Profilin desensitization: A case series.

Abstract:

:The role of profilin as an allergen has long been questioned. The capacity of profilin to induce respiratory symptoms has recently been demonstrated; moreover, over 50% of patients sensitized to profilin experienced symptoms after the ingestion of plant-derived foods, suggesting that profilin should be considered as a clinically relevant food allergen.We describe the cases of seven allergic patients with oral allergy syndrome and other adverse reactions after eating plant-derived food, that have been undergone to profilin desensitization treatment.The protocol started with a drop of profilin solution (50 µg/mL) diluted 1:10(18) in water until the highest dose of 10 drops of undiluted solution three times a week. At the end of the treatment we observed a decreased mean diameter of profilin wheal in skin prick test (SPT) in five of the seven participants and in profilin specific IgE values in six patients that repeated the test. Regarding basophil activation test (BAT) and the detection of IgG4, we do not have significant results because the tests have to be repeated in some patients. Regarding the double-blind placebo-controlled challenges, after about 10 months of induction phase all the patients showed tolerance to several foods that they previously did not tolerate.Moreover, the immunotherapy with profilin has proved to be safe because no serious adverse events have been reported in our patients.In summary, the results of this exploratory study of sublingual immunotherapy (SLIT) for profilin allergy show that it can be a promising therapeutic option that could modify the clinical reactivity of the patients to the intake of plant-derived food.

authors

Nucera E,Aruanno A,Rizzi A,Pecora V,Patriarca G,Buonomo A,Mezzacappa S,Schiavino D

doi

10.1177/0394632015621926

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

529-36

issue

3

eissn

0394-6320

issn

2058-7384

pii

0394632015621926

journal_volume

29

pub_type

信件
  • Interstitial cystitis and infectious agents.

    abstract::Interstitial cystitis (IC) is a syndrome consisting of severe refractory bladder symptoms of unknown etiology. The disease tends to affect Caucasian women with a mean age of 40 years, with 25% of patients under the age of 30. Few population based epidemiological studies of IC have been performed. We analyzed a case of...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200501800424

    authors: Fioriti D,Penta M,Mischitelli M,Degener AM,Pierangeli A,Gentile V,Nicosia R,Gallinelli C,Chiarini F,Pietropaolo V

    更新日期:2005-10-01 00:00:00

  • Establishment of a poisoned animal model of toxic encephalopathy induced by 1,2-dichloroethane.

    abstract::1,2-dichloroethane(1,2-DCE) is toxic, especially by inhalation due to its high vapour pressure. Inhalation of concentrated 1,2-DCE vapor can induce effects on the human nervous system, even encephalopathy. However, 1,2-DCE toxic encephalopathy has seldom been reported, and no adequate data were available to evaluate t...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:

    authors: Zhang Q,Niu Q,Li LY,Yang L,Guo XL,Huang JX,Wang LP,Liang YX

    更新日期:2011-01-01 00:00:00

  • Evaluation of IL6, IL10 and VDR alleles distribution in an Italian large sample of subjects affected by chronic periodontal disease.

    abstract::In recent decades, the role played by the immune response to bacteria in the pathogenesis of chronic periodontal disease (PD) has long been studied. Although from the clinical point of view, adequate oral hygiene is essential to ensure a satisfactory response of the host to infections, modulation of the reaction of im...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/2058738419840844

    authors: Luca S,Francesco C,Damiano M,Alessandro N,Silvia C,Diego R,Michele R,Marco S

    更新日期:2019-01-01 00:00:00

  • Inhaled mucoactive drugs for treating non-cystic fibrosis bronchiectasis in children.

    abstract::Non-cystic fibrosis bronchiectasis (nCFb) is an acquired condition of variable etiology. Medical treatment basically involves antibiotics and chest physiotherapy. An impaired mucociliary clearance seems to be one of the mechanisms behind nCFb, and inhaled therapy with mucoactive agents has frequently been used to try ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件,评审

    doi:10.1177/039463201302600228

    authors: Snijders D,Calgaro S,Bertozzi I,Quartesan S,Kozuh I,Lunardi F,Barbato A

    更新日期:2013-04-01 00:00:00

  • Breath markers of oxidative stress and airway inflammation in Seasonal Allergic Rhinitis.

    abstract::Oxidative stress (OS) is well documented in asthma, but so far, little data has been reported in nonasthmatic patients with Seasonal Allergic Rhinitis (SAR). The aim of this study is to investigate the degree of OS and airway inflammation in patients with SAR, with and without concomitant asthma (SAR+A), using breath ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200802100419

    authors: Gratziou C,Rovina N,Makris M,Simoes DC,Papapetropoulos A,Roussos C

    更新日期:2008-10-01 00:00:00

  • TNF-alpha, IL-4R-alpha and IL-4 polymorphisms in mild to severe asthma from Italian Caucasians.

    abstract::Asthma is a chronic airway inflammatory disease associated with airway hyperresponsiveness which affects subjects with genetic predisposition. An association has been reported between some polymorphisms in various cytokine genes and asthma. Most of them are single nucleotide polymorphisms (SNPs). These polymorphisms a...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201302600107

    authors: Ricciardolo FL,Sorbello V,Silvestri M,Giacomelli M,Debenedetti VM,Malerba M,Ciprandi G,Rossi GA,Rossi A,Bontempelli M

    更新日期:2013-01-01 00:00:00

  • Presepsin: A potential biomarker of PJI? A comparative analysis with known and new infection biomarkers.

    abstract::There is still no "gold standard" for the diagnosis and prognosis of post-operative periprosthetic joint infection (PJI). Among serum biomarkers, an emerging molecule is presepsin, the soluble fraction of CD14, recently described in other settings as a powerful diagnostic tool to detect sepsis at different degrees of ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632017749356

    authors: Marazzi MG,Randelli F,Brioschi M,Drago L,Romanò CL,Banfi G,Massaccesi L,Crapanzano C,Morelli F,Corsi Romanelli MM,Galliera E

    更新日期:2018-01-01 00:00:00

  • Immunogenicity of Ra1A and its tissue-specific expression in hepatocellular carcinoma.

    abstract::In order to understand the immunogenicity of a tumor-associated antigen (TAA), Ras family small GTP binding protein (Ra1A) in hepatocellular carcinoma (HCC), autoantibody responses to RalA were evaluated by enzyme-linked immunosorbent assay (ELISA), Western blotting and indirect immunofluorescence assay in sera from p...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200902200319

    authors: Wang K,Chen Y,Liu S,Qiu S,Gao S,Huang X,Zhang J,Peng X,Qiani W,Zhang JY

    更新日期:2009-07-01 00:00:00

  • Plasma total thiol pool in children with asthma: Modulation during montelukast monotherapy.

    abstract:BACKGROUND:Inflammation, which is a hallmark of asthma, is one of the main sources of oxidative stress in the human body. Thiols are powerful antioxidants that protect cells against the consequences of oxidative stress. We aimed to investigate whether asthma and montelukast monotherapy affect the total plasma thiol poo...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632015621563

    authors: Dilek F,Ozkaya E,Kocyigit A,Yazici M,Guler EM,Dundaroz MR

    更新日期:2016-03-01 00:00:00

  • Adipokines and their role in allergies.

    abstract::Both allergic disorders and obesity keep increasing in industrialized countries. Even though a strong association between obesity and allergy- related diseases has been reported in several studies, no published data show a scientific and firm link in-between the two conditions. In general, obesity and weight gain have...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章,评审

    doi:10.1177/03946320110240S403

    authors: Ciprandi G,Caimmi D,Raschetti R,Miraglia Del Giudice M,Salpietro C,Caimmi S,Castellazzi AM

    更新日期:2011-10-01 00:00:00

  • Sinomenine potentiates P815 cell degranulation via upregulation of Ca2+ mobilization through the Lyn/PLCγ/IP3R pathway.

    abstract::Mast cells are vital mediators of drug allergy and, therefore, studying the relationship between drug allergy and mast cells is essential. Sinomenine is the principal active component of Sinomenium acutum, which has anti-inflammatory and anti-immune effects, and is used to treat various rheumatoid diseases. However, al...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632015621768

    authors: Wang N,Liu R,Liu Y,Zhang R,He L

    更新日期:2016-12-01 00:00:00

  • Natural killer cell activity decreases in workers occupationally exposed to extremely low frequency magnetic fields exceeding 1 microT.

    abstract::In a preliminary study a reduction in natural killer (NK) cell activity in peripheral blood lymphocytes (PBL) was observed in a group of workers exposed to levels of extremely low frequency-magnetic fields (ELF-MF) exceeding 1 microT. This study was performed to confirm the results. In 121 workers engaged in various o...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200902200422

    authors: Gobba F,Bargellini A,Bravo G,Scaringi M,Cauteruccio L,Borella P

    更新日期:2009-10-01 00:00:00

  • Treatment of psoriasis with different dosage regimens of etanercept: preliminary results from the Tαranta Plastic Study Group.

    abstract::This pilot open-label study is aimed to assess clinical response in psoriasis patients receiving diverse dose regimens of etanercept, consisting of the same global cumulative dose of etanercept administered over different treatment periods. Eligible patients were assigned sequentially in a 1:1 ratio to receive: etaner...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1177/039463201002300314

    authors: Cassano N,Loconsole F,Miracapillo A,Travaglini M,Digiuseppe MD,Congedo M,Galluccio A,Buquicchio R,Mastrandrea V,Filieri M,Raho G,Pezza M,Vena GA

    更新日期:2010-07-01 00:00:00

  • Contact allergic dermatitis to gold in a tattoo: a case report.

    abstract::The art of tattooing has increasing in recent decades. Allergic sensitivity to one of the pigments is the most frequent cause of dermatological reactions at the site of the tattoo. Gold is a new pigment used in tattooing, because of its bright yellow color and luster. Allergy to this metal is uncommon. To our knowledg...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463201102400432

    authors: Tammaro A,Tuchinda P,Persechino S,Gaspari A

    更新日期:2011-10-01 00:00:00

  • Heparin protects BALB/c mice from mite-induced airway allergic inflammation.

    abstract::More and more studies have demonstrated the anti-inflammatory effects of heparin. However, in the aspect of allergic airway inflammation, data about its daily use in animal model is scarce. To evaluate the efficacy of 22-day intranasal heparin administration in mite-induced airway allergic inflammation in BALB/c mice,...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201302600208

    authors: Fu LS,Tsai JJ,Chen YJ,Lin HK,Tsai MC,Chang MD

    更新日期:2013-04-01 00:00:00

  • Allergenic pollens and spores in the working environment of Japanese pear farmers.

    abstract::Occupational allergies such as pollinosis are reported in several agricultural works in Japan. Many pollens and spores were observed in Japanese pear orchard during the artificial pollination season. By the study on daily symptoms in an allergic farmer, we confirmed that the pollinosis symptoms were most common and mo...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/03946320070200S213

    authors: Teranishi H,Uchida M,Hayashi S,Yamada N

    更新日期:2007-04-01 00:00:00

  • Carbon nanotubes: Properties, biomedical applications, advantages and risks in patients and occupationally-exposed workers.

    abstract::Since the beginning of the 21st century, carbon-based nanomaterials (CNTs) have been introduced in pharmacy and medicine for drug delivery system in therapeutics. CNTs have proved able to transport a wide range of molecules across membranes and into living cells; therefore, they have attracted great interest in biomed...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 社论,评审

    doi:10.1177/0394632015572559

    authors: Lamberti M,Pedata P,Sannolo N,Porto S,De Rosa A,Caraglia M

    更新日期:2015-03-01 00:00:00

  • IL-31 a Th2 cytokine involved in immunity and inflammation.

    abstract::Cytokines are immunal regulatory proteins, however they also play a relevant role in inflammatory diseases. IL-31 is a newly discovered cytokine expressed primarily in TH2 cells, introduced by activated CD4+ T cells. IL-31 is capable of inducing chemokines and other cytokines in several inflammatory diseases via its s...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 社论

    doi:10.1177/039463201002300304

    authors: Castellani ML,Felaco P,Galzio RJ,Tripodi D,Toniato E,De Lutiis MA,Fulcheri M,Caraffa A,Antinolfi P,Tetè S,Felaco M,Conti F,Pandolfi F,Theoharides TC,Shaik-Dasthagirisaheb YB

    更新日期:2010-07-01 00:00:00

  • Protein kinase C zeta regulation of hypertrophic and apoptotic events occurring during rat neonatal heart development and growth.

    abstract::The development and growth of the rat heart implies hyperplasia, which stops at birth, and hypertrophy, allowing cardiac mass to grow in response to programmed genetic events along with to haemodynamic overload. Moreover, hypertrophy is accomplished to apoptosis which controls the final number of myocardial cells, del...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200501800106

    authors: Centurione L,Di Giulio C,Santavenere E,Cacchio M,Sabatini N,Rapino C,Bianchi G,Rapino M,Bosco D,Antonucci A,Cataldi A

    更新日期:2005-01-01 00:00:00

  • Allergic and non-allergic drug hypersensitivity reactions in children.

    abstract::Adverse drug reactions (ADR) are an important medical problem. The aim of this study is to investigate the clinical characteristics of children with ADR and to assess the tolerability of alternative drugs in children (under 16 yrs of age) with a history of ADR. We studied 278 children (132 males and 146 females). Pati...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201002300324

    authors: Buonomo A,Altomonte G,De Pasquale T,Lombardo C,Pecora V,Sabato V,Colagiovanni A,Rizzi A,Aruanno A,Pascolini L,Patriarca G,Nucera E,Schiavino D

    更新日期:2010-07-01 00:00:00

  • Sequence uniqueness as a molecular signature of HIV-1-derived B-cell epitopes.

    abstract::The complex pathophysiology of human immunodeficiency virus (HIV) infection and the relatively high mutation rate of the retrovirus make it challenging to design effective anti-HIV vaccines. Several attempts have been made during the last decades to elucidate the enigmatic immunology of HIV infection and to predict po...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200902200309

    authors: Lucchese A,Serpico R,Crincoli V,Shoenfeld Y,Kanduc D

    更新日期:2009-07-01 00:00:00

  • Involvement of caspace-3 in the cleavage of terminal transferase.

    abstract::To investigate the in vivo role of caspase-3 in Terminal Transferase metabolism DMSO-treated RPMI-8402, a human pre-T cell line was used. In DMSO treated samples (3)H-dGTP incorporation and TdT phosphorylation occurs after 4 hours of treatment. After 8 hours cells undergo TdT proteolysis in addition to its inactivatio...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200201500306

    authors: Trubiani O,Guarnieri S,Paganelli R,Di Primio R

    更新日期:2002-09-01 00:00:00

  • The POLISMAIL lesson: sublingual immunotherapy may be prescribed also in polysensitized patients.

    abstract::Polysensitization is a feature of allergic rhinitis (AR) that significantly impairs the quality of life (QoL) of AR patients. Allergen-specific immunotherapy is the only causal therapy for AR. However, the polysensitization phenomenon may represent a crucial obstacle as far as it concerns the choice of the allergen ex...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件,多中心研究

    doi:10.1177/039463201002300227

    authors: Ciprandi G,Incorvaia C,Puccinelli P,Scurati S,Masieri S,Frati F

    更新日期:2010-04-01 00:00:00

  • Comparison study of different indoleamine-2,3 dioxygenase inhibitors from the perspective of pharmacodynamic effects.

    abstract:INTRODUCTION:Indoleamine 2,3-dioxygenase (IDO) was a potential tumor immunotherapy target. IDO inhibitors showed inconsistent results in clinical trials, but no preclinical comparative study was reported. The purpose of this study was to evaluate the differences of representative IDO inhibitors (PCC0208009, INCB024360,...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/2058738420950584

    authors: Jiang X,Li X,Zheng S,Du G,Ma J,Zhang L,Wang H,Tian J

    更新日期:2020-01-01 00:00:00

  • Phloretin alleviates dinitrochlorobenzene-induced dermatitis in BALB/c mice.

    abstract::Atopic dermatitis (AD) is a chronic inflammatory disease of the skin that substantially affects a patient's quality of life. While steroids are the most common therapy used to temporally alleviate the symptoms of AD, effective and nontoxic alternatives are urgently needed. In this study, we utilized a natural, plant-d...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/2058738420929442

    authors: Wu CS,Lin SC,Li S,Chiang YC,Bracci N,Lehman CW,Tang KT,Lin CC

    更新日期:2020-01-01 00:00:00

  • Psoriasis induced by infliximab in a patient suffering from Crohn's disease.

    abstract::We describe the case of a 30-year-old female with no family history of psoriasis and suffering from Crohn's disease successfully treated with infliximab at the dosage of 5 mg/kg. On the 15th week from the start of therapy, the patient developed a palmoplantar pustular psoriasis, which spread to the arms, trunk and sca...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463200902200331

    authors: Manni E,Barachini P

    更新日期:2009-07-01 00:00:00

  • HSP60 activity on human bronchial epithelial cells.

    abstract::HSP60 has been implicated in chronic inflammatory disease pathogenesis, including chronic obstructive pulmonary disease (COPD), but the mechanisms by which this chaperonin would act are poorly understood. A number of studies suggest a role for extracellular HSP60, since it can be secreted from cells and bind Toll-like...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632017734479

    authors: Sangiorgi C,Vallese D,Gnemmi I,Bucchieri F,Balbi B,Brun P,Leone A,Giordano A,Conway de Macario E,Macario AJ,Cappello F,Di Stefano A

    更新日期:2017-12-01 00:00:00

  • Strategies for successful vaccination against hepatocellular carcinoma.

    abstract::Current therapies against hepatocellular carcinoma (HCC) are not curative in the majority of patients. In the past, immunotherapy approaches aimed to non-specifically stimulate immune response were quite ineffective. New treatments based on stimulation of specific anti-tumor immune response are currently proposed and ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 社论

    doi:10.1177/039463200902200203

    authors: Rinaldi M,Iurescia S,Fioretti D,Ponzetto A,Carloni G

    更新日期:2009-04-01 00:00:00

  • The lack of cytomegalovirus-specific cellular immune response may contribute to the onset of organ infection and disease in lung transplant recipients.

    abstract::Cellular immune response has been demonstrated to play a role in the control of human cytomegalovirus (HCMV) replication in organ transplant recipients. Herein, HCMV-specific T-cell response and association to the onset of organ infection/disease were prospectively evaluated by EliSPOT assay in a population of 46 lung...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201202500417

    authors: Costa C,Saldan A,Sinesi F,Sidoti F,Balloco C,Simeone S,Piceghello A,Mantovani S,Di Nauta A,Solidoro P,Cavallo R

    更新日期:2012-10-01 00:00:00

  • Progesterone inhibits mast cell secretion.

    abstract::Mast cells are involved in allergic reactions, where they secrete numerous vasoactive, inflammatory and nociceptive mediators in response to immunoglobulin E (IgE) and antigen. However, they have also been implicated in inflammatory conditions, such as painful bladder syndrome/interstitial cystitis (PBS/IC), irritable...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200601900408

    authors: Vasiadi M,Kempuraj D,Boucher W,Kalogeromitros D,Theoharides TC

    更新日期:2006-10-01 00:00:00