Abstract：
:We studied the significance of age as a factor affecting prognosis and anti-AChR antibody levels in myasthenia gravis, comparing patients with symptom onset before 50 (37 patients) and at or after 50 (33 patients). More of the older patients, compared to younger ones (69.9% versus 32.4%,p<0. 05) progressed to severe disease in the first three years of treatment. Five older patients died during myasthenic crises, whereas no deaths occured in the younger group. In addition; older patients did not respond as favorably as younger ones to anticholinesterase treatment and more of them required combination therapy. AntiAChR antibody levels were significantly lower in older patients (9.2 versus 34.9 nM, p<0.005). We conclude that symptom onset at or after the age of 50 predicts unfavorable outcome in myasthenia gravis and is associated with lower anti-AChR antibody levels. This group of patients requires earlier treatment with corticosteroids, immunosuppressive drugs or both.
journal_name
Int J Immunopathol Pharmacolauthors
Kapinas K,Kimiskidis VK,Kazis AD,Kokkas B,Tsolaki M,Georgiadis Gkeywords:
subject
Has Abstractpub_date
1999-09-01 00:00:00pages
127-131issue
3eissn
0394-6320issn
2058-7384pii
3journal_volume
12pub_type
杂志文章abstract：:Salmonellosis-induced diarrhea, is one of the commonest cause of childhood mortality in developing countries. Using of probiotics is viewed as a promising means for reducing the pathogenic loads of bacterial infection. The current study aimed to evaluate the potential antimicrobial and immunomodulatory efficacy of iso...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/0394632015592099
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abstract：:Many oncogenis and tumour suppressor genes found inside normal and pathological cells are fundamental for the processes of development, proliferation and tissue differentiation. The purpose of our study is to show the presence and a possible relationship of the VEGF protein during different phases of the development o...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463200501800319
更新日期：2005-07-01 00:00:00
abstract：:Occupational exposure to chromium may cause airway inflammation and bronchial asthma. In this study we investigated the effect of chromium on the respiratory tract of exposed and non-exposed electroplating workers using spirometry and analysis of induced sputum (IS), exhaled breath condensate (EBC) and nasal lavage fl...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：
更新日期：2006-10-01 00:00:00
abstract：:Allergic drug reactions can be classified as immediate, accelerated or delayed. This classification usually correlates with the mechanism involved: immediate reactions are IgE mediated and delayed reactions are T cell dependent. We analyzed lymphocyte involvement in patients with these reactions by determining cell su...
journal_title：International journal of immunopathology and pharmacology
pub_type： 临床试验,杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:More and more studies have demonstrated the anti-inflammatory effects of heparin. However, in the aspect of allergic airway inflammation, data about its daily use in animal model is scarce. To evaluate the efficacy of 22-day intranasal heparin administration in mite-induced airway allergic inflammation in BALB/c mice,...
journal_title：International journal of immunopathology and pharmacology
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journal_title：International journal of immunopathology and pharmacology
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abstract：:In an effort to define the antigenic mechanism that contributes to beneficial therapeutic outcome in patients with polycythemia vera (PV), we screened a human testis cDNA library with serological cloning derived from sera of three PV patients who had undergone therapeutic-induced remission. As a result, we identified ...
journal_title：International journal of immunopathology and pharmacology
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journal_title：International journal of immunopathology and pharmacology
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abstract：:Atopic dermatitis (AD) is a chronic inflammatory disease of the skin that substantially affects a patient's quality of life. While steroids are the most common therapy used to temporally alleviate the symptoms of AD, effective and nontoxic alternatives are urgently needed. In this study, we utilized a natural, plant-d...
journal_title：International journal of immunopathology and pharmacology
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journal_title：International journal of immunopathology and pharmacology
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journal_title：International journal of immunopathology and pharmacology
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abstract：INTRODUCTION:Indoleamine 2,3-dioxygenase (IDO) was a potential tumor immunotherapy target. IDO inhibitors showed inconsistent results in clinical trials, but no preclinical comparative study was reported. The purpose of this study was to evaluate the differences of representative IDO inhibitors (PCC0208009, INCB024360,...
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pub_type： 社论
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更新日期：2012-10-01 00:00:00
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journal_title：International journal of immunopathology and pharmacology
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journal_title：International journal of immunopathology and pharmacology
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journal_title：International journal of immunopathology and pharmacology
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journal_title：International journal of immunopathology and pharmacology
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