A comparison of antibiotic release between a cement scaffold, a perforated cement scaffold and a cement scaffold mixed to calcium sulphate: in vitro study.

Abstract:

:One of the most dangerous possible complications in joint replacement is infection due to bacteria adhere to prosthesis surface making biofilm difficult to erase. The gold standard treatment consists in prosthesis removal, placement of antibiotic-impregnated cement spacer and systemic antibiotics therapy. When the infection heals a new prosthesis is implanted. The antibiotic-impregnated spacer is important to maintain the prosthesis space and to guarantee a local high concentration of antibiotics. The release of the antibiotic by the cement happens at its surface so that, increasing this, the concentration of antibiotic should be increased as well. The aim of the present study is to verify the different release of antibiotic in plasma by different groups of scaffolds to identify the best solution to make the antibiotic spacer in septic prosthesis revision. Six groups of three antibiotic impregnated cement cube-shaped have been done. The first, made by only antibiotic and cement, the second by a double concentration of the antibiotic and cement, the third made by the antibiotic cement and perforated in every surface with a needle before hardening, the fourth similar to the previous but with a double concentration of antibiotic, the fifth by antibiotic-impregnated cement mixed with calcium sulphate pellets, the sixth similar to the previous with a double concentration of antibiotic. The cubes were immersed in plasma and the concentration of antibiotic released valued at specific times. The perforated cement scaffold demonstrated the best result during the first four weeks.

authors

Zoccali C,Contestabile M,Di Segni S,Nuvoli B,Prencipe U,Erba F

doi

10.1177/03946320110241S202

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

7-9

issue

1 Suppl 2

eissn

0394-6320

issn

2058-7384

pii

2

journal_volume

24

pub_type

杂志文章
  • IL-8 and pH values in exhaled condensate after antibiotics in cystic fibrosis children.

    abstract::Interleukin (IL)-8 is a major factor in inflammatory response and the IL-8 levels in exhaled breath condensate (EBC) may be used as a marker of airway inflammation. Airway acidification is implicated in the pathophysiology of obstructive airway diseases and pH EBC values have been used as a marker of airway acidificat...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200702000305

    authors: Bodini A,D'Orazio C,Peroni DG,Corradi M,Zerman L,Folesani G,Assael BM,Boner AL,Piacentini GL

    更新日期:2007-07-01 00:00:00

  • Immunomodulatory and protective properties of tacrolimus in experimental scorpion envenomation.

    abstract::Involvement of imbalance between pro- and anti-inflammatory events has been reported in the developed pathogenesis after scorpion envenomation. The immunosuppressive and anti-inflammatory properties of tacrolimus (FK-506) have been investigated: i) to better understand evolution of signaling pathways which are involve...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201402700109

    authors: Kabrine M,Laraba-Djebari F

    更新日期:2014-01-01 00:00:00

  • Interleukin-2 enhances susceptibility of colon cancer cells to FasR mediated apoptosis by up-regulating Fas receptor level and down-regulating FAP-1 expression.

    abstract::Colon cancer cells are resistant to FasR-mediated apoptosis, which contributes to their evasion from immune attack by CTLs and NK cells. FasR refractoriness of the malignancies was reported to result from loss of Fas receptors and overepression of Fas-associated phosphatase-1 (FAP-1). Therefore, we investigated the ef...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:

    authors: Song E,Chen J,Antus B,Wang M,Xie Y,Yao H,Exton MS

    更新日期:2000-09-01 00:00:00

  • Dysregulation of autoimmunity caused by silica exposure and alteration of Fas-mediated apoptosis in T lymphocytes derived from silicosis patients.

    abstract::Silicosis patients suffer from pulmonary fibrosis caused by silica inhalation, as well as autoimmune diseases known as the adjuvant effects of silica. Caplan syndrome complicated with rheumatoid arthritis (RA) is well known epidemiologically, and the incidence of complicated systemic sclerosis (SSc), systemic lupus er...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章,评审

    doi:

    authors: Otsuki T,Hayashi H,Nishimura Y,Hyodo F,Maeda M,Kumagai N,Miura Y,Kusaka M,Uragami K

    更新日期:2011-01-01 00:00:00

  • Phloretin alleviates dinitrochlorobenzene-induced dermatitis in BALB/c mice.

    abstract::Atopic dermatitis (AD) is a chronic inflammatory disease of the skin that substantially affects a patient's quality of life. While steroids are the most common therapy used to temporally alleviate the symptoms of AD, effective and nontoxic alternatives are urgently needed. In this study, we utilized a natural, plant-d...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/2058738420929442

    authors: Wu CS,Lin SC,Li S,Chiang YC,Bracci N,Lehman CW,Tang KT,Lin CC

    更新日期:2020-01-01 00:00:00

  • Virulence traits in Escherichia coli strains isolated from outpatients with urinary tract infections.

    abstract::This study aims to characterize phenotypic and genotypic virulence traits in Escherichia coli strains, isolated from outpatients with urinary tract infections, comparing with those obtained from inpatients. Information on the pathogenic behavior of the uropathogenic strains was obtained by monitoring different biologi...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200802100326

    authors: Longhi C,Cossu A,Iebba V,Massaro MR,Cipriani D,Chiarini F,Conte MP,Seganti L,Osborn J,Schippa S

    更新日期:2008-07-01 00:00:00

  • CD1A and CD1E gene polymorphisms are associated with susceptibility to multiple sclerosis.

    abstract::Multiple sclerosis (MS) is thought to be an autoimmune T-cell-mediated disease directed at myelin antigens of the central nervous system. Besides myelin proteins, lipid components of CNS are supposed to play a role as antigens for T cells in MS. CD1 is a family of MHC-like glycoproteins specialized in capturing and pr...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201102400120

    authors: Caporale CM,Notturno F,Pace M,Aureli A,Di Tommaso V,De Luca G,Farina D,Giovannini A,Uncini A

    更新日期:2011-01-01 00:00:00

  • Serratiopeptidase reduces the invasion of osteoblasts by Staphylococcus aureus.

    abstract::Finding new strategies to counteract periprosthetic infection and implant failure is a main target in orthopedics. Staphylococcus aureus, the leading etiologic agent of orthopedic implant infections, is able to enter and kill osteoblasts, to stimulate pro-inflammatory chemokine secretion, to recruit osteoclasts, and t...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632017745762

    authors: Selan L,Papa R,Ermocida A,Cellini A,Ettorre E,Vrenna G,Campoccia D,Montanaro L,Arciola CR,Artini M

    更新日期:2017-12-01 00:00:00

  • Infection following bone tumor resection and reconstruction with tumoral prostheses: a literature review.

    abstract::Bone resection is the choice treatment of malignant bone tumors. Tumor prosthesis is one of the most common solutions of reconstruction following resection of bone tumor located to the metaphysis of long bones. Periprosthetic infections are a frequent complication of limb-salvage surgery which is largely due to prolon...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 社论,评审

    doi:10.1177/039463201002300405

    authors: Graci C,Maccauro G,Muratori F,Spinelli MS,Rosa MA,Fabbriciani C

    更新日期:2010-10-01 00:00:00

  • Plasma total thiol pool in children with asthma: Modulation during montelukast monotherapy.

    abstract:BACKGROUND:Inflammation, which is a hallmark of asthma, is one of the main sources of oxidative stress in the human body. Thiols are powerful antioxidants that protect cells against the consequences of oxidative stress. We aimed to investigate whether asthma and montelukast monotherapy affect the total plasma thiol poo...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632015621563

    authors: Dilek F,Ozkaya E,Kocyigit A,Yazici M,Guler EM,Dundaroz MR

    更新日期:2016-03-01 00:00:00

  • Increased levels of NF-kappaB inhibitors (IkappaBalpha and IkappaBgamma) in the intestinal mucosa of Crohn's disease patients during infliximab treatment.

    abstract::The treatment with infliximab is employed successfully in Crohn's disease (CD) but predictors of efficacy are lacking. Activation of the transcription factor NF-kB has been demonstrated in CD and its inhibition is one of the mechanisms by which anti-inflammatory agents exert their effects. We evaluated the production ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200501800116

    authors: Guidi L,Costanzo M,Ciarniello M,De Vitis I,Pioli C,Gatta L,Pace L,Tricerri A,Bartoloni C,Coppola L,Balistreri P,Doria G,Fedeli G,Gasbarrini GB

    更新日期:2005-01-01 00:00:00

  • Lateralized exanthem mimicking figurate inflammatory dermatosis of infancy after methimazole therapy.

    abstract::We reported a case of an 11-year-old girl admitted to our hospital for goiter, tachycardia, sweating, and visible and palpable thyroid. Thyroid function tests revealed a low thyrotropin level (<0.004 mIU/L) and elevated free thyroxine level (3.4 ng/ dL) diagnosed with Graves' disease and treated with methimazole. This...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632016652412

    authors: Arrigo T,Cutroneo PM,Vaccaro M,Impollonia D,Squadrito V,Mecchio A,Salpietro C,Altavilla D

    更新日期:2016-12-01 00:00:00

  • A novel monoclonal antibody against human CD80 and its immune protection in a mouse lupus-like disease.

    abstract::Blockade of the interactions between CD28/CTLA-4 and their ligands, CD80 (B7, B7.1)/CD86 (B70, B7.2), is an attractive means to induce antigen-specific peripheral tolerance in autoimmune disease and organ transplantation. In this study, we generated and characterized a monoclonal antibody (Clone 4E5) against human CD8...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201102400304

    authors: Shi Q,Gao ZY,Xie F,Wang LF,Gu YP,Yang TJ,Huang L,Qian QH,Qiu YH

    更新日期:2011-07-01 00:00:00

  • TNF-alpha, IL-4R-alpha and IL-4 polymorphisms in mild to severe asthma from Italian Caucasians.

    abstract::Asthma is a chronic airway inflammatory disease associated with airway hyperresponsiveness which affects subjects with genetic predisposition. An association has been reported between some polymorphisms in various cytokine genes and asthma. Most of them are single nucleotide polymorphisms (SNPs). These polymorphisms a...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201302600107

    authors: Ricciardolo FL,Sorbello V,Silvestri M,Giacomelli M,Debenedetti VM,Malerba M,Ciprandi G,Rossi GA,Rossi A,Bontempelli M

    更新日期:2013-01-01 00:00:00

  • Increased expression of CCL4/MIP-1β in CD8+ cells and CD4+ cells in sarcoidosis.

    abstract::Sarcoidosis is a granulomatous disease with an increased accumulation of T cells in lungs as a result of on-site proliferation and chemotaxis induced by chemokines. It has already been demonstrated that CCL3-5 levels were increased in BAL fluid of sarcoidosis patients. To analyze the expression of CCL3-5 chemokines by...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201402700205

    authors: Barczyk A,Pierzchała E,Caramori G,Sozańska E

    更新日期:2014-04-01 00:00:00

  • Enzyme-linked immunosorbent assay, immunofluorescent assay, and recombinant immunoblotting in the serodiagnosis of early Lyme borreliosis.

    abstract::Serum samples from Bulgarian patients with physician-diagnosed erythema migrans (EM) (n=105) were examined using Borrelia burgdorferi ELISA (Boehring, Germany) after previous absorption with Treponema phagedenis. For IgM antibody detection sera were additionally pretreated with anti-IgG serum (RF absorbent). Serum sam...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200301600312

    authors: Christova I

    更新日期:2003-09-01 00:00:00

  • Sublingual allergoid immunotherapy: a new 4-day induction phase in patients allergic to house dust mites.

    abstract::Sublingual immunotherapy with monomeric allergoid (allergoid SLIT), given according to the standard scheme, has proved effective and safe in many clinical trials. However, its build-up phase requires a long time ranging from 16 days to 14 weeks. This study therefore investigated whether, with a four-day up-dosing, the...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/039463201002300217

    authors: D'Anneo RW,Bruno ME,Falagiani P

    更新日期:2010-04-01 00:00:00

  • Determinants of bronchial hyperresponsiveness in subjects with rhinitis.

    abstract::Subjects with rhinitis but without asthma may have coexisting bronchial hyperresponsiveness, although the reasons for this are uncertain. To evaluate the factors that determine BHR in rhinitis we examined 410 patients with symptomatic rhinitis with forced expiratory volume in 1 second (FEV1) and forced vital capacity ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200501800414

    authors: Di Lorenzo G,Pacor ML,Mansueto P,Esposito Pellitteri M,Lo Bianco C,Ditta V,Leto-Barone MS,Napoli N,Di Fede G,Rini GB

    更新日期:2005-10-01 00:00:00

  • Protective effect of diallyl trisulfide against naphthalene-induced oxidative stress and inflammatory damage in mice.

    abstract::The aim of this study was to investigate the possible protective effects of diallyl trisulfide (DATS) against naphthalene-induced oxidative and inflammatory damage in the livers and lungs of mice. Elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels showed significant hepatic damag...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632015627160

    authors: Zhang F,Zhang Y,Wang K,Liu G,Yang M,Zhao Z,Li S,Cai J,Cao J

    更新日期:2016-06-01 00:00:00

  • Myasthenia gravis: correlation of age with clinical course and anti-AChr antibody levels.

    abstract::We studied the significance of age as a factor affecting prognosis and anti-AChR antibody levels in myasthenia gravis, comparing patients with symptom onset before 50 (37 patients) and at or after 50 (33 patients). More of the older patients, compared to younger ones (69.9% versus 32.4%,p<0. 05) progress...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:

    authors: Kapinas K,Kimiskidis VK,Kazis AD,Kokkas B,Tsolaki M,Georgiadis G

    更新日期:1999-09-01 00:00:00

  • Impact of nickel oral hyposensitization on quality of life in systemic nickel allergy syndrome.

    abstract::Nickel (Ni) oral hyposensitization treatment (NiOHT) is an effective management approach for Ni allergy. No health-related quality of life (HRQoL) data exist for the pre- and post-treatment with NiOHT in systemic nickel allergy syndrome (SNAS). The aims of this study were (a) to explore HRQoL in SNAS patients, (b) to ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/2058738420934629

    authors: Rizzi A,Di Rienzo A,Buonomo A,Aruanno A,Carusi V,Ricci AG,Centrone M,Mezzacappa S,Romeo L,Schiavino D,Inchingolo R,Gasbarrini A,Nucera E

    更新日期:2020-01-01 00:00:00

  • Ikaros family transcription factors expression in rat thymus: detection of impaired development.

    abstract::The expression of Ikaros family transcription factors and consequently their signalling pathway is limiting for hematopoietic and lymphocyte development in mice and human. Due to their importance, these transcription factors are highly homologous between species. As an initial approach to examining the possible involv...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201202500407

    authors: Paradzik M,Novak S,Mokrovic G,Bordukalo Niksic T,Heckel D,Stipic J,Pavicic Baldani D,Cicin-Sain L,Antica M

    更新日期:2012-10-01 00:00:00

  • Electrochemical behaviour of titanium in ammine and stannous fluoride and chlorhexidine 0.2 percent mouthwashes.

    abstract::Titanium (Ti) is widely used in dentistry. Fluorides at acid pH could destabilize Ti oxide and make it susceptible to corrosion. The behaviour of IV grade machined Ti disks in 5 electrolytic solutions: Fusayama artificial saliva (Fas), ammine fluoride-stannous fluoride (Am-SnF2), 0.2 percent Chlorexidine (CHX) 0.20 pe...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201002300132

    authors: Quaranta A,Ronconi LF,Di Carlo F,Vozza I,Quaranta M

    更新日期:2010-01-01 00:00:00

  • Psoriasis induced by infliximab in a patient suffering from Crohn's disease.

    abstract::We describe the case of a 30-year-old female with no family history of psoriasis and suffering from Crohn's disease successfully treated with infliximab at the dosage of 5 mg/kg. On the 15th week from the start of therapy, the patient developed a palmoplantar pustular psoriasis, which spread to the arms, trunk and sca...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463200902200331

    authors: Manni E,Barachini P

    更新日期:2009-07-01 00:00:00

  • Role of steroid therapy in pseudoxanthoma elasticum-like papillary dermal elastolysis.

    abstract::Pseudoxanthoma Elasticum-like Papillary Dermal Elastolysis (PXE-PDE) is a peculiar idiopathic elastolytic disorder that clinically resembles Psudoxanthoma elasticum(PXE). It is histologically characterized by a total or partial loss of elastic fibers in the papillary dermis. It more often affects elderly women and is ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201302600423

    authors: Pranteda G,Muscianese M,Marmo G,Fidanza L,Pranteda G,Tamburi F,Bottoni U,Nisticò S

    更新日期:2013-10-01 00:00:00

  • Inhaled mucoactive drugs for treating non-cystic fibrosis bronchiectasis in children.

    abstract::Non-cystic fibrosis bronchiectasis (nCFb) is an acquired condition of variable etiology. Medical treatment basically involves antibiotics and chest physiotherapy. An impaired mucociliary clearance seems to be one of the mechanisms behind nCFb, and inhaled therapy with mucoactive agents has frequently been used to try ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件,评审

    doi:10.1177/039463201302600228

    authors: Snijders D,Calgaro S,Bertozzi I,Quartesan S,Kozuh I,Lunardi F,Barbato A

    更新日期:2013-04-01 00:00:00

  • Aberrant miR-219-5p is correlated with TLR4 and serves as a novel biomarker in patients with multiple organ dysfunction syndrome caused by acute paraquat poisoning.

    abstract::This study aimed to investigate the clinical significance of serum microRNA-219-5p (miR-219-5p) in patients with multiple organ dysfunction syndrome (MODS) caused by acute paraquat (PQ) poisoning, and its correlation with Toll-like Receptor 4 (TLR4). Luciferase reporter assay was used to investigate in vitro the corre...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/2058738420974888

    authors: Dai Y,Liu X,Gao Y

    更新日期:2020-01-01 00:00:00

  • Vascular endothelial growth factor (VEGF) in human tooth germ center.

    abstract::Many oncogenis and tumour suppressor genes found inside normal and pathological cells are fundamental for the processes of development, proliferation and tissue differentiation. The purpose of our study is to show the presence and a possible relationship of the VEGF protein during different phases of the development o...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200501800319

    authors: Mastrangelo F,Piccirilli M,Dolci M,Teté S,Speranza L,Patruno A,Gizzi F,Felaco M,Artese L,De Lutiis MA

    更新日期:2005-07-01 00:00:00

  • A pilot study of feasibility of ultra-rush (20-25 minutes) sublingual-swallow immunotherapy in 679 patients (699 sessions) with allergic rhinitis and/or asthma.

    abstract::Few studies have evaluated the occurrence of immediate adverse reactions in allergic patients after an ultra-rush regimen of different commercial allergen extracts for sublingual immunotherapy (SLIT) Methods: 679 patients took part in trials of specific ultra-rush SLIT for the treatment of IgE-mediated rhinitis and/or...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1177/039463200501800210

    authors: Rossi RE,Monasterolo G

    更新日期:2005-04-01 00:00:00

  • Reduced sebum production in Turner syndrome: a study of twenty-two patients.

    abstract::Turner's syndrome (TS) is a genetic disorder caused by numeric and/or structural abnormalities of the X chromosome. In a previous study it was observed that acne is less frequent in TS than in the general population. Since the onset of acne in pre-pubertal or pubertal age is related to sebum production, this study eva...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463201102400325

    authors: Brazzelli V,Calcaterra V,Muzio F,Klersy C,Larizza D,Borroni G

    更新日期:2011-07-01 00:00:00