Abstract：
PURPOSE:In longitudinal studies, the onset of the index condition (e.g. exposure) does not always coincide with the start of a study's observation period, leading to the possibility of bias in estimation that derives from studying prevalent exposure rather than new exposure. We investigate the possible role of this bias in the relationship between periodontitis progression and coronary heart disease (CHD) among a cohort of men participating in the Veterans Administration Dental Longitudinal Study. METHODS:At baseline, there were 298 men with existing (i.e., prevalent) periodontitis. During follow-up, routine dental inspection identified 163 new (i.e., incident) cases of periodontitis. Change in mean alveolar bone loss score (MBLS) served as the measure of disease progression. Tabular analyses were performed to obtain crude, stratified, and adjusted measures of the association for periodontitis cases overall and separately for prevalent and incident cases. Potential bias was evaluated by comparing estimates across these subcohorts. RESULTS:Among all periodontitis cases, increasing MBLS was associated with increasing risk of CHD event. Subdividing periodontal cases into new and prevalent cases revealed that the relationship was most pronounced among incident periodontitis cases (incident rate ratio for MBLS change >0.5 = 5.4), compared with prevalent cases (incident rate ratio for MBLS change >0.5 = 2.5). CONCLUSIONS:Studying prevalent cases of periodontitis underestimates the association between incidence periodontitis and CHD.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Heaton B,Applebaum KM,Rothman KJ,Brooks DR,Heeren T,Dietrich T,Garcia RIdoi
10.1016/j.annepidem.2014.07.006subject
Has Abstractpub_date
2014-10-01 00:00:00pages
741-6issue
10eissn
1047-2797issn
1873-2585pii
S1047-2797(14)00351-2journal_volume
24pub_type
杂志文章abstract：PURPOSE:A U-shaped relation between alcohol use and mortality may be due to biological hormesis, differential response (i.e., effect modification) by health status or changes in alcohol use with ill-health and aging (i.e., reverse causality).We examined whether alcohol had the same association with mortality in healthy...
journal_title：Annals of epidemiology
pub_type： 杂志文章
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更新日期：2009-06-01 00:00:00
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journal_title：Annals of epidemiology
pub_type： 历史文章,杂志文章
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journal_title：Annals of epidemiology
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journal_title：Annals of epidemiology
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journal_title：Annals of epidemiology
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更新日期：2013-09-01 00:00:00
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pub_type： 杂志文章
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journal_title：Annals of epidemiology
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journal_title：Annals of epidemiology
pub_type： 杂志文章
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更新日期：2007-11-01 00:00:00
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journal_title：Annals of epidemiology
pub_type： 杂志文章
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更新日期：2008-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：1992-07-01 00:00:00
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journal_title：Annals of epidemiology
pub_type： 杂志文章
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更新日期：1998-05-01 00:00:00
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journal_title：Annals of epidemiology
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更新日期：2006-12-01 00:00:00
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journal_title：Annals of epidemiology
pub_type： 杂志文章
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更新日期：2000-10-01 00:00:00
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journal_title：Annals of epidemiology
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journal_title：Annals of epidemiology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1990-10-01 00:00:00
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journal_title：Annals of epidemiology
pub_type： 杂志文章
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更新日期：2011-02-01 00:00:00
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journal_title：Annals of epidemiology
pub_type： 杂志文章
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更新日期：1997-10-01 00:00:00
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journal_title：Annals of epidemiology
pub_type： 杂志文章
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更新日期：2018-02-01 00:00:00
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journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2013.12.013
更新日期：2014-05-01 00:00:00
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journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2011.07.003
更新日期：2011-12-01 00:00:00
