Abstract：
:The risk and benefit of oral immunomodulation using heat-killed Enterococcus faecalis FK-23 preparation (FK-23) were evaluated in healthy dogs. Dogs were administered perorally 100 mg/kg of FK23 daily for 3 months. FK-23 did not affect the findings of complete blood count, leukocyte differential count, blood chemistry, serum electrolyte, radiography, or physical conditions of the dogs tested. Increase in myeloid/erythroid ratio and granulocytic lineage was found in bone marrow of the FK-23 treated dogs. Neutrophil function assessed by zymosan-dependent chemiluminescence was activated by treatment of the drug. FK-23 also stimulated in vitro lymphocyte blast transformation of PHA, Con A, and LPS. FK-23 thus appears to be a useful immunomodulating drug to stimulate non-specific host immune responses without adverse side effects.
journal_name
Int J Immunopathol Pharmacolauthors
Hasegawa T,Shimazu N,Inomata T,Yamamoto T,Abe S,Yamaguchi Hkeywords:
subject
Has Abstractpub_date
1999-05-01 00:00:00pages
81-87issue
2eissn
0394-6320issn
2058-7384pii
5journal_volume
12pub_type
杂志文章abstract：:Silicosis patients suffer from pulmonary fibrosis caused by silica inhalation, as well as autoimmune diseases known as the adjuvant effects of silica. Caplan syndrome complicated with rheumatoid arthritis (RA) is well known epidemiologically, and the incidence of complicated systemic sclerosis (SSc), systemic lupus er...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:Since the beginning of the 21st century, carbon-based nanomaterials (CNTs) have been introduced in pharmacy and medicine for drug delivery system in therapeutics. CNTs have proved able to transport a wide range of molecules across membranes and into living cells; therefore, they have attracted great interest in biomed...
journal_title：International journal of immunopathology and pharmacology
pub_type： 社论,评审
doi：10.1177/0394632015572559
更新日期：2015-03-01 00:00:00
abstract：:Isoprostanes are prostaglandin isomers produced from the peroxidation of polyunsaturated fatty acids from the cellular membrane. They have been used as a specific index of cellular lipoperoxidation and as an indirect measure of oxidative stress. However, these molecules also present several biological activities. An o...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463200501800309
更新日期：2005-07-01 00:00:00
abstract：:Similar to many complex autoimmune diseases, genetic and environmental factors including diet, infection and xenobiotics play a critical role in the development of autism. In this study, we postulated that infectious agent antigens such as streptokinase, dietary peptides (gliadin and casein) and ethyl mercury (xenobio...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463200301600302
更新日期：2003-09-01 00:00:00
abstract：:Few studies have evaluated the occurrence of immediate adverse reactions in allergic patients after an ultra-rush regimen of different commercial allergen extracts for sublingual immunotherapy (SLIT) Methods: 679 patients took part in trials of specific ultra-rush SLIT for the treatment of IgE-mediated rhinitis and/or...
journal_title：International journal of immunopathology and pharmacology
pub_type： 临床试验,杂志文章
doi：10.1177/039463200501800210
更新日期：2005-04-01 00:00:00
abstract：:Ionizing irradiation causes damage and functional failure of irradiation-sensitive systems and tissues such as small intestine. The molecular mechanisms underlying inflammatory and adaptive responses to acute irradiation damage are poorly understood. Using a mouse model of total-body γ-irradiation, we assessed the irr...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463201002300415
更新日期：2010-10-01 00:00:00
abstract：:Mast cells play important role in allergic inflammation by releasing histamine, tryptase and several inflammatory cytokines. Human leukemic mast cells (HMC-1) have been used to study mast cell mediator and their role in inflammatory mechanisms. HMC-1 contain and release several inflammatory mediators, of which the pro...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463200301600106
更新日期：2003-01-01 00:00:00
abstract：:Varicocele is a common cause of sperm damage. Some studies showed higher concentration of seminal leukocytes in patients with varicocele. The aim of the study was to evaluate seminal leukocyte subpopulations in patients with varicocele. We enrolled 20 patients with varicocele and 20 age-matched healthy men. Sperm anal...
journal_title：International journal of immunopathology and pharmacology
pub_type： 信件
doi：10.1177/2058738420925719
更新日期：2020-01-01 00:00:00
abstract：:The possible use of cell therapies for neurological lesions and disorders is regarded as a very promising strategy. However, many issues related to cell type, tissue donor, expected biological action etc., are still open. In this study human mesenchymal stem cells derived from different fetal and adult tissues were ex...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463201402700309
更新日期：2014-07-01 00:00:00
abstract：:Immunosuppressive treatment has changed the prognosis of Lupus nephritis over time, but improvement in prognosis is difficult to analyze in different historical periods, and should be better demonstrated in comparison with life expectancy of sex-and age-matched people. Long-term patient and renal survival of 90 patien...
journal_title：International journal of immunopathology and pharmacology
pub_type： 信件
doi：10.1177/039463200902200432
更新日期：2009-10-01 00:00:00
abstract：:Current therapies against hepatocellular carcinoma (HCC) are not curative in the majority of patients. In the past, immunotherapy approaches aimed to non-specifically stimulate immune response were quite ineffective. New treatments based on stimulation of specific anti-tumor immune response are currently proposed and ...
journal_title：International journal of immunopathology and pharmacology
pub_type： 社论
doi：10.1177/039463200902200203
更新日期：2009-04-01 00:00:00
abstract：:The role of profilin as an allergen has long been questioned. The capacity of profilin to induce respiratory symptoms has recently been demonstrated; moreover, over 50% of patients sensitized to profilin experienced symptoms after the ingestion of plant-derived foods, suggesting that profilin should be considered as a...
journal_title：International journal of immunopathology and pharmacology
pub_type： 信件
doi：10.1177/0394632015621926
更新日期：2016-09-01 00:00:00
abstract：:Occupational allergies such as pollinosis are reported in several agricultural works in Japan. Many pollens and spores were observed in Japanese pear orchard during the artificial pollination season. By the study on daily symptoms in an allergic farmer, we confirmed that the pollinosis symptoms were most common and mo...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/03946320070200S213
更新日期：2007-04-01 00:00:00
abstract：:Multiple sclerosis (MS) is thought to be an autoimmune T-cell-mediated disease directed at myelin antigens of the central nervous system. Besides myelin proteins, lipid components of CNS are supposed to play a role as antigens for T cells in MS. CD1 is a family of MHC-like glycoproteins specialized in capturing and pr...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463201102400120
更新日期：2011-01-01 00:00:00
abstract：:Nickel ingested with food can elicit either systemic cutaneous or gastrointestinal symptoms causing a systemic nickel allergy syndrome (SNAS) that can be treated with tolerance by oral ingestion of the metal. It has been suggested that interleukins 2 (IL-2) and 10 (IL-10) are involved in the mechanisms underlying oral...
journal_title：International journal of immunopathology and pharmacology
pub_type： 临床试验,信件
doi：10.1177/039463201302600127
更新日期：2013-01-01 00:00:00
abstract：:The complex pathophysiology of human immunodeficiency virus (HIV) infection and the relatively high mutation rate of the retrovirus make it challenging to design effective anti-HIV vaccines. Several attempts have been made during the last decades to elucidate the enigmatic immunology of HIV infection and to predict po...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463200902200309
更新日期：2009-07-01 00:00:00
abstract：:The beneficial effects of hot springs have been known for centuries and treatments with sulphurous thermal waters are recommended in a number of chronic pathologies as well as acute recurrent infections. However, the positive effects of the therapy are often evaluated in terms of subjective sense of wellbeing and symp...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463201302600307
更新日期：2013-07-01 00:00:00
abstract：:More and more studies have demonstrated the anti-inflammatory effects of heparin. However, in the aspect of allergic airway inflammation, data about its daily use in animal model is scarce. To evaluate the efficacy of 22-day intranasal heparin administration in mite-induced airway allergic inflammation in BALB/c mice,...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463201302600208
更新日期：2013-04-01 00:00:00
abstract：:Allergic drug reactions can be classified as immediate, accelerated or delayed. This classification usually correlates with the mechanism involved: immediate reactions are IgE mediated and delayed reactions are T cell dependent. We analyzed lymphocyte involvement in patients with these reactions by determining cell su...
journal_title：International journal of immunopathology and pharmacology
pub_type： 临床试验,杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Involvement of imbalance between pro- and anti-inflammatory events has been reported in the developed pathogenesis after scorpion envenomation. The immunosuppressive and anti-inflammatory properties of tacrolimus (FK-506) have been investigated: i) to better understand evolution of signaling pathways which are involve...
journal_title：International journal of immunopathology and pharmacology
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abstract：:Icatibant, an antagonist of the bradykinin B2 receptor, was approved for the treatment of acute attacks of hereditary angioedema in the EU in 2008. This paper presents the case of a 65-year-old woman affected by frequent acute attacks of hereditary angioedema who benefitted from a change of therapy to icatibant, follo...
journal_title：International journal of immunopathology and pharmacology
pub_type： 信件
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journal_title：International journal of immunopathology and pharmacology
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更新日期：2002-09-01 00:00:00
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journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章,评审
doi：10.1177/2058738419855226
更新日期：2019-01-01 00:00:00
abstract：:This update on treatment of asthma exacerbations in children is the result of an Italian Pediatric Society Task-force, made up of a panel of experts working in 2007-2008. The aim is to give clear indications on the use of the drugs most employed in children, grading the quality of evidence and the strength of recommen...
journal_title：International journal of immunopathology and pharmacology
pub_type： 社论
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abstract：:About three decades ago, the primary mechanism of action of the non-steroidal anti-inflammatory drugs (NSAIDs) was elucidated when their inhibitory action on the production of prostaglandins was discovered. It was found that their action is centred on the inhibition of the cyclooxygenase (COX) enzyme responsible for c...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章,评审
doi：
更新日期：2003-05-01 00:00:00
abstract：:The aim of this study was to evaluate the concentrations of CD45pos leukocytes in the semen samples of infertile patients with low testicular volume (TV) compared to subjects with normal TV. The testis was considered normal in size when it had a volume between 15 and 25 cm(3), low-normal with a volume between 10 and 1...
journal_title：International journal of immunopathology and pharmacology
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更新日期：2015-03-01 00:00:00
abstract：:The aim of this study was to evaluate the effect of the Heat Shock Proteins GroES, GroEL and DnaK on the expression of the costimulatory molecules CD80/CD86 in B cells and macrophages. The interactions among these molecules are able to highly influence the immune response through the regulation of cytokine liberation ...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
doi：10.1177/039463200501800404
更新日期：2005-10-01 00:00:00
abstract：:To prevent and control disease caused by exposure to various agents, it is necessary to determine the harmful level of intervention and to establish a method for measuring that level. In-air microparticle-induced X-ray emission (in-air micro-PIXE) analysis is based on irradiation of specimens with a proton ion microbe...
journal_title：International journal of immunopathology and pharmacology
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abstract：:Septic shock (SS) leads to a high mortality rate for sepsis patients. Norepinephrine (NE) is a preferred vasoactive agent in SS treatment. This study aimed to assess the effects of NE at different administration time and NE combined with SP treatment on the cardiac function and prognosis of SS.SS patients received NE ...
journal_title：International journal of immunopathology and pharmacology
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abstract：:Oxidative stress (OS) is well documented in asthma, but so far, little data has been reported in nonasthmatic patients with Seasonal Allergic Rhinitis (SAR). The aim of this study is to investigate the degree of OS and airway inflammation in patients with SAR, with and without concomitant asthma (SAR+A), using breath ...
journal_title：International journal of immunopathology and pharmacology
pub_type： 杂志文章
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更新日期：2008-10-01 00:00:00
