Abstract：
PURPOSE:We previously proposed an oxidative balance score (OBS) and illustrated its practical application by using data from previously completed case-control studies of two neoplasms - sporadic colorectal adenoma and prostate cancer. In the present study we extend our analysis by substituting questionnaire-based measures with systemic biomarkers of pro- and anti-oxidant exposures. METHODS:Low, medium and high pro-oxidant exposures, and high, medium and low antioxidant exposures were assigned 0, 1 and 2 points, respectively and individual points for all exposures were then summed to calculate the overall score. Case and controls were compared using logistic regression analysis after adjusting for covariates. RESULTS:When OBS was treated as a continuous variable the adjusted odds ratios and 95% confidence intervals (CI) for each additional score point were the same: 0.90 (95% CI: 0.83-0.97) for each study. When the OBS was divided into three approximately equal intervals, a comparison of the lowest to highest category showed similar adjusted ORs (95% CIs) of 0.34 (0.13-0.88) and 0.34 (0.14-0.86) for colorectal adenoma and prostate cancer, respectively. CONCLUSIONS:Our analyses provide support for the stated hypothesis that combined measures of pro- and anti-oxidant exposures may be associated with oxidative stress-related conditions.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Goodman M,Bostick RM,Gross M,Thyagarajan B,Dash C,Flanders WDdoi
10.1016/j.annepidem.2010.08.011subject
Has Abstractpub_date
2010-12-01 00:00:00pages
955-7issue
12eissn
1047-2797issn
1873-2585pii
S1047-2797(10)00349-2journal_volume
20pub_type
杂志文章abstract：PURPOSE:Medications can have unintended effects. High medication use populations may benefit from increased regimen oversight. Limited knowledge exists concerning racial and regional polypharmacy variation. We estimated total medication distributions (excluding supplements) of American black and white adults and assess...
journal_title：Annals of epidemiology
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abstract：:Many organizations in the United States recommend mammography screening at 1- to 2-year intervals for those 40 to 49 years old. In most areas of Canada and Europe, screening mammography is not recommended for women 40 to 49 years old. These differences have arisen over interpretation of data from the Health Insurance ...
journal_title：Annals of epidemiology
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journal_title：Annals of epidemiology
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pub_type： 杂志文章
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更新日期：2005-02-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1998-10-01 00:00:00
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journal_title：Annals of epidemiology
pub_type： 杂志文章,评审
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更新日期：2016-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-10-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/1047-2797(90)90019-o
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journal_title：Annals of epidemiology
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journal_title：Annals of epidemiology
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journal_title：Annals of epidemiology
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更新日期：2021-01-01 00:00:00
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journal_title：Annals of epidemiology
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journal_title：Annals of epidemiology
pub_type： 杂志文章
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更新日期：2001-08-01 00:00:00
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journal_title：Annals of epidemiology
pub_type： 杂志文章
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更新日期：2001-11-01 00:00:00
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journal_title：Annals of epidemiology
pub_type： 杂志文章
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journal_title：Annals of epidemiology
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journal_title：Annals of epidemiology
pub_type： 杂志文章
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更新日期：2008-02-01 00:00:00
