Ultradian variation of nerve growth factor plasma levels in healthy and schizophrenic subjects.

Abstract:

:Some studies in animal models showed that several neurotrophins may be implicated in the regulation of light-dependent suprachiasmatic pacemaker and in other functions implicated in long-term memory acquisition during sleep. However, no data are known about the role played by NGF in ultradian regulation in humans. The aim of this study was to investigate whether or not there is a natural diurnal fluctuation during daytime in healthy and schizophrenic subjects with a normal light/dark cycle. In a sample of 33 subjects (10 male schizophrenics and 23 healthy subjects) an ELISA assay was used to study the ultradian NGF cycle in blood samples at 9.00, 13.00 and 20.00 hours. The study showed an ultradian rhythm of NGF in healthy subjects with a "V" trend: higher at 9:00 and 20:00 and lower at 13:00. We also show significant differences between male and female controls. No NGF ultradian rhythm among schizophrenic patients compared to healthy subjects was found. The results of this study lead to a rhythmic NGF regulation that appears altered in schizophrenics, where higher levels in the morning and lower levels in the evening were observed, compared to the controls, and support the hypothesis of a role played by NGF in schizophrenia.

authors

Bersani G,Iannitelli A,Massoni E,Garavini A,Grilli A,Di Giannantonio M,Conti CM,Pancheri P

doi

10.1177/039463200401700316

keywords:

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

367-72

issue

3

eissn

0394-6320

issn

2058-7384

pii

16

journal_volume

17

pub_type

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