Expression of lymphocytes Fc epsilon RII/CD23 in allergic children undergoing hyposensitization.

Abstract:

:Owing to the proposed role of Fc epsilon RII/CD23 in allergic diseases, we analyzed the expression of this receptor on peripheral blood lymphocytes (pan-B, pan-T and CD4+ or CD8+ T cells) and its autoproteolytic product sCD23 in serum. This was done in 10 asthmatic children allergic to Dermatophagoides pteronyssinus (Dpt) before and 6 weeks after hyposensitization. FACS analysis of double, direct immunofluorescence staining of the whole blood revealed an elevated percentage of Fc epsilon RII/CD23+ lymphocytes in allergic children (10.29 +/- 5.0), a significantly higher percentage than in nonallergic children (5.7 +/- 2.4, p < 0.05). The majority of Fc epsilon RII/CD23+ were on B cells. A significant positive correlation between the percentages of CD23+ lymphocytes and serum IgE levels was found (Spearman rank = 0.63, p < 0.05). The percentage of CD20+CD23+ lymphocytes significantly decreased after 6 weeks of hyposensitization (6.2 +/- 3.6, p < 0.05), while the percentage of CD20+ lymphocytes remained unchanged. Similarly, hyposensitization was followed by a reduction of total serum IgE levels, but Dpt-specific IgG4 and IgE remained unchanged.

authors

Gagro A,Rabatić S,Tresćec A,Dekaris D,Medar-Lasić M

doi

10.1159/000236520

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

203-8

issue

2

eissn

1018-2438

issn

1423-0097

journal_volume

101

pub_type

杂志文章
  • Food allergy in Ghanaian schoolchildren: data on sensitization and reported food allergy.

    abstract:BACKGROUND:Epidemiological data on food allergy are scarce in African countries. We studied the prevalence of food sensitization in Ghanaian schoolchildren. METHODS:Children (5-16 years; n = 1,714) from 9 Ghanaian schools were given parental consent to participate in the study. Adverse reactions and food consumption w...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000318704

    authors: Obeng BB,Amoah AS,Larbi IA,Yazdanbakhsh M,van Ree R,Boakye DA,Hartgers FC

    更新日期:2011-01-01 00:00:00

  • IgE lambda monoclonal gammopathy and amyloidosis.

    abstract::The prevalence of IgE myeloma is 0.01% in all plasmocytomas. Although signs and symptoms are similar, it is generally accepted that IgE myeloma has a more malignant clinical course than other forms of plasmocytoma with monoclonal gammopathy. The disease has widely variable presentation. Most of the reported cases were...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000237490

    authors: Jako JM,Gesztesi T,Kaszas I

    更新日期:1997-04-01 00:00:00

  • Clinical studies in oral allergen-specific immunotherapy: differences among allergens.

    abstract::Oral immunotherapy (OIT) is a significant focus of treatment of food allergy. OIT appears to be effective in inducing desensitization, however, patients receiving OIT frequently developmild/moderate symptoms during the therapy. It has not been clearly established whether the clinical tolerance induced by OIT resembles...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000361025

    authors: Sato S,Yanagida N,Ogura K,Imai T,Utsunomiya T,Iikura K,Goto M,Asaumi T,Okada Y,Koike Y,Syukuya A,Ebisawa M

    更新日期:2014-01-01 00:00:00

  • Bed bug saliva causes release of monocytic inflammatory mediators: plausible cause of cutaneous bite reactions.

    abstract::Bed bugs may cause mild to severe cutaneous reactions. We studied the ability of bed bug salivary extract (SGE) to induce inflammatory reactions responsible for cutaneous manifestations and found that SGE stimulated the production of several potent chemokines and cytokines from macrophages. Chemokines induced by SGE i...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000345134

    authors: Goddard J,Hasenkampf N,Edwards KT,de Shazo R,Embers ME

    更新日期:2013-01-01 00:00:00

  • Efficacy of intravenous gammaglobulin for immunoglobulin G subclass and/or antibody deficiency in adults.

    abstract:BACKGROUND:The clinical significance and efficacy of treating patients who have immunoglobulin (Ig) G subclass deficiency and/or antibody deficiency with Ig-replacement therapy has been debated. There are no clear guidelines to recommend intravenous gammaglobulin (IgIV) in these patients as there are few published stud...

    journal_title:International archives of allergy and immunology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000199723

    authors: Abdou NI,Greenwell CA,Mehta R,Narra M,Hester JD,Halsey JF

    更新日期:2009-01-01 00:00:00

  • Activation of human mast cells through stem cell factor receptor (KIT) is associated with expression of bcl-2.

    abstract:BACKGROUND:Mast cells (MCs) are multifunctional effector cells of the immune system. These cells originate from pluripotent hemopoietic progenitors. In contrast to basophils and other leukocytes, MCs exhibit a remarkably long life span (years) in vivo. Although a role for stem cell factor (SCF) and SCF receptor (KIT) i...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000066773

    authors: Baghestanian M,Jordan JH,Kiener HP,Bevec D,Agis H,Fritsch G,Müller MR,Bankl HC,Schernthaner GH,Lechner K,Valent P

    更新日期:2002-11-01 00:00:00

  • Inhibition of enteropathogenic Escherichia coli (EPEC) adhesion to HeLa cells by human colostrum: detection of specific sIgA related to EPEC outer-membrane proteins.

    abstract::Human colostrum and a high molecular weight colostrum fraction (HMWF; > 14,000 D) prevented the adhesion of localized adherent (LA+) O111:H-enteropathogenic Escherichia coli (EPEC) to HeLa cells. This effect was abolished after absorption with an O111:H-LA + EPEC strain, but absorption with a LA- strain of same seroty...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236645

    authors: Camara LM,Carbonare SB,Silva ML,Carneiro-Sampaio MM

    更新日期:1994-01-01 00:00:00

  • Chronic Spontaneous Urticaria: A Survey of 852 Cases of Childhood-Onset Systemic Lupus Erythematosus.

    abstract:BACKGROUND:Data regarding the prevalence of chronic spontaneous urticaria (CSU) in childhood-onset systemic lupus erythematosus (cSLE) patients and possible associated factors are limited to a few case reports. The objectives of this study were to assess CSU in a large cSLE population, in order to evaluate the demograp...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000438723

    authors: Ferriani MP,Silva MF,Pereira RM,Terreri MT,Saad Magalhães C,Bonfá E,Pastorino AC,Carolina Dos Santos M,Appenzeller S,Ferriani VP,Len CA,Sallum AM,Libório J,Monteiro de Castro TC,Silva CA

    更新日期:2015-01-01 00:00:00

  • Interest of ImmunoCAP system to recombinant omega-5 gliadin for the diagnosis of exercise-induced wheat allergy.

    abstract:BACKGROUND:omega-5 gliadin is a major allergen in exercise-induced wheat allergy (EIWA), but it is also implicated in immediate-type reactions to wheat. An ImmunoCAP assay to measure omega-5 gliadin-specific IgE has become available. This study aimed to evaluate this new biological test in wheat allergy diagnosis and t...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000176309

    authors: Jacquenet S,Morisset M,Battais F,Denery-Papini S,Croizier A,Baudouin E,Bihain B,Moneret-Vautrin DA

    更新日期:2009-01-01 00:00:00

  • Is the effect of prenatal paracetamol exposure on wheezing in preschool children modified by asthma in the mother?

    abstract:BACKGROUND:There seems to be an association between paracetamol consumption during late pregnancy and the prevalence of wheezing in infancy and childhood. The aim of the present study is to determine whether the aforementioned association is modified by the presence of asthma in the mother. METHODS:A total of 1,741 ch...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000176304

    authors: Garcia-Marcos L,Sanchez-Solis M,Perez-Fernandez V,Pastor-Vivero MD,Mondejar-Lopez P,Valverde-Molina J

    更新日期:2009-01-01 00:00:00

  • Recent advances in eosinophil biology.

    abstract::Eosinophils are pleiotropic multi-functional leukocytes involved in initiation and propagation of diverse inflammatory responses. Recent studies examining eosinophil biology have focused on delineating the molecular basis of FIP1L1/PDGRFalpha-fusion gene induced HES, the molecular steps involved in eosinophil recruitm...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000101398

    authors: Hogan SP

    更新日期:2007-01-01 00:00:00

  • Soluble CD23 levels are inversely associated with atopy and parasite-specific IgE levels but not with polyclonal IgE levels in people exposed to helminth infection.

    abstract:BACKGROUND:Protective acquired immunity against helminths and allergic sensitisation are both characterised by high IgE antibody levels. Levels of IgE antibodies are naturally tightly regulated by several mechanisms including binding of the CD23 receptor. Following observations that helminth infections and allergic sen...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000346545

    authors: Rujeni N,Nausch N,Midzi N,Gwisai R,Mduluza T,Taylor DW,Mutapi F

    更新日期:2013-01-01 00:00:00

  • The use of complementary and alternative medicine by pediatric food-allergic patients in Japan.

    abstract:BACKGROUND:In developed countries, increasing food allergy prevalence and concern regarding food allergies have been reported. Although the use of complementary and alternative medicine (CAM) for the treatment of allergic diseases has increased in some Western countries, the actual proportion and patterns of CAM use fo...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000338936

    authors: Nakano T,Shimojo N,Okamoto Y,Ebisawa M,Kurihara K,Hoshioka A,Yamaguchi K,Ito K,Fujisawa T,Kameda M,Suehiro Y,Ogura H,Shibata R,Suzuki S,Takahashi Y,Ikeda M,Kohno Y

    更新日期:2012-01-01 00:00:00

  • Kinetic analysis of pepsin digestion of chicken egg white ovomucoid and allergenic potential of pepsin fragments.

    abstract:BACKGROUND:The allergenic potential of chicken egg white ovomucoid (OVM) is thought to depend on its stability to heat treatment and digestion. Pepsin-digested fragments have been speculated to continue to exert an allergenic potential. OVM was digested in simulated gastric fluid (SGF) to examine the reactivity of the ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000082581

    authors: Takagi K,Teshima R,Okunuki H,Itoh S,Kawasaki N,Kawanishi T,Hayakawa T,Kohno Y,Urisu A,Sawada J

    更新日期:2005-01-01 00:00:00

  • Anti-Thy-1 antibody provokes reverse passive cutaneous anaphylaxis-like reactions.

    abstract::Antibodies to rat Thy-1, and also to murine Thy-1, could provoke reverse passive cutaneous anaphylaxis-like (RPCA-like) reactions. The threshold amount of purified anti-Thy-1 antibodies for RPCA-like reactions was 12.5 microg/ml. No RPCA-like reactions were obtained with IgG1 F(ab')2 anti-Thy-1. Cross-linking the muri...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237662

    authors: Yamaji C,Hirano T,Miyajima H,Hashimoto H,Okumura K,Ovary Z

    更新日期:1997-10-01 00:00:00

  • The synthetic PPARgamma agonist troglitazone inhibits eotaxin-enhanced eosinophil adhesion to ICAM-1-coated plates.

    abstract::Accumulation and activation of eosinophils in tissue are critical events in the allergic inflammatory response and adhesion molecules play important roles in this process. We previously demonstrated that human eosinophils expressed a nuclear receptor, peroxisome proliferator-activated receptor gamma (PPARgamma), and t...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000126054

    authors: Hirasawa H,Chiba T,Ueki S,Kamada Y,Ito W,Takeda M,Fujita M,Kato H,Kayaba H,Chihara J

    更新日期:2008-01-01 00:00:00

  • Immediate-Type Hypersensitivity Cross-Reactions to Proton Pump Inhibitors: A Descriptive Study of Data from the French National Pharmacovigilance Database.

    abstract:BACKGROUND:Proton pump inhibitors (PPIs) can trigger immediate-type hypersensitivity reactions (HSRs). Three main patterns of cross-reactivity have been identified: reactions to a single PPI, selective cross-reactions, and cross-reactions with all PPIs. Several hypotheses have been advanced, but no consensus has been r...

    journal_title:International archives of allergy and immunology

    pub_type:

    doi:10.1159/000493581

    authors: Tourillon C,Mahe J,Baron A,Lambert A,Yélehé-Okouma M,Veyrac G,Jolliet P

    更新日期:2019-01-01 00:00:00

  • Selective regulation of T cell IL-5 synthesis by OM-01, JTE-711 and p38 MAP kinase inhibitor: independent control of Th2 cytokines, IL-4 and IL-5.

    abstract:BACKGROUND:Helper T cells are involved in chronic eosinophilic inflammation. Control of cytokine production seems to be an effective management. METHODS:The effect of nonactin, SB203580, a p38 MAP kinase inhibitor, and JTE-711 on the cytokine production of allergen-specific T cell clones was determined. The effect of ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000053702

    authors: Mori A,Okudaira H,Kobayashi N,Akiyama K

    更新日期:2001-01-01 00:00:00

  • Change in referral diagnoses and diagnostic delay in hypogammaglobulinaemic patients during 28 years in a single referral centre.

    abstract:BACKGROUND:The classical clinical manifestation of untreated immunoglobulin deficiency comprises predominantly recurrent and complicated respiratory tract infections. Before the 1980s, little was known about the clinical manifestation of immunodeficiency in the general medical population, and also the availability of s...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000301584

    authors: Litzman J,Stikarovska D,Pikulova Z,Pavlik T,Pesak S,Thon V,Kuklinek P,Lokaj J

    更新日期:2010-01-01 00:00:00

  • Identification of allergens in the box jellyfish Chironex yamaguchii that cause sting dermatitis.

    abstract:BACKGROUND:Jellyfish stings cause painful, papular-urticarial eruptions due to the immediate allergic, acute toxic and persistent inflammatory responses. In spite of many marine accidents and their economic impact, modes of first-aid treatment remain conventional and specific allergen and medical treatment are not yet ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000434721

    authors: Horiike T,Nagai H,Kitani S

    更新日期:2015-01-01 00:00:00

  • Prolonged antigen exposure ameliorates airway inflammation but not remodeling in a mouse model of bronchial asthma.

    abstract:BACKGROUND:In naive rodents, repeated exposure to aerosolized antigen induces suppression of the Th2 response to the antigen. We hypothesized that more prolonged exposure of established asthma model to antigen aerosols may downregulate asthmatic phenotype. METHODS:After establishing an ovalbumin (OVA)-induced asthma m...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000049503

    authors: Sakai K,Yokoyama A,Kohno N,Hamada H,Hiwada K

    更新日期:2001-10-01 00:00:00

  • Influence of glycosphingolipids on the release of histamine and sulfidopeptide leukotrienes from human basophils.

    abstract::Glycosphingolipids (GSLs) are physiological membrane components known to modulate various cellular functions. In order to study their influence on basophil mediator release washed leukocytes obtained from allergic asthmatics and nonatopics were preincubated with varying concentrations of different GSLs. Cells were was...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236636

    authors: Lichey J,Zuberbier T,Luck W,Lau S,Wahn U

    更新日期:1994-01-01 00:00:00

  • cDNA cloning, biological and immunological characterization of the alkaline serine protease major allergen from Penicillium chrysogenum.

    abstract:BACKGROUND:Penicillium chrysogenum (Penicillium notatum) is a prevalent airborne Penicillium species. A 34-kD major IgE-reacting component from P. chrysogenum has been identified as an alkaline serine protease (Pen ch 13, also known as Pen n 13 before) by immunoblot and N-terminal amino acid sequence analysis. METHODS...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000048165

    authors: Chou H,Lai HY,Tam MF,Chou MY,Wang SR,Han SH,Shen HD

    更新日期:2002-01-01 00:00:00

  • Oral Immunotherapy in Japanese Children with Anaphylactic Peanut Allergy.

    abstract:BACKGROUND:Reports on oral immunotherapy (OIT) for anaphylactic food allergy are lacking. We investigated the efficacy and safety of peanut OIT for anaphylactic patients. METHODS:We enrolled 22 peanut anaphylactic patients who underwent OIT between 2011 and 2013, all of whom demonstrated anaphylaxis during a baseline ...

    journal_title:International archives of allergy and immunology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000486310

    authors: Nagakura KI,Sato S,Yanagida N,Nishino M,Asaumi T,Ogura K,Ebisawa M

    更新日期:2018-01-01 00:00:00

  • Correlates of sensitization to Blomia tropicalis and Dermatophagoides pteronyssinus in asthma in Barbados.

    abstract:BACKGROUND:Sensitivity to the mite Blomia tropicalis is related to asthma in tropical climates, but correlates of sensitivity to B. tropicalis and its relationship to Dermatophagoides pteronyssinus sensitivity have not been widely examined in families with asthma. The main objective of this study was to determine preva...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000070927

    authors: Manolio TA,Barnes KC,Naidu RP,Levett PN,Beaty TH,Wilson AF

    更新日期:2003-06-01 00:00:00

  • Constipation and cow's milk allergy: a review of the literature.

    abstract::The causal association between cow's milk allergy (CMA) and constipation is not well established. Some guidelines describe constipation as a possible symptom of CMA, while others do not mention it. We conducted a literature review and found 10 prospective clinical trials. In all of them, an oral food challenge was per...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000362365

    authors: Miceli Sopo S,Arena R,Greco M,Bergamini M,Monaco S

    更新日期:2014-01-01 00:00:00

  • The Diagnosis of Ceftriaxone Hypersensitivity in a Paediatric Population.

    abstract:INTRODUCTION:Penicillins and cephalosporins are the most frequent causes of hypersensitivity reactions (HRs) to drugs in children. Among cephalosporins for intravenous use, ceftriaxone (CT) is the most frequently prescribed in Italy. The aims of this study were to evaluate the diagnostic methods for CT hypersensitivity...

    journal_title:International archives of allergy and immunology

    pub_type: 新闻

    doi:10.1159/000495302

    authors: Mori F,Liccioli G,Piccorossi A,Sarti L,Barni S,Giovannini M,Azzari C,Manfredi M,Novembre E

    更新日期:2019-01-01 00:00:00

  • Smoking attenuates increase in exhaled nitric oxide in atopic but not in nonatopic young adults with asthma.

    abstract:BACKGROUND:Measurement of fractional exhaled nitric oxide (FENO) is useful in assessing eosinophilic airway inflammation. Smoking may modify airway inflammation and reduce FENO levels, compromising the diagnostic value of FENO in smokers. How smoking influences FENO in atopic versus nonatopic asthmatics is unknown. The...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000283029

    authors: Rouhos A,Ekroos H,Karjalainen J,Sarna S,Haahtela T,Sovijärvi AR

    更新日期:2010-01-01 00:00:00

  • Dissociation of allergenic and immunogenic functions in contact sensitivity to para-phenylenediamine.

    abstract::Contact sensitivity to para-phenylenediamine (PPD) is a frequent delayed-type hypersensitivity resulting in contact dermatitis. The aim of the present study, conducted in 16 patients allergic to PPD (as assessed by a positive patch test), was to get better insight into the mechanism of T-cell activation in PPD contact...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236573

    authors: Krasteva M,Nicolas JF,Chabeau G,Garrigue JL,Bour H,Thivolet J,Schmitt D

    更新日期:1993-01-01 00:00:00

  • Early DNA synthesis and cytokine expression in the nickel activation of peripheral blood mononuclear cells in nickel-allergic subjects.

    abstract:BACKGROUND AND OBJECTIVE:Nickel sulphate stimulates the proliferation of lymphocytes in nickel-allergic subjects. However, nickel-induced stimulation of lymphocytes from control persons without clinical symptoms of nickel allergy has also been reported. The aim of the present study was to correlate T cell activity, mea...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000024437

    authors: Falsafi-Amin H,Lundeberg L,Bakhiet M,Nordlind K

    更新日期:2000-10-01 00:00:00