Abstract：
PURPOSE:Medications can have unintended effects. High medication use populations may benefit from increased regimen oversight. Limited knowledge exists concerning racial and regional polypharmacy variation. We estimated total medication distributions (excluding supplements) of American black and white adults and assessed racial and regional polypharmacy variation. METHODS:REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort data (n = 30,239 U.S. blacks and whites aged ≥45 years) were analyzed. Home pill bottle inspections assessed the last two weeks' medications. Polypharmacy (≥8 medications) was determined by summing prescription and/or over-the-counter ingredients. Population-weighted logistic regression assessed polypharmacy's association with census region, race, and sex. RESULTS:The mean ingredient number was 4.12 (standard error = 0.039), with 15.7% of REGARDS using 8 ingredients or more. In crude comparisons, women used more medications than men, and blacks and whites reported similar mean ingredients. A cross-sectional, logistic model adjusting for demographics, socioeconomics, and comorbidities showed increased polypharmacy prevalence in whites versus blacks (OR [95% CI]: 0.63, [0.55-0.72]), women (1.94 [1.68-2.23]), and Southerners (broadly Southeasterners and Texans; 1.48 [1.17-1.87]) versus Northeasterners (broadly New England and upper Mid-Atlantic). Possible limitations include polypharmacy misclassification and model misspecification. CONCLUSION:Polypharmacy is common. Race and geography are associated with polypharmacy variation. Further study of underlying factors explaining these differences is warranted.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Cashion W,McClellan W,Howard G,Goyal A,Kleinbaum D,Goodman M,Prince V,Muntner P,McClure LA,McClellan A,Judd Sdoi
10.1016/j.annepidem.2015.01.018subject
Has Abstractpub_date
2015-06-01 00:00:00pages
433-438.e1issue
6eissn
1047-2797issn
1873-2585pii
S1047-2797(15)00046-0journal_volume
25pub_type
杂志文章abstract：PURPOSE:To examine chronic disease disparities by sexual orientation measurement among sexual minorities. METHODS:We pooled data from the 2009-2014 National Health and Nutrition Examination Survey to examine differences in chronic disease prevalence between heterosexual and sexual minority people as defined by sexual ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2017.12.001
更新日期：2018-02-01 00:00:00
abstract：PURPOSE:Undiagnosed diabetes disproportionately affects medically underserved groups. It is unknown whether being an immigrant confers additional risk for undiagnosed diabetes. The purpose of this study was to examine independent associations of immigrant status and race/ethnicity with the prevalence of diagnosed and u...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2020.07.009
更新日期：2020-11-01 00:00:00
abstract：PURPOSE:While high levels of obesity prevalence and incidence have been well documented, there is less research on obesity dynamics over time. In this article, we sought to understand the body mass index (BMI) trajectories in and out of obesity from adolescence to adulthood. METHODS:We used the National Longitudinal S...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2019.12.003
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:To assess intake of several vitamins in preparation for a large cohort study investigating the effect of diet on risk of colon and prostate cancer. METHODS:The dietary intake of several vitamins were assessed using eight different 24-hour recalls and a 200-item food frequency questionnaire (FFQ) from each subj...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(01)00224-1
更新日期：2001-08-01 00:00:00
abstract：:Prospective data from the National Heart, Lung, and Blood Institute (NHLBI) Twin Study were used to investigate the relationship of risk factors measured in 1970 to 1971 to 16-year incidence of ischemic heart disease (IHD) in 905 males born between 1917 and 1927. A newly developed methodology, tree-structured survival...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(94)90097-3
更新日期：1994-05-01 00:00:00
abstract：PURPOSE:The purpose of this study is to examine how nutrients can affect the relationship between the development of metabolic syndrome (MS) and socioeconomic factors. METHODS:This study was based on data obtained from the 2005 Korea National Health and Nutrition Examination Survey was conducted as a health survey of ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2011.07.006
更新日期：2011-12-01 00:00:00
abstract：PURPOSE:To examine the association between folic acid (FA) supplementation obtained through either single FA tablets or multivitamins (MVs) and menstrual cycle characteristics among 5386 women aged 18-40 years, enrolled in an Internet-based study of Danish women attempting pregnancy during 2007-2011. METHODS:In a cros...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2015.05.008
更新日期：2015-10-01 00:00:00
abstract：:The incidence of Lyme disease (LD) reported to the Maryland Department of Health and Mental Hygiene during 1992 was 6.5/100,000 population, ranging from 29.3 cases/100,000 on the Eastern Shore (74.4% of all cases) to no cases in the mountains of western Maryland. Among the 317 reported patients, 44.4% gave a history o...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(95)00096-8
更新日期：1996-01-01 00:00:00
abstract：PURPOSE:We aimed to explore the relationship between physician characteristics and their prescribing behavior regarding category D and X drugs for pregnant women by using a population-based data set in Taiwan. METHODS:The sampled population for the study included 14,430 women. These women received a total of 198,420 p...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2012.11.007
更新日期：2013-02-01 00:00:00
abstract：PURPOSE:To examine the associations among Alzheimer's disease, hip fractures, and falls in elderly Canadians > or = 65 years of age (n=1513) who participated in the National Population Health Survey for Health Institutions between 1994 and 1995. METHODS:The survey was designed to provide health-related information for...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2003.08.005
更新日期：2004-05-01 00:00:00
abstract：:The Expanded Programme on Immunization (EPI) of the World Health Organization developed a cluster survey design for the rapid assessment of children's vaccination coverage in developing countries. Because of its simplicity and familiarity, the EPI methodology has been used for additional purposes, including the detect...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(94)90086-8
更新日期：1994-07-01 00:00:00
abstract：:Phase I of the Trials of Hypertension Prevention was designed to test the effectiveness and safety of three life-style (weight loss, sodium restriction, and stress management) and four nutrition supplement (calcium, magnesium, potassium, and fish oil) interventions in reducing diastolic blood pressure (DBP) in persons...
journal_title：Annals of epidemiology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/1047-2797(92)90062-u
更新日期：1992-05-01 00:00:00
abstract：PURPOSE:To evaluate the association between active and passive smoking and frequency of colds in women. METHODS:Data on cigarette smoking and frequency and duration of colds were analyzed in the Women's Health Study (WHS), a randomized, double-blind, placebo-controlled trial of low-dose aspirin and vitamin E in the pr...
journal_title：Annals of epidemiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s1047-2797(00)00214-3
更新日期：2001-05-01 00:00:00
abstract：PURPOSE:The Black Women's Health Study (BWHS) was designed to investigate determinants of health and disease in US black women. More than 64,000 women are enrolled in the BWHS cohort. This study assessed the relative validity of the 68-item food frequency questionnaire (FFQ) used in the BWHS baseline questionnaire. ME...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(02)00253-3
更新日期：2003-02-01 00:00:00
abstract：PURPOSE:C-reactive protein (CRP), androgens, and menopausal loss of endogenous estrogens are associated with cardiovascular disease (CVD). We hypothesized that high androgens, low estradiol, and low sex hormone-binding globulin (SHBG) would be associated with high CRP in postmenopausal women. METHODS:CRP, SHBG, estrad...
journal_title：Annals of epidemiology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.annepidem.2005.07.055
更新日期：2006-02-01 00:00:00
abstract：PURPOSE:Accidental falls are a major public health concern among people of all ages. Little is known about whether an individual-level housing-based socioeconomic status measure is associated with the risk of accidental falls. METHODS:Among 12,286 Mayo Clinic Biobank participants residing in Olmsted County, Minnesota,...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2017.05.019
更新日期：2017-07-01 00:00:00
abstract：PURPOSE:Health and mortality of people released from incarceration have received increased attention, and yet little is known about the postrelease experiences of those hospitalized during incarceration. METHODS:For persons incarcerated and released from the North Carolina (NC) state prison system between January 1, 2...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2020.03.006
更新日期：2020-05-01 00:00:00
abstract：:PURPOSE: Although most US women who undergo mammography screening also receive a Clinical Breast Examination (CBE), factors that predict cancer detection during a CBE have not been well studied to date.METHODS: We analyzed 752,081 National Breast and Cervical Cancer Early Detection Program (NBCCEDP) screening records ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(00)00099-5
更新日期：2000-10-01 00:00:00
abstract：PURPOSE:Alcohol consumption has been implicated in the pathogenesis of cataract in some, but not all analytic studies. To date, no prospective analysis of the relationship between alcohol consumption and cataract has been conducted in women. METHODS:We examined the association between alcohol consumption and cataract ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(00)00054-5
更新日期：2000-08-01 00:00:00
abstract：PURPOSE:The purpose of this study was to investigate whether individual, family, and community assets can 1) protect youth from binge drinking in the face of negative life events and 2) modify the relationship between negative life events and binge drinking. METHODS:Data from waves 2-5 of the Youth Asset Study were an...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2020.04.005
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:Although prospective data are limited, recent cross-sectional studies support obesity as a cause of asthma. They also suggest that the association is present only among women. Our analysis examines possible sex-race differences in the relationship between obesity and asthma. METHODS:We examined data from the 2...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(03)00054-1
更新日期：2003-11-01 00:00:00
abstract：PURPOSE:Incidence studies of occupational factors and cancer in the United States are problematic because the use of population-based registries to identify cases requires development of historical data on subjects' residences and often severely restricts the time period of follow up. This article describes procedures ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2005.06.055
更新日期：2006-03-01 00:00:00
abstract：:A study of blood lipid levels in adolescent students in rural and urban areas of Greece was undertaken. Blood samples were drawn from 307 adolescents aged 12 to 18 years attending two rural and two urban high schools of different socioeconomic level (urban/lower, urban/higher). Obesity among adolescents had statistica...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(94)00094-a
更新日期：1995-07-01 00:00:00
abstract：PURPOSE:Heterocyclic amines (HCAs), which are found mainly in well-cooked meat, require metabolic activation to function as mutagens and animal carcinogens. Enzymes such as cytochrome P4501A2 (CYP1A2) and N-acetyltransferase (NAT2) perform this task and are subject to interindividual variation. The source of this varia...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(97)00027-6
更新日期：1997-07-01 00:00:00
abstract：:Populations vary in consistency of diets. The precision of estimates (E) of nutrient intake depends both on the ratio (R) of intraindividual to interindividual variances, as well as on the number of days of dietary intake recorded (k). We present baseline data from 872 participants in the Trial of Antihypertensive Int...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(93)90085-i
更新日期：1993-11-01 00:00:00
abstract：:The longitudinal relationship between serum levels of lipoproteins and lifestyle measures (e.g., intake of cholesterol, carbohydrates, saturated fatty acids [SFA], polyunsaturated fatty acids [PUFA], the PUFA/SFA (P:S) ratio, alcohol consumption, smoking behavior, and daily physical activity) was investigated over a p...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(96)00003-8
更新日期：1996-05-01 00:00:00
abstract：PURPOSE:We sought to examine the importance of childhood circumstances, adult socioeconomic status, and material circumstances to physical and mental functioning among middle-aged women and men. METHODS:The data were collected among the employees of the City of Helsinki by mailed questionnaires from 2000 to 2002 (7148...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2006.11.003
更新日期：2007-06-01 00:00:00
abstract：PURPOSE:To examine the mortality risk associated with diabetes in the Mexico City Diabetes Study (MCDS) and the San Antonio Heart Study (SAHS). METHODS:Prospective cohorts conducted 1990-2007 in MCDS and 1979-2000 in SAHS. Mortality risk was examined using Cox proportional hazard models in 1402 non-Hispanic whites (NH...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2011.07.003
更新日期：2011-12-01 00:00:00
abstract：PURPOSE:The purpose of this study was to assess the relationship of alcohol consumption and intake of 15 selected micronutrients with risk of liver cirrhosis. METHODS:Data from a case-control study performed in 1989-1990 in central Italy involving 115 incident cases and 167 hospital controls were used. RESULTS:Cases ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(97)00193-2
更新日期：1998-04-01 00:00:00
abstract：:Injuries are the leading cause of death for females 1 to 34 years old, and a major source of preventable morbidity and mortality in middle-aged and elderly women. In the United States, 43,000 women die from injuries and approximately 1 million women are hospitalized for injuries annually. The leading causes of injury ...
journal_title：Annals of epidemiology
pub_type： 杂志文章,评审
doi：10.1016/1047-2797(94)90059-0
更新日期：1994-03-01 00:00:00
