当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY期刊下所有文献 > Bridging the gap between the clinician and the patient with cryopyrin-associated periodic syndromes.

Bridging the gap between the clinician and the patient with cryopyrin-associated periodic syndromes.

Abstract：

:Cryopyrin-associated periodic syndromes are categorized as a spectrum of three autoinflammatory diseases, namely familial cold auto-inflammatory syndrome, Muckle-Wells syndrome and chronic infantile neurological cutaneous articular syndrome. All are caused by mutations in the NLRP3 gene coding for cryopyrin and result in active interleukin-1 release: their rarity and shared clinical indicators involving skin, joints, central nervous system and eyes often mean that correct diagnosis is delayed. Onset occurs early in childhood, and life-long therapy with interleukin-1 blocking agents usually leads to tangible clinical remission and inflammatory marker normalization in a large number of patients, justifying the need to facilitate early diagnosis and thus avoid irreversible negative consequences for tissues and organs.

journal_name

Int J Immunopathol Pharmacol

journal_title

International journal of immunopathology and pharmacology

authors

Cantarini L,Lucherini OM,Frediani B,Brizi MG,Bartolomei B,Cimaz R,Galeazzi M,Rigante D

doi

10.1177/039463201102400402

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

827-36

issue

4

eissn

0394-6320

issn

2058-7384

pii

2

journal_volume

24

pub_type

社论

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