Smoking during first pregnancy and breast cancer: a case-control study using Washington State registry data.

Abstract:

PURPOSE:To examine whether smoking during first pregnancy, a time of potential vulnerability to tobacco mutagens, is associated with breast cancer. METHODS:We conducted a nested case-control study within a cohort of Washington State residents with first deliveries during 1984-1999, identified in birth and fetal death records. Linkage to population-based cancer registry data identified 1,099 women in the cohort aged 65 years and younger diagnosed with breast cancer in 1985-2000. Controls (N=10,922) were matched by year and age of first delivery, race/ethnicity, and birth outcome. Maternal smoking and other variables characterizing the pregnancy were obtained from birth and fetal death records. Conditional logistic regression was used to analyze the data. RESULTS:The adjusted risk ratio for breast cancer was 0.8, 95% confidence interval 0.7-0.9, among women who smoked during their pregnancy compared with similar women who did not smoke. When the sample was restricted to known state residents at the time of the matched case's diagnosis, there was no association (risk ratio 1.0; 0.8-1.1). CONCLUSIONS:Our results do not suggest that cigarette smoking during first pregnancy increases the risk of breast cancer.

journal_name

Ann Epidemiol

journal_title

Annals of epidemiology

authors

DeRoo LA,Cummings P,Daling JR,Mueller BA

doi

10.1016/j.annepidem.2010.09.004

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

53-5

issue

1

eissn

1047-2797

issn

1873-2585

pii

S1047-2797(10)00368-6

journal_volume

21

pub_type

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