Abstract:
BACKGROUND:Farming has been widely reported to be associated with decreased risk of developing atopic disorders, but underlying immunomodulatory mechanisms are still not fully defined. We delineated T-cell functions after induction of mucosal tolerance in the context of intranasally delivered organic dust compounds, lipopolysaccharides (LPS). METHODS:BALB/c mice were pretreated intranasally with ovalbumin (OVA) with or without LPS (Escherichia coli) three times (days -21, -14, -7) prior to systemic OVA sensitization (days 1 and 14) and airway allergen challenges (days 28-30). CD4+ spleen T cells from pretreated and sensitized donors were characterized for cytokine function, and transferred into naive recipients prior to subsequent OVA sensitization and challenges. RESULTS:Intranasal OVA pretreatment suppressed Th2-mediated immune and inflammatory responses and enhanced frequency of regulatory T cells in OVA-sensitized and -challenged mice. Addition of LPS to OVA, but not LPS alone, inhibited development of allergen-induced sensitization and eosinophilic airway infiltration, and markedly enhanced allergen-specific IgG1 serum levels and frequencies of IL-10- and IFN-gamma-producing CD4+ T cells. Transfer of CD4+ spleen T cells from OVA-pretreated animals protected naive recipients against subsequent allergen sensitization and airway disease, whereas transfer from LPS/OVA-pretreated animals only protected against allergen sensitization. CONCLUSION:Microbial LPS modulated mucosal tolerance by inducing allergen-specific IgG1 production and distinct effector CD4+ T cells with a mixed regulatory/Th1 phenotype. Organic dust components such as LPS might therefore be important immune modulators in naturally occurring or preventive allergen-specific tolerance induction.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Gerhold K,Avagyan A,Reichert E,Blumchen K,Wahn U,Hamelmann Edoi
10.1159/000128583subject
Has Abstractpub_date
2008-01-01 00:00:00pages
25-34issue
1eissn
1018-2438issn
1423-0097pii
000128583journal_volume
147pub_type
杂志文章abstract:BACKGROUND:Jellyfish stings cause painful, papular-urticarial eruptions due to the immediate allergic, acute toxic and persistent inflammatory responses. In spite of many marine accidents and their economic impact, modes of first-aid treatment remain conventional and specific allergen and medical treatment are not yet ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000434721
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Th17 is a subset of T-helper lymphocytes that produce proinflammatory cytokines, mainly IL-17. Serum IL-17 is increased in allergic patients and relates to clinical severity. Recently, it has been reported that CD161 is a highly upregulated gene in Th17 clones and all IL-17-producing cells are contained in C...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000330903
更新日期:2012-01-01 00:00:00
abstract::The present study has extended histochemical and functional investigations into rat mast cell heterogeneity using isolated mast cells from four connective tissue locations; the peritoneum, mesentery, lung and skin. On histological examination, mast cells from these locations displayed a range of phenotypes following f...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236161
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Atopic dermatitis (AD) and food allergy (FA) are common childhood diseases, which may either be interrelated or be the result of skin barrier disruption and gut mucosal dysbiosis. Although some evidence suggests the efficacy of emollients and synbiotics, there is no conclusive evidence on the use of these in...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000501636
更新日期:2019-01-01 00:00:00
abstract::IgE responsiveness to Dermatophagoides farinae body extract was compared by immunoblotting among four groups of mite-sensitive asthmatic children: group I aged 0-3, group II aged 4-7, group III aged 8-11 and group IV aged 12-15. In the group I subjects, the 15-kD component was bound by 88% of sera and strongly by 56% ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236605
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Nitrosative and acid stress play an important role in the pathogenesis of asthma. The aim of this study was to evaluate whether, in asthmatics, a link exists between the concentrations of nitrite/nitrate, ammonia and pH values in exhaled breath condensate (EBC) and asthma severity, lung function, exhaled nit...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000335674
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Serum-derived hyaluronan (HA)-associated proteins (SHAPs), the heavy chains of inter-α-trypsin inhibitor, covalently bind to HA to form the SHAP-HA complex. The SHAP-HA complex is involved in the pathophysiology of inflammatory diseases, including rheumatoid arthritis. We investigated whether this complex is...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000314362
更新日期:2010-01-01 00:00:00
abstract::Because of the importance of cytokines in the regulation of allergic inflammation, we investigated the effects of SCF, IL-3, IL-5 and GM-CSF on immunological histamine release from sensitized human lung fragments as well as human leukocytes. SCF (0.2-20 ng/ml) caused a concentration-related enhancement of anti-IgE (1/...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236798
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Recently, the relationship between antigen contact via skin (skin sensitization) and the development of food allergies has gained increasing attention. However, few studies have examined the effects of skin sensitization on healthy skin. OBJECTIVE:To examine the effect of sensitization in healthy skin on Ig...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000511239
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND:T cells are key regulators of immunologic disease parameters. However, their contribution to the process of tissue remodeling is ill defined. In the present study, we investigated gene expression of allergy-characteristic, IL-4-rich T cell cDNAs to monitor expression of genes that might participate in the pa...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000072139
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVE:To evaluate whether activated partial thromboplastin time (APTT) could be used in the laboratory diagnosis of hereditary or acquired angioedema (HAE or AAE) with and without C1 inhibitor (C1-INH) deficiency. METHODS:In a prospective investigation, APTT and other coagulation parameters were determined in 149 ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000447695
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND AND AIM:Although still controversial, drug provocation tests (DPTs) are considered by many as the gold standard for diagnosis of drug hypersensitivity. No studies have addressed the opinion of patients submitted to DPT. We aimed to determine patient satisfaction with diagnostic DPT and their perception of it...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,多中心研究
doi:10.1159/000323898
更新日期:2011-01-01 00:00:00
abstract::Eosinophils used to be thought of as regulators of allergic inflammation, but there is now evidence to the contrary; eosinophils have been found to be the major effector cells responsible for the late asthmatic response (LAR), airway hyperresponsiveness (AHR) and, at least in part, airway remodeling by releasing leuko...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000053829
更新日期:2001-08-01 00:00:00
abstract::The last decade has seen the rapid development of research investigating the mechanisms of apoptosis in a variety of experimental systems. Among the multitude of changes observed in apoptotic cells, chromatin cleavage is considered a biochemical hallmark of apoptosis. Chromatin fragmentation is an enzymatic process wh...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000236778
更新日期:1994-12-01 00:00:00
abstract::Hypersensitivity pneumonitis remains an important industrial disease in mushroom workers. It has a significant morbidity, and early diagnosis and removal from exposure to the antigen are critically important in its management. Recently, several new allergens have been described, particularly those from mushroom specie...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000083298
更新日期:2005-01-01 00:00:00
abstract::Thioredoxin (TRX) is a redox-active protein that regulates reactive oxidative metabolism and plays a crucial role in the antioxidant system in regulating the reduction/oxidation balance by scavenging reactive oxygen species, which is implicated in the mechanism of asthma. As for the mechanisms by which TRX exerts its ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000327501
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Numerous strategies have been proposed for the treatment of peanut allergies, but despite the steady advancement in our understanding of atopic immune responses and the increasing number of deaths each year from peanut anaphylaxis, there is still no safe, effective, specific therapy for the peanut-sensitive ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000053672
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Allergic conjunctivitis is characterized by itchy, watery and swollen eyes which occur in response to exposure to seasonal or environmental allergens. The early phase reaction of allergic conjunctivitis is primarily mediated by mast cell degranulation while the late phase reaction is driven by Th2 cells and ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000328769
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND/AIMS:The antioxidant properties of vitamin C and E are considered to be important for their anti-inflammatory activity. Recently, antioxidant resveratrol was found to suppress neopterin production and tryptophan degradation in mitogen-treated human peripheral blood mononuclear cells. METHODS:In this study, ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000096438
更新日期:2007-01-01 00:00:00
abstract::CD95 (APO-1) is a member of the TNF/nerve growth factor receptor superfamily, which is expressed on the surface of different types of cells. Cross-linking of CD95 leads to the induction of apoptosis. This may be of importance in many physiological systems, but seems to play a special role for the maintenance of immuno...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237293
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Evidence regarding sublingual immunotherapy (SLIT) efficacy and its good safety profile has been demonstrated with pollen and house dust mite (HDM) allergens in the treatment of airway allergies. In addition, the use of grass pollen presents a SLIT disease-modifying treatment for respiratory allergies. OBJE...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000446155
更新日期:2016-01-01 00:00:00
abstract::Glycosphingolipids (GSLs) are physiological membrane components known to modulate various cellular functions. In order to study their influence on basophil mediator release washed leukocytes obtained from allergic asthmatics and nonatopics were preincubated with varying concentrations of different GSLs. Cells were was...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236636
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Several studies have suggested that sublingual immunotherapy (SLIT) involves a dose-response relationship and inadequate dosage might not achieve a favorable clinical effect. OBJECTIVE:The aim of this prospective study was to investigate the efficacy and safety of increasing SLIT dosage at 6 months in patie...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000505746
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Nonpathogenic Escherichia coli strain Nissle 1917 (EcN) has immunomodulatory properties and can act on different cells which are important for the allergic immune response. Herein, we investigated the efficacy and tolerability of EcN in subjects with grass pollen-dependent allergic rhinoconjunctivitis. METH...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000356328
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Recently, the high affinity receptor for IgE (Fc epsilonRI), which plays a major role in allergies, has been identified on a number of different antigen-presenting cell types, including human monocytes from atopic and nonatopic donors. In this report human monocytic cell lines were used to test for the expre...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237621
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:Cow's milk (CM) allergy is the second most common food allergy developed during infancy in Japan. To identify predictors of persistent CM allergy, we investigated the tolerance acquisition rate based on an oral food challenge in children under 6 years of age, diagnosed with immediate-type CM allergy. METHOD...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000486311
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:The coexistence of asthma and allergic rhinitis (AR) and its distinct association with obesity have been reported. However, few studies have differentiated the two types of AR, i.e., perennial (PAR) and seasonal AR (SAR), with regard to their associations with asthma and obesity. The aim of this study was to...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000488329
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:While searching for antigliadin and anticasein antibodies in sera from coeliac patients we investigated more than 20 persons suffering from this enteropathy. In some of sera, we registered antibodies against gliadin and in parallel the appearance of anticasein antibodies. A high percentage of glutamic acid h...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024003
更新日期:1998-10-01 00:00:00
abstract:BACKGROUND:Cross-sectional epidemiological studies have demonstrated that farm milk from traditional farm settings possesses allergoprotective properties. Up to now, it has not been clarified which milk ingredient is responsible for protection against allergic diseases. As farm milk is rich in conjugated linoleic acids...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000358523
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Sweating can worsen atopic dermatitis (AD). The purpose of this work was to study the associations between reactivity to autologous sweat and the clinical severity of AD as well as investigate the possible wheal-inducing factors of sweat. METHODS:Intracutaneous skin tests with autologous sweat were performe...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000447638
更新日期:2016-01-01 00:00:00