Abstract：
PURPOSE:Physical activity helps maintain mobility, physical functioning, bone mineral density (BMD), muscle strength, balance and, therefore, may help prevent falls and fractures among the elderly. Meanwhile, it is theoretically possible that physical activity increases risk of fractures as it may increase risk of falls and has only a modest effect on BMD. This review aims to assess the potential causal association between physical activity and osteoporotic fractures from an epidemiological viewpoint. METHODS:As the medical literature lacks direct evidence from randomized controlled trials (RCTs) with fracture end points, a meta-analysis of 13 prospective cohort studies with hip fracture end point is presented. The current evidence base regarding the link between exercise and fracture risk determinants (namely, falls, BMD, and bone quality) are also summarized. RESULTS:Moderate-to-vigorous physical activity is associated with a hip fracture risk reduction of 45% (95% CI, 31-56%) and 38% (95% CI, 31-44%), respectively, among men and women. Risk of falling is suggested to be generally reduced among physically active people with a potential increased risk in the most active and inactive people. Positive effects of physical activity on BMD and bone quality are of a questionable magnitude for reduction of fracture risk. CONCLUSION:The complexity of relationship between physical activity and osteoporotic fractures points out to the need for RCTs to be conducted with fractures as the primary end point.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Moayyeri Adoi
10.1016/j.annepidem.2008.08.007subject
Has Abstractpub_date
2008-11-01 00:00:00pages
827-35issue
11eissn
1047-2797issn
1873-2585pii
S1047-2797(08)00166-Xjournal_volume
18pub_type
杂志文章,meta分析abstract：:Injuries are the leading cause of death for females 1 to 34 years old, and a major source of preventable morbidity and mortality in middle-aged and elderly women. In the United States, 43,000 women die from injuries and approximately 1 million women are hospitalized for injuries annually. The leading causes of injury ...
journal_title：Annals of epidemiology
pub_type： 杂志文章,评审
doi：10.1016/1047-2797(94)90059-0
更新日期：1994-03-01 00:00:00
abstract：PURPOSE:Alcohol consumption has been implicated in the pathogenesis of cataract in some, but not all analytic studies. To date, no prospective analysis of the relationship between alcohol consumption and cataract has been conducted in women. METHODS:We examined the association between alcohol consumption and cataract ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(00)00054-5
更新日期：2000-08-01 00:00:00
abstract：PURPOSE:The mucosa of the small intestine encompasses about 90% of the luminal surface area of the digestive system, but only 2% of the total annual gastrointestinal cancer incidence in the United States. METHODS:The remarkable contrast in age-standardized cancer incidence between the small and large intestine has bee...
journal_title：Annals of epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.annepidem.2008.10.004
更新日期：2009-01-01 00:00:00
abstract：PURPOSE:To examine prospectively the relationship between vegetable consumption and long-term survival. METHODS:In 1965, a total of 1536 Italian males from two Italian rural cohorts of the Seven Countries Study, aged 45-65 years, were examined. Information on lifestyle and food consumption collected at this visit, and...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(02)00457-x
更新日期：2003-07-01 00:00:00
abstract：:Information obtained during the past decade suggests that the onset of myocardial infarction and sudden cardiac death is frequently triggered by daily activities. The importance of physical or mental stress in triggering coronary thrombosis is supported by finding that (1) the frequencies of the onset of myocardial in...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(92)90088-8
更新日期：1992-07-01 00:00:00
abstract：PURPOSE:To examine the association of depressive symptoms with coronary heart disease (CHD) end points by race and income. METHODS:Study participants were blacks and whites (n = 24,443) without CHD at baseline from the national Reasons for Geographical and Racial Differences in Stroke cohort. Outcomes included acute C...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2015.03.014
更新日期：2015-06-01 00:00:00
abstract：PURPOSE:Birth weight (BW) is associated with risk of cardiovascular (CV) disease. The findings from studies examined the association of BW with metabolic markers of CV risk were inconsistent and controversial. We examined the association of BW with insulin resistance and blood lipids using repeated measures up to mid-a...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2016.07.013
更新日期：2016-09-01 00:00:00
abstract：PURPOSE:The aim of this work was to evaluate whether the number of components influences the diagnostic accuracy of a diet quality index and whether this association is affected by the intercorrelation structure of components and by the association of components with an outcome (intracorrelation). METHODS:Simulated da...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2009.03.019
更新日期：2009-10-01 00:00:00
abstract：:National and international policy-making organizations advocate nonpharmacologic therapies to reduce blood pressure (BP). However, data to support such recommendations in older persons are virtually nonexistent. The Trials of Nonpharmacologic Intervention in the Elderly (TONE) is a randomized, controlled trial that wi...
journal_title：Annals of epidemiology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/1047-2797(94)00056-y
更新日期：1995-03-01 00:00:00
abstract：:We take a critical look at the meaning behind the number 87% given to 25-year-old Sophie, a BRCA1 and BRCA2 carrier. Sophie has been told she has an 87% chance of getting breast cancer. She is contemplating a preventive double mastectomy after genetic counseling and her physician's advice. Some 92% of British general ...
journal_title：Annals of epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.annepidem.2017.09.005
更新日期：2017-10-01 00:00:00
abstract：PURPOSE:Depression is a risk factor for incident coronary heart disease (CHD), and predicts poor prognosis for patients post-myocardial infarction (MI). Few population-based, prospective studies have tested a gradient risk for depressive symptoms on CHD incidence. METHODS:The sample (n=1302) was derived from the Nova ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2004.08.006
更新日期：2005-04-01 00:00:00
abstract：PURPOSE:Many negative cognitive and behavioral outcomes have been identified among children living in households with parental violence, but few studies have examined academic performance. In a rural population-based cohort, we examine the role of parental violence on standardized test score performance. METHODS:The c...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2007.06.004
更新日期：2007-11-01 00:00:00
abstract：PURPOSE:To assess the relationships between lipid levels and sexual maturity, independently of age-related differences, and to investigate possible differences related to sexual maturity across the percentiles of the lipid distributions. METHODS:Fasting serum total cholesterol and triglyceride concentrations were meas...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(00)00056-9
更新日期：2000-07-01 00:00:00
abstract：PURPOSE:Previous studies suggest the association of recipient hepatitis C seropositivity (HCV+) and use of tacrolimus (TAC) with post-transplant diabetes mellitus (PTDM) may differ by manifestations of type I or type II diabetes, but this has not been assessed in the era of current immunosuppression. METHODS:We perfor...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2004.10.003
更新日期：2005-09-01 00:00:00
abstract：PURPOSE:To demonstrate how principal components analysis can be used to describe patterns of weight changes in response to an intensive lifestyle intervention. METHODS:Principal components analysis was applied to monthly percent weight changes measured on 2,485 individuals enrolled in the lifestyle arm of the Action f...
journal_title：Annals of epidemiology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.annepidem.2009.06.001
更新日期：2009-10-01 00:00:00
abstract：PURPOSE:Burden of disease (BoD) assessments typically rely on national-level incidence rates for the health outcomes of interest. The impact of using a constant national-level incidence rate, versus a more granular spatially varying rate, remains unknown and understudied in the literature. There has been an increasing ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2020.08.063
更新日期：2021-01-01 00:00:00
abstract：PURPOSE:The Multiple Risk Factor Intervention Trial (MRFIT), a randomized clinical trial for the primary prevention of coronary heart disease, enrolled 12,866 men (including 8194 cigarette smokers) aged 35-57 years at 22 clinical centers across the United States. Participants were randomized either to special intervent...
journal_title：Annals of epidemiology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s1047-2797(96)00123-8
更新日期：1997-02-01 00:00:00
abstract：PURPOSE:The purpose of this study was to investigate whether or not clustering of biological coronary heart disease (CHD) risk factors exists and to investigate the longitudinal relationship between lifestyle parameters (dietary intake, daily physical activity, smoking behaviour, alcohol consumption) and a biological C...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(00)00202-7
更新日期：2001-04-01 00:00:00
abstract：:The purpose of this report is to examine the association of histologic chorioamnionitis with microorganisms isolated from the fetal membranes and to evaluate whether microorganisms with or without inflammation are associated with labor characteristics and with pregnancy complications. Inflammation was more common amon...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(93)90013-t
更新日期：1993-01-01 00:00:00
abstract：PURPOSE:We previously proposed an oxidative balance score (OBS) and illustrated its practical application by using data from previously completed case-control studies of two neoplasms - sporadic colorectal adenoma and prostate cancer. In the present study we extend our analysis by substituting questionnaire-based measu...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2010.08.011
更新日期：2010-12-01 00:00:00
abstract：PURPOSE:Although prospective data are limited, recent cross-sectional studies support obesity as a cause of asthma. They also suggest that the association is present only among women. Our analysis examines possible sex-race differences in the relationship between obesity and asthma. METHODS:We examined data from the 2...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(03)00054-1
更新日期：2003-11-01 00:00:00
abstract：PURPOSE:Undiagnosed diabetes disproportionately affects medically underserved groups. It is unknown whether being an immigrant confers additional risk for undiagnosed diabetes. The purpose of this study was to examine independent associations of immigrant status and race/ethnicity with the prevalence of diagnosed and u...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2020.07.009
更新日期：2020-11-01 00:00:00
abstract：PURPOSE:The purpose of this study is to examine the relationship between labor force participation and gender differences in the prevalence of arthritis, diabetes, and hypertension. METHODS:The Mexican Health and Aging Survey (MHAS) data is nationally representative sample of older Mexicans 50 years and older. Binomia...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2008.04.005
更新日期：2008-08-01 00:00:00
abstract：PURPOSE:To examine whether maternal fever during pregnancy is associated with reduced head circumference and risk of microcephaly at birth. METHODS:A prospective study of 86,980 live-born singletons within the Danish National Birth Cohort was carried out. Self-reported maternal fever exposure was ascertained in two in...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2017.11.011
更新日期：2018-02-01 00:00:00
abstract：PURPOSE:Determinants of oxidative capacity, such as fitness and level of adiposity, are strongly associated with type 2 diabetes. Whether decreased oxidative capacity itself is a cause or consequence of insulin resistance and diabetes is unknown. METHODS:We examined the association of plasma lactate, a marker of oxida...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2013.09.005
更新日期：2013-12-01 00:00:00
abstract：PURPOSE:This study examined how race-ethnicity, nativity, and education interact to influence disparities in cardiovascular (CV) health, a new concept defined by the American Heart Association. We assessed whether race-ethnicity and nativity disparities in CV health vary by education and whether the foreign-born differ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2013.04.012
更新日期：2013-07-01 00:00:00
abstract：PURPOSE:We used a multiple logistic regression model to calculate benchmark doses (BMDs) and their 95% lower confidence bound (BMDL) of working hours for subjective fatigue symptoms. METHODS:A self-administered questionnaire survey was conducted in 3069 male daytime workers between the ages of 18 and 60 years who work...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2006.01.003
更新日期：2006-09-01 00:00:00
abstract：PURPOSE:While high levels of obesity prevalence and incidence have been well documented, there is less research on obesity dynamics over time. In this article, we sought to understand the body mass index (BMI) trajectories in and out of obesity from adolescence to adulthood. METHODS:We used the National Longitudinal S...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2019.12.003
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:To examine the relationship of gender, cigarette smoking, and a history of hypertension to the risk of aneurysmal subarachnoid hemorrhage (SAH), using a case-control study. METHODS:Case subjects consisted of a consecutive series of 201 patients with spontaneous SAH with aneurysm(s) confirmed by angiography and...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2005.02.001
更新日期：2005-11-01 00:00:00
abstract：PURPOSE:The purpose of this study was to estimate the heart rate variability (HRV)-related lifetime cardiovascular disease (CVD) risk. METHODS:We followed 9744 participants without baseline CVD and used a life-table approach to estimate lifetime CVD risk (coronary heart disease, heart failure, and stroke) from 45 thro...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2017.08.024
更新日期：2017-10-01 00:00:00
