abstract：INTRODUCTION:Hereditary angioedema (HAE) with C1 inhibitor (C1-INH) deficiency is a rare autosomal dominant disease. Although the first symptoms can appear in childhood, the diagnosis's delay has a strong impact on the patient's quality of life. We analyzed clinical and laboratory characteristics and the drug therapy o...

journal_title：International archives of allergy and immunology

authors： Araújo-Simões J,Boanova AGP,Constantino-Silva RN,Fragnan NTML,Pinto JA,Minafra FG,Gonçalves RF,Valle SRD,Alonso MLO,Dortas SD,Goudouris ES,Rêgo-Silva AM,Marques MM,Serpa FS,Chong-Neto HJ,Nelson RF,Mansour E,Moreira IF,

更新日期：2021-01-28 00:00:00

abstract：:A high-dose, accelerated escalation schedule during subcutaneous allergen-specific immunotherapy (AIT) is safe and well-tolerated in adults. However, there are no data in children and adolescents. The aim of the present trial was to assess safety and tolerability of an accelerated dose escalation schedule of an AIT wi...

journal_title：International archives of allergy and immunology

authors： Bovermann X,Ricklefs I,Vogelberg C,Klimek L,Kopp MV

更新日期：2021-01-27 00:00:00

abstract：BACKGROUND:Epinephrine autoinjector (EAI) is prescribed to prevent a fatal outcome in the case of a repeated anaphylactic reactions. We wanted to determine how adult patients who received their first prescription as part of an urgent treatment of an anaphylactic reaction or at their family physician were instructed on ...

journal_title：International archives of allergy and immunology

authors： Kadivec S,Košnik M

更新日期：2021-01-22 00:00:00

abstract：INTRODUCTION:Unique gut microbial colonisation patterns are associated with the onset of allergic disease in infants; however, there is insufficient evidence to determine if aberrant microbial composition patterns persist in adult allergic rhinitis (AR) sufferers. OBJECTIVE:To compare the gut microbiome composition be...

journal_title：International archives of allergy and immunology

authors： Watts AM,West NP,Zhang P,Smith PK,Cripps AW,Cox AJ

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Recently, the relationship between antigen contact via skin (skin sensitization) and the development of food allergies has gained increasing attention. However, few studies have examined the effects of skin sensitization on healthy skin. OBJECTIVE:To examine the effect of sensitization in healthy skin on Ig...

journal_title：International archives of allergy and immunology

authors： Koshiba R,Oba T,Fuwa A,Arai K,Sasaki N,Kitazawa G,Hattori M,Matsuda H,Yoshida T

更新日期：2020-11-11 00:00:00

abstract：INTRODUCTION:Cow's milk protein allergy (CMA) is the most common type of food allergy in childhood and exclusion diet is a challenge for patients. OBJECTIVE:The study aim was to investigate the frequency of tolerance to baked foods containing milk and evaluate immediate skin prick test (SPT) and specific IgEs for diff...

journal_title：International archives of allergy and immunology

authors： Vilar LK,Araújo FA,Santos TP,Menezes TT,Cheik MF,Segundo GRS

更新日期：2020-10-14 00:00:00

abstract：BACKGROUND:Allergic bronchopulmonary aspergillosis (ABPA) develops in the presence of predisposing conditions such as asthma and cystic fibrosis. Even ABPA accompanied by asthma is often complicated by chronic Pseudomonas aeruginosa or nontuberculous mycobacterial infection of the lower respiratory tract, rendering tre...

journal_title：International archives of allergy and immunology

authors： Tomomatsu K,Oguma T,Baba T,Toyoshima M,Komase Y,Taniguchi M,Asano K,Japan ABPM Research Program.

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:House dust mite contains several allergen components and causes perennial allergy. Lately, a new major allergen, Der p 23, was described with relatively high sensitization rates in different European Countries. In addition, Der p 23 is supposed to cause asthmatic disease. OBJECTIVE:We would like to questi...

journal_title：International archives of allergy and immunology

authors： Eder K,Becker S,Gellrich D,Zieglmayer P,Gröger M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Several studies have suggested that sublingual immunotherapy (SLIT) involves a dose-response relationship and inadequate dosage might not achieve a favorable clinical effect. OBJECTIVE:The aim of this prospective study was to investigate the efficacy and safety of increasing SLIT dosage at 6 months in patie...

journal_title：International archives of allergy and immunology

authors： Gao Y,Lin X,Ma J,Wei X,Wang Q,Wang M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Hymenoptera venom allergy (HVA) has a prevalence of 3% in adults. Although patients have no ongoing symptoms, they often suffer from an impairment of their psychological well-being and quality of life. OBJECTIVE:The aim of this study was to analyze sex-specific differences regarding the psychological burden...

journal_title：International archives of allergy and immunology

authors： Schoeben LS,Bubak C,Schaarschmidt ML,Schmieder A

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:One of the most frequent abnormalities of B cells in common variable immunodeficiency (CVID) is reduced number of class-switched memory B cells, suggesting an impaired germinal center response. Therefore, due to its pivotal role in regulating the development of humoral immunity, the objective of this study...

journal_title：International archives of allergy and immunology

authors： Kasahara TM,Bento CAM,Gupta S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Chronic granulomatous disease (CGD) is a rare genetic disorder characterized by failure of phagocytic leukocytes to destroy certain microbes. We present a study on CGD patients enrolled at a single medical center concerning the infectious and noninfectious complications and genetic properties of the disease....

journal_title：International archives of allergy and immunology

authors： Aygun D,Koker MY,Nepesov S,Koker N,van Leeuwen K,de Boer M,Kıykım A,Ozsoy S,Cokugras H,Kuijpers T,Roos D,Camcıoglu Y

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Wheat is known as the most widely consumed food all over the world. Although many types of wheat allergy have been recognized, their treatment still has a long way to go due to the complex pathogenesis. Oral immunotherapy (OIT) is under investigation for the treatment of wheat allergies. Previous studies hav...

journal_title：International archives of allergy and immunology

authors： Li X,Miyakawa T,Takano T,Nakajima-Adachi H,Tanokura M,Hachimura S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Transforming growth factor-β1 (TGF-β1)-in-duced proliferation of airway smooth muscle cells plays critical roles in the development of airway remodeling. Six1 (sine oculis homeobox homolog 1) has been demonstrated to be involved in airway inflammation and remodeling in asthmatic mice. OBJECTIVES:The aim of ...

journal_title：International archives of allergy and immunology

authors： Yang Z,Qu Z,Yi M,Lv Z,Wang Y,Shan Y,Ran N,Liu X

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:High antibiotic prescribing rates for adults with an asthma exacerbation have been reported in developed countries, but few studies have assessed the variation of antibiotic and adjunctive treatment in the routine care of children. OBJECTIVE:We evaluated the trends in health resource utilization for childre...

journal_title：International archives of allergy and immunology

authors： Okubo Y,Horimukai K,Michihata N,Morita K,Matsui H,Fushimi K,Yasunaga H

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Immunoglobulin G4-related disease (IgG4-RD) is a systemic immunological disorder characterized by fibro-inflammatory conditions; however, the pathobiology of IgG4-RD has not been fully identified. OBJECTIVE:This study aimed to analyze systemic differences of innate and adaptive immune cells from healthy con...

journal_title：International archives of allergy and immunology

authors： Sohn KH,Ham J,Chung SJ,Kang HR,Kim HY

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION:Obesity-associated asthma is characterized by type 2-low airway inflammation. We previously showed that EM900, which is a 12-membered nonantibiotic macrolide, suppressed airway inflammation in a mouse model of asthma exacerbation. The aim of this study was to clarify the effects of EM900 in obesity-associa...

journal_title：International archives of allergy and immunology

authors： Sadamatsu H,Takahashi K,Tashiro H,Kurihara Y,Kato G,Uchida M,Noguchi Y,Kurata K,Ōmura S,Sunazuka T,Kimura S,Sueoka-Aragane N

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) and food allergy (FA) are common childhood diseases, which may either be interrelated or be the result of skin barrier disruption and gut mucosal dysbiosis. Although some evidence suggests the efficacy of emollients and synbiotics, there is no conclusive evidence on the use of these in...

journal_title：International archives of allergy and immunology

authors： Dissanayake E,Tani Y,Nagai K,Sahara M,Mitsuishi C,Togawa Y,Suzuki Y,Nakano T,Yamaide F,Ohno H,Shimojo N

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Proton pump inhibitors (PPIs) can trigger immediate-type hypersensitivity reactions (HSRs). Three main patterns of cross-reactivity have been identified: reactions to a single PPI, selective cross-reactions, and cross-reactions with all PPIs. Several hypotheses have been advanced, but no consensus has been r...

journal_title：International archives of allergy and immunology

authors： Tourillon C,Mahe J,Baron A,Lambert A,Yélehé-Okouma M,Veyrac G,Jolliet P

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The implementation of allergen immunotherapy (AIT) requires extensive knowledge of allergen distribution in the region to identify high-risk regions for AIT utilization. However, the geographical distribution patterns of the major Dermatophagoides allergens in China remain unclear despite the increasing prev...

journal_title：International archives of allergy and immunology

authors： Chen ZG,Li YT,Wang WH,Tan KS,Zheng R,Yang LF,Guan WJ,Hong HY,Yang QT

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The Notch signaling pathway plays an important role in regulating human immune function, but the relationship between allergic rhinitis (AR) and Notch signaling remains unclear. OBJECTIVE:To investigate the role of Notch signaling in the pathogenesis of AR and its regulation on Foxp3-Treg cells. METHOD:The...

journal_title：International archives of allergy and immunology

authors： Jiao WE,Wei JF,Kong YG,Xu Y,Tao ZZ,Chen SM

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Asthma, allergic conditions, and COPD overlap, but the effect of them and their combinations on disease severity, need for drugs, use of healthcare, and costs is poorly known. OBJECTIVE:To study how different allergic diseases co-occur in asthma and allergy patients and evaluate the use of medication well a...

journal_title：International archives of allergy and immunology

authors： Jantunen J,Haahtela T,Salimäki J,Linna M,Mäkelä M,Pelkonen A,Kauppi P

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Pathologic accumulation and activation of mast cells and eosinophils are implicated in allergic and inflammatory diseases. Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is an inhibitory receptor selectively expressed on mast cells, eosinophils and, at a lower extent, basophils. When engaged wit...

journal_title：International archives of allergy and immunology

authors： Youngblood BA,Brock EC,Leung J,Falahati R,Bryce PJ,Bright J,Williams J,Shultz LD,Greiner DL,Brehm MA,Bebbington C,Tomasevic N

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:We have previously shown that human monocyte-derived dendritic cells (moDCs) may participate in immune system-mediated hypercoagulable state through enhanced tissue factor (TF) expression and that the complement system may be involved in this process. OBJECTIVES:The aim of this study was to explore the role...

journal_title：International archives of allergy and immunology

authors： Kasuda S,Sakurai Y,Tatsumi K,Takeda T,Kudo R,Yuui K,Hatake K

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Chronic rhinosinusitis (CRS) is a multifaceted disease with a significant genetic component. The importance of taste receptor signaling has recently been highlighted in CRS; single nucleotide polymorphisms (SNPs) of bitter tastant-responsive G-protein-coupled receptors have been linked with CRS and with alte...

journal_title：International archives of allergy and immunology

authors： Purnell PR,Addicks BL,Zalzal HG,Shapiro S,Wen S,Ramadan HH,Setola V,Siderovski DP

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Nasal polyps are a common health problem that can significantly impact the quality of life. OBJECTIVE:To analyze the impact of allergy and peripheral eosinophils (EOS) on the morbidity of chronic rhinosinusitis with nasal polyps (CRSwNP) in Northwest China. METHODS:A retrospective cohort of 323 patients wh...

journal_title：International archives of allergy and immunology

authors： Chen F,Wen L,Qiao L,Shi Z,Xue T,Chen X,Li X

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Venom immunotherapy (VIT) is considered to be the gold-standard treatment for patients with Hymenoptera venom allergy. Data regarding VIT in bee venom (BV) allergic patients are scarce. AIM:The aim of this study was to evaluate the outcome of VIT in patients with exclusive BV allergy and to try to define ...

journal_title：International archives of allergy and immunology

authors： Rosman Y,Nashef F,Cohen-Engler A,Meir-Shafrir K,Lachover-Roth I,Confino-Cohen R

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Penicillins and cephalosporins are the most frequent causes of hypersensitivity reactions (HRs) to drugs in children. Among cephalosporins for intravenous use, ceftriaxone (CT) is the most frequently prescribed in Italy. The aims of this study were to evaluate the diagnostic methods for CT hypersensitivity...

journal_title：International archives of allergy and immunology

authors： Mori F,Liccioli G,Piccorossi A,Sarti L,Barni S,Giovannini M,Azzari C,Manfredi M,Novembre E

更新日期：2019-01-01 00:00:00

abstract：AIM:To investigate the potential risk factors in patients who have experienced anaphylaxis from drugs. METHOD:The study included 281 adult patients (median age 40 years; 76.5% female) who experienced immediate types of hypersensitivity reaction to a drug. The patients were divided into an anaphylaxis group and a nonan...

journal_title：International archives of allergy and immunology

authors： Demir S,Erdenen F,Gelincik A,Unal D,Olgac M,Coskun R,Colakoglu B,Buyukozturk S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Assessing high-sensitivity C-reactive protein (hs-CRP) in relation to allergic endpoints can shed light on both the mechanisms of allergic disease development and early non-communicable disease prevention. However, only a few epidemiological studies so far have investigated the relationship in children and a...

journal_title：International archives of allergy and immunology

authors： Yang BY,Markevych I,Harris C,Standl M,Schikowski T,Koletzko S,Herberth G,Bauer CP,von Berg A,Berdel D,Dong GH,Heinrich J

更新日期：2019-01-01 00:00:00

abstract：:Studies in migrant populations provide vital opportunities to investigate the role of environmental factors in the pathogenesis of allergic disorders. Differences in allergy prevalence have been observed between migrants and native-born subjects living in the same geographical location. Immigrants who migrate from les...

journal_title：International archives of allergy and immunology

authors： Tham EH,Loo EXL,Zhu Y,Shek LP

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the interplay between multiple genetic and environmental factors. The pathogenesis of AD remains incompletely understood. Treatment with topical steroids for chronic AD symptoms has severe side effects and so a new treatment is re...

journal_title：International archives of allergy and immunology

authors： Li Y,Yu H,Jin Y,Li M,Qu C

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Severe asthma is a heterogeneous disease, which is characterized by airway damage and remodeling. All triggers of asthma, such as allergens, bacteria, viruses, and pollutants, interact with the airway epithelial cells, which drive the airway inflammatory response through the release of cytokines, particularl...

journal_title：International archives of allergy and immunology

authors： Boita M,Heffler E,Omedè P,Bellocchia M,Bussolino C,Solidoro P,Giorgis V,Guerrera F,Riva G,Brussino L,Bucca C,Rolla G

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Partially hydrolyzed cow's milk protein-based formula (pHF) possesses low allergenicity. Here, we investigate the safety and efficacy of oral immunotherapy using pHF for children with cow's milk protein allergy (CMPA). OBJECTIVES:A randomized, double-blind, controlled single-center trial was conducted to ev...

journal_title：International archives of allergy and immunology

authors： Inuo C,Tanaka K,Suzuki S,Nakajima Y,Yamawaki K,Tsuge I,Urisu A,Kondo Y

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Cow's milk (CM) allergy is the second most common food allergy developed during infancy in Japan. To identify predictors of persistent CM allergy, we investigated the tolerance acquisition rate based on an oral food challenge in children under 6 years of age, diagnosed with immediate-type CM allergy. METHOD...

journal_title：International archives of allergy and immunology

authors： Koike Y,Sato S,Yanagida N,Asaumi T,Ogura K,Ohtani K,Imai T,Ebisawa M

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The coexistence of asthma and allergic rhinitis (AR) and its distinct association with obesity have been reported. However, few studies have differentiated the two types of AR, i.e., perennial (PAR) and seasonal AR (SAR), with regard to their associations with asthma and obesity. The aim of this study was to...

journal_title：International archives of allergy and immunology

authors： Matsumoto M,Konno S,Kimura H,Takei N,Kimura H,Shimizu K,Goudarzi H,Suzuki M,Hashino S,Nishimura M

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Depression and smoking contribute to the prognosis of autoimmune rheumatoid arthritis (RA). Advanced glycation end products (AGEs) are also detected in RA patients. This study correlates RA in patients with various levels of depression and a history of smoking through the detection of antibodies against AGEs...

journal_title：International archives of allergy and immunology

authors： Alouffi S,Sherwani S,Al-Mogbel MS,Sherwani MKA,Ali Khan MW

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Reports on oral immunotherapy (OIT) for anaphylactic food allergy are lacking. We investigated the efficacy and safety of peanut OIT for anaphylactic patients. METHODS:We enrolled 22 peanut anaphylactic patients who underwent OIT between 2011 and 2013, all of whom demonstrated anaphylaxis during a baseline ...

journal_title：International archives of allergy and immunology

authors： Nagakura KI,Sato S,Yanagida N,Nishino M,Asaumi T,Ogura K,Ebisawa M

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The prevalence of allergic rhinitis (AR) is increasing rapidly in Central China. The skin prick test (SPT) is the standard tool with which to determine the allergen sensitization status in AR patients. Changes in allergen sensitization patterns have been observed within countries and regions due to geographi...

journal_title：International archives of allergy and immunology

authors： Wang J,Wu Y,Li J,Huang X,Zhu R

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Anti-inflammatory therapy is a logical approach to slowing the inevitable lung function deterioration in cystic fibrosis (CF) patients. This study's aim was to evaluate inflammatory markers and disease progression in paediatric CF patients chronically treated with azithromycin or low-dose prednisolone. METH...

journal_title：International archives of allergy and immunology

authors： Shmarina G,Pukhalsky A,Avakian L,Semykin S,Pukhalskaya D,Alioshkin V

更新日期：2017-01-01 00:00:00