Pathology of upper tract urothelial carcinoma with emphasis on staging.

Abstract:

:Classification of upper tract urothelial preneoplastic and neoplastic lesions mirrors that of the urinary bladder, with all lesions of the bladder urothelium being possible in the upper tract and vice versa. There are three major groups of non-invasive urothelial neoplasms: flat, papillary, and inverted. These three groups share a similar morphological spectrum of intraurothelial changes, ranging from hyperplasia to dysplasia to carcinoma in situ. However, they differ in terms of architectural growth pattern compared to the surrounding non-neoplastic mucosal surface. Infiltrating urothelial carcinoma is defined as a urothelial tumor that invades beyond the basement membrane. Unlike in non-invasive papillary urothelial neoplasms (pTa), the role of histologic grade in pT1 and higher stage tumors has been suggested to be of only relative importance. The vast majority of tumors of the upper urinary tract are urothelial carcinoma. More commonly seen, however, are foci of squamous differentiation and, less frequently, glandular differentiation. Pure urothelial carcinomas also display a wide range of variant morphologies, and recognition of these morphologies is important for diagnosis, classification, and prognosis.

authors

Mazzucchelli R,Scarpelli M,Galosi AB,Di Primio R,Lopez-Beltran A,Cheng L,Montironi R

doi

10.1177/039463201402700406

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

509-16

issue

4

eissn

0394-6320

issn

2058-7384

pii

6

journal_volume

27

pub_type

社论,评审
  • Natural killer cell activity decreases in workers occupationally exposed to extremely low frequency magnetic fields exceeding 1 microT.

    abstract::In a preliminary study a reduction in natural killer (NK) cell activity in peripheral blood lymphocytes (PBL) was observed in a group of workers exposed to levels of extremely low frequency-magnetic fields (ELF-MF) exceeding 1 microT. This study was performed to confirm the results. In 121 workers engaged in various o...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200902200422

    authors: Gobba F,Bargellini A,Bravo G,Scaringi M,Cauteruccio L,Borella P

    更新日期:2009-10-01 00:00:00

  • Ink spot lentigo: singular clinical features in a case series of patients.

    abstract::Ink spot lentigo, also known as reticulated black solar lentigo, is a melanotic macula commonly described in fair-skinned individuals on sun-exposed areas of the body. Clinically it is a darkly pigmented type of solar lentigo; herein the term ink spot lentigo. In contrast to common solar lentigines, ink spot lentigo i...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201302600413

    authors: Bottoni U,Nisticò S,Amoruso GF,Schipani G,Arcidiacono V,Scali E,Tassone P,Greco M,Amorosi A

    更新日期:2013-10-01 00:00:00

  • Perioperative period: immunological modifications.

    abstract::Surgical stress induces complex modifications in the hemodynamic, metabolic, neuro-hormonal and immune response of the individual. The magnitude of these alterations depends on preoperative events leading to surgery, the severity of surgical trauma, and also on post-operative/post-traumatic complications (multiple hit...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章,评审

    doi:10.1177/03946320110240s302

    authors: Cardinale F,Chinellato I,Caimmi S,Peroni DG,Franceschini F,Miraglia Del Giudice M,Bernardini R

    更新日期:2011-07-01 00:00:00

  • Ultradian variation of nerve growth factor plasma levels in healthy and schizophrenic subjects.

    abstract::Some studies in animal models showed that several neurotrophins may be implicated in the regulation of light-dependent suprachiasmatic pacemaker and in other functions implicated in long-term memory acquisition during sleep. However, no data are known about the role played by NGF in ultradian regulation in humans. The...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1177/039463200401700316

    authors: Bersani G,Iannitelli A,Massoni E,Garavini A,Grilli A,Di Giannantonio M,Conti CM,Pancheri P

    更新日期:2004-09-01 00:00:00

  • Myasthenia gravis: correlation of age with clinical course and anti-AChr antibody levels.

    abstract::We studied the significance of age as a factor affecting prognosis and anti-AChR antibody levels in myasthenia gravis, comparing patients with symptom onset before 50 (37 patients) and at or after 50 (33 patients). More of the older patients, compared to younger ones (69.9% versus 32.4%,p<0. 05) progress...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:

    authors: Kapinas K,Kimiskidis VK,Kazis AD,Kokkas B,Tsolaki M,Georgiadis G

    更新日期:1999-09-01 00:00:00

  • Bone microstructure evaluation near unloaded dental implants combining confocal scanning laser microscopy, circularly polarized light microscopy, and SEM backscattered electrons imaging.

    abstract::The aim of this report is to present a new investigative approach to implant dentistry based on the correlation of qualitative and quantitative data reported on the same figure by overlapping different images collected on the specimen with different investigative systems. Six unloaded titanium dental implants retrieve...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200702001s09

    authors: Traini T,Degidi M,Murmura G,Piattelli A,Caputi S

    更新日期:2007-01-01 00:00:00

  • Response of crypt paneth cells in the small intestine following total-body gamma-irradiation.

    abstract::Ionizing irradiation causes damage and functional failure of irradiation-sensitive systems and tissues such as small intestine. The molecular mechanisms underlying inflammatory and adaptive responses to acute irradiation damage are poorly understood. Using a mouse model of total-body γ-irradiation, we assessed the irr...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201002300415

    authors: Gorbunov NV,Garrison BR,Kiang JG

    更新日期:2010-10-01 00:00:00

  • Decreased interstitial FOXP3(+) lymphocytes in usual interstitial pneumonia with discrepancy of CXCL12/CXCR4 axis.

    abstract::Regulatory T cells (Treg) play a critical role in immune homeostasis and expansion of Treg is controlled by chemokine receptors. The chemokine CXCL12 and its G-protein-coupled receptor (CXCR4) are involved in the development of idiopathic pulmonary fibrosis (IPF), but the association of Treg with the CXCL12/CXCR4 axis...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201002300207

    authors: Shimizu Y,Dobashi K,Endou K,Ono A,Yanagitani N,Utsugi M,Sano T,Ishizuka T,Shimizu K,Tanaka S,Mori M

    更新日期:2010-04-01 00:00:00

  • Functional anatomy of the Eustachian tube.

    abstract::The Eustachian tube (ET) is divided in 3 portions: a bony portion, a cartilaginous portion, and a junctional portion. From an anatomical-functional point of view, the bony portion of ET is the region of ventilation and clearance of secretions, and is lined by pseudostratified, ciliated, columnar epithelium, with an an...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章,评审

    doi:

    authors: Cunsolo E,Marchioni D,Leo G,Incorvaia C,Presutti L

    更新日期:2010-01-01 00:00:00

  • Paraneoplastic sensitive neuropathy associated with anti-hu antibodies in a neuroendocrine tumor of duodenum: a case report.

    abstract::Paraneoplastic sensitive neuropathy is one of the most common presentations among a group of cancer-related disorders known as Paraneoplastic Neurological Syndromes (PNS). PNS likely have an autoimmune etiology since they have been associated with the presence of antibodies against neuronal antigens expressed by tumor...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463201002300435

    authors: Nappi L,Formisano L,Damiano V,Matano E,Bianco R,Tortora G

    更新日期:2010-10-01 00:00:00

  • Sexual distress, sexual dysfunction and relationship quality in women with systemic sclerosis: correlation with clinical variables.

    abstract::To assess the rate of sexual distress, sexual dysfunction and relationship quality and their association with clinical variables in women with systemic sclerosis (SSc), 102 sexually active women with SSc were recruited. Sexual distress, sexual dysfunction and dissatisfaction with relationship quality were investigated...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463201402700216

    authors: Rosato E,Rossi C,Molinaro I,Di Giulio MA,Trombetta AC,Marra AM,Gigante A,Barbano B,Quarta S,Pisarri S,Afeltra A,Salsano F

    更新日期:2014-04-01 00:00:00

  • Acute impact of volcanic ash on asthma symptoms and treatment.

    abstract::Information about the impacts of disasters on health is useful for establishing hazard prediction maps and action plans of disaster management. This study aims at learning effective asthma management from the volcano disaster of Mount Asama eruption in Japan on September 1, 2004. We conducted a cross-sectional study t...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/03946320070200S203

    authors: Shimizu Y,Dobashi K,Hisada T,Ono A,Todokoro M,Iijima H,Utsugi M,Kakegawa S,Iizuka K,Ishizuka T,Morikawa A,Mori M

    更新日期:2007-04-01 00:00:00

  • Characteristic patterns of HLA presentation and T cell differentiation in adult-onset Still's disease.

    abstract::We examined the expression of human leukocyte antigen (HLA) and composition of differentiated T cells in the peripheral blood to understand the characteristics of the immune changes in patients with adult-onset Still's disease (AOSD). This study enrolled patients with AOSD (n = 14), patients with rheumatoid arthritis ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/2058738418791284

    authors: Jung JY,Choi B,Sayeed HM,Suh CH,Kim YW,Kim HA,Sohn S

    更新日期:2018-01-01 00:00:00

  • Inhaled mucoactive drugs for treating non-cystic fibrosis bronchiectasis in children.

    abstract::Non-cystic fibrosis bronchiectasis (nCFb) is an acquired condition of variable etiology. Medical treatment basically involves antibiotics and chest physiotherapy. An impaired mucociliary clearance seems to be one of the mechanisms behind nCFb, and inhaled therapy with mucoactive agents has frequently been used to try ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件,评审

    doi:10.1177/039463201302600228

    authors: Snijders D,Calgaro S,Bertozzi I,Quartesan S,Kozuh I,Lunardi F,Barbato A

    更新日期:2013-04-01 00:00:00

  • A scavenger role for nitric oxide in the aged rat kidney.

    abstract::Progressive ageing is associated with an increment of biomolecules modified through oxidation as a result of the action of free radicals deriving from reactive oxygen species that attack biomolecules. During ageing many alterations of renal functions have been reported. Renal ageing is associated with a progressive de...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200401700306

    authors: De Lutiis MA,Felaco M,Gizzi F,Patruno A,Speranza L,Di Giulio C,Conti P,Castellani ML,Petrarca C,Grilli A

    更新日期:2004-09-01 00:00:00

  • Establishment of a poisoned animal model of toxic encephalopathy induced by 1,2-dichloroethane.

    abstract::1,2-dichloroethane(1,2-DCE) is toxic, especially by inhalation due to its high vapour pressure. Inhalation of concentrated 1,2-DCE vapor can induce effects on the human nervous system, even encephalopathy. However, 1,2-DCE toxic encephalopathy has seldom been reported, and no adequate data were available to evaluate t...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:

    authors: Zhang Q,Niu Q,Li LY,Yang L,Guo XL,Huang JX,Wang LP,Liang YX

    更新日期:2011-01-01 00:00:00

  • Oxymatrine exhibits anti-tumor activity in gastric cancer through inhibition of IL-21R-mediated JAK2/STAT3 pathway.

    abstract::Oxymatrine (OMT) as a type of alkaloids collected from Sophora flavescens Ait exerts some biological functions including anticancer properties. Here, we investigated the therapeutic effects of OMT in gastric cancer cells (HGC 27 and AGS). As a result, the exposure of gastric cancer (GC) cells to OMT contributed to the...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/2058738418781634

    authors: Huang Y,Zhang J,Wang G,Chen X,Zhang R,Liu H,Zhu J

    更新日期:2018-01-01 00:00:00

  • Surgical debridement plus topical cyclosporine A in the treatment of vernal shield ulcers.

    abstract::Vernal keratoconjunctivitis (VKC) is a severe chronic bilateral inflammation of the ocular surface characterized by seasonal exacerbations. Long-term prognosis is generally good; however, 6% develop sequelae responsible for permanent visual impairment. Corneal involvement is almost always present, consisting of puncta...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201202500326

    authors: Caputo R,Pucci N,Mori F,De Libero C,Di Grande L,Bacci GM

    更新日期:2012-07-01 00:00:00

  • B lymphocyte subsets and their functional activity in the early months of life.

    abstract::In the present study we evaluated B-cell subsets and their functional development in 74 newborns from birth to 6 months of life. Moreover, we evaluated natural antibody production in vitro. The results documented a predominance of naive B-lymphocytes at all time-points evaluated, decreasing from birth to 6 months (p=0...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201002300122

    authors: Avanzini MA,Maccario R,Belloni C,Carrera G,Bertaina A,Cagliuso M,La Rocca M,Valsecchi C,Mantelli M,Castellazzi AM,Quinti I,De Silvestri A,Marconi M

    更新日期:2010-01-01 00:00:00

  • Protective effect of diallyl trisulfide against naphthalene-induced oxidative stress and inflammatory damage in mice.

    abstract::The aim of this study was to investigate the possible protective effects of diallyl trisulfide (DATS) against naphthalene-induced oxidative and inflammatory damage in the livers and lungs of mice. Elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels showed significant hepatic damag...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632015627160

    authors: Zhang F,Zhang Y,Wang K,Liu G,Yang M,Zhao Z,Li S,Cai J,Cao J

    更新日期:2016-06-01 00:00:00

  • Efficacy, safety and potential clinical roles of the COX-2-specific inhibitors.

    abstract::About three decades ago, the primary mechanism of action of the non-steroidal anti-inflammatory drugs (NSAIDs) was elucidated when their inhibitory action on the production of prostaglandins was discovered. It was found that their action is centred on the inhibition of the cyclooxygenase (COX) enzyme responsible for c...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章,评审

    doi:

    authors: van der Bijl P,van der Bijl P Jr

    更新日期:2003-05-01 00:00:00

  • TNF-alpha, IL-4R-alpha and IL-4 polymorphisms in mild to severe asthma from Italian Caucasians.

    abstract::Asthma is a chronic airway inflammatory disease associated with airway hyperresponsiveness which affects subjects with genetic predisposition. An association has been reported between some polymorphisms in various cytokine genes and asthma. Most of them are single nucleotide polymorphisms (SNPs). These polymorphisms a...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201302600107

    authors: Ricciardolo FL,Sorbello V,Silvestri M,Giacomelli M,Debenedetti VM,Malerba M,Ciprandi G,Rossi GA,Rossi A,Bontempelli M

    更新日期:2013-01-01 00:00:00

  • Increased expression of CCL4/MIP-1β in CD8+ cells and CD4+ cells in sarcoidosis.

    abstract::Sarcoidosis is a granulomatous disease with an increased accumulation of T cells in lungs as a result of on-site proliferation and chemotaxis induced by chemokines. It has already been demonstrated that CCL3-5 levels were increased in BAL fluid of sarcoidosis patients. To analyze the expression of CCL3-5 chemokines by...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201402700205

    authors: Barczyk A,Pierzchała E,Caramori G,Sozańska E

    更新日期:2014-04-01 00:00:00

  • IL-8 and pH values in exhaled condensate after antibiotics in cystic fibrosis children.

    abstract::Interleukin (IL)-8 is a major factor in inflammatory response and the IL-8 levels in exhaled breath condensate (EBC) may be used as a marker of airway inflammation. Airway acidification is implicated in the pathophysiology of obstructive airway diseases and pH EBC values have been used as a marker of airway acidificat...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200702000305

    authors: Bodini A,D'Orazio C,Peroni DG,Corradi M,Zerman L,Folesani G,Assael BM,Boner AL,Piacentini GL

    更新日期:2007-07-01 00:00:00

  • Carbon nanotubes: Properties, biomedical applications, advantages and risks in patients and occupationally-exposed workers.

    abstract::Since the beginning of the 21st century, carbon-based nanomaterials (CNTs) have been introduced in pharmacy and medicine for drug delivery system in therapeutics. CNTs have proved able to transport a wide range of molecules across membranes and into living cells; therefore, they have attracted great interest in biomed...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 社论,评审

    doi:10.1177/0394632015572559

    authors: Lamberti M,Pedata P,Sannolo N,Porto S,De Rosa A,Caraglia M

    更新日期:2015-03-01 00:00:00

  • Enhancement of fibroblast proliferation, collagen biosynthesis and production of growth factors as a result of combining sodium hyaluronate and aminoacids.

    abstract::Fibroblasts play a key role in tissue healing by producing the majority of extracellular matrix components, favouring granulation tissue formation, and stimulating re-epithelialization. Hyaluronan is a component of ECM and its anti-inflammatory effects and properties in enhancing wound closure are well known. In this ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200902200225

    authors: Mariggiò MA,Cassano A,Vinella A,Vincenti A,Fumarulo R,Lo Muzio L,Maiorano E,Ribatti D,Favia G

    更新日期:2009-04-01 00:00:00

  • Type 1 diabetes onset and pandemic influenza A (H1N1).

    abstract::Type 1 diabetes (T1D) is a heterogeneous disorder characterized by destruction of pancreatic beta cells, culminating in loss of insulin secretion. Data from large epidemiologic studies worldwide indicate that during the last decades the incidence of T1D has increased significantly, reaching percentages of 2-5% annuall...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 评论,信件

    doi:10.1177/039463201202500228

    authors: Piccini B,Toni S,Lenzi L,Guasti M,Barni F,De Martino M

    更新日期:2012-04-01 00:00:00

  • Morning sudden cardiac death.

    abstract::A circadian variation of cardiac function with peak in the early morning was documented about twenty years ago. A circadian rhythm of platelet aggregability, in the same time of the day, was demonstrated in healthy young male subjects. The morning hours were also reported as crucial for sympathetic nervous system acti...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200001300109

    authors: Guagnano MT,Davi G,Sensi S

    更新日期:2000-01-01 00:00:00

  • Bridging the gap between the clinician and the patient with cryopyrin-associated periodic syndromes.

    abstract::Cryopyrin-associated periodic syndromes are categorized as a spectrum of three autoinflammatory diseases, namely familial cold auto-inflammatory syndrome, Muckle-Wells syndrome and chronic infantile neurological cutaneous articular syndrome. All are caused by mutations in the NLRP3 gene coding for cryopyrin and result...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 社论

    doi:10.1177/039463201102400402

    authors: Cantarini L,Lucherini OM,Frediani B,Brizi MG,Bartolomei B,Cimaz R,Galeazzi M,Rigante D

    更新日期:2011-10-01 00:00:00

  • Profilin desensitization: A case series.

    abstract::The role of profilin as an allergen has long been questioned. The capacity of profilin to induce respiratory symptoms has recently been demonstrated; moreover, over 50% of patients sensitized to profilin experienced symptoms after the ingestion of plant-derived foods, suggesting that profilin should be considered as a...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/0394632015621926

    authors: Nucera E,Aruanno A,Rizzi A,Pecora V,Patriarca G,Buonomo A,Mezzacappa S,Schiavino D

    更新日期:2016-09-01 00:00:00