and to determine the association of diabetes with cognitive performance. METHODS:A previously validated test, the Telephone Interview of Cognitive Screening-Modified (TICSm) was given to asses...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/S1047-2797(03)00059-0
更新日期：2003-10-01 00:00:00
abstract：:PURPOSE: Although prison inmates are reported to exhibit substantially elevated rates of HIV infection, little is known about HIV treatment patterns, particularly pharmacotherapy, in correctional institutions. The purpose of the present study, therefore, was to describe antiretroviral prescribing patterns in one of th...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(00)00128-9
更新日期：2000-10-01 00:00:00
abstract：PURPOSE:Maternal asthma increases adverse neonatal respiratory outcomes, and pollution may further increase risk. Air quality in relation to neonatal respiratory health has not been studied. METHODS:Transient tachypnea of the newborn (TTN), asphyxia, and respiratory distress syndrome (RDS) were identified using medica...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2018.06.003
更新日期：2018-09-01 00:00:00
abstract：PURPOSE:Breast density and body mass index (BMI) are correlated attributes and are both potentially modifiable risk factors for breast cancer. However, relationships between these factors and risk of molecularly-defined subtypes of breast cancer have not been established. METHODS:We used breast density and BMI data co...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2012.02.002
更新日期：2012-05-01 00:00:00
abstract：PURPOSE:The purpose of the study was to evaluate overdose death rates in relation to socioeconomic characteristics and measures of socioeconomic residential segregation at substate geography. METHODS:County overdose deaths were linked to socioeconomic characteristics that are related to social vulnerability. Dissimila...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2019.04.009
更新日期：2019-07-01 00:00:00
abstract：:The association between premature menopause and low back pain was examined among 5325 women surveyed in the second National Health and Nutrition Examination survey. Nearly 49% of the women were postmenopausal. In a multiple logistic regression model that included age, postmenopausal women were approximately twice as l...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(94)90077-9
更新日期：1994-09-01 00:00:00
abstract：PURPOSE:To examine geographic variation in the incidence of ischemic stroke (IS) and acute myocardial infarction (AMI) in Finland during 1991-2003. METHODS:Data included all cases of first IS (n = 115,383) and AMI (n = 205,213) in persons aged 35-84 years. We used full Bayesian spatial shared component disease models ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2007.10.008
更新日期：2008-03-01 00:00:00
abstract：PURPOSE:We examined the role of smoking in the two dimensions behind the time trends in adult mortality in European countries, that is, rectangularization of the survival curve (mortality compression) and longevity extension (increase in the age-at-death). METHODS:Using data on national sex-specific populations aged 5...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2015.01.007
更新日期：2015-04-01 00:00:00
abstract：PURPOSE:The role of estrogen in cardiovascular health remains contested with discrepancies between findings from randomized controlled trials and observational studies. Mendelian randomization, which assesses the effect of lifelong endogenous exposure, may help elucidate these discrepancies. METHODS:We used separate s...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2016.01.005
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:Life expectancy is used to measure population health, but large differences in mortality can be masked even when there is no life expectancy gap. We demonstrate how Arriaga's decomposition method can be used to assess inequality in mortality between populations with near equal life expectancy. METHODS:We calcu...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2014.05.006
更新日期：2014-08-01 00:00:00
abstract：PURPOSE:Describing weight trajectories using functional methods may further our understanding of how weight impacts health. We characterize weight patterns and describe correlates of these patterns. METHODS:Using a subset of the Framingham Heart Study original cohort limited-access data set (n=1,429), we conducted a f...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2009.11.013
更新日期：2010-03-01 00:00:00
abstract：PURPOSE:To examine the association between folic acid (FA) supplementation obtained through either single FA tablets or multivitamins (MVs) and menstrual cycle characteristics among 5386 women aged 18-40 years, enrolled in an Internet-based study of Danish women attempting pregnancy during 2007-2011. METHODS:In a cros...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2015.05.008
更新日期：2015-10-01 00:00:00
abstract：PURPOSE:In 1991, California implemented a law that mandated a background check for all firearm purchases with limited exceptions (comprehensive background check or CBC policy) and prohibited firearm purchase and possession for persons convicted within the past 10 years of certain violent crimes classified as misdemeano...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2018.10.001
更新日期：2019-02-01 00:00:00
abstract：PURPOSE:To estimate the risk of blood exposure to non-intact skin in U.S. paramedics; to estimate risk ratios for selected management practices. METHODS:A mail survey was conducted among a national sample of licensed paramedics in the United States in 2002-2003. RESULTS:The adjusted response rate was 55% (N = 2,664)....
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2009.08.006
更新日期：2009-12-01 00:00:00
abstract：PURPOSE:In prospective cohort studies, incidence is typically estimated by the ratio of the observed number of events to person-time at risk. This crude estimator is consistent for the true population incidence rate (IR) under mild assumptions. Here we consider a different setting where only cross-sectional data are av...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2020.06.005
更新日期：2021-01-01 00:00:00
abstract：:We have provided recent evidence suggesting that a systematic error may be operating in prospective epidemiological mortality studies that have reported "light" or "moderate" regular use of alcohol to be "protective" against coronary heart disease. Using meta-analysis as a research tool, a hypothesis first suggested b...
journal_title：Annals of epidemiology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.annepidem.2007.01.005
更新日期：2007-05-01 00:00:00
abstract：PURPOSE:Maternal marriage is protective against preterm birth (PTB), whereas advanced maternal age is associated with increased PTB risk. Because relations between social factors and health may vary during the life course, we assessed how the relation between marital status and PTB risk may change with maternal age. M...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2012.01.002
更新日期：2012-03-01 00:00:00
abstract：PURPOSE:Minority group membership in old age has been implicated as a risk factor for lower scores on cognitive function tests, independent of education level. In addition, differential rates of cognitive decline by ethnic group have been identified in several epidemiologic studies. However, others have not been able t...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2009.06.008
更新日期：2009-11-01 00:00:00
abstract：PURPOSE:Massachusetts cancer registry and case-control data suggest that breast cancer incidence is elevated on Cape Cod relative to other parts of the state. We examined the association between length of residence on Cape Cod and breast cancer, since residential history could be acting as a surrogate for unidentified ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/S1047-2797(03)00120-0
更新日期：2004-02-01 00:00:00
abstract：PURPOSE:Cost analyses of tuberculosis (TB) in the United States have not included elements that may be prevented if TB were prevented, such as losses associated with TB-related disability, personal and other costs to society. Unmeasured TB costs lead to underestimates of the benefit of prevention and create conditions ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2009.09.004
更新日期：2010-01-01 00:00:00
abstract：:Because of previously reported associations among the total leukocyte count, cigarette smoking, and risk of cardiovascular disease, we examined the relation of cigarette smoking to various leukocyte subpopulations among 3467 men aged 31 to 45 years. The median total leukocyte count was 36% higher (7840 vs. 5760 cells/...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(96)00024-5
更新日期：1996-07-01 00:00:00
