Abstract:
:The aim of this study is to investigate the expression of the chromosomal passenger protein Aurora B and its activated (phosphorylated) form in a large series of human oral squamous cell cancers (OSCC) and to evaluate its clinical and prognostic significance. Western blotting analysis revealed overexpression of both Aurora B and Thr-232 Phopsho-Aurora B in OSCC lines as compared to normal keratinocytes and bladder cancer cells. Furthermore, protein expression was analysed by immunohistochemistry in 101 OSCC of different site, stage and histological grade and in normal peritumoural areas. The intracellular localization of Aurora B in tumour cells was mainly nuclear, especially in proliferative areas, and significant overexpression was found in tumours in comparison to normal peritumoural areas (P=0.012). Staining results were correlated with clinicopathological parameters and long-term follow-up, and a significant association was found between protein expression and tumour stage (stage II, III and IV vs stage I, P=0.030) and size (<2cm vs >2cm, P=0.010). Cox regression analysis confirmed a poorer disease-free survival in cases with high expression of Aurora B protein. Kaplan-Meier curves showed shorter time to progression in patients with high levels of Aurora B expression (p<0.05). Moreover, the tumoral group with nuclear Aurora B immunolocalization had the worst prognosis (P=0.0364 in disease free survival). Our results suggest that assessing Aurora B expression might help in patients risk stratification and serve as a novel therapeutic target in advanced OSCCs.
journal_name
Int J Immunopathol Pharmacolauthors
Pannone G,Hindi SA,Santoro A,Sanguedolce F,Rubini C,Cincione RI,De Maria S,Tortorella S,Rocchetti R,Cagiano S,Pedicillo C,Serpico R,Lo Muzio L,Bufo Pdoi
10.1177/039463201102400110subject
Has Abstractpub_date
2011-01-01 00:00:00pages
79-88issue
1eissn
0394-6320issn
2058-7384pii
10journal_volume
24pub_type
杂志文章abstract::The aim of this work is to study a correlation between phenotype and genotype in clinical isolates of erythromycin-resistant Streptococcus spp. Among the 25 erythromycin-resistant S. pyogenes, we detected six strains with iMLSB, nine with cMLSB and two with M phenotypes. Among 14 erythromycin-resistant S. agalactiae, ...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200601900418
更新日期:2006-10-01 00:00:00
abstract::The expression of Ikaros family transcription factors and consequently their signalling pathway is limiting for hematopoietic and lymphocyte development in mice and human. Due to their importance, these transcription factors are highly homologous between species. As an initial approach to examining the possible involv...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201202500407
更新日期:2012-10-01 00:00:00
abstract::Nickel sulphate allergy is the most common contact allergy. In fact, nickel sulphate is an ubiquitous element, contained in various objects and food; it occurs in igneous rocks, as a free metal and together with iron, but it is also a component of living organism, mainly vegetables. We carried out a clinical trial of ...
journal_title:International journal of immunopathology and pharmacology
pub_type: 信件
doi:10.1177/039463200902200330
更新日期:2009-07-01 00:00:00
abstract::This study aimed to investigate the effects of a novel patented Mg-3Nd-0.2Zn-0.4Zr (weight %, JDBM) alloy on osteoblastic cell function, as these cells play an important role in bone repair and remodeling. The associated effects of the JDBM alloy on osteoblastic cell function involving cell adhesion, cell proliferatio...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201202500306
更新日期:2012-07-01 00:00:00
abstract::Surgical stress induces complex modifications in the hemodynamic, metabolic, neuro-hormonal and immune response of the individual. The magnitude of these alterations depends on preoperative events leading to surgery, the severity of surgical trauma, and also on post-operative/post-traumatic complications (multiple hit...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章,评审
doi:10.1177/03946320110240s302
更新日期:2011-07-01 00:00:00
abstract::We studied the significance of age as a factor affecting prognosis and anti-AChR antibody levels in myasthenia gravis, comparing patients with symptom onset before 50 (37 patients) and at or after 50 (33 patients). More of the older patients, compared to younger ones (69.9% versus 32.4%,p<0. 05) progress...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
abstract::The aim of this study was to investigate the possible protective effects of diallyl trisulfide (DATS) against naphthalene-induced oxidative and inflammatory damage in the livers and lungs of mice. Elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels showed significant hepatic damag...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/0394632015627160
更新日期:2016-06-01 00:00:00
abstract::Adverse drug reactions (ADR) are an important medical problem. The aim of this study is to investigate the clinical characteristics of children with ADR and to assess the tolerability of alternative drugs in children (under 16 yrs of age) with a history of ADR. We studied 278 children (132 males and 146 females). Pati...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201002300324
更新日期:2010-07-01 00:00:00
abstract::This study reports the immunomodulatory activity on human monocyte derived dendritic cells (MDDCs) of a vaccine preparation shown to be effective against an HPV16-related tumour in an animal model. The vaccine is composed of extract from Nicotiana benthamiana leaves containing HPV16 E7 protein expressed by a potato vi...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200902200412
更新日期:2009-10-01 00:00:00
abstract::Both allergic disorders and obesity keep increasing in industrialized countries. Even though a strong association between obesity and allergy- related diseases has been reported in several studies, no published data show a scientific and firm link in-between the two conditions. In general, obesity and weight gain have...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章,评审
doi:10.1177/03946320110240S403
更新日期:2011-10-01 00:00:00
abstract::Classification of upper tract urothelial preneoplastic and neoplastic lesions mirrors that of the urinary bladder, with all lesions of the bladder urothelium being possible in the upper tract and vice versa. There are three major groups of non-invasive urothelial neoplasms: flat, papillary, and inverted. These three g...
journal_title:International journal of immunopathology and pharmacology
pub_type: 社论,评审
doi:10.1177/039463201402700406
更新日期:2014-10-01 00:00:00
abstract::Few studies have evaluated the occurrence of immediate adverse reactions in allergic patients after an ultra-rush regimen of different commercial allergen extracts for sublingual immunotherapy (SLIT) Methods: 679 patients took part in trials of specific ultra-rush SLIT for the treatment of IgE-mediated rhinitis and/or...
journal_title:International journal of immunopathology and pharmacology
pub_type: 临床试验,杂志文章
doi:10.1177/039463200501800210
更新日期:2005-04-01 00:00:00
abstract::The art of tattooing has increasing in recent decades. Allergic sensitivity to one of the pigments is the most frequent cause of dermatological reactions at the site of the tattoo. Gold is a new pigment used in tattooing, because of its bright yellow color and luster. Allergy to this metal is uncommon. To our knowledg...
journal_title:International journal of immunopathology and pharmacology
pub_type: 信件
doi:10.1177/039463201102400432
更新日期:2011-10-01 00:00:00
abstract::More and more studies have demonstrated the anti-inflammatory effects of heparin. However, in the aspect of allergic airway inflammation, data about its daily use in animal model is scarce. To evaluate the efficacy of 22-day intranasal heparin administration in mite-induced airway allergic inflammation in BALB/c mice,...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201302600208
更新日期:2013-04-01 00:00:00
abstract::1,2-dichloroethane(1,2-DCE) is toxic, especially by inhalation due to its high vapour pressure. Inhalation of concentrated 1,2-DCE vapor can induce effects on the human nervous system, even encephalopathy. However, 1,2-DCE toxic encephalopathy has seldom been reported, and no adequate data were available to evaluate t...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::The objective of the study is to verify effects of nebulized 3% saline hypertonic solution (HS) in comparison to normal saline (NS) in addition to epinephrine in hospitalized children with bronchiolitis. Infants were randomly assigned either to receive every 6 hours nebulized NS (group I) or 3% HS (group II) in additi...
journal_title:International journal of immunopathology and pharmacology
pub_type: 信件,随机对照试验
doi:10.1177/039463201202500218
更新日期:2012-04-01 00:00:00
abstract::Regulatory T cells (Treg) play a critical role in immune homeostasis and expansion of Treg is controlled by chemokine receptors. The chemokine CXCL12 and its G-protein-coupled receptor (CXCR4) are involved in the development of idiopathic pulmonary fibrosis (IPF), but the association of Treg with the CXCL12/CXCR4 axis...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201002300207
更新日期:2010-04-01 00:00:00
abstract::This pilot open-label study is aimed to assess clinical response in psoriasis patients receiving diverse dose regimens of etanercept, consisting of the same global cumulative dose of etanercept administered over different treatment periods. Eligible patients were assigned sequentially in a 1:1 ratio to receive: etaner...
journal_title:International journal of immunopathology and pharmacology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1177/039463201002300314
更新日期:2010-07-01 00:00:00
abstract::Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by a progressive cognitive and memory decline. Among peripheral markers of AD, great interest has been focused on the amyloid precursor protein (APP). In this regard, platelets represent an important peripheral source of APP since it has be...
journal_title:International journal of immunopathology and pharmacology
pub_type: 信件
doi:10.1177/039463201102400229
更新日期:2011-04-01 00:00:00
abstract::Nickel (Ni) oral hyposensitization treatment (NiOHT) is an effective management approach for Ni allergy. No health-related quality of life (HRQoL) data exist for the pre- and post-treatment with NiOHT in systemic nickel allergy syndrome (SNAS). The aims of this study were (a) to explore HRQoL in SNAS patients, (b) to ...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/2058738420934629
更新日期:2020-01-01 00:00:00
abstract::Similar to many complex autoimmune diseases, genetic and environmental factors including diet, infection and xenobiotics play a critical role in the development of autism. In this study, we postulated that infectious agent antigens such as streptokinase, dietary peptides (gliadin and casein) and ethyl mercury (xenobio...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200301600302
更新日期:2003-09-01 00:00:00
abstract::This study aimed to investigate the clinical significance of serum microRNA-219-5p (miR-219-5p) in patients with multiple organ dysfunction syndrome (MODS) caused by acute paraquat (PQ) poisoning, and its correlation with Toll-like Receptor 4 (TLR4). Luciferase reporter assay was used to investigate in vitro the corre...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/2058738420974888
更新日期:2020-01-01 00:00:00
abstract::Since the introduction of the cytological screening programs, a significant reduction in the incidence of cervical cancer has been achieved. Almost all of these cancers are related to high-risk (HR) Human Papillomavirus (HPV) cervical infections. However, the natural history of HPV infection seems to be different in y...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201102400219
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Inflammation, which is a hallmark of asthma, is one of the main sources of oxidative stress in the human body. Thiols are powerful antioxidants that protect cells against the consequences of oxidative stress. We aimed to investigate whether asthma and montelukast monotherapy affect the total plasma thiol poo...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/0394632015621563
更新日期:2016-03-01 00:00:00
abstract::We describe the case of a child affected by milk-protein induced enterocolitis, in which oral challenge with corn was performed without symptoms after a negative specific Atopy Patch Test. Food protein-induced enterocolitis syndrome (FPIES) is an uncommon nonIgE-mediated gastrointestinal food hypersensitivity of infan...
journal_title:International journal of immunopathology and pharmacology
pub_type: 信件
doi:10.1177/039463201302600327
更新日期:2013-07-01 00:00:00
abstract::Interleukin (IL)-8 is a major factor in inflammatory response and the IL-8 levels in exhaled breath condensate (EBC) may be used as a marker of airway inflammation. Airway acidification is implicated in the pathophysiology of obstructive airway diseases and pH EBC values have been used as a marker of airway acidificat...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200702000305
更新日期:2007-07-01 00:00:00
abstract::One of the most dangerous possible complications in joint replacement is infection due to bacteria adhere to prosthesis surface making biofilm difficult to erase. The gold standard treatment consists in prosthesis removal, placement of antibiotic-impregnated cement spacer and systemic antibiotics therapy. When the inf...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/03946320110241S202
更新日期:2011-01-01 00:00:00
abstract::Nickel ingested with food can elicit either systemic cutaneous or gastrointestinal symptoms causing a systemic nickel allergy syndrome (SNAS) that can be treated with tolerance by oral ingestion of the metal. It has been suggested that interleukins 2 (IL-2) and 10 (IL-10) are involved in the mechanisms underlying oral...
journal_title:International journal of immunopathology and pharmacology
pub_type: 临床试验,信件
doi:10.1177/039463201302600127
更新日期:2013-01-01 00:00:00
abstract::Turner's syndrome (TS) is a genetic disorder caused by numeric and/or structural abnormalities of the X chromosome. In a previous study it was observed that acne is less frequent in TS than in the general population. Since the onset of acne in pre-pubertal or pubertal age is related to sebum production, this study eva...
journal_title:International journal of immunopathology and pharmacology
pub_type: 信件
doi:10.1177/039463201102400325
更新日期:2011-07-01 00:00:00
abstract::Cytokines are immunal regulatory proteins, however they also play a relevant role in inflammatory diseases. IL-31 is a newly discovered cytokine expressed primarily in TH2 cells, introduced by activated CD4+ T cells. IL-31 is capable of inducing chemokines and other cytokines in several inflammatory diseases via its s...
journal_title:International journal of immunopathology and pharmacology
pub_type: 社论
doi:10.1177/039463201002300304
更新日期:2010-07-01 00:00:00