当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY期刊下所有文献 > Inhibitory effect of retinoic acid on proliferation, maturation and tryptase level in human leukemic mast cells (HMC-1).

Inhibitory effect of retinoic acid on proliferation, maturation and tryptase level in human leukemic mast cells (HMC-1).

Abstract：

:Mast cells play important role in allergic inflammation by releasing histamine, tryptase and several inflammatory cytokines. Human leukemic mast cells (HMC-1) have been used to study mast cell mediator and their role in inflammatory mechanisms. HMC-1 contain and release several inflammatory mediators, of which the proteolytic enzyme tryptase is most characteristic. Retinoids, including retinoic acid, are naturally occurring and synthetic derivatives of vitamin A. All-trans-retinoic (ATRA) acid had been previously reported to inhibit cell proliferation, differentiation and apoptosis. In the present study, we investigated the effect of ATRA on the proliferation and secretion of tryptase in HMC-1. HMC-1 were treated with ATRA at 10(-4M), 10(-5M) or 10(-6M) for 3, 4 or 5 days in culture. Control HMC-1 were treated with equal amount of culture medium only. ATRA decreased the number of HMC-1 as compared to the control group. The same treatment for 3, 4 or 5 days also decreased intracellular tryptase levels. These results indicate that ATRA significantly inhibits both proliferation and growth as shown by the decreased intracellular tryptase levels in HMC-1. ATRA may be a useful agent in the treatment of mast cell proliferative disorders.

journal_name

Int J Immunopathol Pharmacol

journal_title

International journal of immunopathology and pharmacology

authors

Alexandrakis MG,Kyriakou DS,Seretakis D,Boucher W,Letourneau R,Kempuraj D,Theoharides TC

doi

10.1177/039463200301600106

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

43-7

issue

1

eissn

0394-6320

issn

2058-7384

pii

6

journal_volume

16

pub_type

杂志文章

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