Depressive symptoms have an independent, gradient risk for coronary heart disease incidence in a random, population-based sample.

Abstract:

PURPOSE:Depression is a risk factor for incident coronary heart disease (CHD), and predicts poor prognosis for patients post-myocardial infarction (MI). Few population-based, prospective studies have tested a gradient risk for depressive symptoms on CHD incidence. METHODS:The sample (n=1302) was derived from the Nova Scotia Health Survey-1995 (NSHS95), an age- and sex-stratified, random, population-based health survey. All subjects were 45 years or older, free of overt CHD at baseline, and completed the Center for Epidemiological Studies-Depression (CES-D) scale. Covariates included age, sex, body mass index, physical activity level, family history of premature CHD, diastolic blood pressure, lipids, smoking, alcohol use, diabetes, and education level. For the 4 years following NSHS95, MI-related hospitalizations (ICD-9-CM code 410) and CHD-related deaths (ICD-9-CM codes 410-414) were extracted from the provincial, universal healthcare registry. RESULTS:Fifty-two participants experienced a CHD event. A one standard-deviation increase in CES-D score was associated with a 1.32 hazard risk (confidence interval, 1.01-1.71) of CHD events, controlling for established CHD risk factors. CONCLUSIONS:An independent, gradient association between depression and incident CHD was detected in a population-based sample with complete 4-year CHD data. This evidence supports the value of investigating mechanisms linking depression and CHD.

journal_name

Ann Epidemiol

journal_title

Annals of epidemiology

authors

Rowan PJ,Haas D,Campbell JA,Maclean DR,Davidson KW

doi

10.1016/j.annepidem.2004.08.006

keywords:

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

316-20

issue

4

eissn

1047-2797

issn

1873-2585

pii

S1047-2797(04)00269-8

journal_volume

15

pub_type

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