Abstract:
BACKGROUND:Kawasaki disease (KD) is an acute, systemic vasculitis in children, with an etiology that is not completely understood. It is assumed that the development of KD is mediated by an immunologic response. Several reports from East Asia have found a higher prevalence of atopic diseases among patients with KD, but a large-scale study of a non-Asian population regarding this correlation is still lacking. The purpose of this article was to achieve this goal. METHODS:We conducted a cross-sectional, large-scale study to estimate the correlation of KD with allergic diseases. The medical history of 1,187,757 Israeli teenagers (aged 16-20 years during the years 1998-2013) was retrieved. The study population was divided into 3 groups according to a past history of noncomplicated and complicated KD and a control group. The prevalence of allergic diseases among these groups was further investigated. RESULTS:The prevalence of atopic diseases in the 3 study groups was presented (asthma in 11.4, 8.1 and 3.5%, respectively; angioedema/urticaria in 7.1, 0 and 0.46%, respectively; allergic rhinitis in 20, 12.1 and 6.7%, respectively). In noncomplicated KD, a statistically significant link to asthma [odds ratio (OR) 2.4; p = 0.048] and a borderline significant link to allergic rhinitis (OR 1.9; p = 0.06) were found. In KD complicated with cardiac disease, statistically significant links were found for all the allergic conditions, asthma (OR 3.5; p = 0.003), allergic rhinitis (OR 3.5; p < 0.001) and angioedema/urticaria (OR 16.48; p < 0.001). CONCLUSION:KD is associated with allergic diseases. This association increases with the severity of the disease.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Hassidim A,Merdler I,Chorin O,Merdler-Rabinowicz R,Dallal I,Perlman M,Chorin Edoi
10.1159/000447639subject
Has Abstractpub_date
2016-01-01 00:00:00pages
92-6issue
2eissn
1018-2438issn
1423-0097pii
000447639journal_volume
170pub_type
杂志文章abstract::Transforming growth factor-beta 1 (TGF-beta(1)) is a key regulator of immune tolerance. TGF-beta(1) controls T lymphocyte activation and is involved in the immunosuppressive function and generation of regulatory T lymphocytes. Connective tissue growth factor (CTGF) has an essential role in the formation of connective ...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000137284
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Allergic reactions occur rarely in patients with chronic helminth infections, although FcepsilonRI-bearing cells are sensitized with anti-parasite IgE and are exposed to antigen. The inhibition of allergic reactivity is due to 'blocking antibodies', predominantly IgG4. IgG4 antibodies represent 50-95% of ant...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024099
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Cat allergens are ubiquitous because the clothing of cat owners constitutes an important source of distribution of Fel d 1 in cat-free environments. Since Fel d 1 can adhere to a variety of surfaces, we sought to verify if human hair belonging to individuals with or without a cat at home might represent a re...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000085793
更新日期:2005-06-01 00:00:00
abstract::In contrast to mast cells and basophils, the high affinity IgE receptor (FcepsilonRI) on antigen-presenting cells (APC) shows structural and functional differences. It consists only of a minimal structure of one alpha- and two gamma-chains and enables APC to efficiently take up and present antigen in IgE-mediated dela...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000053662
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:High osmolal ionic radiocontrast media (RCM) cause vascular release of endothelin-1 (ET-1) and activate mast cells. Iomeprol, a nonionic RCM, has recently been reported not to activate cardiac mast cells. This coronary angiography study was performed to extend those findings using another nonionic RCM, iopro...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000070435
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:It is not known why some foods sensitizing via the gastrointestinal tract are prevalent allergenic foods and others are not. Eating habits, processing, and the food matrix have been suggested to influence the allergenicity of a given food. Factors related to protein structure, such as stability to digestion,...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000321200
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Intravenous immunoglobulin (IVIG) is the mainstay therapy in human immune deficiency states characterized by qualitative and quantitative reductions in B cells. In addition, however, there is widespread use of IVIG in a number of other areas, including neuroimmunologic, infectious, dermatologic, hematologic,...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000093204
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Cannabinoid (CB) 2 is expressed on immune and inflammatory cells. Identification of 2-arachidonyl glycerol (2-AG) and anandamide as endogenous CB2 ligands has allowed investigations of the roles of CB2 and its endogenous ligand system in inflammatory cells. However, the roles of this receptor-ligand system i...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000336167
更新日期:2012-01-01 00:00:00
abstract::Mast cell hyperplasia is found in different pathologies such as chronic inflammatory processes, fibrotic disorders, wound healing or neoplastic tissue transformation. The functional significance of the accumulation of mast cells in these processes is largely unknown. It is now established that bone marrow-derived mast...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000048181
更新日期:2002-02-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000368405
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Loss-of-function mutations of the filaggrin (FLG) gene cause an impaired skin barrier and increase the risk of atopic dermatitis. Interestingly, FLG mutations have also been found to be associated with a high risk of peanut allergy. OBJECTIVE:We investigated the association of FLG mutations with self-report...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000345949
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Lactation is associated with an inhibited hypothalamic-pituitary-adrenal axis response to physical and psychological stress in women and female rats. However, suckling also improved mood and calmness in nonatopic lactating women. Relaxation by humor reduced allergen-induced skin wheal responses, while variou...
journal_title:International archives of allergy and immunology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000074906
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:The widespread house ant, Monomorium pharaonis (pharaoh ant, PA), was recently identified as a potential cause of respiratory allergies. However, there are no reports of the distribution of PA allergens in various environments. We developed specific ELISA inhibition assays and measured the distribution and a...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000103999
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Segmental allergen challenge is a powerful tool to study inflammatory reactions in asthmatic airways. There is little information on the early events at 5 min and 4 h after allergen challenge with respect to the cell influx and the chemokine interleukin-8 (IL-8). METHODS:Seven mild to moderate allergic asth...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024174
更新日期:1999-05-01 00:00:00
abstract::For each medicinal product quality, safety and efficacy have to be proven to obtain a marketing authorisation. The national competent health authorities and the European Medicines Agency (EMEA) with support of the Heads of Medicines Agencies (HMA) work together to grant marketing authorisations for medicinal products....
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000146074
更新日期:2008-01-01 00:00:00
abstract::Nonspecific hyperreactivity to a number of physical, chemical and pharmacological agents in a common characteristics of allergic subjects, which is strictly related to the inflammatory events consequent to an allergic reaction. Hyperosmolar stimulus has previously been shown to cause an inflammatory response inducing ...
journal_title:International archives of allergy and immunology
pub_type: 临床试验,杂志文章
doi:10.1159/000236713
更新日期:1994-05-01 00:00:00
abstract::Fibroblast-derived growth factors like SCF are able to upregulate the expression of mast cell characteristics in human multilineage hematopoietic progenitor cells. Other factors, like GM-CSF, have been reported to inhibit this process, probably by the competitive recruitment of cells not belonging to the mast cell lin...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237574
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Flavonoids exert antiallergic and antioxidant effects. We investigated the efficacy of enzymatically modified isoquercitrin (EMIQ), a flavonoid, to relieve symptoms of pollinosis. METHODS:In a parallel-group, double-blind placebo-controlled study design, 20 subjects with Japanese cedar pollinosis took two c...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000205582
更新日期:2009-01-01 00:00:00
abstract::Phosphoinositide 3-kinases (PI3Ks) are known to be involved in a variety of cellular responses such as cell survival, proliferation, differentiation and cell migration. Recently, PI3Ks have been associated with the pathogenesis of asthma because various immune cells regulate allergic responses. Among the three classes...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000312132
更新日期:2010-01-01 00:00:00
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journal_title:International archives of allergy and immunology
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doi:10.1159/000126054
更新日期:2008-01-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000053702
更新日期:2001-01-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000049503
更新日期:2001-10-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 临床试验,杂志文章
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更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Previously we have shown that intranasal administration of ovalbumin (OVA) together with cholera toxin (CT) abrogates nasal tolerance to OVA, resulting in the induction of specific IgE antibody (Ab) responses, and that intraperitoneal injection of OVA coupled with liposomes (OVA-liposomes) induces a selectiv...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000024305
更新日期:2000-02-01 00:00:00
abstract::Owing to the proposed role of Fc epsilon RII/CD23 in allergic diseases, we analyzed the expression of this receptor on peripheral blood lymphocytes (pan-B, pan-T and CD4+ or CD8+ T cells) and its autoproteolytic product sCD23 in serum. This was done in 10 asthmatic children allergic to Dermatophagoides pteronyssinus (...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236520
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:2-Arachidonoylglycerol (2-AG), an endogenous ligand for the cannabinoid receptors (CB1 and CB2), has been shown to exhibit a variety of cannabimimetic activities in vitro and in vivo. Recently, we found that human eosinophilic leukemia EoL-1 cells and human peripheral blood eosinophils express the CB2 recept...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000092704
更新日期:2006-01-01 00:00:00
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journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000236006
更新日期:2010-01-01 00:00:00
abstract::We examined the capacity of interleukin-4 (IL) production from lymphocytes and basophils, isolated from the peripheral blood of allergic patients sensitive to house dust mite, after stimulation with mite extract. IL-4 production was measured by a sensitive bioassay based on coculture with CT.h4S (a human IL-4-responsi...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章
doi:10.1159/000237375
更新日期:1996-11-01 00:00:00
abstract::Penicillium and Aspergillus species have been identified as prevalent indoor airborne fungi that are associated with extrinsic bronchial asthma. We have recently analyzed the IgE-binding components in 8 prevalent Penicillium and Aspergillus species (P. citrinum, P. notatum, P. oxalicum, P. brevicompactum, A. fumigatus...
journal_title:International archives of allergy and immunology
pub_type: 杂志文章,评审
doi:10.1159/000024202
更新日期:1999-08-01 00:00:00