Abstract:
:Icatibant, an antagonist of the bradykinin B2 receptor, was approved for the treatment of acute attacks of hereditary angioedema in the EU in 2008. This paper presents the case of a 65-year-old woman affected by frequent acute attacks of hereditary angioedema who benefitted from a change of therapy to icatibant, following years of treatment with C1-inhibitor.
journal_name
Int J Immunopathol Pharmacolauthors
Firinu D,Barca MP,Serusi L,Lorrai MM,Peralta MM,Manconi PE,Del Giacco SRdoi
10.1177/039463201202500130subject
Has Abstractpub_date
2012-01-01 00:00:00pages
269-73issue
1eissn
0394-6320issn
2058-7384pii
30journal_volume
25pub_type
信件abstract::Classification of upper tract urothelial preneoplastic and neoplastic lesions mirrors that of the urinary bladder, with all lesions of the bladder urothelium being possible in the upper tract and vice versa. There are three major groups of non-invasive urothelial neoplasms: flat, papillary, and inverted. These three g...
journal_title:International journal of immunopathology and pharmacology
pub_type: 社论,评审
doi:10.1177/039463201402700406
更新日期:2014-10-01 00:00:00
abstract::Malacoplakia is a rare inflammatory condition characterized by the accumulation of benign macrophages associated with pathognomonic Michaelis-Gutmann bodies (MGBs). It is usually found in the genito-urinary tract, and has been associated with immunocompromised states. In this short report, we present 5 patients with p...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201202500316
更新日期:2012-07-01 00:00:00
abstract::Hematide is a synthetic PEGylated peptidic erythropoiesis stimulating agent (ESA) that is presently being developed for the correction of anemia in patients with chronic renal failure. Unlike currently marketed ESAs, Hematide does not possess any sequence homology to erythropoietin (EPO) and has not elicited moribund ...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201002300111
更新日期:2010-01-01 00:00:00
abstract::Multiple sclerosis (MS) is thought to be an autoimmune T-cell-mediated disease directed at myelin antigens of the central nervous system. Besides myelin proteins, lipid components of CNS are supposed to play a role as antigens for T cells in MS. CD1 is a family of MHC-like glycoproteins specialized in capturing and pr...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201102400120
更新日期:2011-01-01 00:00:00
abstract::Although dental implants have undergone impressive evolution in recent years, periimplantitis still remains a relevant problem and information on the susceptibility of commercial implants to bacterial colonization is insufficient. This work evaluated the susceptibility of different commercial implants to bacterial col...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201302600218
更新日期:2013-04-01 00:00:00
abstract::Biological and technical failures of implants have already been reported. Mechanical factors are certainly of importance in implant failures, even if their exact nature has not yet been established. The abutment screw fracture or loosening represents a rare, but quite unpleasant failure. The aim of the present researc...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/03946320110240S214
更新日期:2011-04-01 00:00:00
abstract::Cyclosporine A (CsA) has been in clinical use for some decades, primarily for the prevention and treatment of organ transplant rejection and graft-versus-host disease. In more recent years, Cyclosporine has been recognized as beneficial in the treatment of dermatologic diseases, such as: psoriasis, lichen planus, Behc...
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abstract::Colon cancer cells are resistant to FasR-mediated apoptosis, which contributes to their evasion from immune attack by CTLs and NK cells. FasR refractoriness of the malignancies was reported to result from loss of Fas receptors and overepression of Fas-associated phosphatase-1 (FAP-1). Therefore, we investigated the ef...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract::Orofacial clefts are common congenital defects whose prevalence differs between geographical regions and ethnic groups. The inheritance is complex, involving the contribution of both genetic and environmental factors. The involvement of genes belonging to the folate pathway is still matter of debate, with strong evide...
journal_title:International journal of immunopathology and pharmacology
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doi:10.1177/2058738419855571
更新日期:2019-01-01 00:00:00
abstract::Occupational allergies such as pollinosis are reported in several agricultural works in Japan. Many pollens and spores were observed in Japanese pear orchard during the artificial pollination season. By the study on daily symptoms in an allergic farmer, we confirmed that the pollinosis symptoms were most common and mo...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/03946320070200S213
更新日期:2007-04-01 00:00:00
abstract::Mast cells are involved in allergic reactions, where they secrete numerous vasoactive, inflammatory and nociceptive mediators in response to immunoglobulin E (IgE) and antigen. However, they have also been implicated in inflammatory conditions, such as painful bladder syndrome/interstitial cystitis (PBS/IC), irritable...
journal_title:International journal of immunopathology and pharmacology
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更新日期:2006-10-01 00:00:00
abstract::Four clinical cases regarding the correct diagnosis of early ocular Chlamydia trachomatis (Ct) inflammation, performed by two different modalities on the ocular ecosystem, are discussed. The present study was carried out in parallel using a cotton flock ocular swab and the scraping of upper lid conjunctiva. The ocular...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201202500427
更新日期:2012-10-01 00:00:00
abstract::Interleukin (IL)-8 is a major factor in inflammatory response and the IL-8 levels in exhaled breath condensate (EBC) may be used as a marker of airway inflammation. Airway acidification is implicated in the pathophysiology of obstructive airway diseases and pH EBC values have been used as a marker of airway acidificat...
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更新日期:2007-07-01 00:00:00
abstract::When through the skin a foreign antigen enters it provokes an immune response and inflammatory reaction. Mast cells are located around small vessels that are involved in vasaldilation. They mature under the influence of local tissue to various cytokines. Human skin mast cells play an essential role in diverse physiolo...
journal_title:International journal of immunopathology and pharmacology
pub_type: 社论,评审
doi:10.1177/039463201302600403
更新日期:2013-10-01 00:00:00
abstract::The expression of Ikaros family transcription factors and consequently their signalling pathway is limiting for hematopoietic and lymphocyte development in mice and human. Due to their importance, these transcription factors are highly homologous between species. As an initial approach to examining the possible involv...
journal_title:International journal of immunopathology and pharmacology
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更新日期:2012-10-01 00:00:00
abstract::Some studies in animal models showed that several neurotrophins may be implicated in the regulation of light-dependent suprachiasmatic pacemaker and in other functions implicated in long-term memory acquisition during sleep. However, no data are known about the role played by NGF in ultradian regulation in humans. The...
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pub_type: 临床试验,杂志文章
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更新日期:2004-09-01 00:00:00
abstract::Deficits in glucose, impaired insulin signalling and brain insulin resistance are common in the pathogenesis of Alzheimer's disease (AD); therefore, some scholars even called AD type 3 diabetes mellitus. Curcumin can reduce the amyloid pathology in AD. Moreover, it is a well-known fact that curcumin has anti-oxidant a...
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abstract::After birth various bacterial species, mainly streptococci, colonize the oral cavity and are frequently isolated from carious lesions in children. Previous studies suggest that an earlier colonization of a child's mouth by cariogenic organisms might be related to a higher risk of caries. The aim of this study is to as...
journal_title:International journal of immunopathology and pharmacology
pub_type: 信件
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更新日期:2014-01-01 00:00:00
abstract::Behcets disease (BD) is a chronic, relapsing, multi-system inflammatory disorder, clinically characterized by recurrent oral and genital ulcers, skin lesions, and uveitis. Other manifestations include arthritis, a positive pathergy test, thrombophlebitis, central nervous system disease and gastrointestinal ulcerations...
journal_title:International journal of immunopathology and pharmacology
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abstract::The narrow therapeutic index and large inter-individual variability in sirolimus pharmacokinetics (PK) make therapeutic drug monitoring (TDM) necessary. Factors responsible for PK variability are not well understood, and published PK studies do not include pediatric patients with immune cytopenia. The objective of thi...
journal_title:International journal of immunopathology and pharmacology
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abstract::Similar to many complex autoimmune diseases, genetic and environmental factors including diet, infection and xenobiotics play a critical role in the development of autism. In this study, we postulated that infectious agent antigens such as streptokinase, dietary peptides (gliadin and casein) and ethyl mercury (xenobio...
journal_title:International journal of immunopathology and pharmacology
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abstract::Blockade of the interactions between CD28/CTLA-4 and their ligands, CD80 (B7, B7.1)/CD86 (B70, B7.2), is an attractive means to induce antigen-specific peripheral tolerance in autoimmune disease and organ transplantation. In this study, we generated and characterized a monoclonal antibody (Clone 4E5) against human CD8...
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doi:10.1177/039463201102400304
更新日期:2011-07-01 00:00:00
abstract::Since the beginning of the 21st century, carbon-based nanomaterials (CNTs) have been introduced in pharmacy and medicine for drug delivery system in therapeutics. CNTs have proved able to transport a wide range of molecules across membranes and into living cells; therefore, they have attracted great interest in biomed...
journal_title:International journal of immunopathology and pharmacology
pub_type: 社论,评审
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更新日期:2015-03-01 00:00:00
abstract::Antimuscarinic drugs are the first line pharmacotherapy for overactive bladder, but they are not always effective to achieve complete continence. Nevertheless in some patients urodynamic investigations reveal insufficient effects with continuing incontinence events even with dose optimization. The aim of this study is...
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pub_type: 杂志文章,随机对照试验
doi:10.1177/03946320120250s106
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abstract::Salmonellosis-induced diarrhea, is one of the commonest cause of childhood mortality in developing countries. Using of probiotics is viewed as a promising means for reducing the pathogenic loads of bacterial infection. The current study aimed to evaluate the potential antimicrobial and immunomodulatory efficacy of iso...
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abstract::Acrodermatitis enteropathic (AE) is a rare autosomal recessive disorder due to a zinc deficiency and characterized by a classical triad of symptoms: dermatitis, alopecia, and diarrhea. The defective gene is SLC39A4, which encodes a zinc transporter. Nevertheless many abnormalities in SLC39A4 have been relieved, only 5...
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abstract::The risk and benefit of oral immunomodulation using heat-killed Enterococcus faecalis FK-23 preparation (FK-23) were evaluated in healthy dogs. Dogs were administered perorally 100 mg/kg of FK23 daily for 3 months. FK-23 did not affect the findings of complete blood count, leukocyte differential count, blood chemistry...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:
更新日期:1999-05-01 00:00:00
abstract::One of the most dangerous possible complications in joint replacement is infection due to bacteria adhere to prosthesis surface making biofilm difficult to erase. The gold standard treatment consists in prosthesis removal, placement of antibiotic-impregnated cement spacer and systemic antibiotics therapy. When the inf...
journal_title:International journal of immunopathology and pharmacology
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abstract::More and more studies have demonstrated the anti-inflammatory effects of heparin. However, in the aspect of allergic airway inflammation, data about its daily use in animal model is scarce. To evaluate the efficacy of 22-day intranasal heparin administration in mite-induced airway allergic inflammation in BALB/c mice,...
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abstract::Mast cells play important role in allergic inflammation by releasing histamine, tryptase and several inflammatory cytokines. Human leukemic mast cells (HMC-1) have been used to study mast cell mediator and their role in inflammatory mechanisms. HMC-1 contain and release several inflammatory mediators, of which the pro...
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