Plasma total thiol pool in children with asthma: Modulation during montelukast monotherapy.

Abstract:

BACKGROUND:Inflammation, which is a hallmark of asthma, is one of the main sources of oxidative stress in the human body. Thiols are powerful antioxidants that protect cells against the consequences of oxidative stress. We aimed to investigate whether asthma and montelukast monotherapy affect the total plasma thiol pool in children. METHODS:A total of 60 children with asthma and 35 healthy controls participated in the study. Group I consisted of newly diagnosed asthmatics who did not have regular anti-asthmatic therapy previously. Group II consisted of patients who had been undertaking montelukast monotherapy regularly for at least 4 months. Plasma total antioxidant status (TAS) and plasma total thiol (PTT) were measured using spectrophotometric methods. RESULTS:Bronchial asthma patients in both groups I and II had decreased median TAS levels compared with the control group (1.59 [interquartile range, 1.04-1.70] and 1.67 [1.50-1.75] vs. 2.98 [2.76-3.16] Trolox equiv./L, respectively; P<0.001). Group I had decreased PTT concentrations compared with the control group (0.18 [0.16-0.20] vs. 0.21 [0.19-0.22] mmol/L; P<0.001), and group II had similar PTT levels to the control group (0.20 [0.17-0.22] mmol/L; P>0.05). In addition, the median TAS and PTT levels for groups I and II were not statistically different (P>0.05). There was a positive correlation between TAS and PTT levels (rho=0.38, P<0.05) in group I. CONCLUSION:In order to balance the oxidative stress, both TAS and PTT which are markers of the antioxidant system are reduced in children with asthma. Montelukast monotherapy can limit oxidative stress and thus restore PTT levels but not TAS levels in asthmatic children.

authors

Dilek F,Ozkaya E,Kocyigit A,Yazici M,Guler EM,Dundaroz MR

doi

10.1177/0394632015621563

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

84-9

issue

1

eissn

0394-6320

issn

2058-7384

pii

0394632015621563

journal_volume

29

pub_type

杂志文章
  • Enhancement of lysosomal glycohydrolase activity in human primary B lymphocytes during spontaneous apoptosis.

    abstract::It has been shown that lysosomes are involved in B cell apoptosis but lysosomal glycohydrolases have never been investigated during this event. In this study we determined the enzymatic activities of some lysosomal glycohydrolases in human tonsil B lymphocytes (TBL) undergoing in vitro spontaneous apoptosis. Fluorimet...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200702000208

    authors: Rosati E,Mencarelli S,Magini A,Sabatini R,Tassi C,Orlacchio A,Coaccioli S,Frenguelli A,Marconi P,Emiliani C

    更新日期:2007-04-01 00:00:00

  • Contact allergic dermatitis to gold in a tattoo: a case report.

    abstract::The art of tattooing has increasing in recent decades. Allergic sensitivity to one of the pigments is the most frequent cause of dermatological reactions at the site of the tattoo. Gold is a new pigment used in tattooing, because of its bright yellow color and luster. Allergy to this metal is uncommon. To our knowledg...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463201102400432

    authors: Tammaro A,Tuchinda P,Persechino S,Gaspari A

    更新日期:2011-10-01 00:00:00

  • Association between oral cleft and transcobalamin 2 polymorphism in a sample study from Nassiriya, Iraq.

    abstract::Orofacial clefts are common congenital defects whose prevalence differs between geographical regions and ethnic groups. The inheritance is complex, involving the contribution of both genetic and environmental factors. The involvement of genes belonging to the folate pathway is still matter of debate, with strong evide...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/2058738419855571

    authors: Carinci F,Palmieri A,Scapoli L,Cura F,Abenavoli F,Giannì AB,Russillo A,Docimo R,Martinelli M

    更新日期:2019-01-01 00:00:00

  • Treatment of psoriasis with different dosage regimens of etanercept: preliminary results from the Tαranta Plastic Study Group.

    abstract::This pilot open-label study is aimed to assess clinical response in psoriasis patients receiving diverse dose regimens of etanercept, consisting of the same global cumulative dose of etanercept administered over different treatment periods. Eligible patients were assigned sequentially in a 1:1 ratio to receive: etaner...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1177/039463201002300314

    authors: Cassano N,Loconsole F,Miracapillo A,Travaglini M,Digiuseppe MD,Congedo M,Galluccio A,Buquicchio R,Mastrandrea V,Filieri M,Raho G,Pezza M,Vena GA

    更新日期:2010-07-01 00:00:00

  • Inhibitory effect of retinoic acid on proliferation, maturation and tryptase level in human leukemic mast cells (HMC-1).

    abstract::Mast cells play important role in allergic inflammation by releasing histamine, tryptase and several inflammatory cytokines. Human leukemic mast cells (HMC-1) have been used to study mast cell mediator and their role in inflammatory mechanisms. HMC-1 contain and release several inflammatory mediators, of which the pro...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200301600106

    authors: Alexandrakis MG,Kyriakou DS,Seretakis D,Boucher W,Letourneau R,Kempuraj D,Theoharides TC

    更新日期:2003-01-01 00:00:00

  • Bridging the gap between the clinician and the patient with cryopyrin-associated periodic syndromes.

    abstract::Cryopyrin-associated periodic syndromes are categorized as a spectrum of three autoinflammatory diseases, namely familial cold auto-inflammatory syndrome, Muckle-Wells syndrome and chronic infantile neurological cutaneous articular syndrome. All are caused by mutations in the NLRP3 gene coding for cryopyrin and result...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 社论

    doi:10.1177/039463201102400402

    authors: Cantarini L,Lucherini OM,Frediani B,Brizi MG,Bartolomei B,Cimaz R,Galeazzi M,Rigante D

    更新日期:2011-10-01 00:00:00

  • The immunosuppressor st1959, a 3,5-diaryl-s-triazole derivative, inhibits T cell activation by reducing NFAT nuclear residency.

    abstract::3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole (ST1959) has shown therapeutic effects in several animal models of autoimmune diseases. In this study the effects of ST1959 were further investigated in a murine model of colitis. The evidence obtained indicates that the beneficial effects exerted by ST1959 rely ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200902200105

    authors: Lindstedt R,Ruggiero V,D' Alessio V,Manganello S,Petronzelli F,Stasi MA,Vendetti S,Assandri A,Carminati P,De Santis R

    更新日期:2009-01-01 00:00:00

  • Safety and efficacy of etanercept in children with juvenile-onset Behcets disease.

    abstract::Behcets disease (BD) is a chronic, relapsing, multi-system inflammatory disorder, clinically characterized by recurrent oral and genital ulcers, skin lesions, and uveitis. Other manifestations include arthritis, a positive pathergy test, thrombophlebitis, central nervous system disease and gastrointestinal ulcerations...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463200902200235

    authors: Cantarini L,Tinazzi I,Caramaschi P,Bellisai F,Brogna A,Galeazzi M

    更新日期:2009-04-01 00:00:00

  • Increased levels of NF-kappaB inhibitors (IkappaBalpha and IkappaBgamma) in the intestinal mucosa of Crohn's disease patients during infliximab treatment.

    abstract::The treatment with infliximab is employed successfully in Crohn's disease (CD) but predictors of efficacy are lacking. Activation of the transcription factor NF-kB has been demonstrated in CD and its inhibition is one of the mechanisms by which anti-inflammatory agents exert their effects. We evaluated the production ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200501800116

    authors: Guidi L,Costanzo M,Ciarniello M,De Vitis I,Pioli C,Gatta L,Pace L,Tricerri A,Bartoloni C,Coppola L,Balistreri P,Doria G,Fedeli G,Gasbarrini GB

    更新日期:2005-01-01 00:00:00

  • A pilot study of feasibility of ultra-rush (20-25 minutes) sublingual-swallow immunotherapy in 679 patients (699 sessions) with allergic rhinitis and/or asthma.

    abstract::Few studies have evaluated the occurrence of immediate adverse reactions in allergic patients after an ultra-rush regimen of different commercial allergen extracts for sublingual immunotherapy (SLIT) Methods: 679 patients took part in trials of specific ultra-rush SLIT for the treatment of IgE-mediated rhinitis and/or...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1177/039463200501800210

    authors: Rossi RE,Monasterolo G

    更新日期:2005-04-01 00:00:00

  • Endothelial progenitor cell-derived microvesicles improve neovascularization in a murine model of hindlimb ischemia.

    abstract::Paracrine mediators released from endothelial progenitor cells (EPCs) have been implicated in neoangiogenesis following ischemia. Recently, we demonstrated that microvesicles (MVs) derived from EPCs are able to activate an angiogenic program in quiescent endothelial cells by a horizontal transfer of RNA. In this study...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201202500110

    authors: Ranghino A,Cantaluppi V,Grange C,Vitillo L,Fop F,Biancone L,Deregibus MC,Tetta C,Segoloni GP,Camussi G

    更新日期:2012-01-01 00:00:00

  • Topical cyclosporin in the treatment of dermatologic diseases.

    abstract::Cyclosporine A (CsA) has been in clinical use for some decades, primarily for the prevention and treatment of organ transplant rejection and graft-versus-host disease. In more recent years, Cyclosporine has been recognized as beneficial in the treatment of dermatologic diseases, such as: psoriasis, lichen planus, Behc...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200201500203

    authors: Feliciani C,Tulli A

    更新日期:2002-05-01 00:00:00

  • In vitro action of sho-seiryu-to on allergen-exposed mononuclear cells.

    abstract::Although Sho-seiryu-to (SST), used as a traditional herbal (Kampo) medicine mainly in China and Korea, is shown to have immunomodulating potential, such as an anti-allergic one, its underlying mechanism has not been completely clarified. To partially address the issue, we explored its effects on allergen-exposed monon...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463201402700416

    authors: Tanaka M,Inoue K,Kitamura Y,Shimada A,Takano H

    更新日期:2014-10-01 00:00:00

  • Modulation of costimulatory molecules CD80/CD86 on B cells and macrophages by stress proteins GroEL, GroES and DnaK.

    abstract::The aim of this study was to evaluate the effect of the Heat Shock Proteins GroES, GroEL and DnaK on the expression of the costimulatory molecules CD80/CD86 in B cells and macrophages. The interactions among these molecules are able to highly influence the immune response through the regulation of cytokine liberation ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200501800404

    authors: Galdiero M,Pisciotta MG,Gorga F,Petrillo G,Marinelli A,Galdiero E

    更新日期:2005-10-01 00:00:00

  • Cyclic Amp phosphodiesterase activity in normal and inflamed human dental pulp.

    abstract::Cyclic AMP phosphodiesterase (cAMP PDE) seems to be important in pulp tissues. High levels of cAMP PDE have been demonstrated to be in dental pulp cells. In the present study cAMP PDE activity was analyzed in normal healthy human dental pulps, in reversible pulpitis and in irreversible pulpitis. Enzymatic cAMP PDE con...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:

    authors: Spoto G,Menna V,Serra E,Santoleri F,Perfetti G,Ciavarelli L,Trentini P

    更新日期:2004-09-01 00:00:00

  • Effects of degradable MG-ND-ZN-ZR alloy on osteoblastic cell function.

    abstract::This study aimed to investigate the effects of a novel patented Mg-3Nd-0.2Zn-0.4Zr (weight %, JDBM) alloy on osteoblastic cell function, as these cells play an important role in bone repair and remodeling. The associated effects of the JDBM alloy on osteoblastic cell function involving cell adhesion, cell proliferatio...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201202500306

    authors: Wang Y,Ouyang Y,Pang X,Mao L,Yuan G,Jiang Y,He Y

    更新日期:2012-07-01 00:00:00

  • Heterogeneity in the genetic alterations and in the clinical presentation of acrodermatitis enteropathic: Case report and review of the literature.

    abstract::Acrodermatitis enteropathic (AE) is a rare autosomal recessive disorder due to a zinc deficiency and characterized by a classical triad of symptoms: dermatitis, alopecia, and diarrhea. The defective gene is SLC39A4, which encodes a zinc transporter. Nevertheless many abnormalities in SLC39A4 have been relieved, only 5...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632015606845

    authors: Ricci G,Ferrari S,Calamelli E,Ricci L,Neri I,Patrizi A

    更新日期:2016-06-01 00:00:00

  • Intestinal mucosa-associated bacteria modulate rat mast cell reactivity.

    abstract::It is well known that in some conditions bacteria of physiological flora of gastrointestinal tract may become pathogenic. Each complaint which causes injury of gastrointestinal wall integrity permits bacteria to penetrate the tissues and affect the tissue cells. Since mast cells represent one of very important and num...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:

    authors: Brzezińska-Blaszczyk E,Olejnik AK

    更新日期:1999-01-01 00:00:00

  • Percutaneous steroidal treatment in relapses of chronic tendinopathies: a pilot study.

    abstract::Relapses are frequently observed in subjects with chronic tendinopathies. Corticosteroid injections are usually performed with positive results, but are uncomfortable for the patient and not free from side effects. The aim of this pilot study is to evaluate the short-term efficacy and tolerability of an occlusive Beta...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1177/039463201102400125

    authors: Salini V,Abate M

    更新日期:2011-01-01 00:00:00

  • Sequence uniqueness as a molecular signature of HIV-1-derived B-cell epitopes.

    abstract::The complex pathophysiology of human immunodeficiency virus (HIV) infection and the relatively high mutation rate of the retrovirus make it challenging to design effective anti-HIV vaccines. Several attempts have been made during the last decades to elucidate the enigmatic immunology of HIV infection and to predict po...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200902200309

    authors: Lucchese A,Serpico R,Crincoli V,Shoenfeld Y,Kanduc D

    更新日期:2009-07-01 00:00:00

  • Corrigendum.

    abstract::Acosta YY, Montes-Casado M, Aragoneses L et al. (2014) Suppression of CD4(+) T lymphocyte activation "in vitro" and experimental encephalomyelitis "in vivo" by the phosphatidyl inositol 3-kinase inhibitor PIK-75. International Journal of Immunopathology and Pharmacology 27(1): 53-67. In the Acknowledgements section of...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章,已发布勘误

    doi:10.1177/0394632015572738

    authors:

    更新日期:2015-03-01 00:00:00

  • Protective effect of diallyl trisulfide against naphthalene-induced oxidative stress and inflammatory damage in mice.

    abstract::The aim of this study was to investigate the possible protective effects of diallyl trisulfide (DATS) against naphthalene-induced oxidative and inflammatory damage in the livers and lungs of mice. Elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels showed significant hepatic damag...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632015627160

    authors: Zhang F,Zhang Y,Wang K,Liu G,Yang M,Zhao Z,Li S,Cai J,Cao J

    更新日期:2016-06-01 00:00:00

  • Antibiotic-coated nails in orthopedic and trauma surgery: state of the art.

    abstract::Optimal management of deep infections in orthopedic and trauma surgery is often challenging. Traditional prophylactic and treatment approaches are based on the systemic administration of relatively high doses of antibiotics, which may result in a number of side effects. Furthermore, systemically administered antimicro...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章,多中心研究,评审

    doi:10.1177/03946320110241S223

    authors: Nizegorodcew T,Palmieri G,Marzetti E

    更新日期:2011-01-01 00:00:00

  • Sudden progression from impaired glucose tolerance to type 2 diabetes after discontinuation of administration of anti-tumor necrosis factor-alpha antibody infliximab.

    abstract::We present the case of a 45-year-old man with psoriasis and psoriatic arthritis and concomitant impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). In this patient, refractory to DMARD's, infliximab was started to control the arthritis. After achieving clinical remission of the disease, infliximab was...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463201002300334

    authors: Ursini F,Succurro E,Grembiale A,Rudi S,Grembiale RD,Arturi F

    更新日期:2010-07-01 00:00:00

  • Sublingual allergoid immunotherapy: a new 4-day induction phase in patients allergic to house dust mites.

    abstract::Sublingual immunotherapy with monomeric allergoid (allergoid SLIT), given according to the standard scheme, has proved effective and safe in many clinical trials. However, its build-up phase requires a long time ranging from 16 days to 14 weeks. This study therefore investigated whether, with a four-day up-dosing, the...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/039463201002300217

    authors: D'Anneo RW,Bruno ME,Falagiani P

    更新日期:2010-04-01 00:00:00

  • TNF-alpha, IL-4R-alpha and IL-4 polymorphisms in mild to severe asthma from Italian Caucasians.

    abstract::Asthma is a chronic airway inflammatory disease associated with airway hyperresponsiveness which affects subjects with genetic predisposition. An association has been reported between some polymorphisms in various cytokine genes and asthma. Most of them are single nucleotide polymorphisms (SNPs). These polymorphisms a...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201302600107

    authors: Ricciardolo FL,Sorbello V,Silvestri M,Giacomelli M,Debenedetti VM,Malerba M,Ciprandi G,Rossi GA,Rossi A,Bontempelli M

    更新日期:2013-01-01 00:00:00

  • Acute polyradiculoneuropathy occurring after hymenoptera stings: a clinical case study.

    abstract::Hymenoptera stings may be responsible for both local and systemic reactions; these can be immediate or delayed, depending on the time between the sting and the development of signs or symptoms. Delayed clinical reactions have been reported, although unusual, due to serum sickness and/or affecting organs or systems gen...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200501800220

    authors: Ridolo E,Albertini R,Borghi L,Meschi T,Montanari E,Dall'Aglio PP

    更新日期:2005-04-01 00:00:00

  • Serratiopeptidase reduces the invasion of osteoblasts by Staphylococcus aureus.

    abstract::Finding new strategies to counteract periprosthetic infection and implant failure is a main target in orthopedics. Staphylococcus aureus, the leading etiologic agent of orthopedic implant infections, is able to enter and kill osteoblasts, to stimulate pro-inflammatory chemokine secretion, to recruit osteoclasts, and t...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632017745762

    authors: Selan L,Papa R,Ermocida A,Cellini A,Ettorre E,Vrenna G,Campoccia D,Montanaro L,Arciola CR,Artini M

    更新日期:2017-12-01 00:00:00

  • Sulphurous thermal water increases the release of the anti-inflammatory cytokine IL-10 and modulates antioxidant enzyme activity.

    abstract::The beneficial effects of hot springs have been known for centuries and treatments with sulphurous thermal waters are recommended in a number of chronic pathologies as well as acute recurrent infections. However, the positive effects of the therapy are often evaluated in terms of subjective sense of wellbeing and symp...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201302600307

    authors: Prandelli C,Parola C,Buizza L,Delbarba A,Marziano M,Salvi V,Zacchi V,Memo M,Sozzani S,Calza S,Uberti D,Bosisio D

    更新日期:2013-07-01 00:00:00

  • Evaluation of seminal fluid leukocyte subpopulations in patients with varicocele.

    abstract::Varicocele is a common cause of sperm damage. Some studies showed higher concentration of seminal leukocytes in patients with varicocele. The aim of the study was to evaluate seminal leukocyte subpopulations in patients with varicocele. We enrolled 20 patients with varicocele and 20 age-matched healthy men. Sperm anal...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/2058738420925719

    authors: Mongioì LM,Alamo A,Calogero AE,Compagnone M,Giacone F,Cannarella R,La Vignera S,Condorelli RA

    更新日期:2020-01-01 00:00:00