当前位置： SCI文献检索 > INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY期刊下所有文献 > Peripheral blood T lymphocytes and basophils, freshly isolated from house-dust-mite-sensitive patients, produce interleukin-4 in response to allergen-specific stimulation.

Peripheral blood T lymphocytes and basophils, freshly isolated from house-dust-mite-sensitive patients, produce interleukin-4 in response to allergen-specific stimulation.

Abstract：

:We examined the capacity of interleukin-4 (IL) production from lymphocytes and basophils, isolated from the peripheral blood of allergic patients sensitive to house dust mite, after stimulation with mite extract. IL-4 production was measured by a sensitive bioassay based on coculture with CT.h4S (a human IL-4-responsive cell line). Lymphocytes and basophils from patients with elevated serum IgE specific to mite allergen [radioallergosorbent test (RAST) score > 3] could produce detectable levels of IL-4 in response to mite extract, whereas those from patients with a RAST score of less than 2 or normal volunteers could not. The sensitivity of basophils to mite extract was high, so that a lower concentration of mite extract (1-10 ng/ml) could induce maximal IL-4 production. On the other hand, a higher concentration (10 micrograms/ml) was required for maximal IL-4 production from the lymphocytes. These findings demonstrate that allergen-specific IL-4-producing cells, lymphocytes and basophils, are generated in vivo in allergic patients and also that there exist characteristic differences between lymphocytes and basophils related to the in vivo source of IL-4.

journal_name

Int Arch Allergy Immunol

journal_title

International archives of allergy and immunology

authors

Ochi H,Tanaka T,Katada Y,Naka T,Aitani M,Hashimoto S,Maeda K,Toyoshima K,Igarashi T,Suemura M,Kishimoto T

doi

10.1159/000237375

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

253-61

issue

3

eissn

1018-2438

issn

1423-0097

journal_volume

111

pub_type

杂志文章

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