Abstract:
:Many oncogenis and tumour suppressor genes found inside normal and pathological cells are fundamental for the processes of development, proliferation and tissue differentiation. The purpose of our study is to show the presence and a possible relationship of the VEGF protein during different phases of the development of human dental germ centers. After cephalometric investigation in 8 orthodontic patients with a mean age of 13 years, (4 females and 4 males), hyperdivergence of the third molars were extracted. The 40 surgical samples were tested with monoclonal human anti-VEGFs antibodies carrying out a semi-quantitative analysis to look for a positive reaction. Reaction for anti-VEGF antibodies was detected in normal embryological tissues and in microvessels near odontogenic cells. During different phases of embryologic development of the dental bud our search showed intracytoplasmatic positive immunoreactions both in the ameloblastic and odontoblastic cells. Additionally, a positive reaction was observed for the VEGF protein in the cells of the stellate reticulum and in those endothelial tissue surrounding the microvessels in all the samples examined.
journal_name
Int J Immunopathol Pharmacolauthors
Mastrangelo F,Piccirilli M,Dolci M,Teté S,Speranza L,Patruno A,Gizzi F,Felaco M,Artese L,De Lutiis MAdoi
10.1177/039463200501800319keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
587-94issue
3eissn
0394-6320issn
2058-7384pii
19journal_volume
18pub_type
杂志文章abstract::Blockade of the interactions between CD28/CTLA-4 and their ligands, CD80 (B7, B7.1)/CD86 (B70, B7.2), is an attractive means to induce antigen-specific peripheral tolerance in autoimmune disease and organ transplantation. In this study, we generated and characterized a monoclonal antibody (Clone 4E5) against human CD8...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201102400304
更新日期:2011-07-01 00:00:00
abstract::Optimal management of deep infections in orthopedic and trauma surgery is often challenging. Traditional prophylactic and treatment approaches are based on the systemic administration of relatively high doses of antibiotics, which may result in a number of side effects. Furthermore, systemically administered antimicro...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章,多中心研究,评审
doi:10.1177/03946320110241S223
更新日期:2011-01-01 00:00:00
abstract::Although dental implants have undergone impressive evolution in recent years, periimplantitis still remains a relevant problem and information on the susceptibility of commercial implants to bacterial colonization is insufficient. This work evaluated the susceptibility of different commercial implants to bacterial col...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201302600218
更新日期:2013-04-01 00:00:00
abstract::Nasal cytology represents a valid method in the differential diagnosis of allergic and non-allergic nasal diseases, as it is simple, safe, non-invasive, cost-effective, and easy to perform both in the medical and paediatric office. In particular, through cytological investigation it is possible to diagnose a group of ...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章,评审
doi:
更新日期:2010-01-01 00:00:00
abstract::MicroRNAs (miRNAs) exhibit a crucial role in the regulation of angiogenesis and tumor progression, of which miR-199a-5p (miR-199a) has been reported to function as a tumor suppressor in multiple malignancies. However, the precise mechanisms underlying miR-199a in hemangiomas (HAs) remain elusive. In this study, we fou...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/0394632017749357
更新日期:2018-01-01 00:00:00
abstract::The treatment with infliximab is employed successfully in Crohn's disease (CD) but predictors of efficacy are lacking. Activation of the transcription factor NF-kB has been demonstrated in CD and its inhibition is one of the mechanisms by which anti-inflammatory agents exert their effects. We evaluated the production ...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200501800116
更新日期:2005-01-01 00:00:00
abstract::The question of whether T cell responses to SEREX-defined tumor antigens are under regulation of naturally occurring CD4+CD25+ regulatory T cells (nTreg cells) has not been answered. To address this issue, we first identified an HLA-A2.1-restricted T cell antigen epitope of SEREX-identified tumor antigen CML66L, 66Pa....
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200702000109
更新日期:2007-01-01 00:00:00
abstract::The complex pathophysiology of human immunodeficiency virus (HIV) infection and the relatively high mutation rate of the retrovirus make it challenging to design effective anti-HIV vaccines. Several attempts have been made during the last decades to elucidate the enigmatic immunology of HIV infection and to predict po...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200902200309
更新日期:2009-07-01 00:00:00
abstract::The present study investigated the sources of discomfort and the symptoms reported by earthquake victims residing in temporary emergency prefabricated accommodation (prefab). The investigation was carried out by means of a questionnaire. 203 prefab occupants and 13 inhabitants of houses, who were chosen as reference p...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/03946320040170S217
更新日期:2004-05-01 00:00:00
abstract::Plague is still endemic in different regions of the world. Current vaccines raise concern for their side effects and limited protection, highlighting the need for an efficacious and rapidly producible vaccine. F1 and V antigens of Yersinia pestis, and F1-V fusion protein produced in Nicotiana benthamiana administered ...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200902200115
更新日期:2009-01-01 00:00:00
abstract::Subjects with rhinitis but without asthma may have coexisting bronchial hyperresponsiveness, although the reasons for this are uncertain. To evaluate the factors that determine BHR in rhinitis we examined 410 patients with symptomatic rhinitis with forced expiratory volume in 1 second (FEV1) and forced vital capacity ...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200501800414
更新日期:2005-10-01 00:00:00
abstract::Nickel ingested with food can elicit either systemic cutaneous or gastrointestinal symptoms causing a systemic nickel allergy syndrome (SNAS) that can be treated with tolerance by oral ingestion of the metal. It has been suggested that interleukins 2 (IL-2) and 10 (IL-10) are involved in the mechanisms underlying oral...
journal_title:International journal of immunopathology and pharmacology
pub_type: 临床试验,信件
doi:10.1177/039463201302600127
更新日期:2013-01-01 00:00:00
abstract::This study aimed to explore the role and mechanism(s) of flunarizine hydrochloride in the intracerebral hemorrhage (ICH) rats. The 32 adult male Sprague Dawley (SD) rats were randomly assigned into four groups: control group, sham group, ICH group, and FLU + ICH group. The effects of flunarizine hydrochloride were ass...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/0394632017742224
更新日期:2017-12-01 00:00:00
abstract::We aimed to analyze the action of berberine on the neuropathic pain and neuroglia activation in experimental diabetes mellitus (DM) model. Diabetes in mice was induced by intraperitoneal injection of streptozotocin (STZ) followed by the administration of berberine. Mechanical allodynia and thermal hyperalgesia and act...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/2058738419866379
更新日期:2019-01-01 00:00:00
abstract::We describe the case of a child affected by milk-protein induced enterocolitis, in which oral challenge with corn was performed without symptoms after a negative specific Atopy Patch Test. Food protein-induced enterocolitis syndrome (FPIES) is an uncommon nonIgE-mediated gastrointestinal food hypersensitivity of infan...
journal_title:International journal of immunopathology and pharmacology
pub_type: 信件
doi:10.1177/039463201302600327
更新日期:2013-07-01 00:00:00
abstract::The aim of this experimental study was to evaluate the effects of nicotine on sperm motility and on non-conventional sperm parameters in vitro. Capacitated spermatozoa isolated from 10 normozoospermic, healthy, non-smoker men were evaluated. Spermatozoa were exposed to increasing concentrations of nicotine (0, 1, 10, ...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201302600317
更新日期:2013-07-01 00:00:00
abstract::Allergic drug reactions can be classified as immediate, accelerated or delayed. This classification usually correlates with the mechanism involved: immediate reactions are IgE mediated and delayed reactions are T cell dependent. We analyzed lymphocyte involvement in patients with these reactions by determining cell su...
journal_title:International journal of immunopathology and pharmacology
pub_type: 临床试验,杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::There is still no "gold standard" for the diagnosis and prognosis of post-operative periprosthetic joint infection (PJI). Among serum biomarkers, an emerging molecule is presepsin, the soluble fraction of CD14, recently described in other settings as a powerful diagnostic tool to detect sepsis at different degrees of ...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/0394632017749356
更新日期:2018-01-01 00:00:00
abstract::Orofacial clefts are common congenital defects whose prevalence differs between geographical regions and ethnic groups. The inheritance is complex, involving the contribution of both genetic and environmental factors. The involvement of genes belonging to the folate pathway is still matter of debate, with strong evide...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/2058738419855571
更新日期:2019-01-01 00:00:00
abstract::Septic shock (SS) leads to a high mortality rate for sepsis patients. Norepinephrine (NE) is a preferred vasoactive agent in SS treatment. This study aimed to assess the effects of NE at different administration time and NE combined with SP treatment on the cardiac function and prognosis of SS.SS patients received NE ...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/2058738420950583
更新日期:2020-01-01 00:00:00
abstract::3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole (ST1959) has shown therapeutic effects in several animal models of autoimmune diseases. In this study the effects of ST1959 were further investigated in a murine model of colitis. The evidence obtained indicates that the beneficial effects exerted by ST1959 rely ...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200902200105
更新日期:2009-01-01 00:00:00
abstract::When through the skin a foreign antigen enters it provokes an immune response and inflammatory reaction. Mast cells are located around small vessels that are involved in vasaldilation. They mature under the influence of local tissue to various cytokines. Human skin mast cells play an essential role in diverse physiolo...
journal_title:International journal of immunopathology and pharmacology
pub_type: 社论,评审
doi:10.1177/039463201302600403
更新日期:2013-10-01 00:00:00
abstract::Myrcene (MC), an organic hydrocarbon, was found to exert anti-inflammatory, analgesic, antimutagenic and antioxidant properties. However, the protective role of MC has not been reported against neonatal asthma. Wistar rats induced with asthma were administered with MC; while asthma control and vehicle control were mai...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/2058738420954948
更新日期:2020-01-01 00:00:00
abstract::Cellular immune response has been demonstrated to play a role in the control of human cytomegalovirus (HCMV) replication in organ transplant recipients. Herein, HCMV-specific T-cell response and association to the onset of organ infection/disease were prospectively evaluated by EliSPOT assay in a population of 46 lung...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201202500417
更新日期:2012-10-01 00:00:00
abstract::To prevent and control disease caused by exposure to various agents, it is necessary to determine the harmful level of intervention and to establish a method for measuring that level. In-air microparticle-induced X-ray emission (in-air micro-PIXE) analysis is based on irradiation of specimens with a proton ion microbe...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201002300101
更新日期:2010-01-01 00:00:00
abstract::Icatibant, an antagonist of the bradykinin B2 receptor, was approved for the treatment of acute attacks of hereditary angioedema in the EU in 2008. This paper presents the case of a 65-year-old woman affected by frequent acute attacks of hereditary angioedema who benefitted from a change of therapy to icatibant, follo...
journal_title:International journal of immunopathology and pharmacology
pub_type: 信件
doi:10.1177/039463201202500130
更新日期:2012-01-01 00:00:00
abstract::Mast cells are vital mediators of drug allergy and, therefore, studying the relationship between drug allergy and mast cells is essential. Sinomenine is the principal active component of Sinomenium acutum, which has anti-inflammatory and anti-immune effects, and is used to treat various rheumatoid diseases. However, al...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/0394632015621768
更新日期:2016-12-01 00:00:00
abstract::Antimuscarinic drugs are the first line pharmacotherapy for overactive bladder, but they are not always effective to achieve complete continence. Nevertheless in some patients urodynamic investigations reveal insufficient effects with continuing incontinence events even with dose optimization. The aim of this study is...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章,随机对照试验
doi:10.1177/03946320120250s106
更新日期:2012-01-01 00:00:00
abstract::In order to understand the immunogenicity of a tumor-associated antigen (TAA), Ras family small GTP binding protein (Ra1A) in hepatocellular carcinoma (HCC), autoantibody responses to RalA were evaluated by enzyme-linked immunosorbent assay (ELISA), Western blotting and indirect immunofluorescence assay in sera from p...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200902200319
更新日期:2009-07-01 00:00:00
abstract::The role of profilin as an allergen has long been questioned. The capacity of profilin to induce respiratory symptoms has recently been demonstrated; moreover, over 50% of patients sensitized to profilin experienced symptoms after the ingestion of plant-derived foods, suggesting that profilin should be considered as a...
journal_title:International journal of immunopathology and pharmacology
pub_type: 信件
doi:10.1177/0394632015621926
更新日期:2016-09-01 00:00:00