Vascular endothelial growth factor (VEGF) in human tooth germ center.

Abstract:

:Many oncogenis and tumour suppressor genes found inside normal and pathological cells are fundamental for the processes of development, proliferation and tissue differentiation. The purpose of our study is to show the presence and a possible relationship of the VEGF protein during different phases of the development of human dental germ centers. After cephalometric investigation in 8 orthodontic patients with a mean age of 13 years, (4 females and 4 males), hyperdivergence of the third molars were extracted. The 40 surgical samples were tested with monoclonal human anti-VEGFs antibodies carrying out a semi-quantitative analysis to look for a positive reaction. Reaction for anti-VEGF antibodies was detected in normal embryological tissues and in microvessels near odontogenic cells. During different phases of embryologic development of the dental bud our search showed intracytoplasmatic positive immunoreactions both in the ameloblastic and odontoblastic cells. Additionally, a positive reaction was observed for the VEGF protein in the cells of the stellate reticulum and in those endothelial tissue surrounding the microvessels in all the samples examined.

authors

Mastrangelo F,Piccirilli M,Dolci M,Teté S,Speranza L,Patruno A,Gizzi F,Felaco M,Artese L,De Lutiis MA

doi

10.1177/039463200501800319

keywords:

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

587-94

issue

3

eissn

0394-6320

issn

2058-7384

pii

19

journal_volume

18

pub_type

杂志文章
  • A novel monoclonal antibody against human CD80 and its immune protection in a mouse lupus-like disease.

    abstract::Blockade of the interactions between CD28/CTLA-4 and their ligands, CD80 (B7, B7.1)/CD86 (B70, B7.2), is an attractive means to induce antigen-specific peripheral tolerance in autoimmune disease and organ transplantation. In this study, we generated and characterized a monoclonal antibody (Clone 4E5) against human CD8...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201102400304

    authors: Shi Q,Gao ZY,Xie F,Wang LF,Gu YP,Yang TJ,Huang L,Qian QH,Qiu YH

    更新日期:2011-07-01 00:00:00

  • Antibiotic-coated nails in orthopedic and trauma surgery: state of the art.

    abstract::Optimal management of deep infections in orthopedic and trauma surgery is often challenging. Traditional prophylactic and treatment approaches are based on the systemic administration of relatively high doses of antibiotics, which may result in a number of side effects. Furthermore, systemically administered antimicro...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章,多中心研究,评审

    doi:10.1177/03946320110241S223

    authors: Nizegorodcew T,Palmieri G,Marzetti E

    更新日期:2011-01-01 00:00:00

  • In vitro adhesion of commensal and pathogenic bacteria to commercial titanium implants with different surfaces.

    abstract::Although dental implants have undergone impressive evolution in recent years, periimplantitis still remains a relevant problem and information on the susceptibility of commercial implants to bacterial colonization is insufficient. This work evaluated the susceptibility of different commercial implants to bacterial col...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201302600218

    authors: Passariello C,Pera F,Gigola P

    更新日期:2013-04-01 00:00:00

  • Role of nasal cytology.

    abstract::Nasal cytology represents a valid method in the differential diagnosis of allergic and non-allergic nasal diseases, as it is simple, safe, non-invasive, cost-effective, and easy to perform both in the medical and paediatric office. In particular, through cytological investigation it is possible to diagnose a group of ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章,评审

    doi:

    authors: Gelardi M,Fiorella ML,Russo C,Fiorella R,Ciprandi G

    更新日期:2010-01-01 00:00:00

  • miR-199a-5p inhibits proliferation and induces apoptosis in hemangioma cells through targeting HIF1A.

    abstract::MicroRNAs (miRNAs) exhibit a crucial role in the regulation of angiogenesis and tumor progression, of which miR-199a-5p (miR-199a) has been reported to function as a tumor suppressor in multiple malignancies. However, the precise mechanisms underlying miR-199a in hemangiomas (HAs) remain elusive. In this study, we fou...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632017749357

    authors: Wang Y,Dai YX,Wang SQ,Qiu MK,Quan ZW,Liu YB,Ou JM

    更新日期:2018-01-01 00:00:00

  • Increased levels of NF-kappaB inhibitors (IkappaBalpha and IkappaBgamma) in the intestinal mucosa of Crohn's disease patients during infliximab treatment.

    abstract::The treatment with infliximab is employed successfully in Crohn's disease (CD) but predictors of efficacy are lacking. Activation of the transcription factor NF-kB has been demonstrated in CD and its inhibition is one of the mechanisms by which anti-inflammatory agents exert their effects. We evaluated the production ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200501800116

    authors: Guidi L,Costanzo M,Ciarniello M,De Vitis I,Pioli C,Gatta L,Pace L,Tricerri A,Bartoloni C,Coppola L,Balistreri P,Doria G,Fedeli G,Gasbarrini GB

    更新日期:2005-01-01 00:00:00

  • HLA-A2.1-restricted T cells react to SEREX-defined tumor antigen CML66L and are suppressed by CD4+CD25+ regulatory T cells.

    abstract::The question of whether T cell responses to SEREX-defined tumor antigens are under regulation of naturally occurring CD4+CD25+ regulatory T cells (nTreg cells) has not been answered. To address this issue, we first identified an HLA-A2.1-restricted T cell antigen epitope of SEREX-identified tumor antigen CML66L, 66Pa....

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200702000109

    authors: Yan Y,Chen Y,Yang F,Chen IH,Xiong Z,Wang J,Lachman LB,Wang H,Yang XF

    更新日期:2007-01-01 00:00:00

  • Sequence uniqueness as a molecular signature of HIV-1-derived B-cell epitopes.

    abstract::The complex pathophysiology of human immunodeficiency virus (HIV) infection and the relatively high mutation rate of the retrovirus make it challenging to design effective anti-HIV vaccines. Several attempts have been made during the last decades to elucidate the enigmatic immunology of HIV infection and to predict po...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200902200309

    authors: Lucchese A,Serpico R,Crincoli V,Shoenfeld Y,Kanduc D

    更新日期:2009-07-01 00:00:00

  • Sick building syndrome in like symptoms in emergency prefabricated accommodation.

    abstract::The present study investigated the sources of discomfort and the symptoms reported by earthquake victims residing in temporary emergency prefabricated accommodation (prefab). The investigation was carried out by means of a questionnaire. 203 prefab occupants and 13 inhabitants of houses, who were chosen as reference p...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/03946320040170S217

    authors: Muzi G,Accattoli MP,dell'Omo M,Frillici C,Sapia IE,Abbritti G

    更新日期:2004-05-01 00:00:00

  • Plant-derived recombinant F1, V, and F1-V fusion antigens of Yersinia pestis activate human cells of the innate and adaptive immune system.

    abstract::Plague is still endemic in different regions of the world. Current vaccines raise concern for their side effects and limited protection, highlighting the need for an efficacious and rapidly producible vaccine. F1 and V antigens of Yersinia pestis, and F1-V fusion protein produced in Nicotiana benthamiana administered ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200902200115

    authors: Del Prete G,Santi L,Andrianaivoarimanana V,Amedei A,Domarle O,D' Elios MM,Arntzen CJ,Rahalison L,Mason HS

    更新日期:2009-01-01 00:00:00

  • Determinants of bronchial hyperresponsiveness in subjects with rhinitis.

    abstract::Subjects with rhinitis but without asthma may have coexisting bronchial hyperresponsiveness, although the reasons for this are uncertain. To evaluate the factors that determine BHR in rhinitis we examined 410 patients with symptomatic rhinitis with forced expiratory volume in 1 second (FEV1) and forced vital capacity ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200501800414

    authors: Di Lorenzo G,Pacor ML,Mansueto P,Esposito Pellitteri M,Lo Bianco C,Ditta V,Leto-Barone MS,Napoli N,Di Fede G,Rini GB

    更新日期:2005-10-01 00:00:00

  • Systemic nickel allergy: oral desensitization and possible role of cytokines interleukins 2 and 10.

    abstract::Nickel ingested with food can elicit either systemic cutaneous or gastrointestinal symptoms causing a systemic nickel allergy syndrome (SNAS) that can be treated with tolerance by oral ingestion of the metal. It has been suggested that interleukins 2 (IL-2) and 10 (IL-10) are involved in the mechanisms underlying oral...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 临床试验,信件

    doi:10.1177/039463201302600127

    authors: Ricciardi L,Carni A,Loschiavo G,Gangemi S,Tigano V,Arena E,Mannucci C,Calapai G

    更新日期:2013-01-01 00:00:00

  • Role of flunarizine hydrochloride in secondary brain injury following intracerebral hemorrhage in rats.

    abstract::This study aimed to explore the role and mechanism(s) of flunarizine hydrochloride in the intracerebral hemorrhage (ICH) rats. The 32 adult male Sprague Dawley (SD) rats were randomly assigned into four groups: control group, sham group, ICH group, and FLU + ICH group. The effects of flunarizine hydrochloride were ass...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632017742224

    authors: Niu J,Hu R

    更新日期:2017-12-01 00:00:00

  • Berberine reduces neuroglia activation and inflammation in streptozotocin-induced diabetic mice.

    abstract::We aimed to analyze the action of berberine on the neuropathic pain and neuroglia activation in experimental diabetes mellitus (DM) model. Diabetes in mice was induced by intraperitoneal injection of streptozotocin (STZ) followed by the administration of berberine. Mechanical allodynia and thermal hyperalgesia and act...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/2058738419866379

    authors: Liu M,Gao L,Zhang N

    更新日期:2019-01-01 00:00:00

  • Usefulness of Atopy Patch Test on a child with milk protein-induced enterocolitis syndrome: a case report.

    abstract::We describe the case of a child affected by milk-protein induced enterocolitis, in which oral challenge with corn was performed without symptoms after a negative specific Atopy Patch Test. Food protein-induced enterocolitis syndrome (FPIES) is an uncommon nonIgE-mediated gastrointestinal food hypersensitivity of infan...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463201302600327

    authors: Scaparrotta A,Di Pillo S,Consilvio NP,Attanasi M,Cingolani A,Rapino D,Cerasa M,Pucci N,Di Gioacchino M,Chiarelli F

    更新日期:2013-07-01 00:00:00

  • In vitro effects of nicotine on sperm motility and bio-functional flow cytometry sperm parameters.

    abstract::The aim of this experimental study was to evaluate the effects of nicotine on sperm motility and on non-conventional sperm parameters in vitro. Capacitated spermatozoa isolated from 10 normozoospermic, healthy, non-smoker men were evaluated. Spermatozoa were exposed to increasing concentrations of nicotine (0, 1, 10, ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201302600317

    authors: Condorelli RA,La Vignera S,Giacone F,Iacoviello L,Vicari E,Mongioi' L,Calogero AE

    更新日期:2013-07-01 00:00:00

  • T cell assessment in allergic drug reactions during the acute phase according to the time of occurrence.

    abstract::Allergic drug reactions can be classified as immediate, accelerated or delayed. This classification usually correlates with the mechanism involved: immediate reactions are IgE mediated and delayed reactions are T cell dependent. We analyzed lymphocyte involvement in patients with these reactions by determining cell su...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 临床试验,杂志文章

    doi:

    authors: Torres MJ,Mayorga C,Fernández TD,Cornejo-García JA,Antúnez C,Valenzuela M,Del Prado MF,Rodriguez-Pena R,Blanca M

    更新日期:2006-01-01 00:00:00

  • Presepsin: A potential biomarker of PJI? A comparative analysis with known and new infection biomarkers.

    abstract::There is still no "gold standard" for the diagnosis and prognosis of post-operative periprosthetic joint infection (PJI). Among serum biomarkers, an emerging molecule is presepsin, the soluble fraction of CD14, recently described in other settings as a powerful diagnostic tool to detect sepsis at different degrees of ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632017749356

    authors: Marazzi MG,Randelli F,Brioschi M,Drago L,Romanò CL,Banfi G,Massaccesi L,Crapanzano C,Morelli F,Corsi Romanelli MM,Galliera E

    更新日期:2018-01-01 00:00:00

  • Association between oral cleft and transcobalamin 2 polymorphism in a sample study from Nassiriya, Iraq.

    abstract::Orofacial clefts are common congenital defects whose prevalence differs between geographical regions and ethnic groups. The inheritance is complex, involving the contribution of both genetic and environmental factors. The involvement of genes belonging to the folate pathway is still matter of debate, with strong evide...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/2058738419855571

    authors: Carinci F,Palmieri A,Scapoli L,Cura F,Abenavoli F,Giannì AB,Russillo A,Docimo R,Martinelli M

    更新日期:2019-01-01 00:00:00

  • Effect of norepinephrine combined with sodium phosphocreatine on cardiac function and prognosis of patients with septic shock.

    abstract::Septic shock (SS) leads to a high mortality rate for sepsis patients. Norepinephrine (NE) is a preferred vasoactive agent in SS treatment. This study aimed to assess the effects of NE at different administration time and NE combined with SP treatment on the cardiac function and prognosis of SS.SS patients received NE ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/2058738420950583

    authors: Kang D,Yu J,Xia J,Li X,Wang H,Zhao Y

    更新日期:2020-01-01 00:00:00

  • The immunosuppressor st1959, a 3,5-diaryl-s-triazole derivative, inhibits T cell activation by reducing NFAT nuclear residency.

    abstract::3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole (ST1959) has shown therapeutic effects in several animal models of autoimmune diseases. In this study the effects of ST1959 were further investigated in a murine model of colitis. The evidence obtained indicates that the beneficial effects exerted by ST1959 rely ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200902200105

    authors: Lindstedt R,Ruggiero V,D' Alessio V,Manganello S,Petronzelli F,Stasi MA,Vendetti S,Assandri A,Carminati P,De Santis R

    更新日期:2009-01-01 00:00:00

  • Impact of mast cells on the skin.

    abstract::When through the skin a foreign antigen enters it provokes an immune response and inflammatory reaction. Mast cells are located around small vessels that are involved in vasaldilation. They mature under the influence of local tissue to various cytokines. Human skin mast cells play an essential role in diverse physiolo...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 社论,评审

    doi:10.1177/039463201302600403

    authors: Kritas SK,Saggini A,Varvara G,Murmura G,Caraffa A,Antinolfi P,Toniato E,Pantalone A,Neri G,Frydas S,Rosati M,Tei M,Speziali A,Saggini R,Pandolfi F,Cerulli G,Theoharides TC,Conti P

    更新日期:2013-10-01 00:00:00

  • Myrcene exerts anti-asthmatic activity in neonatal rats via modulating the matrix remodeling.

    abstract::Myrcene (MC), an organic hydrocarbon, was found to exert anti-inflammatory, analgesic, antimutagenic and antioxidant properties. However, the protective role of MC has not been reported against neonatal asthma. Wistar rats induced with asthma were administered with MC; while asthma control and vehicle control were mai...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/2058738420954948

    authors: Du Y,Luan J,Jiang RP,Liu J,Ma Y

    更新日期:2020-01-01 00:00:00

  • The lack of cytomegalovirus-specific cellular immune response may contribute to the onset of organ infection and disease in lung transplant recipients.

    abstract::Cellular immune response has been demonstrated to play a role in the control of human cytomegalovirus (HCMV) replication in organ transplant recipients. Herein, HCMV-specific T-cell response and association to the onset of organ infection/disease were prospectively evaluated by EliSPOT assay in a population of 46 lung...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201202500417

    authors: Costa C,Saldan A,Sinesi F,Sidoti F,Balloco C,Simeone S,Piceghello A,Mantovani S,Di Nauta A,Solidoro P,Cavallo R

    更新日期:2012-10-01 00:00:00

  • Analysis on the co-localization of asbestos bodies and Fas or CD163 expression in asbestos lung tissue by in-air micro-pixe.

    abstract::To prevent and control disease caused by exposure to various agents, it is necessary to determine the harmful level of intervention and to establish a method for measuring that level. In-air microparticle-induced X-ray emission (in-air micro-PIXE) analysis is based on irradiation of specimens with a proton ion microbe...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201002300101

    authors: Matsuzaki S,Shimizu Y,Dobashi K,Nagamine T,Satoh T,Ohkubo T,Yokoyama A,Ishii Y,Kamiya T,Arakawa K,Makino S,Utsugi M,Ishizuka T,Tanaka S,Shimizu K,Mori M

    更新日期:2010-01-01 00:00:00

  • Switch to icatibant in a patient affected by hereditary angioedema with high disease activity: a case report.

    abstract::Icatibant, an antagonist of the bradykinin B2 receptor, was approved for the treatment of acute attacks of hereditary angioedema in the EU in 2008. This paper presents the case of a 65-year-old woman affected by frequent acute attacks of hereditary angioedema who benefitted from a change of therapy to icatibant, follo...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463201202500130

    authors: Firinu D,Barca MP,Serusi L,Lorrai MM,Peralta MM,Manconi PE,Del Giacco SR

    更新日期:2012-01-01 00:00:00

  • Sinomenine potentiates P815 cell degranulation via upregulation of Ca2+ mobilization through the Lyn/PLCγ/IP3R pathway.

    abstract::Mast cells are vital mediators of drug allergy and, therefore, studying the relationship between drug allergy and mast cells is essential. Sinomenine is the principal active component of Sinomenium acutum, which has anti-inflammatory and anti-immune effects, and is used to treat various rheumatoid diseases. However, al...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632015621768

    authors: Wang N,Liu R,Liu Y,Zhang R,He L

    更新日期:2016-12-01 00:00:00

  • Combined antimuscarinics for treatment of neurogenic overactive bladder.

    abstract::Antimuscarinic drugs are the first line pharmacotherapy for overactive bladder, but they are not always effective to achieve complete continence. Nevertheless in some patients urodynamic investigations reveal insufficient effects with continuing incontinence events even with dose optimization. The aim of this study is...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/03946320120250s106

    authors: Nardulli R,Losavio E,Ranieri M,Fiore P,Megna G,Bellomo RG,Cristella G,Megna M

    更新日期:2012-01-01 00:00:00

  • Immunogenicity of Ra1A and its tissue-specific expression in hepatocellular carcinoma.

    abstract::In order to understand the immunogenicity of a tumor-associated antigen (TAA), Ras family small GTP binding protein (Ra1A) in hepatocellular carcinoma (HCC), autoantibody responses to RalA were evaluated by enzyme-linked immunosorbent assay (ELISA), Western blotting and indirect immunofluorescence assay in sera from p...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200902200319

    authors: Wang K,Chen Y,Liu S,Qiu S,Gao S,Huang X,Zhang J,Peng X,Qiani W,Zhang JY

    更新日期:2009-07-01 00:00:00

  • Profilin desensitization: A case series.

    abstract::The role of profilin as an allergen has long been questioned. The capacity of profilin to induce respiratory symptoms has recently been demonstrated; moreover, over 50% of patients sensitized to profilin experienced symptoms after the ingestion of plant-derived foods, suggesting that profilin should be considered as a...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/0394632015621926

    authors: Nucera E,Aruanno A,Rizzi A,Pecora V,Patriarca G,Buonomo A,Mezzacappa S,Schiavino D

    更新日期:2016-09-01 00:00:00