Abstract：
:This article proposes that the nation undertake a study of a cohort which will be followed from pregnancy to death- a research project that will require more than 100 years. The project would take advantage of the recent completion of the human genome study, the accelerating development of new non-invasive measurement technologies, as well as new information about the complexity and long duration of the causal period for diseases. This complexity involves increasing awareness of long developmental processes which do not fit the typical picture of disease and that do not always have an obvious demarcation of disease onset. Appreciation for the complexity of the web of causation has expanded as the human genome project has unfolded, because it has become increasingly apparent how intimately the action of genetic material depends on contingencies of the individual interacting with the environment; and that the chances of discovering the action of genes, singly or in clusters, will be greatly enhanced by the ability to characterize the environment during distinct developmental periods. Likewise, the ability to understand environmental influences will depend on knowledge of genes. Additionally, there is new evidence for here-to-fore unsuspected comorbidities, the understanding of which would be greatly benefitted by a conception-to-death cohort study with a broad range of health outcomes. In many cases these developmental processes, contingencies, and comorbidities involve long causal periods, approaching that of the entire human lifespan. A conception-to-death cohort study would provide information on disease, human development, environmental risk and protective factors, and public health that will not be achievable by any other research design.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Eaton Wdoi
10.1016/s1047-2797(01)00314-3keywords:
subject
Has Abstractpub_date
2002-10-01 00:00:00pages
445-51issue
7eissn
1047-2797issn
1873-2585pii
S1047279701003143journal_volume
12pub_type
杂志文章,评审abstract：PURPOSE:The purpose of this study was to use emergency department data to estimate levels of morbidity and risk factors due to earthquake-related mechanisms of injury subsequent to an urban night-time earthquake. METHODS:Data were abstracted from 4190 medical records for the month of January, 1994. Injuries attributab...
journal_title：Annals of epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1016/s1047-2797(01)00220-4
更新日期：2001-07-01 00:00:00
abstract：PURPOSE:To examine the clustering and patterns of obesity-related behaviors in children and their mothers and the concordance between mother and child pairs. METHODS:Primary school-aged children and their mothers in Victoria, Australia, participated (data from 549 mothers, 352 children, and 304 mother/child pairs). Ex...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2010.11.001
更新日期：2011-02-01 00:00:00
abstract：PURPOSE:We examined (1) if child maltreatment (CM) is associated with lower health-related quality of life (HRQoL) and fewer quality-adjusted life years (QALY) over a 9-year follow-up of midlife women and (2) if adulthood psychosocial mediators could explain these associations. METHODS:Women (n = 342) completed the Ch...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2020.01.005
更新日期：2020-03-01 00:00:00
abstract：PURPOSE:Health of the general population is improving along a number of major health dimensions. Using a cumulative deficits approach, we investigated whether such improvements were evident at the level of minor health traits. METHODS:We selected 37 small-effect traits consistently measured in the 9th (performed in 19...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2008.06.005
更新日期：2008-09-01 00:00:00
abstract：PURPOSE:We aim to shed light on progress in cancer medicine through studying time trends in age-specific rates of cancer incidence and mortality over the last quarter century. METHODS:We analyzed age-specific incidence and mortality rates of all cancer sites combined using the high-quality population-based databases o...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2020.04.007
更新日期：2020-08-01 00:00:00
abstract：PURPOSE:Men who have sex with men (MSM) bear a disproportionate burden of new and existing HIV infections in the United States, with black and Hispanic MSM facing the highest rates. A lack of data on MSM population sizes has precluded the understanding of state-level variations in these rates. METHODS:Using a recently...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2018.04.008
更新日期：2018-12-01 00:00:00
abstract：PURPOSE:Selection bias is a form of systematic error that can be severe in compromised study designs such as case-control studies with inappropriate selection mechanisms or follow-up studies that suffer from extensive attrition. External adjustment for selection bias is commonly undertaken when such bias is suspected, ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2014.07.014
更新日期：2014-10-01 00:00:00
abstract：PURPOSE:To examine the mortality risk associated with diabetes in the Mexico City Diabetes Study (MCDS) and the San Antonio Heart Study (SAHS). METHODS:Prospective cohorts conducted 1990-2007 in MCDS and 1979-2000 in SAHS. Mortality risk was examined using Cox proportional hazard models in 1402 non-Hispanic whites (NH...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2011.07.003
更新日期：2011-12-01 00:00:00
abstract：PURPOSE:In this study we explicitly examine the effect of using asset-based and conventional measures of socioeconomic position (SEP) on ethnic differences in health. METHODS:The survey of white (n = 227), Indian and Pakistani (n = 233), and African Caribbean (n = 213) adults aged 18 to 59 years living in Leeds, Unite...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2007.12.006
更新日期：2008-05-01 00:00:00
abstract：PURPOSE:The proportion of cancer deaths in the contemporary United States caused by cigarette smoking (the population attributable fraction [PAF]) is not well documented. METHODS:The PAF of all cancer deaths due to active cigarette smoking among adults 35 years and older in the United States in 2010 was calculated usi...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2014.11.008
更新日期：2015-03-01 00:00:00
abstract：:Elevated blood pressure is a highly prevalent condition that is etiologically related to coronary heart disease and stroke, two of the leading causes of morbidity and mortality throughout the world. Excess salt (sodium chloride) intake is a major determinant of elevated blood pressure. In this article, we discuss the ...
journal_title：Annals of epidemiology
pub_type： 历史文章,杂志文章
doi：10.1016/j.annepidem.2012.04.003
更新日期：2012-06-01 00:00:00
abstract：PURPOSE:This cohort study examined the relationship between maternal intake of individual fatty acids, meat, and fish during pregnancy and the risk of wheeze and eczema in children aged 23-29 months because epidemiologic evidence on this topic is inconclusive. METHODS:Subjects were 1354 Japanese mother-child pairs. Da...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2013.08.004
更新日期：2013-11-01 00:00:00
abstract：:Some of the readjustment problems of Vietnam veterans have been attributed to posttraumatic stress disorder (PTSD). This case-control study compared demographic and military characteristics of 374 Vietnam veterans who had PTSD with 373 healthy Vietnam veterans. Veterans were chosen from the Agent Orange Registry, a De...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(91)90022-5
更新日期：1991-11-01 00:00:00
abstract：PURPOSE:Oxidative stress is defined as an imbalance between pro-oxidants and antioxidants. Previous research found that a single comprehensive oxidative balance score (OBS) that includes individual pro- and anti-oxidant exposures may be associated with various conditions (including prostate cancer) in the absence of as...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2014.02.015
更新日期：2014-06-01 00:00:00
abstract：PURPOSE:We conducted this study to investigate birth seasonality in rural parts of Iran. METHODS:In this study, patterns of 5,536,262 live births in rural parts of Iran between 1992 and 2007 were studied. Information about birth numbers, environmental factors, and sociocultural status of participants was obtained from...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2016.09.009
更新日期：2016-12-01 00:00:00
abstract：:Childhood obesity is a serious public health problem resulting from energy imbalance (when the intake of energy is greater than the amount of energy expended through physical activity). Numerous health authorities have identified policy interventions as promising strategies for creating population-wide improvements in...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2010.03.001
更新日期：2010-06-01 00:00:00
abstract：PURPOSE:Many negative cognitive and behavioral outcomes have been identified among children living in households with parental violence, but few studies have examined academic performance. In a rural population-based cohort, we examine the role of parental violence on standardized test score performance. METHODS:The c...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2007.06.004
更新日期：2007-11-01 00:00:00
abstract：PURPOSE:Socioeconomic status (SES) as a risk factor for mortality in type 1 diabetes (T1D) has not been adequately studied prospectively. METHODS:Complete clinical and SES (income, education, occupation) data were available for 317 T1D participants in the Pittsburgh Epidemiology of Diabetes Complications Study within ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2011.02.011
更新日期：2011-05-01 00:00:00
abstract：PURPOSE:A significant portion of coronary heart disease deaths occur out of the hospital, prior to access to life saving medical care. Improving the immediacy of care could have important impact on coronary mortality. METHODS:The objective of this research is to identify factors associated with the occurrence of out-o...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2003.10.002
更新日期：2004-08-01 00:00:00
abstract：PURPOSE:To reanalyze results reported in 2008, using propensity score matching, to test the treatment effect of non-leisure physical activity on survival. METHODS:McCullagh's ordinal logit model was used to estimate propensity scores, separately for adults aged 35-59 and 60-74 years at baseline in the National Health ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2012.04.019
更新日期：2012-08-01 00:00:00
abstract：:The evidence that treatment of hypertension prevents stroke is incontrovertible. Several observations, however, suggest that improvements in the prevalence of antihypertensive treatment cannot explain all of the recent decline in stroke mortality. Changes in nutritional patterns may explain some of the observed declin...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(93)90119-o
更新日期：1993-09-01 00:00:00
abstract：PURPOSE:Standard estimation of ordered odds ratios requires the constraint that the etiologic effects of exposure are homogenous across thresholds of the ordered response. We present a method to relax this often-unrealistic constraint. METHODS:The kernel of the proposed method is the expansion of observed data into "p...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2003.08.003
更新日期：2004-03-01 00:00:00
abstract：PURPOSE:The purpose of this study is to examine the relationship between labor force participation and gender differences in the prevalence of arthritis, diabetes, and hypertension. METHODS:The Mexican Health and Aging Survey (MHAS) data is nationally representative sample of older Mexicans 50 years and older. Binomia...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2008.04.005
更新日期：2008-08-01 00:00:00
abstract：OBJECTIVES:Information on the epidemiology of end-stage liver disease (ESLD) in US correctional populations is limited. We examined the prevalence, mortality and clinical characteristics of ESLD in the nation's second largest state prison system. METHODS:We collected and analyzed medical and demographic data from 370,...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2007.04.005
更新日期：2007-10-01 00:00:00
abstract：:A food-frequency questionnaire (FFQ) for low-income Mexican-Americans in Starr County, Texas, was developed as part of an epidemiologic study of gallbladder disease during 1985 and 1986. The FFQ was developed from 7-day food records collected from the first sample. In the validity study, using the second sample, corre...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(95)00035-6
更新日期：1995-09-01 00:00:00
abstract：PURPOSE:When conducting analyses of child weight growth trajectories, researchers commonly use Z-scores from a standard instead of the observed weights. However, these Z-scores, calculated from cross-sectional data, may introduce methodological limitations when used in the context of longitudinal analyses. We assessed ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2018.04.006
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:To estimate and compare prevalence rates of lifetime health conditions by inferred duration of illicit drug use among the general U.S. adult population and to investigate associations between duration of use of each specific illicit drug (marijuana, cocaine, heroin, hallucinogens, or inhalant) and each lifetime...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2010.01.003
更新日期：2010-04-01 00:00:00
abstract：PURPOSE:The health of infants that are HIV-exposed and -uninfected (HEU) is a major public health concern as HIV becomes a chronic condition. We investigate the interrelationship between maternal viral suppression, maternal weight status, breastfeeding, and infants that are HEU. METHODS:The Kabeho study followed 502 H...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2020.08.008
更新日期：2021-01-01 00:00:00
abstract：PURPOSE:Diabetes increases the risk of ischemic heart disease (IHD). Stringent control of diabetes does not reliably reduce cardiovascular events. Some global regions, such as East Asia, have low mortality rates from IHD and high rates of diabetes. We hypothesized that some aspects of liver function might underlie this...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2012.08.003
更新日期：2012-11-01 00:00:00
abstract：PURPOSE:To identify individual- and neighborhood-level correlates of membership within high HIV prevalence drug networks. METHODS:We recruited 378 New York City drug users via respondent-driven sampling (2006-2009). Individual-level characteristics and recruiter-recruit relationships were ascertained and merged with 2...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2013.02.006
更新日期：2013-05-01 00:00:00
