Plant-derived recombinant F1, V, and F1-V fusion antigens of Yersinia pestis activate human cells of the innate and adaptive immune system.

Abstract:

:Plague is still endemic in different regions of the world. Current vaccines raise concern for their side effects and limited protection, highlighting the need for an efficacious and rapidly producible vaccine. F1 and V antigens of Yersinia pestis, and F1-V fusion protein produced in Nicotiana benthamiana administered to guinea pigs resulted in immunity and protection against an aerosol challenge of virulent Y. pestis. We examined the effects of plant-derived F1, V, and F1-V on human cells of the innate immunity. F1, V, and F1-V proteins engaged TLR2 signalling and activated IL-6 and CXCL-8 production by monocytes, without affecting the expression of TNF-alpha, IL-12, IL-10, IL-1beta, and CXCL10. Native F1 antigen and recombinant plant-derived F1 (rF1) and rF1-V all induced similar specific T-cell responses, as shown by their recognition by T-cells from subjects who recovered from Y. pestis infection. Native F1 and rF1 were equally well recognized by serum antibodies of Y. pestis-primed donors, whereas serological reactivity to rF1-V hybrid was lower, and that to rV was virtually absent. In conclusion, plant-derived F1, V, and F1-V antigens are weakly reactogenic for human monocytes and elicit cell-mediated and humoral responses similar to those raised by Y. pestis infection.

authors

Del Prete G,Santi L,Andrianaivoarimanana V,Amedei A,Domarle O,D' Elios MM,Arntzen CJ,Rahalison L,Mason HS

doi

10.1177/039463200902200115

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

133-43

issue

1

eissn

0394-6320

issn

2058-7384

pii

15

journal_volume

22

pub_type

杂志文章
  • Immunomodulatory and protective properties of tacrolimus in experimental scorpion envenomation.

    abstract::Involvement of imbalance between pro- and anti-inflammatory events has been reported in the developed pathogenesis after scorpion envenomation. The immunosuppressive and anti-inflammatory properties of tacrolimus (FK-506) have been investigated: i) to better understand evolution of signaling pathways which are involve...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201402700109

    authors: Kabrine M,Laraba-Djebari F

    更新日期:2014-01-01 00:00:00

  • Surgical debridement plus topical cyclosporine A in the treatment of vernal shield ulcers.

    abstract::Vernal keratoconjunctivitis (VKC) is a severe chronic bilateral inflammation of the ocular surface characterized by seasonal exacerbations. Long-term prognosis is generally good; however, 6% develop sequelae responsible for permanent visual impairment. Corneal involvement is almost always present, consisting of puncta...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201202500326

    authors: Caputo R,Pucci N,Mori F,De Libero C,Di Grande L,Bacci GM

    更新日期:2012-07-01 00:00:00

  • alpha-Defensin levels in whole saliva of totally edentulous subjects.

    abstract::Salivary levels of alpha-defensins 1-4 and histatins 1, 3 and 5 were determined in 11 totally edentulous patients, 11 younger healthy adults with normal gingival mucosa (Control group I) and 8 subjects, age-matched with edentulous patients, having a minimum of 25 teeth (Control group II). Whole saliva was treated with...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200802100409

    authors: Fanali C,Inzitari R,Cabras T,Pisano E,Castagnola M,Celletti R,Manni A,Messana I

    更新日期:2008-10-01 00:00:00

  • Immunomodulatory activity of a plant extract containing human papillomavirus 16-E7 protein in human monocyte-derived dendritic cells.

    abstract::This study reports the immunomodulatory activity on human monocyte derived dendritic cells (MDDCs) of a vaccine preparation shown to be effective against an HPV16-related tumour in an animal model. The vaccine is composed of extract from Nicotiana benthamiana leaves containing HPV16 E7 protein expressed by a potato vi...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200902200412

    authors: Di Bonito P,Grasso F,Mangino G,Massa S,Illiano E,Franconi R,Fanales-Belasio E,Falchi M,Affabris E,Giorgi C

    更新日期:2009-10-01 00:00:00

  • Response of ADA and its isoenzymes in mice infected by Trichinella spiralis and treated with mimosine.

    abstract::Infections caused by the nematode Trichinella spiralis (T. spiralis) are characterized by an inflammatory response in the host. The aim of this study was to identify and evaluate markers for monitoring mice infected with T. spiralis and treated with or without mimosine. The markers that have been used were total and d...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200401700211

    authors: Hitoglou S,Frydas S,Hatzistilianou M,Pappa S,Gougoustamou D,Kotsis A

    更新日期:2004-05-01 00:00:00

  • Evidence of LEF1 fetal-maternal interaction in cleft lip with or without cleft palate in a consistent Italian sample study.

    abstract::Epithelial mesenchymal transformation is considered a cardinal process in orofacial development. Several molecular players appear to be involved in this delicate mechanism; the activation of LEF1 transcription factor by transforming growth factor beta 3 seems to be a key step for the correct flow of events. The failur...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/03946320110240S204

    authors: Martinelli M,Carinci F,Morselli PG,Caramelli E,Palmieri A,Girardi A,Riberti C,Scapoli L

    更新日期:2011-04-01 00:00:00

  • Safety and efficacy of etanercept in children with juvenile-onset Behcets disease.

    abstract::Behcets disease (BD) is a chronic, relapsing, multi-system inflammatory disorder, clinically characterized by recurrent oral and genital ulcers, skin lesions, and uveitis. Other manifestations include arthritis, a positive pathergy test, thrombophlebitis, central nervous system disease and gastrointestinal ulcerations...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463200902200235

    authors: Cantarini L,Tinazzi I,Caramaschi P,Bellisai F,Brogna A,Galeazzi M

    更新日期:2009-04-01 00:00:00

  • Perioperative period: immunological modifications.

    abstract::Surgical stress induces complex modifications in the hemodynamic, metabolic, neuro-hormonal and immune response of the individual. The magnitude of these alterations depends on preoperative events leading to surgery, the severity of surgical trauma, and also on post-operative/post-traumatic complications (multiple hit...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章,评审

    doi:10.1177/03946320110240s302

    authors: Cardinale F,Chinellato I,Caimmi S,Peroni DG,Franceschini F,Miraglia Del Giudice M,Bernardini R

    更新日期:2011-07-01 00:00:00

  • Interleukin-2 enhances susceptibility of colon cancer cells to FasR mediated apoptosis by up-regulating Fas receptor level and down-regulating FAP-1 expression.

    abstract::Colon cancer cells are resistant to FasR-mediated apoptosis, which contributes to their evasion from immune attack by CTLs and NK cells. FasR refractoriness of the malignancies was reported to result from loss of Fas receptors and overepression of Fas-associated phosphatase-1 (FAP-1). Therefore, we investigated the ef...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:

    authors: Song E,Chen J,Antus B,Wang M,Xie Y,Yao H,Exton MS

    更新日期:2000-09-01 00:00:00

  • Human mesenchymal stem cells produce bioactive neurotrophic factors: source, individual variability and differentiation issues.

    abstract::The possible use of cell therapies for neurological lesions and disorders is regarded as a very promising strategy. However, many issues related to cell type, tissue donor, expected biological action etc., are still open. In this study human mesenchymal stem cells derived from different fetal and adult tissues were ex...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201402700309

    authors: Paradisi M,Alviano F,Pirondi S,Lanzoni G,Fernandez M,Lizzo G,Giardino L,Giuliani A,Costa R,Marchionni C,Bonsi L,Calza L

    更新日期:2014-07-01 00:00:00

  • Sexual distress, sexual dysfunction and relationship quality in women with systemic sclerosis: correlation with clinical variables.

    abstract::To assess the rate of sexual distress, sexual dysfunction and relationship quality and their association with clinical variables in women with systemic sclerosis (SSc), 102 sexually active women with SSc were recruited. Sexual distress, sexual dysfunction and dissatisfaction with relationship quality were investigated...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463201402700216

    authors: Rosato E,Rossi C,Molinaro I,Di Giulio MA,Trombetta AC,Marra AM,Gigante A,Barbano B,Quarta S,Pisarri S,Afeltra A,Salsano F

    更新日期:2014-04-01 00:00:00

  • Breath markers of oxidative stress and airway inflammation in Seasonal Allergic Rhinitis.

    abstract::Oxidative stress (OS) is well documented in asthma, but so far, little data has been reported in nonasthmatic patients with Seasonal Allergic Rhinitis (SAR). The aim of this study is to investigate the degree of OS and airway inflammation in patients with SAR, with and without concomitant asthma (SAR+A), using breath ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200802100419

    authors: Gratziou C,Rovina N,Makris M,Simoes DC,Papapetropoulos A,Roussos C

    更新日期:2008-10-01 00:00:00

  • Strategies for successful vaccination against hepatocellular carcinoma.

    abstract::Current therapies against hepatocellular carcinoma (HCC) are not curative in the majority of patients. In the past, immunotherapy approaches aimed to non-specifically stimulate immune response were quite ineffective. New treatments based on stimulation of specific anti-tumor immune response are currently proposed and ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 社论

    doi:10.1177/039463200902200203

    authors: Rinaldi M,Iurescia S,Fioretti D,Ponzetto A,Carloni G

    更新日期:2009-04-01 00:00:00

  • Enhancement of lysosomal glycohydrolase activity in human primary B lymphocytes during spontaneous apoptosis.

    abstract::It has been shown that lysosomes are involved in B cell apoptosis but lysosomal glycohydrolases have never been investigated during this event. In this study we determined the enzymatic activities of some lysosomal glycohydrolases in human tonsil B lymphocytes (TBL) undergoing in vitro spontaneous apoptosis. Fluorimet...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200702000208

    authors: Rosati E,Mencarelli S,Magini A,Sabatini R,Tassi C,Orlacchio A,Coaccioli S,Frenguelli A,Marconi P,Emiliani C

    更新日期:2007-04-01 00:00:00

  • Clinical evaluation and treatment of acute asthma exacerbations in children.

    abstract::This update on treatment of asthma exacerbations in children is the result of an Italian Pediatric Society Task-force, made up of a panel of experts working in 2007-2008. The aim is to give clear indications on the use of the drugs most employed in children, grading the quality of evidence and the strength of recommen...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 社论

    doi:10.1177/039463200902200402

    authors: Indinnimeo L,Bertuola F,Cutrera R,De Benedictis FM,Di Pietro P,Duse M,Gianiorio P,Indirli G,La Grutta S,La Rosa M,Longhi R,Miceli Sopo S,Miglioranzi P,Miraglia Del Giudice M,Monaco F,Radzik D,Renna S,Snijders D,Zampog

    更新日期:2009-10-01 00:00:00

  • Human lymphocytic B-leukemia cell line treatment with the bacterial toxin listeriolysin O and rituximab (anti-CD20 antibody): Effects of similar localization of their receptors.

    abstract::Small B-cell lymphocytic lymphoma/chronic lymphocytic leukemia, which typically affects elderly people, is a group of conditions that are not clinically uniform. It has been suggested that using the combined activity of the monoclonal antibody anti-CD20 (rituximab) and Listeria monocytogenes toxin listeriolysin O (LLO...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/0394632015595778

    authors: Gryzik M,Grzywocz Z,Wasilewska D,Kawiak J,Stachowiak R,Bielecki J,Hoser G

    更新日期:2015-09-01 00:00:00

  • Increased expression of CCL4/MIP-1β in CD8+ cells and CD4+ cells in sarcoidosis.

    abstract::Sarcoidosis is a granulomatous disease with an increased accumulation of T cells in lungs as a result of on-site proliferation and chemotaxis induced by chemokines. It has already been demonstrated that CCL3-5 levels were increased in BAL fluid of sarcoidosis patients. To analyze the expression of CCL3-5 chemokines by...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201402700205

    authors: Barczyk A,Pierzchała E,Caramori G,Sozańska E

    更新日期:2014-04-01 00:00:00

  • Association between oral cleft and transcobalamin 2 polymorphism in a sample study from Nassiriya, Iraq.

    abstract::Orofacial clefts are common congenital defects whose prevalence differs between geographical regions and ethnic groups. The inheritance is complex, involving the contribution of both genetic and environmental factors. The involvement of genes belonging to the folate pathway is still matter of debate, with strong evide...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/2058738419855571

    authors: Carinci F,Palmieri A,Scapoli L,Cura F,Abenavoli F,Giannì AB,Russillo A,Docimo R,Martinelli M

    更新日期:2019-01-01 00:00:00

  • Electrochemical behaviour of titanium in ammine and stannous fluoride and chlorhexidine 0.2 percent mouthwashes.

    abstract::Titanium (Ti) is widely used in dentistry. Fluorides at acid pH could destabilize Ti oxide and make it susceptible to corrosion. The behaviour of IV grade machined Ti disks in 5 electrolytic solutions: Fusayama artificial saliva (Fas), ammine fluoride-stannous fluoride (Am-SnF2), 0.2 percent Chlorexidine (CHX) 0.20 pe...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201002300132

    authors: Quaranta A,Ronconi LF,Di Carlo F,Vozza I,Quaranta M

    更新日期:2010-01-01 00:00:00

  • CD1A and CD1E gene polymorphisms are associated with susceptibility to multiple sclerosis.

    abstract::Multiple sclerosis (MS) is thought to be an autoimmune T-cell-mediated disease directed at myelin antigens of the central nervous system. Besides myelin proteins, lipid components of CNS are supposed to play a role as antigens for T cells in MS. CD1 is a family of MHC-like glycoproteins specialized in capturing and pr...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201102400120

    authors: Caporale CM,Notturno F,Pace M,Aureli A,Di Tommaso V,De Luca G,Farina D,Giovannini A,Uncini A

    更新日期:2011-01-01 00:00:00

  • Switch to icatibant in a patient affected by hereditary angioedema with high disease activity: a case report.

    abstract::Icatibant, an antagonist of the bradykinin B2 receptor, was approved for the treatment of acute attacks of hereditary angioedema in the EU in 2008. This paper presents the case of a 65-year-old woman affected by frequent acute attacks of hereditary angioedema who benefitted from a change of therapy to icatibant, follo...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463201202500130

    authors: Firinu D,Barca MP,Serusi L,Lorrai MM,Peralta MM,Manconi PE,Del Giacco SR

    更新日期:2012-01-01 00:00:00

  • Recurrent atrial fibrillation in a patient with ulcerative colitis treated with azathioprine: case report and review of the literature.

    abstract::We present a clinical case report regarding recurrent atrial fibrillation in a patient with ulcerative colitis treated with azathioprine. Atrial fibrillation represents the most common sustained cardiac arrhythmia, occurring in 1-2% of the general population and characterized by seemingly disorganized atrial depolariz...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件,评审

    doi:10.1177/039463201102400131

    authors: Riccioni G,Bucciarelli V,Di Ilio E,Scotti L,Aceto A,D'Orazio N,Martini F,Bucciarelli T

    更新日期:2011-01-01 00:00:00

  • Exhaled nitric oxide is related to bronchial eosinophilia and airway hyperresponsiveness to bradykinin in allergen-induced asthma exacerbation.

    abstract::Exhaled nitric oxide (FeNO) has been associated with bronchial eosinophilia and with airway hyperresponsiveness (AHR) in mild stable asthma. We previously demonstrated in a large project that allergen exposure is able to raise FeNO and to worsen AHR to bradykinin. We postulated that allergen-induced increase in FeN...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/039463201202500120

    authors: Ricciardolo FL,Di Stefano A,Silvestri M,Van Schadewijk AM,Malerba M,Hiemstra PS,Sterk PJ

    更新日期:2012-01-01 00:00:00

  • Acute polyradiculoneuropathy occurring after hymenoptera stings: a clinical case study.

    abstract::Hymenoptera stings may be responsible for both local and systemic reactions; these can be immediate or delayed, depending on the time between the sting and the development of signs or symptoms. Delayed clinical reactions have been reported, although unusual, due to serum sickness and/or affecting organs or systems gen...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200501800220

    authors: Ridolo E,Albertini R,Borghi L,Meschi T,Montanari E,Dall'Aglio PP

    更新日期:2005-04-01 00:00:00

  • Subglotic malt-lymphoma of the larynx: an unusual presentation of chronic cough.

    abstract::Extranodal non-Hodgkin lymphomas limited to the larynx are rare, accounting for less than 1% of all laryngeal neoplasms. The most common site of development of primary laryngeal lymphomas is the supraglottic region. In most cases, the presenting symptoms are hoarseness, dysphagia, dyspnea, and cervical lymphadenopathy...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463201402700319

    authors: Zapparoli M,Trolese AR,Remo A,Sina S,Bonetti A,Micheletto C

    更新日期:2014-07-01 00:00:00

  • Paraneoplastic sensitive neuropathy associated with anti-hu antibodies in a neuroendocrine tumor of duodenum: a case report.

    abstract::Paraneoplastic sensitive neuropathy is one of the most common presentations among a group of cancer-related disorders known as Paraneoplastic Neurological Syndromes (PNS). PNS likely have an autoimmune etiology since they have been associated with the presence of antibodies against neuronal antigens expressed by tumor...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463201002300435

    authors: Nappi L,Formisano L,Damiano V,Matano E,Bianco R,Tortora G

    更新日期:2010-10-01 00:00:00

  • Allergy to nickel: first results on patients administered with an oral hyposensitization therapy.

    abstract::Nickel sulphate allergy is the most common contact allergy. In fact, nickel sulphate is an ubiquitous element, contained in various objects and food; it occurs in igneous rocks, as a free metal and together with iron, but it is also a component of living organism, mainly vegetables. We carried out a clinical trial of ...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 信件

    doi:10.1177/039463200902200330

    authors: Tammaro A,De Marco G,Persechino S,Narcisi A,Camplone G

    更新日期:2009-07-01 00:00:00

  • Sulphurous thermal water increases the release of the anti-inflammatory cytokine IL-10 and modulates antioxidant enzyme activity.

    abstract::The beneficial effects of hot springs have been known for centuries and treatments with sulphurous thermal waters are recommended in a number of chronic pathologies as well as acute recurrent infections. However, the positive effects of the therapy are often evaluated in terms of subjective sense of wellbeing and symp...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463201302600307

    authors: Prandelli C,Parola C,Buizza L,Delbarba A,Marziano M,Salvi V,Zacchi V,Memo M,Sozzani S,Calza S,Uberti D,Bosisio D

    更新日期:2013-07-01 00:00:00

  • Inhibitory effect of retinoic acid on proliferation, maturation and tryptase level in human leukemic mast cells (HMC-1).

    abstract::Mast cells play important role in allergic inflammation by releasing histamine, tryptase and several inflammatory cytokines. Human leukemic mast cells (HMC-1) have been used to study mast cell mediator and their role in inflammatory mechanisms. HMC-1 contain and release several inflammatory mediators, of which the pro...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/039463200301600106

    authors: Alexandrakis MG,Kyriakou DS,Seretakis D,Boucher W,Letourneau R,Kempuraj D,Theoharides TC

    更新日期:2003-01-01 00:00:00

  • Berberine reduces neuroglia activation and inflammation in streptozotocin-induced diabetic mice.

    abstract::We aimed to analyze the action of berberine on the neuropathic pain and neuroglia activation in experimental diabetes mellitus (DM) model. Diabetes in mice was induced by intraperitoneal injection of streptozotocin (STZ) followed by the administration of berberine. Mechanical allodynia and thermal hyperalgesia and act...

    journal_title:International journal of immunopathology and pharmacology

    pub_type: 杂志文章

    doi:10.1177/2058738419866379

    authors: Liu M,Gao L,Zhang N

    更新日期:2019-01-01 00:00:00