Protein tyrosine phosphorylation: A possible common signaling pathway in human Th1 and Th2 cell clones.

Abstract:

BACKGROUND:It has been reported that protein tyrosine phosphorylation is essential for cytokine production in mouse Th1 cells but not in Th2 cells. However, little is known about the difference of signal transduction between human antigen-specific Th1 and Th2 cell clones. METHODS:Purified protein derivative-specific Th1 and Dermatophagoides farinae-specific Th2 cell clones were established. T cell clones were stimulated with anti-CD3 Abs and further treated with goat antimouse immunoglobulin Abs for cross-linking of TCR/CD3 complex. RESULTS:In contrast to murine Th2 clones, tyrosine phosphorylation including both ZAP-70 and phospholipase-C-Al was necessary for cell activation in both types of human T cell clones. This was further supported by the observation that genistein (protein tyrosine kinase inhibitor) inhibits IFN-A production for Th1 and IL-4 for Th2 in a dose-dependent manner. CONCLUSION:Protein tyrosine phosphorylation is thus an essential component in transducing the activation signal from TCR-CD3 complex both in human Th1 and Th2 cells.

authors

Minoguchi K,Yamashita N,Oda N,Takeno M,Kaneoka H,Sakane T

doi

10.1159/000024028

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

30-6

issue

1

eissn

1018-2438

issn

1423-0097

pii

24028

journal_volume

118

pub_type

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