Abstract:
:IgE responsiveness to Dermatophagoides farinae body extract was compared by immunoblotting among four groups of mite-sensitive asthmatic children: group I aged 0-3, group II aged 4-7, group III aged 8-11 and group IV aged 12-15. In the group I subjects, the 15-kD component was bound by 88% of sera and strongly by 56% of sera. The 25-kD component was bound by 40% of sera, but most of the binding reactions were faint. IgE binding to other components was generally low. In the group II subjects, 15- and 25-kD components were bound by 96% and 56% of sera, 30-kD and 110-kD components by 76% and 60% of sera, respectively. In addition, 18-, 40-, 59- and 80-kD components were bound by more than 30% of sera. In group III and IV subjects, the frequencies of IgE binding to these components were not significantly changed as compared with those of group II subjects. The rabbit antisera against Der f I and Der f II specifically reacted with 25- and 15-kD components, respectively. These results suggest that the 15-kD Der f II allergen is the most important antigenic constituent associated with the early IgE response to house dust-mites in mite-reactive asthmatic children.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Shibasaki M,Isoyama S,Takita Hdoi
10.1159/000236605subject
Has Abstractpub_date
1994-01-01 00:00:00pages
53-8issue
1eissn
1018-2438issn
1423-0097journal_volume
103pub_type
杂志文章abstract:BACKGROUND:Jellyfish stings cause painful, papular-urticarial eruptions due to the immediate allergic, acute toxic and persistent inflammatory responses. In spite of many marine accidents and their economic impact, modes of first-aid treatment remain conventional and specific allergen and medical treatment are not yet ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000434721
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Chronic granulomatous disease (CGD) is a rare genetic disorder characterized by failure of phagocytic leukocytes to destroy certain microbes. We present a study on CGD patients enrolled at a single medical center concerning the infectious and noninfectious complications and genetic properties of the disease....
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000507366
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Activated eosinophils are thought to play an important role in allergic inflammation. Prior reports suggest that eosinophils have receptors recognizing IgA, IgG and IgE; however, little is known regarding the direct effects of antigens and antigen-specific immunoglobulins on the functions of eosinophils. ME...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000320226
更新日期:2011-01-01 00:00:00
abstract::The aim of this study was to investigate whether repeated exposure to subclinical doses of cat allergens, not inducing asthma symptoms, could affect eosinophil cationic protein (ECP) levels in bronchoalveolar lavage (BAL) or in peripheral blood, without the appearance of clinical symptoms. Twelve patients with mild as...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024234
更新日期:1999-10-01 00:00:00
abstract::In studies designed to optimize the production and detection of anti-ovalbumin (anti-Oa) IgE in Ham/ICR mice, a range of doses of both Oa and pertussis toxin as the IgE adjuvant was explored. As determined by 48-hour passive cutaneous anaphylaxis (PCA) tests, the highest titre of anti-Oa IgE was obtained in a three-in...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236770
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:Cow's milk (CM) allergy is the second most common food allergy developed during infancy in Japan. To identify predictors of persistent CM allergy, we investigated the tolerance acquisition rate based on an oral food challenge in children under 6 years of age, diagnosed with immediate-type CM allergy. METHOD...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000486311
更新日期:2018-01-01 00:00:00
abstract::Natural rubber latex proteins are a well-recognized cause of type-I allergic reactions that increasingly afflict health-care workers, housekeeping personnel, and other persons using latex gloves or latex products. More than a dozen individual latex allergens have been identified of which eight have received an interna...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000023930
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND:Several studies have suggested that sublingual immunotherapy (SLIT) involves a dose-response relationship and inadequate dosage might not achieve a favorable clinical effect. OBJECTIVE:The aim of this prospective study was to investigate the efficacy and safety of increasing SLIT dosage at 6 months in patie...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000505746
更新日期:2020-01-01 00:00:00
abstract::The low responsiveness of contact sensitivity (CS) in sensitized and challenged mice was induced by using hapten-amino acid derivatives. Subcutaneous injection of trinitrophenyl (TNP)-lysine or oxazolone-glycine inhibited ear swelling responses in mice that received rechallenge. The inhibitory effect was long-lasting ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236556
更新日期:1993-01-01 00:00:00
abstract::The objective of this study was to investigate the role of progesterone in modulating electrophysiological responses to antigenic challenge that are reflective of immune functions in uterine and jejunal mucosae. In the rat-Trichinella spiralis, host-parasite system, an enteric infection with a microscopic nematode sen...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237130
更新日期:1995-10-01 00:00:00
abstract::To assess the role of infection in anti-DNA antibody production, the DNA-binding activity of sera from patients with Escherichia coli bacteremia was analyzed. Among 8 patients with bacteremia documented by blood culture, 5 demonstrated increased levels of antibodies to single-stranded DNA from E. coli as measured by e...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236204
更新日期:1992-01-01 00:00:00
abstract::CD40 is a surface antigen expressed on B cells. The CD40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is critical for proliferation and isotype switching in the context of a response to a T-cell-dependent antigen. Patients with X-linked hyper-IgM syndrome (HIGMX-1) in their CD40...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000236923
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:Staphylococcus aureus-producing superantigens (SAgs), such as staphylococcal enterotoxin B (SEB) or toxic shock syndrome toxin-1 (TSST-1), are frequently observed in atopic dermatitis (AD). However, little has been done to establish the association of immune responses to SAgs and the therapeutic response to ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000095298
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Sensitivity to the mite Blomia tropicalis is related to asthma in tropical climates, but correlates of sensitivity to B. tropicalis and its relationship to Dermatophagoides pteronyssinus sensitivity have not been widely examined in families with asthma. The main objective of this study was to determine preva...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000070927
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND:A negative association has been observed between infections and allergy in several studies. The aim of the present study was to examine whether tuberculosis and leprosy patients have more or fewer allergies than healthy individuals. METHOD:Sera from tuberculosis patients, leprosy patients and healthy contro...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000088722
更新日期:2005-11-01 00:00:00
abstract::Antiphospholipid antibody syndrome (APS) is characterized by autoantibodies against negatively charged phospholipids in the serum, and clinically by multiple thromboses, thrombocytopenia, and recurrent fetal loss. The mechanism(s) by which the antibodies cause the clinical picture are not clear. We review the possible...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000236883
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:The aetiological factors underlying the worldwide increase in the prevalence of asthma and the international patterns of the prevalence of asthma are not well understood. This has led to consideration of factors such as fetomaternal health which may programme the initial susceptibility to allergic sensitisat...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024149
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Recent studies have demonstrated that eosinophils from allergic patients express low levels of FcepsilonRI on their surface, but the regulatory mechanisms of eosinophil surface FcepsilonRI expression are not fully understood. We investigated whether IL-4 and IgE, which are reported to regulate surface Fcepsi...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000053782
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Hypersensitivity to contrast media (CMs) may be common and serious. AIM:To evaluate the prevalence of CM hypersensitivity, risk factors associated with it and the role of skin testing in its diagnosis. METHODS:A structured questionnaire was administered to patients who underwent computed tomography during ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000320760
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The prevalence of allergic rhinitis (AR) is increasing rapidly in Central China. The skin prick test (SPT) is the standard tool with which to determine the allergen sensitization status in AR patients. Changes in allergen sensitization patterns have been observed within countries and regions due to geographi...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000479429
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Th2 cell infiltration is a characteristic feature of allergic chronic sinusitis. However, the mechanisms that cause the predominance of Th2 cells in this disease have yet to be clarified. The airway is often exposed to not only Th2 cytokines but also bacterial products such as lipopolysaccharides (LPS). A CC...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000110085
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Numerous strategies have been proposed for the treatment of peanut allergies, but despite the steady advancement in our understanding of atopic immune responses and the increasing number of deaths each year from peanut anaphylaxis, there is still no safe, effective, specific therapy for the peanut-sensitive ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000053672
更新日期:2001-01-01 00:00:00
abstract::The primary acquired lactase deficiency of the adult is known to cause various disturbances in the gastrointestinal tract while extraintestinal symptoms are unusual. Here we report on a histologically proven chronic eczema requiring corticosteroid treatment for several months. It was obviously induced by a concomitant...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237632
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:Recently, the relationship between antigen contact via skin (skin sensitization) and the development of food allergies has gained increasing attention. However, few studies have examined the effects of skin sensitization on healthy skin. OBJECTIVE:To examine the effect of sensitization in healthy skin on Ig...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000511239
更新日期:2020-11-11 00:00:00
abstract::Homogenates of bovine iris were fractionated by gel filtration chromatography, and the column-eluted proteins were probed with pooled sera obtained from patients with pauciarticular juvenile rheumatoid arthritis (JRA). The serum pool prepared from patients with pauciarticular JRA and a history of anterior uveitis, but...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236431
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Recombinant dog allergens, rCan f 1 and rCan f 2, and their antibodies are good tools for the characterization of dog allergens in order to develop modern therapeutic and preventive methods for dog allergy. METHODS:In this study, cDNA was synthesized from the mRNA of dog salivary glands and cloned into the ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000097498
更新日期:2007-01-01 00:00:00
abstract::Monocytes and lymphocytes from human blood contain 0.043 +/- 0.007 and 0.053 +/- 0.014 pg histamine/cell, respectively, which can be released by a number of stimulants (A 23187, C5a, substance P, specific allergen). The release process takes 60-120 min to reach its end point, in contrast to tissue mast cells which com...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236974
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:Eosinophils develop from bone marrow (BM) progenitors, and interleukin-5 (IL-5) and eotaxin may act in expansion and mobilisation of BM eosinophils in asthma. METHODS:We have examined phenotypic changes as CD34+ cells develop to the eosinophil lineage in vitro, and have evaluated BM eosinophils from asthmat...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024039
更新日期:1999-02-01 00:00:00
abstract::Various methods have been devised to assay eosinophil chemotaxis. In this review, we introduced a rapid and sensitive eosinophil chemotactic assay system based on eosinophil peroxidase (EPO) determination. Eosinophils were semipurified by dextran sedimentation followed by Percoll gradient centrifugation. Eosinophil mi...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000053624
更新日期:2000-05-01 00:00:00
abstract::Endogenous peroxidase has been reported in rat peritoneal mast cells and granules. Mast cell granules have also been shown to avidly bind exogenous eosinophil peroxidase. To examine the possibility that contaminating eosinophil peroxidase contributes to the reported rat mast cell peroxidase activity, mast cells were i...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236655
更新日期:1994-01-01 00:00:00