Food-dependent exercise-induced anaphylaxis: clinical and laboratory findings in 54 subjects.

Abstract:

BACKGROUND:In some subjects, specific foods trigger anaphylaxis when exercise follows ingestion (specific food-dependent exercise-induced anaphylaxis, FDEIAn). Skin test and/or RAST positivity to foods suggest an IgE-mediated pathogenic mechanism. Others suffer from anaphylaxis after all meals followed by exercise, regardless of the food eaten (nonspecific FDEIAn). We sought to identify the culprit foods with a diagnostic protocol. METHODS:We collected detailed histories and performed skin prick tests (SPT) with 26 commercial food allergens, prick plus prick tests (P+P) with 15 fresh foods (including 9 assessed with SPT), and RAST for 31 food allergens. Treadmill stress tests were administered after a meal without any positive food (food plus exercise challenge, FEC). RESULTS:Among the 54 patients, 6 could not recall any suspect food. The other 48 suspected a specific food in at least one episode. The most frequent were tomatoes, cereals and peanuts. Fifty-two subjects were positive to at least one food (22 to more than 20), whereas 2 showed no positive results. All suspect foods were positive. SPT, P+P and RAST displayed different degrees of sensitivity. Each test disclosed some positivities not discovered by others. Two subjects reacted to FEC. Overall, 48 patients probably had specific FDEIAn and the other 6 nonspecific FDEIAn. CONCLUSION:It is useful to test both in vivo and in vitro an extensive panel of foods. Avoidance of foods associated with skin test and/or RAST positivity for at least 4 h before exercise has prevented further episodes in all our patients with specific FDEIAn.

authors

Romano A,Di Fonso M,Giuffreda F,Papa G,Artesani MC,Viola M,Venuti A,Palmieri V,Zeppilli P

doi

10.1159/000053825

keywords:

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

264-72

issue

3

eissn

1018-2438

issn

1423-0097

pii

53825

journal_volume

125

pub_type

杂志文章
  • Impact of Allergy and Eosinophils on the Morbidity of Chronic Rhinosinusitis with Nasal Polyps in Northwest China.

    abstract:BACKGROUND:Nasal polyps are a common health problem that can significantly impact the quality of life. OBJECTIVE:To analyze the impact of allergy and peripheral eosinophils (EOS) on the morbidity of chronic rhinosinusitis with nasal polyps (CRSwNP) in Northwest China. METHODS:A retrospective cohort of 323 patients wh...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000497384

    authors: Chen F,Wen L,Qiao L,Shi Z,Xue T,Chen X,Li X

    更新日期:2019-01-01 00:00:00

  • Respiratory responses of asthmatics to ozone.

    abstract::Asthmatic individuals in the general population appear to be susceptible to disease exacerbation during summertime 'smog' episodes (ambient air pollution containing other pollutants in addition to ozone). Although controlled exposure to ozone causes acute decrements in lung function, asthmatic subjects are only margin...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000236989

    authors: Koren HS,Bromberg PA

    更新日期:1995-05-01 00:00:00

  • N-terminus of a major allergen, Alt a I, of Alternaria alternata defined to be an epitope.

    abstract::A 20mer peptide representing the N-terminus of a major allergen, Alt a I, of Alternaria alternata was synthesized and examined for its antibody binding and antibody induction activities. Alt a I peptide-BSA conjugate reacted with both human IgE and rabbit anti-Alt a I IgG in ELISA, albeit the binding of the peptide to...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237161

    authors: Zhang L,Curran IH,Muradia G,De Vouge MW,Rode H,Vijay HM

    更新日期:1995-11-01 00:00:00

  • Regulation of surface FcepsilonRI expression on human eosinophils by IL-4 and IgE.

    abstract:BACKGROUND:Recent studies have demonstrated that eosinophils from allergic patients express low levels of FcepsilonRI on their surface, but the regulatory mechanisms of eosinophil surface FcepsilonRI expression are not fully understood. We investigated whether IL-4 and IgE, which are reported to regulate surface Fcepsi...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000053782

    authors: Iikura M,Yamaguchi M,Hirai K,Miyamasu M,Yamada H,Nakajima T,Fujisawa T,Ra C,Morita Y,Yamamoto K

    更新日期:2001-04-01 00:00:00

  • The pathophysiological roles of PI3Ks and therapeutic potential of selective inhibitors in allergic inflammation.

    abstract::Phosphoinositide 3-kinases (PI3Ks) are known to be involved in a variety of cellular responses such as cell survival, proliferation, differentiation and cell migration. Recently, PI3Ks have been associated with the pathogenesis of asthma because various immune cells regulate allergic responses. Among the three classes...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000312132

    authors: Takeda M,Ito W,Tanabe M,Ueki S,Kihara J,Kato H,Tanigai T,Kayaba H,Sasaki T,Chihara J

    更新日期:2010-01-01 00:00:00

  • Potential role of antioxidant food supplements, preservatives and colorants in the pathogenesis of allergy and asthma.

    abstract::A significant increase in the incidence of allergy and asthma has been observed during the past decades. The background of this phenomenon has not been well explained, but changes in lifestyle and habits are heavily discussed as contributing factors. Among these is a too clean environment, which may predispose individ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000329137

    authors: Zaknun D,Schroecksnadel S,Kurz K,Fuchs D

    更新日期:2012-01-01 00:00:00

  • Effect of nebulized beclomethasone on airway inflammation and clinical status of children with allergic asthma and rhinitis: a randomized, double-blind, placebo-controlled study.

    abstract::We aimed to evaluate the therapeutic effect of nebulized beclomethasone dipropionate (nBDP) on both allergic asthma and rhinitis. In a randomized, double-blind, placebo-controlled study, 40 children (mean age 10.7 ± 2.1 years) with allergic asthma and rhinitis received either nBDP (daily dose of 800 µg, administered t...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000343137

    authors: Profita M,Riccobono L,Bonanno A,Chanez P,Gagliardo R,Montalbano AM,Albano GD,Liotta G,Gjomarkaj M,La Grutta S

    更新日期:2013-01-01 00:00:00

  • Phantom rhinitis.

    abstract::Sensitivity to strong odors has a broad differential diagnosis. A presentation is made of a 60-year-old man with lifelong mild allergic rhinitis and a superimposed 4-year history of sensitivity to smells. He had no response to medical treatments or allergic immunotherapy. His physical examination was unremarkable. Aft...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000316355

    authors: Myles IA

    更新日期:2010-01-01 00:00:00

  • Assessing the efficacy of immunotherapy with a glutaraldehyde-modified house dust mite extract in children by monitoring changes in clinical parameters and inflammatory markers in exhaled breath.

    abstract:INTRODUCTION:The aim of this study was to evaluate the effectiveness of specific immunotherapy (SIT) management with allergoids in children with allergic asthma by monitoring changes in clinical parameters and inflammatory markers in exhaled breath. METHODS:The study population included 43 patients (24 males) of 6-14 ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000368832

    authors: Lozano J,Cruz MJ,Piquer M,Giner MT,Plaza AM

    更新日期:2014-01-01 00:00:00

  • Identification and characterization of major allergens in excretory/secretory products of the worm Paragonimus ohirai.

    abstract::Allergens present in the excretory/secretory (ES) products of adult Paragonimus ohirai were biochemically identified. Immunoblot analysis using sera from P. ohirai-infected rats revealed only two allergens to be major proteins in the ES products, with apparent molecular masses (M(r)) of 27 and 29 kD. As the ES product...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000064251

    authors: Ikeda T

    更新日期:2002-07-01 00:00:00

  • Reactive oxygen species in psoriasis and psoriasis arthritis: relevance to human disease.

    abstract::Psoriasis (Ps) is a chronic, immune-mediated, skin inflammatory disease affecting up to 3% of the population worldwide. Different environmental triggers initiate this complex multifactorial syndrome. Many individuals affected by Ps (6-26%) develop inflammatory disease in other organs, often in the joints as in psorias...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000375401

    authors: Khmaladze Ia,Nandakumar KS,Holmdahl R

    更新日期:2015-01-01 00:00:00

  • Airway closure after antigen challenge in cynomolgus monkeys: effect of the histamine H1 receptor antagonist, chlorpheniramine maleate.

    abstract:BACKGROUND:Airway closure is frequently observed in human asthma. However, limited information exists on the factors that cause this condition. In this study, an allergic cynomolgus monkey model was used to characterize the condition of airway closure and assess the contribution of histamine H1 receptors to this respon...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000084611

    authors: Skeans S,Lamca JE,House A,Celly CS,Hey JA,Chapman RW

    更新日期:2005-05-01 00:00:00

  • Human hair: an unexpected source of cat allergen exposure.

    abstract:BACKGROUND:Cat allergens are ubiquitous because the clothing of cat owners constitutes an important source of distribution of Fel d 1 in cat-free environments. Since Fel d 1 can adhere to a variety of surfaces, we sought to verify if human hair belonging to individuals with or without a cat at home might represent a re...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000085793

    authors: Liccardi G,Barber D,Russo M,D'Amato M,D'Amato G

    更新日期:2005-06-01 00:00:00

  • Ultrastructural observation of adherence of eosinophils to their surroundings.

    abstract::This study concerned the way in which eosinophils adhere to their surroundings. Many fibrils were seen to adhere to the cell membrane of eosinophils migrating into the submucosa. Those eosinophils migrating into the epithelial layer adhered to the epithelial cells in 2 different ways: through the thin filaments bridgi...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237199

    authors: Watanabe K

    更新日期:1995-01-01 00:00:00

  • Is enhanced fetal growth a risk factor for the development of atopy or asthma?

    abstract:BACKGROUND:The aetiological factors underlying the worldwide increase in the prevalence of asthma and the international patterns of the prevalence of asthma are not well understood. This has led to consideration of factors such as fetomaternal health which may programme the initial susceptibility to allergic sensitisat...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000024149

    authors: Beasley R,Leadbitter P,Pearce N,Crane J

    更新日期:1999-02-01 00:00:00

  • Cloning and molecular characterization of a cDNA from Blomia tropicalis homologous to dust mite group 3 allergens (trypsin-like proteases).

    abstract:BACKGROUND:Exposure to the house dust mite Blomia tropicalis is increasingly being implicated as a major risk factor for asthma exacerbations in sensitized individuals. The objective of this study is to clone and characterize B. Tropicalis allergens in order to better define their role in allergic asthma. METHODS:A la...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000068375

    authors: Flores I,Mora C,Rivera E,Donnelly R,Montealegre F

    更新日期:2003-01-01 00:00:00

  • Successful pregnancy in a Churg-Strauss syndrome patient with a history of intrauterine fetal death.

    abstract::Allergic granulomatosis and angiitis was first reported as a disease entity separate from polyarteritis nodosa in 1951 by Churg and Strauss. It is characterized by bronchial asthma, eosinophilia, and vasculitis and is especially rare in women of reproductive age, though, when present, may be associated with fetal mort...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237140

    authors: Ogasawara M,Kajiura S,Inagaki H,Sasa H,Aoki K,Yagami Y

    更新日期:1995-10-01 00:00:00

  • Mechanisms of action of antiphospholipid antibodies in the antiphospholipid syndrome.

    abstract::Antiphospholipid antibody syndrome (APS) is characterized by autoantibodies against negatively charged phospholipids in the serum, and clinically by multiple thromboses, thrombocytopenia, and recurrent fetal loss. The mechanism(s) by which the antibodies cause the clinical picture are not clear. We review the possible...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000236883

    authors: Aron AL,Gharavi AE,Shoenfeld Y

    更新日期:1995-01-01 00:00:00

  • Fractional Exhaled Nitric Oxide: A Potential Biomarker in Allergic Rhinitis?

    abstract:BACKGROUND:The fractional concentration of exhaled nitric oxide (FeNO) is a surrogate biomarker for Th2-dependent bronchial inflammation. The present study investigated whether FeNO may characterize allergic rhinitis (AR) patients. METHODS:A total of 553 AR patients (497 males, mean age 28.8 years) were evaluated. Tho...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000456548

    authors: Ciprandi G,Gallo F,Ricciardolo FL,Cirillo I

    更新日期:2017-01-01 00:00:00

  • Objectifying the conjunctival provocation test: photography-based rating and digital analysis.

    abstract:BACKGROUND:Patients with allergic rhinoconjunctivitis are susceptible to both nasal and ocular symptoms. The conjunctival provocation test (CPT) is an established diagnostic procedure used in allergic rhinoconjunctivitis, particularly to document a patient's current reactivity to allergens. To date, there are no intern...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000355333

    authors: Dogan S,Astvatsatourov A,Deserno TM,Bock F,Shah-Hosseini K,Michels A,Mösges R

    更新日期:2014-01-01 00:00:00

  • Detection of antibodies against streptococcal peptidoglycan and the peptide subunit (synthetic tetra-D-alanyl-bovine serum albumin complex) in rheumatic-diseases.

    abstract::Serum antibodies reactive with streptococcal cell wall peptidoglycan (PG) and its peptide subunit (synthetic tetra-D-alanine) were measured by enzyme-linked immunosorbent assay (ELISA) in patients with rheumatoid arthritis (RA), juvenile rheumatoid arthritis (JRA), osteoarthritis and acute rheumatic fever (RF) compare...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236137

    authors: Todome Y,Ohkuni H,Mizuse M,Furuya M,Fujikawa S,Tanaka S,Watanabe N,Fujii K,Zabriskie JB

    更新日期:1992-01-01 00:00:00

  • Depletion of CD8+ T cells following primary immunization with ovalbumin results in a high and persistent IgE response.

    abstract::The role of CD8+ T cells in the regulation of IgE was investigated by in vivo CD8+ T-cell depletion. Following intraperitoneal immunization with ovalbumin (OVA), OVA-specific T cell responses were first detected in the draining lymph nodes (LN) and subsequently in the spleen. In vitro depletion of LN CD8+ cells reduce...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237534

    authors: Holmes BJ,MacAry PA,Kemeny DM

    更新日期:1997-05-01 00:00:00

  • Food allergy in Ghanaian schoolchildren: data on sensitization and reported food allergy.

    abstract:BACKGROUND:Epidemiological data on food allergy are scarce in African countries. We studied the prevalence of food sensitization in Ghanaian schoolchildren. METHODS:Children (5-16 years; n = 1,714) from 9 Ghanaian schools were given parental consent to participate in the study. Adverse reactions and food consumption w...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000318704

    authors: Obeng BB,Amoah AS,Larbi IA,Yazdanbakhsh M,van Ree R,Boakye DA,Hartgers FC

    更新日期:2011-01-01 00:00:00

  • Lipopolysaccharides modulate allergen-specific immune regulation in a murine model of mucosal tolerance induction.

    abstract:BACKGROUND:Farming has been widely reported to be associated with decreased risk of developing atopic disorders, but underlying immunomodulatory mechanisms are still not fully defined. We delineated T-cell functions after induction of mucosal tolerance in the context of intranasally delivered organic dust compounds, li...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000128583

    authors: Gerhold K,Avagyan A,Reichert E,Blumchen K,Wahn U,Hamelmann E

    更新日期:2008-01-01 00:00:00

  • Tyk2 is essential for IFN-alpha-induced gene expression in mast cells.

    abstract::Mast cells are recognized not only as the major effector cells of type I hypersensitivity reactions but also as an important player of innate immune response against bacterial infection. Type I IFNs are also involved in the response against bacterial infection. However, the role of type I IFNs and their associated Jan...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000077789

    authors: Mori Y,Hirose K,Suzuki K,Nakajima H,Seto Y,Ikeda K,Shimoda K,Nakayama K,Saito Y,Iwamoto I

    更新日期:2004-06-01 00:00:00

  • Effects of amino acid variations in recombinant Der fII on its human IgE and mouse IgG recognition.

    abstract::Amino acid sequencing of the major mite allergen Der fII purified from mite body extract revealed that it is a mixture of at least two variants. Substitutions were found only at positions in which amino acid variations were predicted from the nucleotide sequences of three cloned cDNAs. When cDNAs corresponding to the ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236804

    authors: Nishiyama C,Yuuki T,Usui Y,Iwamoto N,Okumura Y,Okudaira H

    更新日期:1994-09-01 00:00:00

  • Protein tyrosine phosphorylation: A possible common signaling pathway in human Th1 and Th2 cell clones.

    abstract:BACKGROUND:It has been reported that protein tyrosine phosphorylation is essential for cytokine production in mouse Th1 cells but not in Th2 cells. However, little is known about the difference of signal transduction between human antigen-specific Th1 and Th2 cell clones. METHODS:Purified protein derivative-specific T...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000024028

    authors: Minoguchi K,Yamashita N,Oda N,Takeno M,Kaneoka H,Sakane T

    更新日期:1999-01-01 00:00:00

  • Expression of lymphocytes Fc epsilon RII/CD23 in allergic children undergoing hyposensitization.

    abstract::Owing to the proposed role of Fc epsilon RII/CD23 in allergic diseases, we analyzed the expression of this receptor on peripheral blood lymphocytes (pan-B, pan-T and CD4+ or CD8+ T cells) and its autoproteolytic product sCD23 in serum. This was done in 10 asthmatic children allergic to Dermatophagoides pteronyssinus (...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236520

    authors: Gagro A,Rabatić S,Tresćec A,Dekaris D,Medar-Lasić M

    更新日期:1993-01-01 00:00:00

  • Role of the IgE-mediated system in eosinophil recruitment triggered by two consecutive cycles of sensitisation and challenge in rats.

    abstract::In this study, we postulated that repeated cycles of IgE passive sensitisation and antigen challenge may play a role in up-regulating eosinophil response in allergic conditions. Antigen-mediated stimulation of the pleural cavity of rats passively sensitised with a single injection of IgE anti-DNP resulted in mast cell...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000049530

    authors: Calheiros AS,Aguiar Pires AL,Pereira da Silva J,Cordeiro RS,Martins MA,Lima MC

    更新日期:2001-12-01 00:00:00

  • Prevalence of IgE-binding to Art v 1, Art v 4 and Amb a 1 in mugwort-allergic patients.

    abstract:BACKGROUND:Mugwort (Artemisia vulgaris) represents an important source of weed pollen allergens. The objectives of the present study were (i) to analyze the IgE binding profiles in a group of mugwort-allergic patients, (ii) to identify individual marker allergens crucial for the diagnosis of mugwort allergy and (iii) t...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000108134

    authors: Oberhuber C,Ma Y,Wopfner N,Gadermaier G,Dedic A,Niggemann B,Maderegger B,Gruber P,Ferreira F,Scheiner O,Hoffmann-Sommergruber K

    更新日期:2008-01-01 00:00:00