Abstract：
PURPOSE:To determine whether 3-hydroxy-3-methylglutaryl coenzyme A inhibitors (statins) are associated with a decreased risk of colorectal cancer. METHODS:The population included 159,219 postmenopausal women enrolled in the Women's Health Initiative in which 2000 pathologically confirmed cases of colorectal cancer were identified during an average of 10.7 (S.D. 2.9) years. Information on statins was collected at baseline and years 1, 3, 6, and 9. Self- and interviewer-administered questionnaires were used to collect information on other risk factors. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated by the use of Cox proportional hazards regression to evaluate the relationship between statin use and risk. Statistical tests were two-sided. RESULTS:Statins were used by 12,030 (7.6%) women at baseline. The annualized colorectal cancer rate was 0.13% among users and 0.12% among nonusers. The multivariable adjusted HR for users versus nonusers was 0.99 (95% confidence interval [CI], 0.83-1.20, p = .95), and 0.79 (95% CI, 0.56-1.11) for users of ≥3 years. In the multivariable adjusted time-dependent model, the HR for lovastatin was 0.62 (95% CI, 0.39-0.99). There was no effect of tumor location, stage or grade. CONCLUSIONS:There was a reduction in colorectal cancer risk associated with lovastatin and a nonsignificant association with longer duration of use.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Simon MS,Rosenberg CA,Rodabough RJ,Greenland P,Ockene I,Roy HK,Lane DS,Cauley JA,Khandekar Jdoi
10.1016/j.annepidem.2011.10.006subject
Has Abstractpub_date
2012-01-01 00:00:00pages
17-27issue
1eissn
1047-2797issn
1873-2585pii
S1047-2797(11)00302-4journal_volume
22pub_type
杂志文章abstract：:PURPOSE: To assist in elucidating principles underlying the design of injury case-control studies.APPROACH: We begin by defining "event" as the sequence of circumstances that place a person at risk of injury (e.g. bicycle crash) and "injury given the event" as the resultant physical damage (e.g. head injury in bicycle...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(00)00134-4
更新日期：2000-10-01 00:00:00
abstract：PURPOSE:Understanding how to mitigate the present black-white obesity disparity in the United States is a complex issue, stemming from a multitude of intertwined causes. An appropriate but underused approach to guiding policy approaches to this problem is to account for this complexity using simulation modeling. METHO...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2014.05.012
更新日期：2014-08-01 00:00:00
abstract：PURPOSE:This report describes Centers for Disease Control and Prevention programs that expose students to epidemiology and public health sciences (EPHS). METHODS:The Science Ambassador workshop targets middle and high school teachers and promotes teaching EPHS in the classroom. The National Science Olympiad Disease De...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2017.09.010
更新日期：2017-11-01 00:00:00
abstract：PURPOSE:Exposure to residential magnetic fields may disrupt the normal nocturnal rise in melatonin levels, resulting in increased risk for breast cancer, possibly through increased levels of reproductive hormones. We investigated whether exposure to a 60-Hz magnetic field under controlled conditions is associated with ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2005.11.005
更新日期：2006-08-01 00:00:00
abstract：PURPOSE:To examine whether maternal fever during pregnancy is associated with reduced head circumference and risk of microcephaly at birth. METHODS:A prospective study of 86,980 live-born singletons within the Danish National Birth Cohort was carried out. Self-reported maternal fever exposure was ascertained in two in...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2017.11.011
更新日期：2018-02-01 00:00:00
abstract：:The association of physical activity to plasma lipid and lipoprotein levels was examined cross-sectionally in 634 elderly, postmenopausal women whose mean age was 70.7 years. Leisure-time physical activity in kilocalories per week was assessed by the Paffenbarger Questionnaire, a composite index of sports/recreation, ...
journal_title：Annals of epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1016/1047-2797(93)90061-8
更新日期：1993-07-01 00:00:00
abstract：PURPOSE:To examine associations between racial discrimination, mood disorders, and cardiovascular disease (CVD) among Black Americans. METHODS:Weighted logistic regression analyses were performed on a nationally representative sample of Black Americans (n = 5022) in the National Survey of American Life (NSAL; 2001-200...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2011.10.009
更新日期：2012-02-01 00:00:00
abstract：PURPOSE:C-reactive protein (CRP), Chlamydia pneumonia, Helicobacter pylori, and cytomegalovirus (CMV) have each been associated with atherosclerosis. We assessed how infection and CRP related to risk for subsequent myocardial infarction (MI). METHODS:Using a nested case-control design, we assessed how these factors in...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(02)00276-4
更新日期：2003-03-01 00:00:00
abstract：PURPOSE:Little is known about how seasonal variation in physical activity relates to declining physical activity in adolescence. We quantified how each of daily weather conditions and season affect physical activity during adolescence. METHODS:We followed 1293 students, initially aged 12 to 13 years over 5 years. Part...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2008.12.008
更新日期：2009-03-01 00:00:00
abstract：PURPOSE:We examined whether differences in findings of studies examining mild cognitive impairment (MCI) were associated with recruitment methods by comparing sample characteristics in two contemporaneous Australian studies, using population-based and convenience sampling. METHOD:The Sydney Memory and Aging Study invi...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2013.10.005
更新日期：2014-01-01 00:00:00
abstract：:The association between educational attainment and decline in cognitive function over an interval of 1 year was examined for 14,883 subjects 18 years and older in the National Institute of Mental Health Epidemiologic Catchment Area Study. Cognitive function was assessed at both time points by the Mini-Mental State Exa...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(94)00047-w
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:To determine if the timing for requesting signed permission to access personal health services utilization records affects authorization or survey response rates. METHODS:A screening question about in-principle willingness to permit access to personal health services utilization records was included in a mail-...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(01)00261-7
更新日期：2002-07-01 00:00:00
abstract：PURPOSE:To compare the estimates of HIV-related risk derived from a sample drawn through random digit dialing and that component of the sample drawn from households listed in a telephone directory. METHODS:The prevalence of key outcomes, and their 95% confidence intervals, was estimated for the total sample and for th...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2004.06.003
更新日期：2005-03-01 00:00:00
abstract：PURPOSE:When conducting analyses of child weight growth trajectories, researchers commonly use Z-scores from a standard instead of the observed weights. However, these Z-scores, calculated from cross-sectional data, may introduce methodological limitations when used in the context of longitudinal analyses. We assessed ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2018.04.006
更新日期：2018-08-01 00:00:00
abstract：PURPOSE:The histamine-2 (H(2)) blocker cimetidine may alter androgen, zinc, and prolactin levels, which could alter prostate cancer risk. Increased risk for men filling more than 20 cimetidine prescriptions was reported previously. We examined the association between cimetidine use and prostate cancer risk in a cohort ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2006.03.003
更新日期：2006-12-01 00:00:00
abstract：PURPOSE:We aimed to investigate the prevalence and prognostic impact of tumor mesenchymal epithelial transition factor (MET) expression in stage IV gastric cancers in a real-world clinical setting because existing evidence is sparse. METHODS:The study included archived cancer specimens from 103 stage IV gastric cancer...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2016.05.002
更新日期：2016-07-01 00:00:00
abstract：PURPOSE:Before AIDS, endemic (African) Kaposi sarcoma (KS) was noted to occur in volcanic areas and was postulated to result from dirt chronically embedded in the skin of the lower extremities. The primary cause of all KS types is KS-associated herpesvirus (KSHV) infection, but cofactors contribute to the neoplasia. We...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2009.04.002
更新日期：2009-08-01 00:00:00
abstract：:The validity of a 77-item food-frequency questionnaire (FFQ) developed for a multicenter case-control study on diet and cancer in Italy was assessed. Trained interviewers administered the same FFQ to 452 volunteers from three Italian provinces (Pordenone, Genoa, and Forli) completed in two different seasons, at an int...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(95)00129-8
更新日期：1996-03-01 00:00:00
abstract：PURPOSE:The etiology of congenital cerebral palsy is unclear. Recent studies have suggested that maternal infection is involved. Indirect, but supportive, evidence for an infectious hypothesis would be provided by the finding of space-time clustering. METHODS:We analyzed all 906 cases born during the period 1991-2003 ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2007.07.104
更新日期：2008-02-01 00:00:00
abstract：PURPOSE:We estimated female and male incident AIDS diagnosis rates (IARs) among people who inject drugs (PWID) in U.S. metropolitan statistical areas (MSAs) over time to assess whether declines in IARs varied by sex after combination antiretroviral therapy (cART) dissemination. METHODS:We compared IARs and 95% confide...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2015.01.006
更新日期：2015-04-01 00:00:00
abstract：PURPOSE:The developmental origins of adult disease hypothesis suggests that the intrauterine environment may program postnatal health outcomes through mechanisms such as chronic inflammation. The purpose of this article was to review the literature on the association between infant birth weight and C-reactive protein (...
journal_title：Annals of epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.annepidem.2015.01.003
更新日期：2015-07-01 00:00:00
abstract：PURPOSE:The purpose of this study was to investigate whether or not clustering of biological coronary heart disease (CHD) risk factors exists and to investigate the longitudinal relationship between lifestyle parameters (dietary intake, daily physical activity, smoking behaviour, alcohol consumption) and a biological C...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(00)00202-7
更新日期：2001-04-01 00:00:00
abstract：:PURPOSE: Evaluating the impact of population-based rehabilitation interventions for work-related low back disorders (WR-LBD) requires job exposure factors to be considered as time-varying covariates. The role of job factors in recovery has not been well-established as most studies are based upon clinic samples, not wo...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(00)00165-4
更新日期：2000-10-01 00:00:00
abstract：PURPOSE:To examine the synergism between vital exhaustion and cigarette smoking in producing ischemic stroke. Vital exhaustion (VE), a state characterized by unusual fatigue, irritability, and feelings of demoralization, is measured by the Maastricht questionnaire (MQ), a 21-item inventory of symptoms. METHODS:The Ath...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2003.10.010
更新日期：2004-07-01 00:00:00
abstract：PURPOSE:To demonstrate how principal components analysis can be used to describe patterns of weight changes in response to an intensive lifestyle intervention. METHODS:Principal components analysis was applied to monthly percent weight changes measured on 2,485 individuals enrolled in the lifestyle arm of the Action f...
journal_title：Annals of epidemiology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.annepidem.2009.06.001
更新日期：2009-10-01 00:00:00
abstract：PURPOSE:We sought to explore the effect of economic/political factors and gender progress on femicide. METHODS:An ecological and retrospective study was undertaken that focused on 61 countries and analyzed the relationships of femicide with the following statistics from the period 1990 to 1999: economic indicators (do...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2007.11.007
更新日期：2008-04-01 00:00:00
abstract：PURPOSE:The mucosa of the small intestine encompasses about 90% of the luminal surface area of the digestive system, but only 2% of the total annual gastrointestinal cancer incidence in the United States. METHODS:The remarkable contrast in age-standardized cancer incidence between the small and large intestine has bee...
journal_title：Annals of epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.annepidem.2008.10.004
更新日期：2009-01-01 00:00:00
abstract：:Prospective data from the National Heart, Lung, and Blood Institute (NHLBI) Twin Study were used to investigate the relationship of risk factors measured in 1970 to 1971 to 16-year incidence of ischemic heart disease (IHD) in 905 males born between 1917 and 1927. A newly developed methodology, tree-structured survival...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(94)90097-3
更新日期：1994-05-01 00:00:00
abstract：PURPOSE:To identify, map, and synthesize the individual-level key associations and modes of exposure for hepatitis C virus (HCV) infection in the Middle East and North Africa (MENA), the most affected region by HCV. METHODS:Source of data was the MENA HCV Epidemiology Synthesis Project database, populated through syst...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2018.03.007
更新日期：2018-07-01 00:00:00
abstract：PURPOSE:We examined the role of smoking in the two dimensions behind the time trends in adult mortality in European countries, that is, rectangularization of the survival curve (mortality compression) and longevity extension (increase in the age-at-death). METHODS:Using data on national sex-specific populations aged 5...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2015.01.007
更新日期：2015-04-01 00:00:00
