Abstract:
PURPOSE:The role of estrogen in cardiovascular health remains contested with discrepancies between findings from randomized controlled trials and observational studies. Mendelian randomization, which assesses the effect of lifelong endogenous exposure, may help elucidate these discrepancies. METHODS:We used separate sample instrumental variable analysis to estimate the association of log 17β-estradiol with factors related to cardiovascular disease risk (systolic and diastolic blood pressure, lipids, fasting glucose, body mass index, waist hip ratio, and waist circumference) and Framingham score, a predictor of 10-year risk of ischemic heart disease events, in older Chinese women from the Guangzhou Biobank Cohort Study (GBCS, n = 3092). The estimate was derived using the Wald estimator, that is, the ratio of the association of genetic determinants (rs1008805 and rs2175898) of log 17β-estradiol with cardiovascular disease risk factors and Framingham score in GBCS and the association of these genetic determinants with log 17β-estradiol in a sample of young women from Hong Kong (n = 236). RESULTS:Genetically, higher 17β-estradiol was not associated with any cardiovascular disease-related risk factor or with Framingham score (-0.01, 95% confidence interval = -1.34 to 1.31). CONCLUSIONS:Lifetime exposure to estrogen does not appear to be cardioprotective via the cardiovascular disease-related risk factors examined.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Au Yeung SL,Cheng KK,Zhao J,Zhang W,Jiang C,Lam TH,Leung GM,Schooling CMdoi
10.1016/j.annepidem.2016.01.005subject
Has Abstractpub_date
2016-03-01 00:00:00pages
171-5issue
3eissn
1047-2797issn
1873-2585pii
S1047-2797(16)30036-9journal_volume
26pub_type
杂志文章abstract::Phase I of the Trials of Hypertension Prevention was designed to test the effectiveness and safety of three life-style (weight loss, sodium restriction, and stress management) and four nutrition supplement (calcium, magnesium, potassium, and fish oil) interventions in reducing diastolic blood pressure (DBP) in persons...
journal_title:Annals of epidemiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/1047-2797(92)90062-u
更新日期:1992-05-01 00:00:00
abstract:PURPOSE:Local health statistics are increasingly requested for policy-making and programmatic purposes; however, population-based surveys are often inadequate to support direct estimation for small areas. Model-based estimation techniques can be used to create local estimates for public health outcomes. Using the 2014-...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2018.03.015
更新日期:2018-07-01 00:00:00
abstract:PURPOSE:Existing studies on laxatives, used by roughly 40% of the U.S. population experiencing constipation and colorectal cancer (CRC) have yielded inconsistent results, which may be due to a failure to account for differential risks by major laxative types: bulk (fiber-based), and nonbulk (or nonfiber-based). METHOD...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2018.06.011
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:A U-shaped relation between alcohol use and mortality may be due to biological hormesis, differential response (i.e., effect modification) by health status or changes in alcohol use with ill-health and aging (i.e., reverse causality).We examined whether alcohol had the same association with mortality in healthy...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2009.01.011
更新日期:2009-06-01 00:00:00
abstract::Trends in stroke incidence, prevalence, fatality, and severity were examined in Framingham Study subjects, aged 55 to 64, during 3 successive decades beginning in 1953, 1963, and 1973. There was no significant decline in incidence or prevalence of total stroke and transient ischemic attacks (TIAs). In women, but not m...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/1047-2797(93)90098-o
更新日期:1993-09-01 00:00:00
abstract:PURPOSE:Much cross-sectional work reports an association between neighborhood disadvantage and adverse birth outcomes. Limitations of this work include that mothers with pre-existing unmeasured morbidity may "select" into, or out of, certain neighborhoods. This selection issue remains a key rival explanation for work c...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2019.05.005
更新日期:2019-08-01 00:00:00
abstract:PURPOSE:The aim of this study was to evaluate prospectively smoking dependence as a predictor of repeated use of prescribed opioids in non-cancer patients. METHODS:We conducted a prospective population-based study cohort of 12,848 men and 15,894 women 30-75 years of age in health surveys in Norway during 2000-2002 wit...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2010.03.010
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:To examine associations between macronutrient and total energy intakes with lower urinary tract symptoms (LUTS) in women. METHODS:Cross-sectional analysis of 2060 women aged 30-79 years in the population-based Boston Area Community Health Survey (2002-2005). Data were collected by validated food frequency ques...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2010.11.014
更新日期:2011-06-01 00:00:00
abstract:PURPOSE:Incidence studies of occupational factors and cancer in the United States are problematic because the use of population-based registries to identify cases requires development of historical data on subjects' residences and often severely restricts the time period of follow up. This article describes procedures ...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2005.06.055
更新日期:2006-03-01 00:00:00
abstract::Intervention studies are now viewed as a useful and necessary approach to understanding the relation between nutrition and cancer. Over 20 such studies have been initiated in the past 7 years. Foreign countries may be an attractive site for such investigations, mainly because of desirable population characteristics su...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/1047-2797(90)90010-p
更新日期:1990-12-01 00:00:00
abstract:PURPOSE:To assess the association of antenatal and postnatal social support with postpartum depression (PPD). METHODS:We carried out a prospective cohort study of 534 pregnant women between February and September 2007 in Hunan, China. The association between prenatal and postnatal social support with PPD was examined....
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2009.03.008
更新日期:2009-09-01 00:00:00
abstract:PURPOSE:The goal of this study was to assess the relationship between hospitalization rates and asthma prevalence in New York City children and investigate the role that sociodemographic factors play in asthma. METHODS:A parent-report questionnaire was distributed in 26 randomly selected New York City public elementar...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2005.06.046
更新日期:2006-05-01 00:00:00
abstract:PURPOSE:Consumption of foods high in glycemic index (GI) and glycemic load (GL) is associated with cardiovascular (CV) diseases in adulthood. We examined whether GI and GL predict CV risk factors in children after 2 years of follow-up. METHODS:Three 24-hour recalls were administered at baseline, and individual average...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2019.10.005
更新日期:2019-12-01 00:00:00
abstract:PURPOSE:The association between glycated hemoglobin (HbA1c), medication use/adherence, and mortality stratified by race/ethnicity was examined in a national cohort of veterans with type 2 diabetes. METHODS:A total of 892,223 veterans with diabetes in 2002 were followed through 2006. HbA1c category was the main exposur...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2012.11.002
更新日期:2013-02-01 00:00:00
abstract::PURPOSE: To present the parallel histories of epidemiologic and electronic publishing and consider positive and negative factors that might affect their amalgam.METHODS: We performed a quantitative assessment of the arc of epidemiologic publication from 1966-1999, using major self-designated epidemiologic journals as ...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/s1047-2797(00)00096-x
更新日期:2000-10-01 00:00:00
abstract:PURPOSE:Despite the considerable mortality and morbidity associated with cardiovascular disease (CVD), many developing countries lack reliable surveillance of these ailments and their risk factors to guide intervention. This study aims to provide the first population-based estimates of CVD morbidity and mortality among...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2007.03.016
更新日期:2007-09-01 00:00:00
abstract:PURPOSE:Studies indicate breakfast cereals may reduce the risk of overweight, cardiovascular diseases, and diabetes, but a limited number of longitudinal studies have explored these relationships, indicating the need for further assessment. METHODS:We used 45 and Up Study data to examine the longitudinal association b...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2019.07.004
更新日期:2019-09-01 00:00:00
abstract:PURPOSE:Little is known about how seasonal variation in physical activity relates to declining physical activity in adolescence. We quantified how each of daily weather conditions and season affect physical activity during adolescence. METHODS:We followed 1293 students, initially aged 12 to 13 years over 5 years. Part...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2008.12.008
更新日期:2009-03-01 00:00:00
abstract:PURPOSE:To examine the association between folic acid (FA) supplementation obtained through either single FA tablets or multivitamins (MVs) and menstrual cycle characteristics among 5386 women aged 18-40 years, enrolled in an Internet-based study of Danish women attempting pregnancy during 2007-2011. METHODS:In a cros...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2015.05.008
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:We sought to identify factors related to total mortality in older Japanese men in Japan and Hawaii. METHODS:Baseline data were collected from 1980 to 1982 in 1379 men in Hawaii and 954 men in Japan. Ages ranged from 61 to 81 years, with mortality follow-up during a 19-year period. RESULTS:Compared with Japan,...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2008.09.004
更新日期:2008-12-01 00:00:00
abstract::A cross-sectional analysis of a sample of 3235 males and 2513 females included in a structured framework of case-control studies of various neoplasms conducted in northern Italy assessed the relationship between age at starting smoking and amount of cigarettes smoked per day. Age-standardized proportions of light, mod...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/1047-2797(94)90005-1
更新日期:1994-11-01 00:00:00
abstract:PURPOSE:We analyzed the changes in the body mass index (BMI) distribution for urban Australian adults between 1980 and 2007. METHODS:We used data from participants of six consecutive Australian nation-wide surveys with measured weight and height between 1980 and 2007. We used quantile regression to estimate mean BMI (...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2014.10.008
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:There are limited data on vascular predictors of long-term disability in Hispanics. We hypothesized that (1) functional status declines over time and (2) vascular risk factors predict functional decline. METHODS:The Northern Manhattan Study contains a population-based study of 3298 stroke-free individuals aged...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2013.12.013
更新日期:2014-05-01 00:00:00
abstract:PURPOSE:To estimate the annual incidence, cumulative probability of presumed urinary tract infection (UTI) by age, and the social costs. METHODS:Analysis of a random digit dialing survey of 2000 women in the United States. RESULTS:10.8 percent (95% CI: 9.4, 12.1%) of women aged 18 and older reported at least one pres...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/s1047-2797(00)00072-7
更新日期:2000-11-01 00:00:00
abstract:PURPOSE:The purpose of this study is to map type 2 diabetes susceptibility genes in West African ancestral populations of African-Americans, through an international collaboration between West African and US investigators. DESIGN AND METHODS:Affected sib-pairs (ASP) along with unaffected spouse controls are being enro...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/s1047-2797(00)00180-0
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:The goal of the research was to determine the spreading of Sarcoptes scabiei and the incidence of scabies in the residents of particular districts of the Swietokrzyskie Voivodeship (Central Europe) from 1990 to 1998. METHODS:An epidemiological analysis of scabies incidents was performed, with a focus on the ag...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2005.06.058
更新日期:2006-06-01 00:00:00
abstract:PURPOSE:To determine if the timing for requesting signed permission to access personal health services utilization records affects authorization or survey response rates. METHODS:A screening question about in-principle willingness to permit access to personal health services utilization records was included in a mail-...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/s1047-2797(01)00261-7
更新日期:2002-07-01 00:00:00
abstract:PURPOSE:Most studies, primarily conducted in populations of European ancestry, reported increased risk of head and neck cancer (HNC) associated with leanness (body mass index [BMI] <18.5 kg/m(2)) and decreased for overweight or obesity (25.0 to <30.0 and >30 kg/m(2), respectively), compared with normal weight (18.5 to ...
journal_title:Annals of epidemiology
pub_type: 杂志文章
doi:10.1016/j.annepidem.2013.11.004
更新日期:2014-02-01 00:00:00
abstract:PURPOSE:To evaluate the association between active and passive smoking and frequency of colds in women. METHODS:Data on cigarette smoking and frequency and duration of colds were analyzed in the Women's Health Study (WHS), a randomized, double-blind, placebo-controlled trial of low-dose aspirin and vitamin E in the pr...
journal_title:Annals of epidemiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s1047-2797(00)00214-3
更新日期:2001-05-01 00:00:00
abstract:PURPOSE:The Multiple Risk Factor Intervention Trial (MRFIT), a randomized clinical trial for the primary prevention of coronary heart disease, enrolled 12,866 men (including 8194 cigarette smokers) aged 35-57 years at 22 clinical centers across the United States. Participants were randomized either to special intervent...
journal_title:Annals of epidemiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s1047-2797(96)00123-8
更新日期:1997-02-01 00:00:00