Abstract:
:Malacoplakia is a rare inflammatory condition characterized by the accumulation of benign macrophages associated with pathognomonic Michaelis-Gutmann bodies (MGBs). It is usually found in the genito-urinary tract, and has been associated with immunocompromised states. In this short report, we present 5 patients with pulmonary nodules clinically suspicious for primary or metastatic lung cancer. The histologic examination of the surgical specimens revealed a nonspecific granulomatous chronic disease, and despite the paucity of classical MGBs, a pulmonary malacoplakia was suspected. In all cases the opportunistic pathogen Rhodococcus equi (R. equi) was identified by 16S rRNA gene sequence analysis, leading to the final pathological diagnosis of malacoplakia. We conclude that pulmonary malacoplakia associated with R. equi is a rare disease affecting also immunocompetent patients. The pathogenesis and the diagnostic problems are discussed. Since infection by R. equi is treatable, the importance of its early recognition should be emphasized.
journal_name
Int J Immunopathol Pharmacolauthors
Mulè A,Petrone G,Santoro A,Sanguinetti M,Meacci E,Coli A,Margaritora Sdoi
10.1177/039463201202500316subject
Has Abstractpub_date
2012-07-01 00:00:00pages
703-12issue
3eissn
0394-6320issn
2058-7384pii
16journal_volume
25pub_type
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