Perioperative period: immunological modifications.

Abstract:

:Surgical stress induces complex modifications in the hemodynamic, metabolic, neuro-hormonal and immune response of the individual. The magnitude of these alterations depends on preoperative events leading to surgery, the severity of surgical trauma, and also on post-operative/post-traumatic complications (multiple hit hypothesis). As in other conditions of tissue damage, surgery trauma is followed by an immune-inflammatory response, initiated at the site of injury by the innate immune system, followed by a compensatory anti-inflammatory (or immunosuppressive) response (CARS), involving mainly cells of the adaptive immune system, which predispose the host to septic complications. The up-regulated inflammatory response, together with a profound impairment of macrophage and cell-mediated immunity, appear to be the cause for patients' increased susceptibility in developing subsequent sepsis after major surgery.

authors

Cardinale F,Chinellato I,Caimmi S,Peroni DG,Franceschini F,Miraglia Del Giudice M,Bernardini R

doi

10.1177/03946320110240s302

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

S3-12

issue

3 Suppl

eissn

0394-6320

issn

2058-7384

pii

1

journal_volume

24

pub_type

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