Interleukin-2 enhances susceptibility of colon cancer cells to FasR mediated apoptosis by up-regulating Fas receptor level and down-regulating FAP-1 expression.

abstract：:Cytokines are immunal regulatory proteins, however they also play a relevant role in inflammatory diseases. IL-31 is a newly discovered cytokine expressed primarily in TH2 cells, introduced by activated CD4+ T cells. IL-31 is capable of inducing chemokines and other cytokines in several inflammatory diseases via its s...

journal_title：International journal of immunopathology and pharmacology

authors： Castellani ML,Felaco P,Galzio RJ,Tripodi D,Toniato E,De Lutiis MA,Fulcheri M,Caraffa A,Antinolfi P,Tetè S,Felaco M,Conti F,Pandolfi F,Theoharides TC,Shaik-Dasthagirisaheb YB

更新日期：2010-07-01 00:00:00

abstract：INTRODUCTION:Indoleamine 2,3-dioxygenase (IDO) was a potential tumor immunotherapy target. IDO inhibitors showed inconsistent results in clinical trials, but no preclinical comparative study was reported. The purpose of this study was to evaluate the differences of representative IDO inhibitors (PCC0208009, INCB024360,...

journal_title：International journal of immunopathology and pharmacology

authors： Jiang X,Li X,Zheng S,Du G,Ma J,Zhang L,Wang H,Tian J

更新日期：2020-01-01 00:00:00

abstract：:Similar to many complex autoimmune diseases, genetic and environmental factors including diet, infection and xenobiotics play a critical role in the development of autism. In this study, we postulated that infectious agent antigens such as streptokinase, dietary peptides (gliadin and casein) and ethyl mercury (xenobio...

journal_title：International journal of immunopathology and pharmacology

authors： Vojdani A,Pangborn JB,Vojdani E,Cooper EL

更新日期：2003-09-01 00:00:00

abstract：:Cryopyrin-associated periodic syndromes are categorized as a spectrum of three autoinflammatory diseases, namely familial cold auto-inflammatory syndrome, Muckle-Wells syndrome and chronic infantile neurological cutaneous articular syndrome. All are caused by mutations in the NLRP3 gene coding for cryopyrin and result...

journal_title：International journal of immunopathology and pharmacology

authors： Cantarini L,Lucherini OM,Frediani B,Brizi MG,Bartolomei B,Cimaz R,Galeazzi M,Rigante D

更新日期：2011-10-01 00:00:00

abstract：:The treatment with infliximab is employed successfully in Crohn's disease (CD) but predictors of efficacy are lacking. Activation of the transcription factor NF-kB has been demonstrated in CD and its inhibition is one of the mechanisms by which anti-inflammatory agents exert their effects. We evaluated the production ...

journal_title：International journal of immunopathology and pharmacology

authors： Guidi L,Costanzo M,Ciarniello M,De Vitis I,Pioli C,Gatta L,Pace L,Tricerri A,Bartoloni C,Coppola L,Balistreri P,Doria G,Fedeli G,Gasbarrini GB

更新日期：2005-01-01 00:00:00

abstract：:Allergic drug reactions can be classified as immediate, accelerated or delayed. This classification usually correlates with the mechanism involved: immediate reactions are IgE mediated and delayed reactions are T cell dependent. We analyzed lymphocyte involvement in patients with these reactions by determining cell su...

journal_title：International journal of immunopathology and pharmacology

authors： Torres MJ,Mayorga C,Fernández TD,Cornejo-García JA,Antúnez C,Valenzuela M,Del Prado MF,Rodriguez-Pena R,Blanca M

更新日期：2006-01-01 00:00:00

abstract：:Current therapies against hepatocellular carcinoma (HCC) are not curative in the majority of patients. In the past, immunotherapy approaches aimed to non-specifically stimulate immune response were quite ineffective. New treatments based on stimulation of specific anti-tumor immune response are currently proposed and ...

journal_title：International journal of immunopathology and pharmacology

authors： Rinaldi M,Iurescia S,Fioretti D,Ponzetto A,Carloni G

更新日期：2009-04-01 00:00:00

abstract：:Blockade of the interactions between CD28/CTLA-4 and their ligands, CD80 (B7, B7.1)/CD86 (B70, B7.2), is an attractive means to induce antigen-specific peripheral tolerance in autoimmune disease and organ transplantation. In this study, we generated and characterized a monoclonal antibody (Clone 4E5) against human CD8...

journal_title：International journal of immunopathology and pharmacology

authors： Shi Q,Gao ZY,Xie F,Wang LF,Gu YP,Yang TJ,Huang L,Qian QH,Qiu YH

更新日期：2011-07-01 00:00:00

abstract：:Deficits in glucose, impaired insulin signalling and brain insulin resistance are common in the pathogenesis of Alzheimer's disease (AD); therefore, some scholars even called AD type 3 diabetes mellitus. Curcumin can reduce the amyloid pathology in AD. Moreover, it is a well-known fact that curcumin has anti-oxidant a...

journal_title：International journal of immunopathology and pharmacology

authors： Feng HL,Dang HZ,Fan H,Chen XP,Rao YX,Ren Y,Yang JD,Shi J,Wang PW,Tian JZ

更新日期：2016-12-01 00:00:00

abstract：:Behcets disease (BD) is a chronic, relapsing, multi-system inflammatory disorder, clinically characterized by recurrent oral and genital ulcers, skin lesions, and uveitis. Other manifestations include arthritis, a positive pathergy test, thrombophlebitis, central nervous system disease and gastrointestinal ulcerations...

journal_title：International journal of immunopathology and pharmacology

authors： Cantarini L,Tinazzi I,Caramaschi P,Bellisai F,Brogna A,Galeazzi M

更新日期：2009-04-01 00:00:00

abstract：:This study aims to characterize phenotypic and genotypic virulence traits in Escherichia coli strains, isolated from outpatients with urinary tract infections, comparing with those obtained from inpatients. Information on the pathogenic behavior of the uropathogenic strains was obtained by monitoring different biologi...

journal_title：International journal of immunopathology and pharmacology

authors： Longhi C,Cossu A,Iebba V,Massaro MR,Cipriani D,Chiarini F,Conte MP,Seganti L,Osborn J,Schippa S

更新日期：2008-07-01 00:00:00

abstract：:This pilot open-label study is aimed to assess clinical response in psoriasis patients receiving diverse dose regimens of etanercept, consisting of the same global cumulative dose of etanercept administered over different treatment periods. Eligible patients were assigned sequentially in a 1:1 ratio to receive: etaner...

journal_title：International journal of immunopathology and pharmacology

authors： Cassano N,Loconsole F,Miracapillo A,Travaglini M,Digiuseppe MD,Congedo M,Galluccio A,Buquicchio R,Mastrandrea V,Filieri M,Raho G,Pezza M,Vena GA

更新日期：2010-07-01 00:00:00

abstract：:Cellular immune response has been demonstrated to play a role in the control of human cytomegalovirus (HCMV) replication in organ transplant recipients. Herein, HCMV-specific T-cell response and association to the onset of organ infection/disease were prospectively evaluated by EliSPOT assay in a population of 46 lung...

journal_title：International journal of immunopathology and pharmacology

authors： Costa C,Saldan A,Sinesi F,Sidoti F,Balloco C,Simeone S,Piceghello A,Mantovani S,Di Nauta A,Solidoro P,Cavallo R

更新日期：2012-10-01 00:00:00

abstract：:Paraneoplastic sensitive neuropathy is one of the most common presentations among a group of cancer-related disorders known as Paraneoplastic Neurological Syndromes (PNS). PNS likely have an autoimmune etiology since they have been associated with the presence of antibodies against neuronal antigens expressed by tumor...

journal_title：International journal of immunopathology and pharmacology

authors： Nappi L,Formisano L,Damiano V,Matano E,Bianco R,Tortora G

更新日期：2010-10-01 00:00:00

abstract：:One of the most dangerous possible complications in joint replacement is infection due to bacteria adhere to prosthesis surface making biofilm difficult to erase. The gold standard treatment consists in prosthesis removal, placement of antibiotic-impregnated cement spacer and systemic antibiotics therapy. When the inf...

journal_title：International journal of immunopathology and pharmacology

authors： Zoccali C,Contestabile M,Di Segni S,Nuvoli B,Prencipe U,Erba F

更新日期：2011-01-01 00:00:00

abstract：:This study aimed to investigate the effects of a novel patented Mg-3Nd-0.2Zn-0.4Zr (weight %, JDBM) alloy on osteoblastic cell function, as these cells play an important role in bone repair and remodeling. The associated effects of the JDBM alloy on osteoblastic cell function involving cell adhesion, cell proliferatio...

journal_title：International journal of immunopathology and pharmacology

authors： Wang Y,Ouyang Y,Pang X,Mao L,Yuan G,Jiang Y,He Y

更新日期：2012-07-01 00:00:00

abstract：:Multiple sclerosis (MS) is thought to be an autoimmune T-cell-mediated disease directed at myelin antigens of the central nervous system. Besides myelin proteins, lipid components of CNS are supposed to play a role as antigens for T cells in MS. CD1 is a family of MHC-like glycoproteins specialized in capturing and pr...

journal_title：International journal of immunopathology and pharmacology

authors： Caporale CM,Notturno F,Pace M,Aureli A,Di Tommaso V,De Luca G,Farina D,Giovannini A,Uncini A

更新日期：2011-01-01 00:00:00

abstract：:Ink spot lentigo, also known as reticulated black solar lentigo, is a melanotic macula commonly described in fair-skinned individuals on sun-exposed areas of the body. Clinically it is a darkly pigmented type of solar lentigo; herein the term ink spot lentigo. In contrast to common solar lentigines, ink spot lentigo i...

journal_title：International journal of immunopathology and pharmacology

authors： Bottoni U,Nisticò S,Amoruso GF,Schipani G,Arcidiacono V,Scali E,Tassone P,Greco M,Amorosi A

更新日期：2013-10-01 00:00:00

abstract：:It is of significance to alleviate oxidative damages for the treatment of spinal cord injury (SCI). Studies have ascertained that green tea polyphenols (GTPs) exert protective activities against oxidative damages. In this study, we aimed to investigate the protective effects of GTP against H2O2-caused injuries in PC12...

journal_title：International journal of immunopathology and pharmacology

authors： Liu S,Yu G,Song G,Zhang Q

更新日期：2019-01-01 00:00:00

abstract：:Hypertension has been suggested to exert pro-inflammatory actions through increased expression of several mediators, including chemokines. Chemokines are involved in inflammatory and autoimmune disorders, and in the formation of atherosclerotic lesions through promotion of inflammatory cell migration. The aim of this ...

journal_title：International journal of immunopathology and pharmacology

authors： Antonelli A,Fallahi P,Ferrari SM,Ghiadoni L,Virdis A,Mancusi C,Centanni M,Taddei S,Ferrannini E

更新日期：2012-04-01 00:00:00

abstract：:The possible use of cell therapies for neurological lesions and disorders is regarded as a very promising strategy. However, many issues related to cell type, tissue donor, expected biological action etc., are still open. In this study human mesenchymal stem cells derived from different fetal and adult tissues were ex...

journal_title：International journal of immunopathology and pharmacology

authors： Paradisi M,Alviano F,Pirondi S,Lanzoni G,Fernandez M,Lizzo G,Giardino L,Giuliani A,Costa R,Marchionni C,Bonsi L,Calza L

更新日期：2014-07-01 00:00:00

abstract：:Nickel sulphate allergy is the most common contact allergy. In fact, nickel sulphate is an ubiquitous element, contained in various objects and food; it occurs in igneous rocks, as a free metal and together with iron, but it is also a component of living organism, mainly vegetables. We carried out a clinical trial of ...

journal_title：International journal of immunopathology and pharmacology

authors： Tammaro A,De Marco G,Persechino S,Narcisi A,Camplone G

更新日期：2009-07-01 00:00:00

abstract：:The development and growth of the rat heart implies hyperplasia, which stops at birth, and hypertrophy, allowing cardiac mass to grow in response to programmed genetic events along with to haemodynamic overload. Moreover, hypertrophy is accomplished to apoptosis which controls the final number of myocardial cells, del...

journal_title：International journal of immunopathology and pharmacology

authors： Centurione L,Di Giulio C,Santavenere E,Cacchio M,Sabatini N,Rapino C,Bianchi G,Rapino M,Bosco D,Antonucci A,Cataldi A

更新日期：2005-01-01 00:00:00

abstract：:Infections caused by the nematode Trichinella spiralis (T. spiralis) are characterized by an inflammatory response in the host. The aim of this study was to identify and evaluate markers for monitoring mice infected with T. spiralis and treated with or without mimosine. The markers that have been used were total and d...

journal_title：International journal of immunopathology and pharmacology

authors： Hitoglou S,Frydas S,Hatzistilianou M,Pappa S,Gougoustamou D,Kotsis A

更新日期：2004-05-01 00:00:00

abstract：:Fibroblasts play a key role in tissue healing by producing the majority of extracellular matrix components, favouring granulation tissue formation, and stimulating re-epithelialization. Hyaluronan is a component of ECM and its anti-inflammatory effects and properties in enhancing wound closure are well known. In this ...

journal_title：International journal of immunopathology and pharmacology

authors： Mariggiò MA,Cassano A,Vinella A,Vincenti A,Fumarulo R,Lo Muzio L,Maiorano E,Ribatti D,Favia G

更新日期：2009-04-01 00:00:00

abstract：:Mast cells are involved in allergic reactions, where they secrete numerous vasoactive, inflammatory and nociceptive mediators in response to immunoglobulin E (IgE) and antigen. However, they have also been implicated in inflammatory conditions, such as painful bladder syndrome/interstitial cystitis (PBS/IC), irritable...

journal_title：International journal of immunopathology and pharmacology

authors： Vasiadi M,Kempuraj D,Boucher W,Kalogeromitros D,Theoharides TC

更新日期：2006-10-01 00:00:00

abstract：:Sublingual immunotherapy with monomeric allergoid (allergoid SLIT), given according to the standard scheme, has proved effective and safe in many clinical trials. However, its build-up phase requires a long time ranging from 16 days to 14 weeks. This study therefore investigated whether, with a four-day up-dosing, the...

journal_title：International journal of immunopathology and pharmacology

authors： D'Anneo RW,Bruno ME,Falagiani P

更新日期：2010-04-01 00:00:00

abstract：:This update on treatment of asthma exacerbations in children is the result of an Italian Pediatric Society Task-force, made up of a panel of experts working in 2007-2008. The aim is to give clear indications on the use of the drugs most employed in children, grading the quality of evidence and the strength of recommen...

journal_title：International journal of immunopathology and pharmacology

authors： Indinnimeo L,Bertuola F,Cutrera R,De Benedictis FM,Di Pietro P,Duse M,Gianiorio P,Indirli G,La Grutta S,La Rosa M,Longhi R,Miceli Sopo S,Miglioranzi P,Miraglia Del Giudice M,Monaco F,Radzik D,Renna S,Snijders D,Zampog

更新日期：2009-10-01 00:00:00

abstract：:Interleukin (IL)-8 is a major factor in inflammatory response and the IL-8 levels in exhaled breath condensate (EBC) may be used as a marker of airway inflammation. Airway acidification is implicated in the pathophysiology of obstructive airway diseases and pH EBC values have been used as a marker of airway acidificat...

journal_title：International journal of immunopathology and pharmacology

authors： Bodini A,D'Orazio C,Peroni DG,Corradi M,Zerman L,Folesani G,Assael BM,Boner AL,Piacentini GL

更新日期：2007-07-01 00:00:00

abstract：:It is well known that in some conditions bacteria of physiological flora of gastrointestinal tract may become pathogenic. Each complaint which causes injury of gastrointestinal wall integrity permits bacteria to penetrate the tissues and affect the tissue cells. Since mast cells represent one of very important and num...

journal_title：International journal of immunopathology and pharmacology

authors： Brzezińska-Blaszczyk E,Olejnik AK

更新日期：1999-01-01 00:00:00