The importance of serine proteinases as aeroallergens associated with asthma.

abstract：BACKGROUND:Transforming growth factor-β1 (TGF-β1)-in-duced proliferation of airway smooth muscle cells plays critical roles in the development of airway remodeling. Six1 (sine oculis homeobox homolog 1) has been demonstrated to be involved in airway inflammation and remodeling in asthmatic mice. OBJECTIVES:The aim of ...

journal_title：International archives of allergy and immunology

authors： Yang Z,Qu Z,Yi M,Lv Z,Wang Y,Shan Y,Ran N,Liu X

更新日期：2020-01-01 00:00:00

abstract：:Various methods have been devised to assay eosinophil chemotaxis. In this review, we introduced a rapid and sensitive eosinophil chemotactic assay system based on eosinophil peroxidase (EPO) determination. Eosinophils were semipurified by dextran sedimentation followed by Percoll gradient centrifugation. Eosinophil mi...

journal_title：International archives of allergy and immunology

authors： Nagase H,Yamaguchi M,Jibiki S,Yamada H,Ohta K,Kawasaki H,Yoshie O,Yamamoto K,Morita Y,Hirai K

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Both oral and intravenous inhibitors of cyclic nucleotide phosphodiesterase (PDE) 3 and PDE4 have been shown to have bronchodilator and/or pulmonary antiallergic effects but their adverse effects limit the clinical use. The purpose of the present study was to assess the bronchoprotective effect of intrabronc...

journal_title：International archives of allergy and immunology

authors： Fujimura M,Tachibana H,Myou S,Kita T,Matsuda T

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Data regarding the prevalence of chronic spontaneous urticaria (CSU) in childhood-onset systemic lupus erythematosus (cSLE) patients and possible associated factors are limited to a few case reports. The objectives of this study were to assess CSU in a large cSLE population, in order to evaluate the demograp...

journal_title：International archives of allergy and immunology

authors： Ferriani MP,Silva MF,Pereira RM,Terreri MT,Saad Magalhães C,Bonfá E,Pastorino AC,Carolina Dos Santos M,Appenzeller S,Ferriani VP,Len CA,Sallum AM,Libório J,Monteiro de Castro TC,Silva CA

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:The aim of this study was to evaluate the effectiveness of specific immunotherapy (SIT) management with allergoids in children with allergic asthma by monitoring changes in clinical parameters and inflammatory markers in exhaled breath. METHODS:The study population included 43 patients (24 males) of 6-14 ...

journal_title：International archives of allergy and immunology

authors： Lozano J,Cruz MJ,Piquer M,Giner MT,Plaza AM

更新日期：2014-01-01 00:00:00

abstract：:Besides stem cell factor (SCF), additional fibroblast-derived mast cell growth factors have previously been described. Since keratinocytes have also been shown to produce SCF, we have studied the ability of culture supernatants from the human HaCaT keratinocyte cell line to induce SCF-independent mast cell differentia...

journal_title：International archives of allergy and immunology

authors： Welker P,Grabbe J,Czarnetzki BM

更新日期：1995-05-01 00:00:00

abstract：:Monocytes and lymphocytes from human blood contain 0.043 +/- 0.007 and 0.053 +/- 0.014 pg histamine/cell, respectively, which can be released by a number of stimulants (A 23187, C5a, substance P, specific allergen). The release process takes 60-120 min to reach its end point, in contrast to tissue mast cells which com...

journal_title：International archives of allergy and immunology

authors： Schmutzler W,Bolsmann K,Zwadlo-Klarwasser G

更新日期：1995-05-01 00:00:00

abstract：INTRODUCTION:Hereditary angioedema (HAE) with C1 inhibitor (C1-INH) deficiency is a rare autosomal dominant disease. Although the first symptoms can appear in childhood, the diagnosis's delay has a strong impact on the patient's quality of life. We analyzed clinical and laboratory characteristics and the drug therapy o...

journal_title：International archives of allergy and immunology

authors： Araújo-Simões J,Boanova AGP,Constantino-Silva RN,Fragnan NTML,Pinto JA,Minafra FG,Gonçalves RF,Valle SRD,Alonso MLO,Dortas SD,Goudouris ES,Rêgo-Silva AM,Marques MM,Serpa FS,Chong-Neto HJ,Nelson RF,Mansour E,Moreira IF,

更新日期：2021-01-28 00:00:00

abstract：BACKGROUND:The aetiology of chronic urticaria is heterogeneous. Physical urticaria (PU) is estimated at around 35%, autoimmune urticaria (AIU) at 25% and chronic idiopathic urticaria (CIU) at 35% of all chronic urticaria cases. METHODS:Differences in clinical and laboratory parameters among AIU, PU and CIU groups were...

journal_title：International archives of allergy and immunology

authors： Irinyi B,Széles G,Gyimesi E,Tumpek J,Herédi E,Dimitrios G,Adány R,Hunyadi J,Szegedi A

更新日期：2007-01-01 00:00:00

abstract：:The present study was designed to determine if depletion of the complement system in the circulation with cobra venom factor (CVF) prevented the cellular infiltration in a guinea pig model of asthma. Guinea pigs were sensitized with ovalbumin (OA) alone or OA with complete Freund's adjuvant. Animals were pretreated wi...

journal_title：International archives of allergy and immunology

authors： Regal JF,Fraser DG

更新日期：1996-02-01 00:00:00

abstract：:Guinea pigs were sensitized with 2,4-toluene diisocyanate (TDI) by a repetitive application onto the bilateral nasal vestibules once a day for 5 consecutive days. When these animals were further treated with TDI for additional 9 weeks, a number of these animals exhibited external symptoms similar to those in human ast...

journal_title：International archives of allergy and immunology

authors： Sugawara Y,Okamoto Y,Sawahata T,Tanaka K

更新日期：1993-01-01 00:00:00

abstract：:The clear recognition that asthma has an inflammatory basis has led to a search for genetic and environmental causes. Genetic linkage studies provide evidence for allelic association between polymorphic markers of interleukin-9 on chromosome 5 and a principal component of the allergic phenotype, log IgE. Further studi...

journal_title：International archives of allergy and immunology

authors： Holgate ST,Church MK,Howarth PH,Morton EN,Frew AJ,Djukanović R

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:The development of simple and standardised methods to measure airborne levels of workplace biological allergens is an important step in reducing the incidence of occupational asthma. Such a method would be useful for measuring wheat flour allergens which cause asthma in bakers. Measurement of allergen per se...

journal_title：International archives of allergy and immunology

authors： Wiley K,Smith MM,Allan LJ,Griffin P

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:The human IgE response is associated with allergy and with host defence against parasitic worms. A response to Sm22.6, the dominant IgE antigen in adult Schistosoma mansoni worms, correlates with resistance to re-infection after treatment. Sm22.6 is one of a family of EF-hand containing parasite proteins wit...

journal_title：International archives of allergy and immunology

authors： Fitzsimmons CM,McBeath R,Joseph S,Jones FM,Walter K,Hoffmann KF,Kariuki HC,Mwatha JK,Kimani G,Kabatereine NB,Vennervald BJ,Ouma JH,Dunne DW

更新日期：2007-01-01 00:00:00

abstract：:Hypersensitivity to latex proteins has been reported with increasing frequency in recent years. Elevated levels of latex specific IgE have been detected in the majority of these patients. Severe anaphylaxis and death resulting from latex exposure has also been reported. Nevertheless, the immune mechanism of latex alle...

journal_title：International archives of allergy and immunology

authors： Kurup VP,Kumar A,Choi H,Murali PS,Resnick A,Kelly KJ,Fink JN

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is increasing among the elderly. Staphylococcus aureus colonization is one of the most important aggravating factors in AD. OBJECTIVE:This study analyses the clinical features of AD in elderly patients and determines the pathogenic roles of staphylococcal superantigens in AD with low ...

journal_title：International archives of allergy and immunology

authors： Bozek A,Fisher A,Filipowska B,Mazur B,Jarzab J

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Studies comparing skin prick test (SPT) devices have revealed varying results in performance and there is little known about their use on children. METHODS:We performed 2 complementary studies to test the sensitivity, reproducibility and acceptability of commercially available SPT devices (Stallerpoint, Ant...

journal_title：International archives of allergy and immunology

authors： Buyuktiryaki B,Sahiner UM,Karabulut E,Cavkaytar O,Tuncer A,Sekerel BE

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Allergic reactions occur rarely in patients with chronic helminth infections, although FcepsilonRI-bearing cells are sensitized with anti-parasite IgE and are exposed to antigen. The inhibition of allergic reactivity is due to 'blocking antibodies', predominantly IgG4. IgG4 antibodies represent 50-95% of ant...

journal_title：International archives of allergy and immunology

authors： Agresti A,Vercelli D

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:The European tick, Argas reflexus, is an urban pest parasitizing urban pigeons and may cause a wide range of allergic reactions. METHODS:Specific IgE to A. reflexus, SDS-PAGE and IgE immunoblotting, performed with tick extract, were carried out in the sera of 6 patients who reported allergic reactions after...

journal_title：International archives of allergy and immunology

authors： Rolla G,Nebiolo F,Marsico P,Guida G,Bigo P,Riva G,Zanotta S

更新日期：2004-12-01 00:00:00

abstract：:The JAK (Janus kinase) family of protein tyrosine kinases and the STATs (signal transducers and activators of transcription) have been shown to be activated in response to a number of cytokines and growth factors. In this study, we evaluated the activation of JAK/STAT pathway upon human interleukin-5 (hIL-5) stimulati...

journal_title：International archives of allergy and immunology

authors： Ogata N,Kikuchi Y,Kouro T,Tomonaga M,Takatsu K

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:Shrimp sensitization is common in the general population, but the presence of symptoms is only moderately related to sensitization. A point still at issue is which in vivo and/or in vitro tests (food challenge, component-resolved diagnosis, house dust mite [HDM] sensitization) can help in distinguishing shri...

journal_title：International archives of allergy and immunology

authors： Farioli L,Losappio LM,Giuffrida MG,Pravettoni V,Micarelli G,Nichelatti M,Scibilia J,Mirone C,Cavallarin L,Lamberti C,Balossi LG,Pastorello EA

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Staphylococcus aureus-producing superantigens (SAgs), such as staphylococcal enterotoxin B (SEB) or toxic shock syndrome toxin-1 (TSST-1), are frequently observed in atopic dermatitis (AD). However, little has been done to establish the association of immune responses to SAgs and the therapeutic response to ...

journal_title：International archives of allergy and immunology

authors： Fukushima H,Hirano T,Shibayama N,Miwa K,Ito T,Saito M,Sumida H,Oyake S,Tsuboi R,Oka K

更新日期：2006-01-01 00:00:00

abstract：:Sera of 54 symptomatic workers showing sensitization to isocyanate-human serum albumin (HSA) conjugates were subjected to parallel enzyme allergosorbent test (EAST) and CAP measurements to determine IgE antibodies to diphenyl-methane diisocyanate-HSA, toluene diisocyanate-HSA and hexamethylene diisocyanate-HSA. Result...

journal_title：International archives of allergy and immunology

authors： Baur X,Chen Z,Flagge A,Posch A,Raulf-Heimsoth M

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:It has been reported that protein tyrosine phosphorylation is essential for cytokine production in mouse Th1 cells but not in Th2 cells. However, little is known about the difference of signal transduction between human antigen-specific Th1 and Th2 cell clones. METHODS:Purified protein derivative-specific T...

journal_title：International archives of allergy and immunology

authors： Minoguchi K,Yamashita N,Oda N,Takeno M,Kaneoka H,Sakane T

更新日期：1999-01-01 00:00:00

abstract：:Interaction between vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells and CD49d molecules on eosinophils is thought to mediate the selective infiltration of eosinophils into inflamed tissues in allergic disease. IL-4 and TNF-alpha are associated with allergic conditions, and they have been shown to selec...

journal_title：International archives of allergy and immunology

authors： Saito H,Shimizu H,Mita H,Maeda Y,Akiyama K

更新日期：1996-10-01 00:00:00

abstract：:Human foamy virus (HFV) is a recently characterized member of the retrovirus subfamily Spumaretrovirinae. HFV has a complex structure: it encodes the classical three retroviral structural genes gag, pol and env, but also possesses additional regulatory, so-called bel sequences. Foamy viruses have been discussed occasi...

journal_title：International archives of allergy and immunology

authors： Wick G,Grubeck-Loebenstein B,Trieb K,Kalischnig G,Aguzzi A

更新日期：1992-01-01 00:00:00

abstract：:Asthmatic individuals in the general population appear to be susceptible to disease exacerbation during summertime 'smog' episodes (ambient air pollution containing other pollutants in addition to ozone). Although controlled exposure to ozone causes acute decrements in lung function, asthmatic subjects are only margin...

journal_title：International archives of allergy and immunology

authors： Koren HS,Bromberg PA

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Allergic contact dermatitis (ACD) is an inflammatory skin disease caused by repeated skin exposure to contact allergens. The goal of this pilot study was to identify inflammatory proteins which can serve as biomarkers for ACD. METHODS:We measured levels of 102 cytokines, chemokines, and growth factors in th...

journal_title：International archives of allergy and immunology

authors： Zinkevičienė A,Kainov D,Lastauskienė E,Kvedarienė V,Bychkov D,Byrne M,Girkontaitė I

更新日期：2015-01-01 00:00:00

abstract：:Two cDNA clones named P9* and P1* of 794 and 631 bp, respectively, were isolated from a lambda ZAP cDNA expression library using Parietaria judaica (Pj) pollen-specific IgE antibodies from a pool of sera (n = 23) of patients allergic to Pj. Sequence analysis showed open reading frames of 176 and 138 amino acids. Both ...

journal_title：International archives of allergy and immunology

authors： Duro G,Colombo P,Assunta Costa M,Izzo V,Porcasi R,Di Fiore R,Locorotondo G,Cocchiara R,Geraci D

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Airway closure is frequently observed in human asthma. However, limited information exists on the factors that cause this condition. In this study, an allergic cynomolgus monkey model was used to characterize the condition of airway closure and assess the contribution of histamine H1 receptors to this respon...

journal_title：International archives of allergy and immunology

authors： Skeans S,Lamca JE,House A,Celly CS,Hey JA,Chapman RW

更新日期：2005-05-01 00:00:00