Abstract:
PURPOSE:C-reactive protein (CRP), Chlamydia pneumonia, Helicobacter pylori, and cytomegalovirus (CMV) have each been associated with atherosclerosis. We assessed how infection and CRP related to risk for subsequent myocardial infarction (MI). METHODS:Using a nested case-control design, we assessed how these factors independently and jointly affected risk for myocardial infarction (MI). Cases of first MI (N = 121) were identified from among participants in a multiphasic health check-up cohort. Controls without MI (N = 204) were matched to cases by gender, age, race, and date of serum collection. Sera collected at enrollment were tested for antibodies to infection and for CRP. RESULTS:In multivariate analysis (mean follow-up of 5.1 years), CRP was associated with MI only in subjects older than 51 years (p = 0.004). Although H. pylori infection increased risk for MI, this association was modest (OR = 1.90, 95% CI = 0.97-3.71) and was not evident in non-smokers or when adjusted for education. No association between C. pneumoniae or cytomegalovirus and MI was observed, nor was the association between CRP and MI explained by these infections. CONCLUSIONS:Elevated CRP is a risk factor for subsequent MI in older individuals. The relationship between Hp and MI may be due to confounding or co-linearity with socioeconomic status.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Witherell HL,Smith KL,Friedman GD,Ley C,Thom DH,Orentreich N,Vogelman JH,Parsonnet Jdoi
10.1016/s1047-2797(02)00276-4keywords:
subject
Has Abstractpub_date
2003-03-01 00:00:00pages
170-7issue
3eissn
1047-2797issn
1873-2585pii
S1047279702002764journal_volume
13pub_type
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pub_type: 临床试验,杂志文章,随机对照试验
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