Abstract:
BACKGROUND:The precise roles of T helper (Th)1-type and Th2-type cytokine responses in nickel (Ni)-induced allergic contact dermatitis have not yet been clearly defined. We investigated the involvement of Th2 cytokines in Ni-induced contact hypersensitivity reaction using GATA-3 transgenic (Tg) mice. METHODS:A Ni-titanium (Ti) alloy was implanted under the skin of GATA-3 Tg mice. A Ni solution was then injected 1 month after sensitization. The ear swelling response was measured at several time points after the injection; the cytokine levels in the skin were measured at 48 h after injection, and the serum levels of IgE were measured 1 month after injection. In addition, purified CD4+ splenic cells obtained from the GATA-3 Tg mice sensitized with the Ni-Ti alloy were infused into Rag-2(-/-) mice, and the ear swelling response of these mice after a further challenge with Ni solution was also measured. RESULTS:Marked ear swelling and elevated serum IgE levels and skin tissue levels of IL-4 were observed in Ni-Ti-sensitized GATA-3 Tg mice. The Rag-2(-/-) mice transfused with the CD4+ splenic cells from the Ni-Ti alloy sensitized GATA-3 Tg mice showed a significantly more pronounced ear swelling response than the control mice. CONCLUSION:We confirmed the participation of Th2-type immune reactions in Ni-induced allergy using GATA-3 Tg mice.
journal_name
Int Arch Allergy Immunoljournal_title
International archives of allergy and immunologyauthors
Niiyama S,Tamauchi H,Amoh Y,Terashima M,Matsumura Y,Kanoh M,Habu S,Komotori J,Katsuoka Kdoi
10.1159/000314372subject
Has Abstractpub_date
2010-01-01 00:00:00pages
303-14issue
3eissn
1018-2438issn
1423-0097pii
000314372journal_volume
153pub_type
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