Immunomodulatory activity of a plant extract containing human papillomavirus 16-E7 protein in human monocyte-derived dendritic cells.

Abstract:

:This study reports the immunomodulatory activity on human monocyte derived dendritic cells (MDDCs) of a vaccine preparation shown to be effective against an HPV16-related tumour in an animal model. The vaccine is composed of extract from Nicotiana benthamiana leaves containing HPV16 E7 protein expressed by a potato virus X-derived vector (NbPVX-E7). The effect of the extract was evaluated on MDDC differentiation and maturation by monitoring the phenotypic expression of specific markers. The results show that NbPVX-E7 does not induce monocyte differentiation to dendritic cells, but does induce MDDC maturation. Plant extract does not influence MDDC-uptake of E7-FITC while it significantly improves the Ovalbumin-FITC uptake, considered as a model antigen. Importantly, NbPVX-E7-pulsed MDDCs/PBMCs are able to prime human blood-derived lymphocytes from healthy individuals to induce HPV16 E7-specific cytotoxic activity. This is a propaedeutic study for a possible use of E7-containing plant extract in human immunotherapy of HPV-related lesions.

authors

Di Bonito P,Grasso F,Mangino G,Massa S,Illiano E,Franconi R,Fanales-Belasio E,Falchi M,Affabris E,Giorgi C

doi

10.1177/039463200902200412

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

967-78

issue

4

eissn

0394-6320

issn

2058-7384

pii

12

journal_volume

22

pub_type

杂志文章
  • A novel unconventional antigen MPD5 elicits anti-tumor humoral immune responses in a subset of patients with polycythemia vera.

    abstract::In an effort to define the antigenic mechanism that contributes to beneficial therapeutic outcome in patients with polycythemia vera (PV), we screened a human testis cDNA library with serological cloning derived from sera of three PV patients who had undergone therapeutic-induced remission. As a result, we identified ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200702000218

    authors: Xiong Z,Liu E,Yan Y,Silver RT,Yang F,Chen IH,Hodge I,Verstovsek S,Segura FJ,Wang H,Prchal J,Yang XF

    更新日期:2007-04-01 00:00:00

  • Subglotic malt-lymphoma of the larynx: an unusual presentation of chronic cough.

    abstract::Extranodal non-Hodgkin lymphomas limited to the larynx are rare, accounting for less than 1% of all laryngeal neoplasms. The most common site of development of primary laryngeal lymphomas is the supraglottic region. In most cases, the presenting symptoms are hoarseness, dysphagia, dyspnea, and cervical lymphadenopathy...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463201402700319

    authors: Zapparoli M,Trolese AR,Remo A,Sina S,Bonetti A,Micheletto C

    更新日期:2014-07-01 00:00:00

  • Blockade of CXCR6 reduces invasive potential of gastric cancer cells through inhibition of AKT signaling.

    abstract::Chemokines and their receptors have been implicated in cell migration and metastasis of multiple malignant tumors. But the function of CXCR6 signaling in gastric cancer is not comprehensively understood. In the present study, we hypothesized that CXCR6 signaling might play an essential role in the progression of gastr...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632015584502

    authors: Li Y,Fu LX,Zhu WL,Shi H,Chen LJ,Ye B

    更新日期:2015-06-01 00:00:00

  • Detection of hepatitis C virus-RNA in saliva from chronically HCV-infected patients.

    abstract::The possibility of the non-parenteral Hepatitis C Virus (HCV) transmission is supported by the demonstration that the actual virus is present in several body fluids, including saliva. From a review of the literature many investigators have found the presence of HCV-RNA in saliva, however, widely contrasting results em...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:

    authors: Pastore L,Fiore JR,Tateo M,De Benedittis M,Petruzzi M,Casalino C,Genchi C,Lo Muzio L,Angarano G,Serpico R

    更新日期:2006-01-01 00:00:00

  • Sequence uniqueness as a molecular signature of HIV-1-derived B-cell epitopes.

    abstract::The complex pathophysiology of human immunodeficiency virus (HIV) infection and the relatively high mutation rate of the retrovirus make it challenging to design effective anti-HIV vaccines. Several attempts have been made during the last decades to elucidate the enigmatic immunology of HIV infection and to predict po...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200902200309

    authors: Lucchese A,Serpico R,Crincoli V,Shoenfeld Y,Kanduc D

    更新日期:2009-07-01 00:00:00

  • Impact of nickel oral hyposensitization on quality of life in systemic nickel allergy syndrome.

    abstract::Nickel (Ni) oral hyposensitization treatment (NiOHT) is an effective management approach for Ni allergy. No health-related quality of life (HRQoL) data exist for the pre- and post-treatment with NiOHT in systemic nickel allergy syndrome (SNAS). The aims of this study were (a) to explore HRQoL in SNAS patients, (b) to ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/2058738420934629

    authors: Rizzi A,Di Rienzo A,Buonomo A,Aruanno A,Carusi V,Ricci AG,Centrone M,Mezzacappa S,Romeo L,Schiavino D,Inchingolo R,Gasbarrini A,Nucera E

    更新日期:2020-01-01 00:00:00

  • Human lymphocytic B-leukemia cell line treatment with the bacterial toxin listeriolysin O and rituximab (anti-CD20 antibody): Effects of similar localization of their receptors.

    abstract::Small B-cell lymphocytic lymphoma/chronic lymphocytic leukemia, which typically affects elderly people, is a group of conditions that are not clinically uniform. It has been suggested that using the combined activity of the monoclonal antibody anti-CD20 (rituximab) and Listeria monocytogenes toxin listeriolysin O (LLO...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632015595778

    authors: Gryzik M,Grzywocz Z,Wasilewska D,Kawiak J,Stachowiak R,Bielecki J,Hoser G

    更新日期:2015-09-01 00:00:00

  • Phloretin alleviates dinitrochlorobenzene-induced dermatitis in BALB/c mice.

    abstract::Atopic dermatitis (AD) is a chronic inflammatory disease of the skin that substantially affects a patient's quality of life. While steroids are the most common therapy used to temporally alleviate the symptoms of AD, effective and nontoxic alternatives are urgently needed. In this study, we utilized a natural, plant-d...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/2058738420929442

    authors: Wu CS,Lin SC,Li S,Chiang YC,Bracci N,Lehman CW,Tang KT,Lin CC

    更新日期:2020-01-01 00:00:00

  • Natural killer cell activity decreases in workers occupationally exposed to extremely low frequency magnetic fields exceeding 1 microT.

    abstract::In a preliminary study a reduction in natural killer (NK) cell activity in peripheral blood lymphocytes (PBL) was observed in a group of workers exposed to levels of extremely low frequency-magnetic fields (ELF-MF) exceeding 1 microT. This study was performed to confirm the results. In 121 workers engaged in various o...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200902200422

    authors: Gobba F,Bargellini A,Bravo G,Scaringi M,Cauteruccio L,Borella P

    更新日期:2009-10-01 00:00:00

  • Strategies for successful vaccination against hepatocellular carcinoma.

    abstract::Current therapies against hepatocellular carcinoma (HCC) are not curative in the majority of patients. In the past, immunotherapy approaches aimed to non-specifically stimulate immune response were quite ineffective. New treatments based on stimulation of specific anti-tumor immune response are currently proposed and ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 社论

    doi:10.1177/039463200902200203

    authors: Rinaldi M,Iurescia S,Fioretti D,Ponzetto A,Carloni G

    更新日期:2009-04-01 00:00:00

  • Analysis on the co-localization of asbestos bodies and Fas or CD163 expression in asbestos lung tissue by in-air micro-pixe.

    abstract::To prevent and control disease caused by exposure to various agents, it is necessary to determine the harmful level of intervention and to establish a method for measuring that level. In-air microparticle-induced X-ray emission (in-air micro-PIXE) analysis is based on irradiation of specimens with a proton ion microbe...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201002300101

    authors: Matsuzaki S,Shimizu Y,Dobashi K,Nagamine T,Satoh T,Ohkubo T,Yokoyama A,Ishii Y,Kamiya T,Arakawa K,Makino S,Utsugi M,Ishizuka T,Tanaka S,Shimizu K,Mori M

    更新日期:2010-01-01 00:00:00

  • Detection of Helicobacter pylori by PCR on gastric biopsy specimens taken for CP test: comparison with histopathological analysis.

    abstract::The aims of the present study were: (i) to assess whether H. pylori could be successfully detected by PCR from the same biopsy sample used for CPtest; and ii) to evaluate CPtest comparatively to both PCR and histology for detection of H. pylori infection in dyspeptic patients. Three antral gastric biopsies were collec...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200401700111

    authors: Di Bonaventura G,Neri M,Angelucci D,Rosini S,Piccolomini M,Piccolomini R

    更新日期:2004-01-01 00:00:00

  • Presepsin: A potential biomarker of PJI? A comparative analysis with known and new infection biomarkers.

    abstract::There is still no "gold standard" for the diagnosis and prognosis of post-operative periprosthetic joint infection (PJI). Among serum biomarkers, an emerging molecule is presepsin, the soluble fraction of CD14, recently described in other settings as a powerful diagnostic tool to detect sepsis at different degrees of ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632017749356

    authors: Marazzi MG,Randelli F,Brioschi M,Drago L,Romanò CL,Banfi G,Massaccesi L,Crapanzano C,Morelli F,Corsi Romanelli MM,Galliera E

    更新日期:2018-01-01 00:00:00

  • Oxymatrine exhibits anti-tumor activity in gastric cancer through inhibition of IL-21R-mediated JAK2/STAT3 pathway.

    abstract::Oxymatrine (OMT) as a type of alkaloids collected from Sophora flavescens Ait exerts some biological functions including anticancer properties. Here, we investigated the therapeutic effects of OMT in gastric cancer cells (HGC 27 and AGS). As a result, the exposure of gastric cancer (GC) cells to OMT contributed to the...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/2058738418781634

    authors: Huang Y,Zhang J,Wang G,Chen X,Zhang R,Liu H,Zhu J

    更新日期:2018-01-01 00:00:00

  • Peripheral blood neutrophil granulocytes from patients with head and neck squamous cell carcinoma functionally differ from their counterparts in healthy donors.

    abstract::Solid tumors such as head and neck squamous cell carcinoma (HNSCC) display an intense interaction between tumoral factors and the immune system. Functional modulation of tumor-infiltrating and peripheral blood immune cells plays an important role during tumor progression. In this pilot study we compared biological fun...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201102400314

    authors: Trellakis S,Farjah H,Bruderek K,Dumitru CA,Hoffmann TK,Lang S,Brandau S

    更新日期:2011-07-01 00:00:00

  • Efficacy, safety and potential clinical roles of the COX-2-specific inhibitors.

    abstract::About three decades ago, the primary mechanism of action of the non-steroidal anti-inflammatory drugs (NSAIDs) was elucidated when their inhibitory action on the production of prostaglandins was discovered. It was found that their action is centred on the inhibition of the cyclooxygenase (COX) enzyme responsible for c...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章,评审

    doi:

    authors: van der Bijl P,van der Bijl P Jr

    更新日期:2003-05-01 00:00:00

  • Topical cyclosporin in the treatment of dermatologic diseases.

    abstract::Cyclosporine A (CsA) has been in clinical use for some decades, primarily for the prevention and treatment of organ transplant rejection and graft-versus-host disease. In more recent years, Cyclosporine has been recognized as beneficial in the treatment of dermatologic diseases, such as: psoriasis, lichen planus, Behc...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200201500203

    authors: Feliciani C,Tulli A

    更新日期:2002-05-01 00:00:00

  • Effect of betamethasone in combination with antibiotics on gram positive and gram negative bacteria.

    abstract::Betamethasone is an anti-inflammatory steroid drug used in cases of anaphylactic and allergic reactions, of Alzheimer and Addison diseases and in soft tissue injuries. It modulates gene expression for anti-inflammatory activity suppressing the immune system response. This latter effect might decrease the effectiveness...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463201402700426

    authors: Artini M,Papa R,Cellini A,Tilotta M,Barbato G,Koverech A,Selan L

    更新日期:2014-10-01 00:00:00

  • Cobalt nano-particles modulate cytokine in vitro release by human mononuclear cells mimicking autoimmune disease.

    abstract::The use of particles from micro to nanoscale provides benefits to diverse scientific fields, but because a large percentage of their atoms lie on the surface, nanomaterials could be highly reactive and pose potential risks to humans. Due to their wide range of application, Cobalt nano-particles are of great interest b...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:

    authors: Petrarca C,Perrone A,Verna N,Verginelli F,Ponti J,Sabbioni E,Di Giampaolo L,Dadorante V,Schiavone C,Boscolo P,Mariani Costantini R,Di Gioacchino M

    更新日期:2006-10-01 00:00:00

  • TNF-alpha, IL-4R-alpha and IL-4 polymorphisms in mild to severe asthma from Italian Caucasians.

    abstract::Asthma is a chronic airway inflammatory disease associated with airway hyperresponsiveness which affects subjects with genetic predisposition. An association has been reported between some polymorphisms in various cytokine genes and asthma. Most of them are single nucleotide polymorphisms (SNPs). These polymorphisms a...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201302600107

    authors: Ricciardolo FL,Sorbello V,Silvestri M,Giacomelli M,Debenedetti VM,Malerba M,Ciprandi G,Rossi GA,Rossi A,Bontempelli M

    更新日期:2013-01-01 00:00:00

  • Enhancement of lysosomal glycohydrolase activity in human primary B lymphocytes during spontaneous apoptosis.

    abstract::It has been shown that lysosomes are involved in B cell apoptosis but lysosomal glycohydrolases have never been investigated during this event. In this study we determined the enzymatic activities of some lysosomal glycohydrolases in human tonsil B lymphocytes (TBL) undergoing in vitro spontaneous apoptosis. Fluorimet...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200702000208

    authors: Rosati E,Mencarelli S,Magini A,Sabatini R,Tassi C,Orlacchio A,Coaccioli S,Frenguelli A,Marconi P,Emiliani C

    更新日期:2007-04-01 00:00:00

  • Type 1 diabetes onset and pandemic influenza A (H1N1).

    abstract::Type 1 diabetes (T1D) is a heterogeneous disorder characterized by destruction of pancreatic beta cells, culminating in loss of insulin secretion. Data from large epidemiologic studies worldwide indicate that during the last decades the incidence of T1D has increased significantly, reaching percentages of 2-5% annuall...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 评论,信件

    doi:10.1177/039463201202500228

    authors: Piccini B,Toni S,Lenzi L,Guasti M,Barni F,De Martino M

    更新日期:2012-04-01 00:00:00

  • Intestinal mucosa-associated bacteria modulate rat mast cell reactivity.

    abstract::It is well known that in some conditions bacteria of physiological flora of gastrointestinal tract may become pathogenic. Each complaint which causes injury of gastrointestinal wall integrity permits bacteria to penetrate the tissues and affect the tissue cells. Since mast cells represent one of very important and num...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:

    authors: Brzezińska-Blaszczyk E,Olejnik AK

    更新日期:1999-01-01 00:00:00

  • Evaluation of seminal fluid leukocyte subpopulations in patients with varicocele.

    abstract::Varicocele is a common cause of sperm damage. Some studies showed higher concentration of seminal leukocytes in patients with varicocele. The aim of the study was to evaluate seminal leukocyte subpopulations in patients with varicocele. We enrolled 20 patients with varicocele and 20 age-matched healthy men. Sperm anal...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/2058738420925719

    authors: Mongioì LM,Alamo A,Calogero AE,Compagnone M,Giacone F,Cannarella R,La Vignera S,Condorelli RA

    更新日期:2020-01-01 00:00:00

  • The growth of Streptococcus mutans in different milks for infant feeding.

    abstract::After birth various bacterial species, mainly streptococci, colonize the oral cavity and are frequently isolated from carious lesions in children. Previous studies suggest that an earlier colonization of a child's mouth by cariogenic organisms might be related to a higher risk of caries. The aim of this study is to as...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463201402700119

    authors: Duse M,Zicari AM,Berlutti F,Ernesti I,Occasi F,Leonardi L,Polimeni A

    更新日期:2014-01-01 00:00:00

  • Allergy to nickel: first results on patients administered with an oral hyposensitization therapy.

    abstract::Nickel sulphate allergy is the most common contact allergy. In fact, nickel sulphate is an ubiquitous element, contained in various objects and food; it occurs in igneous rocks, as a free metal and together with iron, but it is also a component of living organism, mainly vegetables. We carried out a clinical trial of ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463200902200330

    authors: Tammaro A,De Marco G,Persechino S,Narcisi A,Camplone G

    更新日期:2009-07-01 00:00:00

  • Morning sudden cardiac death.

    abstract::A circadian variation of cardiac function with peak in the early morning was documented about twenty years ago. A circadian rhythm of platelet aggregability, in the same time of the day, was demonstrated in healthy young male subjects. The morning hours were also reported as crucial for sympathetic nervous system acti...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200001300109

    authors: Guagnano MT,Davi G,Sensi S

    更新日期:2000-01-01 00:00:00

  • Determinants of bronchial hyperresponsiveness in subjects with rhinitis.

    abstract::Subjects with rhinitis but without asthma may have coexisting bronchial hyperresponsiveness, although the reasons for this are uncertain. To evaluate the factors that determine BHR in rhinitis we examined 410 patients with symptomatic rhinitis with forced expiratory volume in 1 second (FEV1) and forced vital capacity ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200501800414

    authors: Di Lorenzo G,Pacor ML,Mansueto P,Esposito Pellitteri M,Lo Bianco C,Ditta V,Leto-Barone MS,Napoli N,Di Fede G,Rini GB

    更新日期:2005-10-01 00:00:00

  • A multicenter open-label experience on the response of psoriasis to Adalimumab and effect of dose escalation in non-responders: the Aphrodite project.

    abstract::There is much evidence to show the efficacy of adalimumab, a human monoclonal antibody targeting tumour necrosis factor-alpha, in the treatment of plaque psoriasis. In this open-label experience, 147 high-need patients suffering from plaque psoriasis, with a mean Psoriasis Area and Severity Index (PASI) of 18.8, and c...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/039463200902200125

    authors: Vena GA,Galluccio A,De Simone C,Mastrandrea V,Buquicchio R,La Greca S,Dattola S,Puglisi Guerra A,Donato L,Cantoresi F,De Pità O,Pezza M,D Agostino M,Vernaci R,Miracapillo A,Valenti G,Cassano N

    更新日期:2009-01-01 00:00:00

  • Carbon nanotubes: Properties, biomedical applications, advantages and risks in patients and occupationally-exposed workers.

    abstract::Since the beginning of the 21st century, carbon-based nanomaterials (CNTs) have been introduced in pharmacy and medicine for drug delivery system in therapeutics. CNTs have proved able to transport a wide range of molecules across membranes and into living cells; therefore, they have attracted great interest in biomed...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 社论,评审

    doi:10.1177/0394632015572559

    authors: Lamberti M,Pedata P,Sannolo N,Porto S,De Rosa A,Caraglia M

    更新日期:2015-03-01 00:00:00