Abstract:
:Human aminopeptidase N carries an apical sorting signal on its ectodomain necessary for its correct transport to the apical membrane in Madin-Darby canine kidney cells. To determine whether the apical sorting signal is localized in the serine/threonine rich stalk or in the catalytic head group, anchor/stalk-minus aminopeptidase N, consisting of the hemagglutinin signal peptide and the catalytic head group of human aminopeptidase N, was expressed in MDCK cells. Anchor/stalk-minus aminopeptidase N was secreted mainly to the apical side. The catalytic head group of human aminopeptidase N thus carries an apical sorting signal.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Vogel LK,Norén O,Sjöström Hdoi
10.1016/0014-5793(92)81039-okeywords:
subject
Has Abstractpub_date
1992-08-10 00:00:00pages
14-7issue
1eissn
0014-5793issn
1873-3468pii
0014-5793(92)81039-Ojournal_volume
308pub_type
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