Abstract：
:To investigate the in vivo role of caspase-3 in Terminal Transferase metabolism DMSO-treated RPMI-8402, a human pre-T cell line was used. In DMSO treated samples (3)H-dGTP incorporation and TdT phosphorylation occurs after 4 hours of treatment. After 8 hours cells undergo TdT proteolysis in addition to its inactivation. The cleavage of TdT into 32- and 58-KDa proteolytic fragments occurred simultaneously with the activation of Caspase-3, but preceded changes associated with the apoptotic process described after 48 hours of treatment. The Caspase-3 peptide inhibitor V, used as a specific inhibitor, prevented TdT proteolysis prolonging its activity and rescued cells from apoptosis. Our experiments suggest that TdT is a nuclear substrate for Caspase-3, the main apoptotic effector protease in many cell types, and that the cleavage of TdT represents a primary step in a signal cascade leading to pre-T cell apoptosis.
journal_name
Int J Immunopathol Pharmacolauthors
Trubiani O,Guarnieri S,Paganelli R,Di Primio Rdoi
10.1177/039463200201500306keywords:
subject
Has Abstractpub_date
2002-09-01 00:00:00pages
201-208issue
3eissn
0394-6320issn
2058-7384pii
6journal_volume
15pub_type
杂志文章abstract：:This study aimed to investigate the clinical significance of serum microRNA-219-5p (miR-219-5p) in patients with multiple organ dysfunction syndrome (MODS) caused by acute paraquat (PQ) poisoning, and its correlation with Toll-like Receptor 4 (TLR4). Luciferase reporter assay was used to investigate in vitro the corre...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/2058738420974888
更新日期：2020-01-01 00:00:00
abstract：:Regulatory T cells (Treg) play a critical role in immune homeostasis and expansion of Treg is controlled by chemokine receptors. The chemokine CXCL12 and its G-protein-coupled receptor (CXCR4) are involved in the development of idiopathic pulmonary fibrosis (IPF), but the association of Treg with the CXCL12/CXCR4 axis...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463201002300207
更新日期：2010-04-01 00:00:00
abstract：:This study is designed to investigate, for the first time, circulating and gastric mucosal levels of IL1-alpha, IL-6, IL-8 and TNF-alpha in patients with ischemic heart disease (IHD) and matched controls, according to the presence or absence of active Helicobacter pylori infection. Furthermore, in order to evaluate wh...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463200702000119
更新日期：2007-01-01 00:00:00
abstract：:Cyclosporine A (CsA) has been in clinical use for some decades, primarily for the prevention and treatment of organ transplant rejection and graft-versus-host disease. In more recent years, Cyclosporine has been recognized as beneficial in the treatment of dermatologic diseases, such as: psoriasis, lichen planus, Behc...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463200201500203
更新日期：2002-05-01 00:00:00
abstract：:Multiple sclerosis (MS) is thought to be an autoimmune T-cell-mediated disease directed at myelin antigens of the central nervous system. Besides myelin proteins, lipid components of CNS are supposed to play a role as antigens for T cells in MS. CD1 is a family of MHC-like glycoproteins specialized in capturing and pr...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463201102400120
更新日期：2011-01-01 00:00:00
abstract：:About three decades ago, the primary mechanism of action of the non-steroidal anti-inflammatory drugs (NSAIDs) was elucidated when their inhibitory action on the production of prostaglandins was discovered. It was found that their action is centred on the inhibition of the cyclooxygenase (COX) enzyme responsible for c...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章,评审
doi：
更新日期：2003-05-01 00:00:00
abstract：:Four clinical cases regarding the correct diagnosis of early ocular Chlamydia trachomatis (Ct) inflammation, performed by two different modalities on the ocular ecosystem, are discussed. The present study was carried out in parallel using a cotton flock ocular swab and the scraping of upper lid conjunctiva. The ocular...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463201202500427
更新日期：2012-10-01 00:00:00
abstract：:Autoantibodies (rheumatoid factor, RF; anti-citrullinated-protein antibodies, ACPA) and complement system are involved in rheumatoid arthritis (RA). ACPA and anti-TNF agents are capable of in vitro modulating complement activity. We investigated the relationships between complement, autoantibodies, and anti-TNF treatm...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463201102400209
更新日期：2011-04-01 00:00:00
abstract：:To prevent and control disease caused by exposure to various agents, it is necessary to determine the harmful level of intervention and to establish a method for measuring that level. In-air microparticle-induced X-ray emission (in-air micro-PIXE) analysis is based on irradiation of specimens with a proton ion microbe...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463201002300101
更新日期：2010-01-01 00:00:00
abstract：:Dysregulation of the Axl receptor tyrosine kinase (RTK) has been implicated in the development and progression of a variety of malignancies. Axl is known to activate strong anti-apoptotic signaling pathways that promote oncogenesis. However, the role of Axl plays in osteosarcoma (OS) remains elusive. The present study...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463201302600117
更新日期：2013-01-01 00:00:00
abstract：:The beneficial effects of hot springs have been known for centuries and treatments with sulphurous thermal waters are recommended in a number of chronic pathologies as well as acute recurrent infections. However, the positive effects of the therapy are often evaluated in terms of subjective sense of wellbeing and symp...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463201302600307
更新日期：2013-07-01 00:00:00
abstract：:It is of significance to alleviate oxidative damages for the treatment of spinal cord injury (SCI). Studies have ascertained that green tea polyphenols (GTPs) exert protective activities against oxidative damages. In this study, we aimed to investigate the protective effects of GTP against H2O2-caused injuries in PC12...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/2058738419872624
更新日期：2019-01-01 00:00:00
abstract：:The use of particles from micro to nanoscale provides benefits to diverse scientific fields, but because a large percentage of their atoms lie on the surface, nanomaterials could be highly reactive and pose potential risks to humans. Due to their wide range of application, Cobalt nano-particles are of great interest b...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：
更新日期：2006-10-01 00:00:00
abstract：:Although dental implants have undergone impressive evolution in recent years, periimplantitis still remains a relevant problem and information on the susceptibility of commercial implants to bacterial colonization is insufficient. This work evaluated the susceptibility of different commercial implants to bacterial col...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463201302600218
更新日期：2013-04-01 00:00:00
abstract：:Polysensitization is a feature of allergic rhinitis (AR) that significantly impairs the quality of life (QoL) of AR patients. Allergen-specific immunotherapy is the only causal therapy for AR. However, the polysensitization phenomenon may represent a crucial obstacle as far as it concerns the choice of the allergen ex...
journal_title：International journal of immunopathology and pharmacology
pub_type： 信件,多中心研究
doi：10.1177/039463201002300227
更新日期：2010-04-01 00:00:00
abstract：:Betamethasone is an anti-inflammatory steroid drug used in cases of anaphylactic and allergic reactions, of Alzheimer and Addison diseases and in soft tissue injuries. It modulates gene expression for anti-inflammatory activity suppressing the immune system response. This latter effect might decrease the effectiveness...
journal_title：International journal of immunopathology and pharmacology
pub_type： 信件
doi：10.1177/039463201402700426
更新日期：2014-10-01 00:00:00
abstract：:We report the case of a child with Smith-Lemli-Opitz Syndrome. The pregnancy was complicated by prenatal growth retardation. The baby was admitted to the Neonatal Intensive Care Unit of Chieti when she was five months old. She showed postnatal growth retardation, trouble sucking and swallowing, microcephaly and multip...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463200601900220
更新日期：2006-04-01 00:00:00
abstract：:1,2-dichloroethane(1,2-DCE) is toxic, especially by inhalation due to its high vapour pressure. Inhalation of concentrated 1,2-DCE vapor can induce effects on the human nervous system, even encephalopathy. However, 1,2-DCE toxic encephalopathy has seldom been reported, and no adequate data were available to evaluate t...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：:Salmonellosis-induced diarrhea, is one of the commonest cause of childhood mortality in developing countries. Using of probiotics is viewed as a promising means for reducing the pathogenic loads of bacterial infection. The current study aimed to evaluate the potential antimicrobial and immunomodulatory efficacy of iso...
journal_title：International journal of immunopathology and pharmacology
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更新日期：2015-12-01 00:00:00
abstract：:Acrodermatitis enteropathic (AE) is a rare autosomal recessive disorder due to a zinc deficiency and characterized by a classical triad of symptoms: dermatitis, alopecia, and diarrhea. The defective gene is SLC39A4, which encodes a zinc transporter. Nevertheless many abnormalities in SLC39A4 have been relieved, only 5...
journal_title：International journal of immunopathology and pharmacology
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journal_title：International journal of immunopathology and pharmacology
pub_type： 临床试验,杂志文章
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更新日期：2004-09-01 00:00:00
abstract：:Non-cystic fibrosis bronchiectasis (nCFb) is an acquired condition of variable etiology. Medical treatment basically involves antibiotics and chest physiotherapy. An impaired mucociliary clearance seems to be one of the mechanisms behind nCFb, and inhaled therapy with mucoactive agents has frequently been used to try ...
journal_title：International journal of immunopathology and pharmacology
pub_type： 信件,评审
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更新日期：2013-04-01 00:00:00
abstract：:Subjects with rhinitis but without asthma may have coexisting bronchial hyperresponsiveness, although the reasons for this are uncertain. To evaluate the factors that determine BHR in rhinitis we examined 410 patients with symptomatic rhinitis with forced expiratory volume in 1 second (FEV1) and forced vital capacity ...
journal_title：International journal of immunopathology and pharmacology
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doi：10.1177/039463200501800414
更新日期：2005-10-01 00:00:00
abstract：:Oxidative stress (OS) is well documented in asthma, but so far, little data has been reported in nonasthmatic patients with Seasonal Allergic Rhinitis (SAR). The aim of this study is to investigate the degree of OS and airway inflammation in patients with SAR, with and without concomitant asthma (SAR+A), using breath ...
journal_title：International journal of immunopathology and pharmacology
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更新日期：2008-10-01 00:00:00
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journal_title：International journal of immunopathology and pharmacology
pub_type： 评论,信件
doi：10.1177/039463201202500228
更新日期：2012-04-01 00:00:00
abstract：:Allergic drug reactions can be classified as immediate, accelerated or delayed. This classification usually correlates with the mechanism involved: immediate reactions are IgE mediated and delayed reactions are T cell dependent. We analyzed lymphocyte involvement in patients with these reactions by determining cell su...
journal_title：International journal of immunopathology and pharmacology
pub_type： 临床试验,杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:It is well known that in some conditions bacteria of physiological flora of gastrointestinal tract may become pathogenic. Each complaint which causes injury of gastrointestinal wall integrity permits bacteria to penetrate the tissues and affect the tissue cells. Since mast cells represent one of very important and num...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Progressive ageing is associated with an increment of biomolecules modified through oxidation as a result of the action of free radicals deriving from reactive oxygen species that attack biomolecules. During ageing many alterations of renal functions have been reported. Renal ageing is associated with a progressive de...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463200401700306
更新日期：2004-09-01 00:00:00
abstract：:We reported a case of an 11-year-old girl admitted to our hospital for goiter, tachycardia, sweating, and visible and palpable thyroid. Thyroid function tests revealed a low thyrotropin level (<0.004 mIU/L) and elevated free thyroxine level (3.4 ng/ dL) diagnosed with Graves' disease and treated with methimazole. This...
journal_title：International journal of immunopathology and pharmacology
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更新日期：2016-12-01 00:00:00
abstract：:This study aimed to investigate the effects of a novel patented Mg-3Nd-0.2Zn-0.4Zr (weight %, JDBM) alloy on osteoblastic cell function, as these cells play an important role in bone repair and remodeling. The associated effects of the JDBM alloy on osteoblastic cell function involving cell adhesion, cell proliferatio...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463201202500306
更新日期：2012-07-01 00:00:00
