Sudden progression from impaired glucose tolerance to type 2 diabetes after discontinuation of administration of anti-tumor necrosis factor-alpha antibody infliximab.

Abstract:

:We present the case of a 45-year-old man with psoriasis and psoriatic arthritis and concomitant impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). In this patient, refractory to DMARD's, infliximab was started to control the arthritis. After achieving clinical remission of the disease, infliximab was discontinued and a 75 g- oral glucose tolerance test (OGTT) was performed. After the test, we observed a conversion from IFG/IGT glucose tolerance status to type 2 diabetes. No diet, lifestyle or therapy modifications were made during the observation period. Autoimmune diabetes was ruled out by serum antibodies determination and body weight remained constant, sustaining a protective role in infliximab in the worsening of glucose tolerance.

authors

Ursini F,Succurro E,Grembiale A,Rudi S,Grembiale RD,Arturi F

doi

10.1177/039463201002300334

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

961-3

issue

3

eissn

0394-6320

issn

2058-7384

pii

34

journal_volume

23

pub_type

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