Abstract:
:Non-cystic fibrosis bronchiectasis (nCFb) is an acquired condition of variable etiology. Medical treatment basically involves antibiotics and chest physiotherapy. An impaired mucociliary clearance seems to be one of the mechanisms behind nCFb, and inhaled therapy with mucoactive agents has frequently been used to try to correct it. The most often used mucoactive agents in this setting are N-acetylcysteine, hypertonic saline solution (HS), mannitol powder and recombinant human DNase (rhDNase). Reviewing the international medical literature on the use of these drugs for patients with nCFb from 1992 to the present day, we retrieved 88 articles, only 12 of which met our selection criteria for this analysis. We found only 2 papers and 2 reviews on the use of rhDNase in children, and in adults 3 trials on HS, 5 on mannitol powder and 2 on rhDNase. In conclusion, no observational or randomized controlled trials (RCT) have been published on the use of these drugs in children with nCFb, while the few conducted on adult patients report some evidence of their effects. Further studies are needed on inhaled mucoactive drugs for the treatment of children with nCFb.
journal_name
Int J Immunopathol Pharmacolauthors
Snijders D,Calgaro S,Bertozzi I,Quartesan S,Kozuh I,Lunardi F,Barbato Adoi
10.1177/039463201302600228subject
Has Abstractpub_date
2013-04-01 00:00:00pages
529-34issue
2eissn
0394-6320issn
2058-7384pii
28journal_volume
26pub_type
信件,评审abstract::Hypertension has been suggested to exert pro-inflammatory actions through increased expression of several mediators, including chemokines. Chemokines are involved in inflammatory and autoimmune disorders, and in the formation of atherosclerotic lesions through promotion of inflammatory cell migration. The aim of this ...
journal_title:International journal of immunopathology and pharmacology
pub_type: 杂志文章
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journal_title:International journal of immunopathology and pharmacology
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