Abstract:
:Monocytes and lymphocytes from human blood contain 0.043 +/- 0.007 and 0.053 +/- 0.014 pg histamine/cell, respectively, which can be released by a number of stimulants (A 23187, C5a, substance P, specific allergen). The release process takes 60-120 min to reach its end point, in contrast to tissue mast cells which complete the release within 1-3 min. Both, ketotifen (10(-7) - 10(-5) M) and disodium cromoglycate (10(-5) - 10(-3) M) inhibited histamine release dose dependently up to 40-45%, which might be particularly relevant during the later stages of acute allergic or pseudoallergic reactions.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Schmutzler W,Bolsmann K,Zwadlo-Klarwasser Gdoi
10.1159/000236974subject
Has Abstractpub_date
1995-05-01 00:00:00pages
194-6issue
1-3eissn
1018-2438issn
1423-0097journal_volume
107pub_type
杂志文章abstract:BACKGROUND:Helper T cells are involved in chronic eosinophilic inflammation. Control of cytokine production seems to be an effective management. METHODS:The effect of nonactin, SB203580, a p38 MAP kinase inhibitor, and JTE-711 on the cytokine production of allergen-specific T cell clones was determined. The effect of ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000053702
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Microbial components in the environment are potent activators of the immune system with capacity to shift the active immune response towards priming of Th1 and/or Th2 cells. Lipopolysaccharide (LPS), a cell-wall component of Gram-negative bacteria, is extensively present in food products like cow's milk. It ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000081306
更新日期:2004-11-01 00:00:00
abstract::Anti-cyclic citrullinated peptide antibodies (anti-CCP) are a new diagnostic marker for rheumatoid arthritis (RA), which shows a specificity of 97% and a sensitivity of 81% in the second generation assay. About 61% of RA patients express HLA-DRB1*0401. In a cohort of patients with RA we investigated whether the expres...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000086463
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:Mercury causes in mouse strains of the H-2s haplotype an autoimmune syndrome with antibodies to the nucleolar protein fibrillarin and systemic immune complex (IC) deposits. Other strains, like BALB/C (H-2d), develop only IC deposits, and most strains are resistant. However, mercury activates the murine immun...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000023959
更新日期:1998-08-01 00:00:00
abstract::IL-3-dependent, murine mast cell lines derived from embryonic yolk sac precursors display a tumoricidal activity that is blocked by antibodies against tumor necrosis factor-alpha, indicating that this cytokine is the major mediator involved in the cytotoxic activity of the cultured mast cell lines. Further, cholera to...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236179
更新日期:1992-01-01 00:00:00
abstract::Aerosolized monoclonal antibodies (mAbs) specific for T-cell receptors (TCR) were used to manipulate T-cell function in airways of ovalbumin (OVA)-sensitized and -challenged mice with airway hyperresponsiveness (AHR). The inhaled mAbs were found to be effective at low doses, had little or no systemic effect and specif...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000077533
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:The high-affinity IgE receptor, FcepsilonRI, is unresponsive on mast cells and basophils from people in several populations through an unknown mechanism. Similarly, FcepsilonRI-positive basophils from 'nonreleasers' are IgE-unresponsive and are deficient in the tyrosine kinase Syk. OBJECTIVE:To test the hyp...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000087355
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Farming has been widely reported to be associated with decreased risk of developing atopic disorders, but underlying immunomodulatory mechanisms are still not fully defined. We delineated T-cell functions after induction of mucosal tolerance in the context of intranasally delivered organic dust compounds, li...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000128583
更新日期:2008-01-01 00:00:00
abstract::CD40 is a surface antigen expressed on B cells. The CD40 ligand (CD40L) is expressed on activated T cells. Interaction between CD40 and CD40L is critical for proliferation and isotype switching in the context of a response to a T-cell-dependent antigen. Patients with X-linked hyper-IgM syndrome (HIGMX-1) in their CD40...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000236923
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:omega-5 gliadin is a major allergen in exercise-induced wheat allergy (EIWA), but it is also implicated in immediate-type reactions to wheat. An ImmunoCAP assay to measure omega-5 gliadin-specific IgE has become available. This study aimed to evaluate this new biological test in wheat allergy diagnosis and t...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000176309
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:High osmolal ionic radiocontrast media (RCM) cause vascular release of endothelin-1 (ET-1) and activate mast cells. Iomeprol, a nonionic RCM, has recently been reported not to activate cardiac mast cells. This coronary angiography study was performed to extend those findings using another nonionic RCM, iopro...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000070435
更新日期:2003-05-01 00:00:00
abstract::Natural rubber latex proteins are a well-recognized cause of type-I allergic reactions that increasingly afflict health-care workers, housekeeping personnel, and other persons using latex gloves or latex products. More than a dozen individual latex allergens have been identified of which eight have received an interna...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000023930
更新日期:1998-06-01 00:00:00
abstract::The effect of ibudilast on anaphylactic bronchoconstriction was studied in guinea pigs sensitized actively with ovalbumin (OA). Animals were treated with indomethacin, tripelennamine and propranolol prior to the antigen challenge. Anaphylactic bronchoconstriction was prevented by ibudilast (1-4 mg/kg i.v. and 5-20 mg/...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236460
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:To evaluate whether activated partial thromboplastin time (APTT) could be used in the laboratory diagnosis of hereditary or acquired angioedema (HAE or AAE) with and without C1 inhibitor (C1-INH) deficiency. METHODS:In a prospective investigation, APTT and other coagulation parameters were determined in 149 ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000447695
更新日期:2016-01-01 00:00:00
abstract:AIM:We evaluated the effect of the 45-kD protein of Trichinella spiralis (gp45), purified by affinity chromatography, on random migration and chemotaxis, the oxidative metabolism of human neutrophils and on the CD11b upregulation induced by formyl-methionyl-leucyl-phenylalanine (f-MLP). METHODS:Donor neutrophils incub...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024359
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Exposure and sensitization to pet allergens are associated with allergic asthma in children. Conflicting data have emerged regarding the potential benefit of air cleaners with respect to a reduction of indoor pet allergens and bronchial hyperresponsiveness (BHR). METHODS:In a randomized controlled trial 36 ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000151502
更新日期:2009-01-01 00:00:00
abstract::We aimed to evaluate the therapeutic effect of nebulized beclomethasone dipropionate (nBDP) on both allergic asthma and rhinitis. In a randomized, double-blind, placebo-controlled study, 40 children (mean age 10.7 ± 2.1 years) with allergic asthma and rhinitis received either nBDP (daily dose of 800 µg, administered t...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000343137
更新日期:2013-01-01 00:00:00
abstract::Recently, the induction of T cell anergy has been considered as a sophisticated form of immunotherapy. However, the multiplicity of T cell allergen epitopes discourages the practical use of this method. Since orally administered antigen proteins are digested to peptides and absorbed into the circulation, oral administ...
journal_title:International archives of allergy and immunology
pub_type: 临床试验,杂志文章
doi:10.1159/000237002
更新日期:1995-05-01 00:00:00
abstract::The primary acquired lactase deficiency of the adult is known to cause various disturbances in the gastrointestinal tract while extraintestinal symptoms are unusual. Here we report on a histologically proven chronic eczema requiring corticosteroid treatment for several months. It was obviously induced by a concomitant...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237632
更新日期:1997-08-01 00:00:00
abstract::The participation of platelets in the protection against larval Taenia taeniaeformis was studied. CB-17 SCID mice, susceptible to T. taeniaeformis, were protected against a challenge infection with T. taeniaeformis by the passive transfer of platelets from T. taeniaeformis-infected normal CB-17 mice, resistant to T. t...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237253
更新日期:1996-03-01 00:00:00
abstract::Nitric oxide (NO) is a potent biological mediator, and has a regulatory role in a wide variety of cellular and tissue functions. In the upper and lower airways, NO has been suggested to be involved in different functions with regulatory, protective, defensive or damaging effects. It is obvious that NO plays an importa...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000324678
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Despite parallel increases in asthma and obesity prevalence, there is little data on obesity as a risk factor for atopy. The latter is an important phenotype in asthmatic patients. This study investigates the association between asthma traits, atopy and obesity-related markers in Chinese adolescents. METHOD...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000189196
更新日期:2009-01-01 00:00:00
abstract::T cells are central regulators and mediators of allergic sensitisation and disease. The house dust mite allergens are a biochemically diverse group of proteins which are present in extracts and the environment in a wide range of concentrations. Here the importance of ascertaining the contribution of the different alle...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000023824
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:The widespread house ant, Monomorium pharaonis (pharaoh ant, PA), was recently identified as a potential cause of respiratory allergies. However, there are no reports of the distribution of PA allergens in various environments. We developed specific ELISA inhibition assays and measured the distribution and a...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000103999
更新日期:2007-01-01 00:00:00
abstract::It has been well documented that environmental factors such as antigen-presenting cells and related cytokines can affect the development of T-helper cells. The purpose of this study was to investigate the role of different antigen-presenting cells on T-cell development. Ovalbumin (OVA) combined with complete Freud's a...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237394
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:Kawasaki disease (KD) is an acute, systemic vasculitis in children, with an etiology that is not completely understood. It is assumed that the development of KD is mediated by an immunologic response. Several reports from East Asia have found a higher prevalence of atopic diseases among patients with KD, but...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000447639
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:High antibiotic prescribing rates for adults with an asthma exacerbation have been reported in developed countries, but few studies have assessed the variation of antibiotic and adjunctive treatment in the routine care of children. OBJECTIVE:We evaluated the trends in health resource utilization for childre...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000507857
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Measurement of fractional exhaled nitric oxide (FENO) is useful in assessing eosinophilic airway inflammation. Smoking may modify airway inflammation and reduce FENO levels, compromising the diagnostic value of FENO in smokers. How smoking influences FENO in atopic versus nonatopic asthmatics is unknown. The...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000283029
更新日期:2010-01-01 00:00:00
abstract::Amino acid sequencing of the major mite allergen Der fII purified from mite body extract revealed that it is a mixture of at least two variants. Substitutions were found only at positions in which amino acid variations were predicted from the nucleotide sequences of three cloned cDNAs. When cDNAs corresponding to the ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236804
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:Severe refractory atopic dermatitis (AD) is a chronic, debilitating condition that is associated with elevated serum immunoglobulin E (IgE) levels. Thymic stromal lymphopoietin (TSLP), thymus and activation-regulated chemokine (TARC) and OX40 ligand (OX40L) are important immunologic factors involved in the p...
journal_title:International archives of allergy and immunology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000350486
更新日期:2013-01-01 00:00:00