Abstract:
:Hematide is a synthetic PEGylated peptidic erythropoiesis stimulating agent (ESA) that is presently being developed for the correction of anemia in patients with chronic renal failure. Unlike currently marketed ESAs, Hematide does not possess any sequence homology to erythropoietin (EPO) and has not elicited moribund immune responses in animal safety studies thereby allowing the generation of a robust safety package. Animals administered marketed ESAs develop anti-EPO antibodies that null the effect of the administered ESA and neutralize endogenous EPO, resulting in severe anemia that precludes the interpretation of chronic safety studies. The primary objective of this study is to determine whether Hematide-specific antibodies are generated when male monkeys are exposed to high Hematide doses (10 mg/kg, intravenous [IV] and subcutaneous [SC]) administered at frequent dosing intervals (every two weeks) for a total of 9 doses; secondary objectives are to evaluate whether developed antibodies impact pharmacokinetics (PK) and pharmacology. In this study, no Hematide-specific antibodies were detected. Hematide exhibits a prolonged plasma half-life and slow clearance by either IV or SC administration. Hematide induced significant erythropoiesis with reticulocytosis and subsequent increases in red blood cells, hematocrit and hemoglobin (Hgb) levels. No erythropoietic differences were noted between the IV and the SC dosed groups with mean +/- SD Hgb levels of 20.9 +/- 2.5 and 20.3 +/- 2.1 g/dL, respectively, occurring on Day 48, corresponding to Hgb increases of 6.5 and 6.7 g/dL, respectively, over pre-dose levels. In conclusion, Hematide is a potent erythropoiesis stimulating agent that exhibits plasma persistence in monkeys. Similar erythropoietic responses were produced following IV and SC administration. The absence of antibody development suggests that Hematide, at the doses and regimen described, has a low immunogenic potential in cynomolgus monkeys.
journal_name
Int J Immunopathol Pharmacolauthors
Woodburn KW,Schatz PJ,Fong KL,Beaumier Pdoi
10.1177/039463201002300111subject
Has Abstractpub_date
2010-01-01 00:00:00pages
121-9issue
1eissn
0394-6320issn
2058-7384pii
11journal_volume
23pub_type
杂志文章abstract::We present the case of a 45-year-old man with psoriasis and psoriatic arthritis and concomitant impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). In this patient, refractory to DMARD's, infliximab was started to control the arthritis. After achieving clinical remission of the disease, infliximab was...
journal_title:International journal of immunopathology and pharmacology
pub_type: 信件
doi:10.1177/039463201002300334
更新日期:2010-07-01 00:00:00
abstract::Cyclosporine A (CsA) has been in clinical use for some decades, primarily for the prevention and treatment of organ transplant rejection and graft-versus-host disease. In more recent years, Cyclosporine has been recognized as beneficial in the treatment of dermatologic diseases, such as: psoriasis, lichen planus, Behc...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200201500203
更新日期:2002-05-01 00:00:00
abstract::We aimed to analyze the action of berberine on the neuropathic pain and neuroglia activation in experimental diabetes mellitus (DM) model. Diabetes in mice was induced by intraperitoneal injection of streptozotocin (STZ) followed by the administration of berberine. Mechanical allodynia and thermal hyperalgesia and act...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/2058738419866379
更新日期:2019-01-01 00:00:00
abstract::Bone resection is the choice treatment of malignant bone tumors. Tumor prosthesis is one of the most common solutions of reconstruction following resection of bone tumor located to the metaphysis of long bones. Periprosthetic infections are a frequent complication of limb-salvage surgery which is largely due to prolon...
journal_title:International journal of immunopathology and pharmacology
pub_type: 社论,评审
doi:10.1177/039463201002300405
更新日期:2010-10-01 00:00:00
abstract::Ticks are obligate hematophagous arthropods that are parasites in every class of vertebrates in most regions of the world. They are also considered to be important vectors for the transmission of human infectious diseases. In the present study we used polymer chain reaction (PCR) amplification analysis to determine th...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200301600203
更新日期:2003-05-01 00:00:00
abstract::Information about the impacts of disasters on health is useful for establishing hazard prediction maps and action plans of disaster management. This study aims at learning effective asthma management from the volcano disaster of Mount Asama eruption in Japan on September 1, 2004. We conducted a cross-sectional study t...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/03946320070200S203
更新日期:2007-04-01 00:00:00
abstract::Serum samples from Bulgarian patients with physician-diagnosed erythema migrans (EM) (n=105) were examined using Borrelia burgdorferi ELISA (Boehring, Germany) after previous absorption with Treponema phagedenis. For IgM antibody detection sera were additionally pretreated with anti-IgG serum (RF absorbent). Serum sam...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200301600312
更新日期:2003-09-01 00:00:00
abstract::Blockade of the interactions between CD28/CTLA-4 and their ligands, CD80 (B7, B7.1)/CD86 (B70, B7.2), is an attractive means to induce antigen-specific peripheral tolerance in autoimmune disease and organ transplantation. In this study, we generated and characterized a monoclonal antibody (Clone 4E5) against human CD8...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201102400304
更新日期:2011-07-01 00:00:00
abstract::Cyclic AMP phosphodiesterase (cAMP PDE) seems to be important in pulp tissues. High levels of cAMP PDE have been demonstrated to be in dental pulp cells. In the present study cAMP PDE activity was analyzed in normal healthy human dental pulps, in reversible pulpitis and in irreversible pulpitis. Enzymatic cAMP PDE con...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:
更新日期:2004-09-01 00:00:00
abstract::This study is designed to investigate, for the first time, circulating and gastric mucosal levels of IL1-alpha, IL-6, IL-8 and TNF-alpha in patients with ischemic heart disease (IHD) and matched controls, according to the presence or absence of active Helicobacter pylori infection. Furthermore, in order to evaluate wh...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200702000119
更新日期:2007-01-01 00:00:00
abstract::The expression of Ikaros family transcription factors and consequently their signalling pathway is limiting for hematopoietic and lymphocyte development in mice and human. Due to their importance, these transcription factors are highly homologous between species. As an initial approach to examining the possible involv...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201202500407
更新日期:2012-10-01 00:00:00
abstract::The aim of this experimental study was to evaluate the effects of nicotine on sperm motility and on non-conventional sperm parameters in vitro. Capacitated spermatozoa isolated from 10 normozoospermic, healthy, non-smoker men were evaluated. Spermatozoa were exposed to increasing concentrations of nicotine (0, 1, 10, ...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201302600317
更新日期:2013-07-01 00:00:00
abstract::The treatment with infliximab is employed successfully in Crohn's disease (CD) but predictors of efficacy are lacking. Activation of the transcription factor NF-kB has been demonstrated in CD and its inhibition is one of the mechanisms by which anti-inflammatory agents exert their effects. We evaluated the production ...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200501800116
更新日期:2005-01-01 00:00:00
abstract::The possible use of cell therapies for neurological lesions and disorders is regarded as a very promising strategy. However, many issues related to cell type, tissue donor, expected biological action etc., are still open. In this study human mesenchymal stem cells derived from different fetal and adult tissues were ex...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201402700309
更新日期:2014-07-01 00:00:00
abstract::Titanium (Ti) is widely used in dentistry. Fluorides at acid pH could destabilize Ti oxide and make it susceptible to corrosion. The behaviour of IV grade machined Ti disks in 5 electrolytic solutions: Fusayama artificial saliva (Fas), ammine fluoride-stannous fluoride (Am-SnF2), 0.2 percent Chlorexidine (CHX) 0.20 pe...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201002300132
更新日期:2010-01-01 00:00:00
abstract::Mast cells play important role in allergic inflammation by releasing histamine, tryptase and several inflammatory cytokines. Human leukemic mast cells (HMC-1) have been used to study mast cell mediator and their role in inflammatory mechanisms. HMC-1 contain and release several inflammatory mediators, of which the pro...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200301600106
更新日期:2003-01-01 00:00:00
abstract::The aim of this study is to investigate the expression of the chromosomal passenger protein Aurora B and its activated (phosphorylated) form in a large series of human oral squamous cell cancers (OSCC) and to evaluate its clinical and prognostic significance. Western blotting analysis revealed overexpression of both A...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201102400110
更新日期:2011-01-01 00:00:00
abstract::Ionizing irradiation causes damage and functional failure of irradiation-sensitive systems and tissues such as small intestine. The molecular mechanisms underlying inflammatory and adaptive responses to acute irradiation damage are poorly understood. Using a mouse model of total-body γ-irradiation, we assessed the irr...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201002300415
更新日期:2010-10-01 00:00:00
abstract::Extranodal non-Hodgkin lymphomas limited to the larynx are rare, accounting for less than 1% of all laryngeal neoplasms. The most common site of development of primary laryngeal lymphomas is the supraglottic region. In most cases, the presenting symptoms are hoarseness, dysphagia, dyspnea, and cervical lymphadenopathy...
journal_title:International journal of immunopathology and pharmacology
pub_type: 信件
doi:10.1177/039463201402700319
更新日期:2014-07-01 00:00:00
abstract::Non-cystic fibrosis bronchiectasis (nCFb) is an acquired condition of variable etiology. An impaired mucociliary clearance seems to be one of the mechanisms behind nCFb, and treatment involves antibiotics, mucoactive agents, and airway clearance techniques (ACTs). Traditional ACTs have four components: postural draina...
journal_title:International journal of immunopathology and pharmacology
pub_type: 社论,评审
doi:10.1177/0394632015584724
更新日期:2015-06-01 00:00:00
abstract::Although dental implants have undergone impressive evolution in recent years, periimplantitis still remains a relevant problem and information on the susceptibility of commercial implants to bacterial colonization is insufficient. This work evaluated the susceptibility of different commercial implants to bacterial col...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463201302600218
更新日期:2013-04-01 00:00:00
abstract::The art of tattooing has increasing in recent decades. Allergic sensitivity to one of the pigments is the most frequent cause of dermatological reactions at the site of the tattoo. Gold is a new pigment used in tattooing, because of its bright yellow color and luster. Allergy to this metal is uncommon. To our knowledg...
journal_title:International journal of immunopathology and pharmacology
pub_type: 信件
doi:10.1177/039463201102400432
更新日期:2011-10-01 00:00:00
abstract::It is well known that change in apoptosis may modulate the natural story of illness, and that many drugs may act through modulation of apoptosis, but the role of steroids in acting through apoptosis in different settings, including renal diseases, has still to be elucidated. We studied the in vivo effects of steroids ...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200601900321
更新日期:2006-07-01 00:00:00
abstract::The aim of this report is to present a new investigative approach to implant dentistry based on the correlation of qualitative and quantitative data reported on the same figure by overlapping different images collected on the specimen with different investigative systems. Six unloaded titanium dental implants retrieve...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200702001s09
更新日期:2007-01-01 00:00:00
abstract::Hymenoptera stings may be responsible for both local and systemic reactions; these can be immediate or delayed, depending on the time between the sting and the development of signs or symptoms. Delayed clinical reactions have been reported, although unusual, due to serum sickness and/or affecting organs or systems gen...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200501800220
更新日期:2005-04-01 00:00:00
abstract::Progressive ageing is associated with an increment of biomolecules modified through oxidation as a result of the action of free radicals deriving from reactive oxygen species that attack biomolecules. During ageing many alterations of renal functions have been reported. Renal ageing is associated with a progressive de...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200401700306
更新日期:2004-09-01 00:00:00
abstract::To investigate the in vivo role of caspase-3 in Terminal Transferase metabolism DMSO-treated RPMI-8402, a human pre-T cell line was used. In DMSO treated samples (3)H-dGTP incorporation and TdT phosphorylation occurs after 4 hours of treatment. After 8 hours cells undergo TdT proteolysis in addition to its inactivatio...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200201500306
更新日期:2002-09-01 00:00:00
abstract::Isoprostanes are prostaglandin isomers produced from the peroxidation of polyunsaturated fatty acids from the cellular membrane. They have been used as a specific index of cellular lipoperoxidation and as an indirect measure of oxidative stress. However, these molecules also present several biological activities. An o...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:10.1177/039463200501800309
更新日期:2005-07-01 00:00:00
abstract::It is well known that in some conditions bacteria of physiological flora of gastrointestinal tract may become pathogenic. Each complaint which causes injury of gastrointestinal wall integrity permits bacteria to penetrate the tissues and affect the tissue cells. Since mast cells represent one of very important and num...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::This pilot open-label study is aimed to assess clinical response in psoriasis patients receiving diverse dose regimens of etanercept, consisting of the same global cumulative dose of etanercept administered over different treatment periods. Eligible patients were assigned sequentially in a 1:1 ratio to receive: etaner...
journal_title:International journal of immunopathology and pharmacology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1177/039463201002300314
更新日期:2010-07-01 00:00:00