当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY期刊下所有文献 > Protein kinase C zeta regulation of hypertrophic and apoptotic events occurring during rat neonatal heart development and growth.

Protein kinase C zeta regulation of hypertrophic and apoptotic events occurring during rat neonatal heart development and growth.

Abstract：

:The development and growth of the rat heart implies hyperplasia, which stops at birth, and hypertrophy, allowing cardiac mass to grow in response to programmed genetic events along with to haemodynamic overload. Moreover, hypertrophy is accomplished to apoptosis which controls the final number of myocardial cells, deletes vestigial structures, and takes part in remodelling the organ. Since at the basis of all these processes, which lead to the complete development of the heart, the activation of specific signalling pathways underlies, attention has been addressed to the role played in vivo by Protein Kinase C zeta (PKC zeta) in regulating NF-kB signalling system and intrinsic mitochondrial apoptotic route at days 1, 4, 10 and 22 of rat life. In fact, a role has been assigned to PKC zeta in indirectly phosphorylating IKBa, which peaks between 10 and 22 days, through a IKK determining, in turn, NF-kB activation, concomitantly to cytochrome c/Apaf 1 co-localization in the cytoplasm and caspase-9/caspase-3 activation, which leads to the occurrence of apoptosis. Thus a key role for PKC zeta in regulating the hypertrophic and apoptotic events leading to establishment of complete function in rat neonatal heart is here suggested.

journal_name

Int J Immunopathol Pharmacol

journal_title

International journal of immunopathology and pharmacology

authors

Centurione L,Di Giulio C,Santavenere E,Cacchio M,Sabatini N,Rapino C,Bianchi G,Rapino M,Bosco D,Antonucci A,Cataldi A

doi

10.1177/039463200501800106

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

49-58

issue

1

eissn

0394-6320

issn

2058-7384

pii

6

journal_volume

18

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY文献大全
  • Complement system and rheumatoid arthritis: relationships with autoantibodies, serological, clinical features, and anti-TNF treatment.

    abstract：:Autoantibodies (rheumatoid factor, RF; anti-citrullinated-protein antibodies, ACPA) and complement system are involved in rheumatoid arthritis (RA). ACPA and anti-TNF agents are capable of in vitro modulating complement activity. We investigated the relationships between complement, autoantibodies, and anti-TNF treatm...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/039463201102400209

    authors： Di Muzio G,Perricone C,Ballanti E,Kroegler B,Greco E,Novelli L,Conigliaro P,Cipriani P,Giacomelli R,Perricone R

    更新日期：2011-04-01 00:00:00

  • Morning sudden cardiac death.

    abstract：:A circadian variation of cardiac function with peak in the early morning was documented about twenty years ago. A circadian rhythm of platelet aggregability, in the same time of the day, was demonstrated in healthy young male subjects. The morning hours were also reported as crucial for sympathetic nervous system acti...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/039463200001300109

    authors： Guagnano MT,Davi G,Sensi S

    更新日期：2000-01-01 00:00:00

  • Natural killer cell activity decreases in workers occupationally exposed to extremely low frequency magnetic fields exceeding 1 microT.

    abstract：:In a preliminary study a reduction in natural killer (NK) cell activity in peripheral blood lymphocytes (PBL) was observed in a group of workers exposed to levels of extremely low frequency-magnetic fields (ELF-MF) exceeding 1 microT. This study was performed to confirm the results. In 121 workers engaged in various o...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/039463200902200422

    authors： Gobba F,Bargellini A,Bravo G,Scaringi M,Cauteruccio L,Borella P

    更新日期：2009-10-01 00:00:00

  • Vascular endothelial growth factor (VEGF) in human tooth germ center.

    abstract：:Many oncogenis and tumour suppressor genes found inside normal and pathological cells are fundamental for the processes of development, proliferation and tissue differentiation. The purpose of our study is to show the presence and a possible relationship of the VEGF protein during different phases of the development o...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/039463200501800319

    authors： Mastrangelo F,Piccirilli M,Dolci M,Teté S,Speranza L,Patruno A,Gizzi F,Felaco M,Artese L,De Lutiis MA

    更新日期：2005-07-01 00:00:00

  • Ritonavir and Saquinavir directly stimulate anterior pituitary prolactin secretion, in vitro.

    abstract：:An association between human immunodeficiency virus type I (HIV-1) protease inhibitors (PIs) and galactorrhoea/hyperprolactinemia adverse effect has recently been reported in four HIV-1-infected women treated with PIs (indinavir, nelfinavir, ritonavir or saquinavir). This could be explained by a direct effect of riton...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/039463200201500109

    authors： Orlando G,Brunetti L,Vacca M

    更新日期：2002-01-01 00:00:00

  • CD1A and CD1E gene polymorphisms are associated with susceptibility to multiple sclerosis.

    abstract：:Multiple sclerosis (MS) is thought to be an autoimmune T-cell-mediated disease directed at myelin antigens of the central nervous system. Besides myelin proteins, lipid components of CNS are supposed to play a role as antigens for T cells in MS. CD1 is a family of MHC-like glycoproteins specialized in capturing and pr...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/039463201102400120

    authors： Caporale CM,Notturno F,Pace M,Aureli A,Di Tommaso V,De Luca G,Farina D,Giovannini A,Uncini A

    更新日期：2011-01-01 00:00:00

  • Increased expression of CCL4/MIP-1β in CD8+ cells and CD4+ cells in sarcoidosis.

    abstract：:Sarcoidosis is a granulomatous disease with an increased accumulation of T cells in lungs as a result of on-site proliferation and chemotaxis induced by chemokines. It has already been demonstrated that CCL3-5 levels were increased in BAL fluid of sarcoidosis patients. To analyze the expression of CCL3-5 chemokines by...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/039463201402700205

    authors： Barczyk A,Pierzchała E,Caramori G,Sozańska E

    更新日期：2014-04-01 00:00:00

  • Surgical debridement plus topical cyclosporine A in the treatment of vernal shield ulcers.

    abstract：:Vernal keratoconjunctivitis (VKC) is a severe chronic bilateral inflammation of the ocular surface characterized by seasonal exacerbations. Long-term prognosis is generally good; however, 6% develop sequelae responsible for permanent visual impairment. Corneal involvement is almost always present, consisting of puncta...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/039463201202500326

    authors： Caputo R,Pucci N,Mori F,De Libero C,Di Grande L,Bacci GM

    更新日期：2012-07-01 00:00:00

  • Cyclic Amp phosphodiesterase activity in normal and inflamed human dental pulp.

    abstract：:Cyclic AMP phosphodiesterase (cAMP PDE) seems to be important in pulp tissues. High levels of cAMP PDE have been demonstrated to be in dental pulp cells. In the present study cAMP PDE activity was analyzed in normal healthy human dental pulps, in reversible pulpitis and in irreversible pulpitis. Enzymatic cAMP PDE con...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：

    authors： Spoto G,Menna V,Serra E,Santoleri F,Perfetti G,Ciavarelli L,Trentini P

    更新日期：2004-09-01 00:00:00

  • Preliminary evidence of modulating Th1 cytokine after allergen challenge.

    abstract：:We wanted to determine whether a paradigm switch in Th1/Th2 phenotypes in splenic lymphocytes could be induced in BALB/c mice after ultraviolet-B (UVB) irradiation and exposure to pollen. Results showed that UVB irradiation increased IL-1 but decreased IL-12 in vivo, and caused significant cell destruction of macropha...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：

    authors： Kasahara S,Fugo H,Cooper EL,Wago H

    更新日期：2001-05-01 00:00:00

  • Phloretin alleviates dinitrochlorobenzene-induced dermatitis in BALB/c mice.

    abstract：:Atopic dermatitis (AD) is a chronic inflammatory disease of the skin that substantially affects a patient's quality of life. While steroids are the most common therapy used to temporally alleviate the symptoms of AD, effective and nontoxic alternatives are urgently needed. In this study, we utilized a natural, plant-d...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/2058738420929442

    authors： Wu CS,Lin SC,Li S,Chiang YC,Bracci N,Lehman CW,Tang KT,Lin CC

    更新日期：2020-01-01 00:00:00

  • Immunomodulatory and protective properties of tacrolimus in experimental scorpion envenomation.

    abstract：:Involvement of imbalance between pro- and anti-inflammatory events has been reported in the developed pathogenesis after scorpion envenomation. The immunosuppressive and anti-inflammatory properties of tacrolimus (FK-506) have been investigated: i) to better understand evolution of signaling pathways which are involve...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/039463201402700109

    authors： Kabrine M,Laraba-Djebari F

    更新日期：2014-01-01 00:00:00

  • Sequence uniqueness as a molecular signature of HIV-1-derived B-cell epitopes.

    abstract：:The complex pathophysiology of human immunodeficiency virus (HIV) infection and the relatively high mutation rate of the retrovirus make it challenging to design effective anti-HIV vaccines. Several attempts have been made during the last decades to elucidate the enigmatic immunology of HIV infection and to predict po...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/039463200902200309

    authors： Lucchese A,Serpico R,Crincoli V,Shoenfeld Y,Kanduc D

    更新日期：2009-07-01 00:00:00

  • Sick building syndrome in like symptoms in emergency prefabricated accommodation.

    abstract：:The present study investigated the sources of discomfort and the symptoms reported by earthquake victims residing in temporary emergency prefabricated accommodation (prefab). The investigation was carried out by means of a questionnaire. 203 prefab occupants and 13 inhabitants of houses, who were chosen as reference p...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/03946320040170S217

    authors： Muzi G,Accattoli MP,dell'Omo M,Frillici C,Sapia IE,Abbritti G

    更新日期：2004-05-01 00:00:00

  • Specific immunotherapy in children: the evidence.

    abstract：:Specific immunotherapy (SIT) is the only treatment able to not only act on the symptoms of allergy but also act on the causes. At present, SIT may be administered in two forms: subcutaneous (SCIT) and sublingual immunotherapy (SLIT). SCIT represents the standard modality of treatment while SLIT has recently been intro...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章,评审

    doi：10.1177/03946320110240S413

    authors： La Rosa M,Lionetti E,Leonardi S,Salpietro A,Bianchi L,Salpietro C,Miraglia Del Giudice M,Ciprandi G,Marseglia GL

    更新日期：2011-10-01 00:00:00

  • The POLISMAIL lesson: sublingual immunotherapy may be prescribed also in polysensitized patients.

    abstract：:Polysensitization is a feature of allergic rhinitis (AR) that significantly impairs the quality of life (QoL) of AR patients. Allergen-specific immunotherapy is the only causal therapy for AR. However, the polysensitization phenomenon may represent a crucial obstacle as far as it concerns the choice of the allergen ex...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 信件,多中心研究

    doi：10.1177/039463201002300227

    authors： Ciprandi G,Incorvaia C,Puccinelli P,Scurati S,Masieri S,Frati F

    更新日期：2010-04-01 00:00:00

  • Analysis and structural examination of screw loosening in oral implants.

    abstract：:Biological and technical failures of implants have already been reported. Mechanical factors are certainly of importance in implant failures, even if their exact nature has not yet been established. The abutment screw fracture or loosening represents a rare, but quite unpleasant failure. The aim of the present researc...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/03946320110240S214

    authors： Scarano A,Murmura G,Sinjiari B,Sollazzo V,Spinelli G,Carinci F

    更新日期：2011-04-01 00:00:00

  • Erythropoiesis equivalence, pharmacokinetics and immune response following repeat hematide administration in cynomolgus monkeys.

    abstract：:Hematide is a synthetic PEGylated peptidic erythropoiesis stimulating agent (ESA) that is presently being developed for the correction of anemia in patients with chronic renal failure. Unlike currently marketed ESAs, Hematide does not possess any sequence homology to erythropoietin (EPO) and has not elicited moribund ...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/039463201002300111

    authors： Woodburn KW,Schatz PJ,Fong KL,Beaumier P

    更新日期：2010-01-01 00:00:00

  • Ocular clinical pictures disclosed by PCR molecular diagnosis of Chlamydia trachomatis infection performed following the appropriate sampling modality in ocular ecosystem.

    abstract：:Four clinical cases regarding the correct diagnosis of early ocular Chlamydia trachomatis (Ct) inflammation, performed by two different modalities on the ocular ecosystem, are discussed. The present study was carried out in parallel using a cotton flock ocular swab and the scraping of upper lid conjunctiva. The ocular...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/039463201202500427

    authors： Gallenga PE,Del Boccio M,Lobefalo L,Rapinese M,Pennelli A,Martinotti S

    更新日期：2012-10-01 00:00:00

  • Pulmonary malacoplakia at early stage: use of polymerase chain reaction for detection of Rhodococcus equi.

    abstract：:Malacoplakia is a rare inflammatory condition characterized by the accumulation of benign macrophages associated with pathognomonic Michaelis-Gutmann bodies (MGBs). It is usually found in the genito-urinary tract, and has been associated with immunocompromised states. In this short report, we present 5 patients with p...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/039463201202500316

    authors： Mulè A,Petrone G,Santoro A,Sanguinetti M,Meacci E,Coli A,Margaritora S

    更新日期：2012-07-01 00:00:00

  • Cobalt nano-particles modulate cytokine in vitro release by human mononuclear cells mimicking autoimmune disease.

    abstract：:The use of particles from micro to nanoscale provides benefits to diverse scientific fields, but because a large percentage of their atoms lie on the surface, nanomaterials could be highly reactive and pose potential risks to humans. Due to their wide range of application, Cobalt nano-particles are of great interest b...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：

    authors： Petrarca C,Perrone A,Verna N,Verginelli F,Ponti J,Sabbioni E,Di Giampaolo L,Dadorante V,Schiavone C,Boscolo P,Mariani Costantini R,Di Gioacchino M

    更新日期：2006-10-01 00:00:00

  • Sudden progression from impaired glucose tolerance to type 2 diabetes after discontinuation of administration of anti-tumor necrosis factor-alpha antibody infliximab.

    abstract：:We present the case of a 45-year-old man with psoriasis and psoriatic arthritis and concomitant impaired fasting glucose (IFG) and impaired glucose tolerance (IGT). In this patient, refractory to DMARD's, infliximab was started to control the arthritis. After achieving clinical remission of the disease, infliximab was...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 信件

    doi：10.1177/039463201002300334

    authors： Ursini F,Succurro E,Grembiale A,Rudi S,Grembiale RD,Arturi F

    更新日期：2010-07-01 00:00:00

  • Increased levels of IGF-1 and beta2-microglobulin in epithelial lining fluid of preterm newborns developing chronic lung disease. effects of rhG-CSF.

    abstract：UNLABELLED:Insulin-like growth factor-1 (IGF-1) is involved in regulating the Th-1/Th-2 balance, favoring the development of the Th-2 compartment which enhances fibrosis, one of the main characteristics of Chronic Lung Disease (CLD) in premature newborns. Limited data is available concerning a possible association betw...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：

    authors： Capoluongo E,Vento G,Ameglio F,Lulli P,Matassa PG,Carrozza C,Santini SA,Antenucci M,Castagnola M,Giardina B,Romagnoli C,Zuppi C

    更新日期：2006-01-01 00:00:00

  • Impact of nickel oral hyposensitization on quality of life in systemic nickel allergy syndrome.

    abstract：:Nickel (Ni) oral hyposensitization treatment (NiOHT) is an effective management approach for Ni allergy. No health-related quality of life (HRQoL) data exist for the pre- and post-treatment with NiOHT in systemic nickel allergy syndrome (SNAS). The aims of this study were (a) to explore HRQoL in SNAS patients, (b) to ...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/2058738420934629

    authors： Rizzi A,Di Rienzo A,Buonomo A,Aruanno A,Carusi V,Ricci AG,Centrone M,Mezzacappa S,Romeo L,Schiavino D,Inchingolo R,Gasbarrini A,Nucera E

    更新日期：2020-01-01 00:00:00

  • Activation of human monocyte-derived dendritic cells in vitro by the biological response modifier arabinoxylan rice bran (MGN-3/Biobran).

    abstract：:Arabinoxylan rice bran (MGN-3/Biobran) is a potent biological response modifier (BRM) that activates natural killer (NK) cells, T cells and monocytes. Currently, little is known regarding the effects of MGN-3 on dendritic cells (DCs), the cell type that bridges innate and adaptive immunity. Therefore, we examined the ...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/039463201102400412

    authors： Ghoneum M,Agrawal S

    更新日期：2011-10-01 00:00:00

  • Ultradian variation of nerve growth factor plasma levels in healthy and schizophrenic subjects.

    abstract：:Some studies in animal models showed that several neurotrophins may be implicated in the regulation of light-dependent suprachiasmatic pacemaker and in other functions implicated in long-term memory acquisition during sleep. However, no data are known about the role played by NGF in ultradian regulation in humans. The...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1177/039463200401700316

    authors： Bersani G,Iannitelli A,Massoni E,Garavini A,Grilli A,Di Giannantonio M,Conti CM,Pancheri P

    更新日期：2004-09-01 00:00:00

  • Interstitial cystitis and infectious agents.

    abstract：:Interstitial cystitis (IC) is a syndrome consisting of severe refractory bladder symptoms of unknown etiology. The disease tends to affect Caucasian women with a mean age of 40 years, with 25% of patients under the age of 30. Few population based epidemiological studies of IC have been performed. We analyzed a case of...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/039463200501800424

    authors： Fioriti D,Penta M,Mischitelli M,Degener AM,Pierangeli A,Gentile V,Nicosia R,Gallinelli C,Chiarini F,Pietropaolo V

    更新日期：2005-10-01 00:00:00

  • Enhancement of fibroblast proliferation, collagen biosynthesis and production of growth factors as a result of combining sodium hyaluronate and aminoacids.

    abstract：:Fibroblasts play a key role in tissue healing by producing the majority of extracellular matrix components, favouring granulation tissue formation, and stimulating re-epithelialization. Hyaluronan is a component of ECM and its anti-inflammatory effects and properties in enhancing wound closure are well known. In this ...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/039463200902200225

    authors： Mariggiò MA,Cassano A,Vinella A,Vincenti A,Fumarulo R,Lo Muzio L,Maiorano E,Ribatti D,Favia G

    更新日期：2009-04-01 00:00:00

  • Effects of degradable MG-ND-ZN-ZR alloy on osteoblastic cell function.

    abstract：:This study aimed to investigate the effects of a novel patented Mg-3Nd-0.2Zn-0.4Zr (weight %, JDBM) alloy on osteoblastic cell function, as these cells play an important role in bone repair and remodeling. The associated effects of the JDBM alloy on osteoblastic cell function involving cell adhesion, cell proliferatio...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 杂志文章

    doi：10.1177/039463201202500306

    authors： Wang Y,Ouyang Y,Pang X,Mao L,Yuan G,Jiang Y,He Y

    更新日期：2012-07-01 00:00:00

  • Profilin desensitization: A case series.

    abstract：:The role of profilin as an allergen has long been questioned. The capacity of profilin to induce respiratory symptoms has recently been demonstrated; moreover, over 50% of patients sensitized to profilin experienced symptoms after the ingestion of plant-derived foods, suggesting that profilin should be considered as a...

    journal_title：International journal of immunopathology and pharmacology

    pub_type： 信件

    doi：10.1177/0394632015621926

    authors： Nucera E,Aruanno A,Rizzi A,Pecora V,Patriarca G,Buonomo A,Mezzacappa S,Schiavino D

    更新日期：2016-09-01 00:00:00