Preliminary evidence of modulating Th1 cytokine after allergen challenge.

Abstract:

:We wanted to determine whether a paradigm switch in Th1/Th2 phenotypes in splenic lymphocytes could be induced in BALB/c mice after ultraviolet-B (UVB) irradiation and exposure to pollen. Results showed that UVB irradiation increased IL-1 but decreased IL-12 in vivo, and caused significant cell destruction of macrophages in vitro. We then gave mice cedar pollen intranasally, UVB irradiation (6kJ/cm2), and then splenic lymphocyte functions were examined. Results revealed that: 1) the level of IFN-gamma of splenic lymphocytes from UVB-irradiated mice was significantly decreased, especially in pollen-exposed mice; 2) UVB irradiation did not augment IL-4 levels; 3) IgE levels from UVB-irradiated mice did not increase. UVB irradiation (6kJ/cm2) did not induce Th2 response but suppressed Th1 cytokine, suggesting that Th1 could be more susceptible to UVB irradiation than Th2.

authors

Kasahara S,Fugo H,Cooper EL,Wago H

keywords:

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

63-69

issue

2

eissn

0394-6320

issn

2058-7384

pii

1

journal_volume

14

pub_type

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