The use of complementary and alternative medicine by pediatric food-allergic patients in Japan.

Abstract:

BACKGROUND:In developed countries, increasing food allergy prevalence and concern regarding food allergies have been reported. Although the use of complementary and alternative medicine (CAM) for the treatment of allergic diseases has increased in some Western countries, the actual proportion and patterns of CAM use for pediatric food allergies in Japan are still unknown. METHODS:Fourteen allergy centers in Japan participated in the study using a questionnaire survey regarding the use of CAM by pediatric patients. A diagnosis of food allergy was made at each hospital by pediatric allergists. RESULTS:Surveys were completed by parents/guardians, and data were collected for a total of 962 pediatric food-allergic patients. Overall, 8.4% of the participants used CAM to treat a food allergy. The major CAM therapies used were herbal teas (22.2%), including several Japanese herbal teas, Chinese herbal medicine (18.5%) and lactic acid bacteria (16%). Among the participants using CAM to treat food allergy, 13.6% thought that the CAM being used was very effective, while 11.1% of participants thought that CAM caused some type of side effect. CONCLUSIONS:Our study is the first large-scale national survey regarding the use of CAM in pediatric patients with food allergies in Japan. Unlike in the USA, which has a higher rate of CAM use (17%), approximately 8.4% of food-allergic patients used CAM in Japan. Interestingly, the major types of CAM used in Japan differed from those used in the USA. Cultural differences and food customs may affect the use of CAM.

authors

Nakano T,Shimojo N,Okamoto Y,Ebisawa M,Kurihara K,Hoshioka A,Yamaguchi K,Ito K,Fujisawa T,Kameda M,Suehiro Y,Ogura H,Shibata R,Suzuki S,Takahashi Y,Ikeda M,Kohno Y

doi

10.1159/000338936

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

410-5

issue

4

eissn

1018-2438

issn

1423-0097

pii

000338936

journal_volume

159

pub_type

杂志文章,多中心研究
  • Peptide specificity, HLA class II restriction, and T-cell subsets of the T-cell clones specific to either Cry j 1 or Cry j 2, the major allergens of Japanese cedar (Cryptomeria japonica) pollen.

    abstract:BACKGROUND:Cry j 1 and Cry j 2 are thought to be the major allergens of Japanese cedar pollen. HLA class II types capable of presenting T-cell epitopes in both allergens and their role in induction of T-cell subsets are not well known. METHODS:CD4+ T (Th)-cell clones (TCCs) specific to either Cry j 1 or Cry j 2 were g...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000024194

    authors: Sone T,Morikubo K,Shimizu K,Komiyama N,Tsunoo H,Kino K

    更新日期:1999-07-01 00:00:00

  • Involvement of the endogenous cannabinoid 2 ligand 2-arachidonyl glycerol in allergic inflammation.

    abstract:BACKGROUND:Cannabinoid (CB) 2 is expressed on immune and inflammatory cells. Identification of 2-arachidonyl glycerol (2-AG) and anandamide as endogenous CB2 ligands has allowed investigations of the roles of CB2 and its endogenous ligand system in inflammatory cells. However, the roles of this receptor-ligand system i...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000336167

    authors: Mimura T,Oka S,Koshimoto H,Ueda Y,Watanabe Y,Sugiura T

    更新日期:2012-01-01 00:00:00

  • Prevalence of IgE-binding to Art v 1, Art v 4 and Amb a 1 in mugwort-allergic patients.

    abstract:BACKGROUND:Mugwort (Artemisia vulgaris) represents an important source of weed pollen allergens. The objectives of the present study were (i) to analyze the IgE binding profiles in a group of mugwort-allergic patients, (ii) to identify individual marker allergens crucial for the diagnosis of mugwort allergy and (iii) t...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000108134

    authors: Oberhuber C,Ma Y,Wopfner N,Gadermaier G,Dedic A,Niggemann B,Maderegger B,Gruber P,Ferreira F,Scheiner O,Hoffmann-Sommergruber K

    更新日期:2008-01-01 00:00:00

  • Can the use of HEPA cleaners in homes of asthmatic children and adolescents sensitized to cat and dog allergens decrease bronchial hyperresponsiveness and allergen contents in solid dust?

    abstract:BACKGROUND:Exposure and sensitization to pet allergens are associated with allergic asthma in children. Conflicting data have emerged regarding the potential benefit of air cleaners with respect to a reduction of indoor pet allergens and bronchial hyperresponsiveness (BHR). METHODS:In a randomized controlled trial 36 ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000151502

    authors: Sulser C,Schulz G,Wagner P,Sommerfeld C,Keil T,Reich A,Wahn U,Lau S

    更新日期:2009-01-01 00:00:00

  • The influence of CpG motifs on a protein or DNA-based Th2-type immune response against major pollen allergens Bet v 1a, Phl p 2 and Escherichia coli-derived beta-galactosidase.

    abstract:BACKGROUND:DNA immunization and protein immunization with CpG motifs as adjuvants represent promising approaches in allergen-specific immunotherapy. OBJECTIVE:We investigated the effect of coinjection or prepriming with CpG-ODN on Th2-type responses induced by gene gun and protein immunization. METHODS:BALB/c mice we...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000053772

    authors: Hochreiter R,Hartl A,Freund J,Valenta R,Ferreira F,Thalhamer J

    更新日期:2001-01-01 00:00:00

  • Atopic asthma is dominant in elderly onset asthmatics: possibility for an alteration of mast cell function by aging through Fc receptor expression.

    abstract::The morbidity and mortality of elderly onset asthma have recently been on the increase. To evaluate the allergic status of the elderly onset asthmatics, we performed skin tests for allergens and estimated serum total IgE levels of the patients. The proportion of the skin-test-positive patients among the elderly onset ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000053600

    authors: Atsuta R,Akiyama K,Shirasawa T,Okumura K,Fukuchi Y,Ra C

    更新日期:1999-01-01 00:00:00

  • Inhibition of stem cell factor dependent formation of human mast cells by interleukin-3 and interleukin-4.

    abstract::In murines, interleukins (IL) 3, 4, 9, and 10, nerve growth factor, and stem cell factor induce or promote growth and differentiation of mast cells (MC). Increased stimulation and synergy was observed when combinations of cytokines were used. In man, no growth factor for human MCs had been identified until recently, w...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236767

    authors: Sillaber C,Sperr WR,Agis H,Spanblöchl E,Lechner K,Valent P

    更新日期:1994-11-01 00:00:00

  • Effect of ibudilast, a novel antiasthmatic agent, on anaphylactic bronchoconstriction: predominant involvement of endogenous slow reacting substance of anaphylaxis.

    abstract::The effect of ibudilast on anaphylactic bronchoconstriction was studied in guinea pigs sensitized actively with ovalbumin (OA). Animals were treated with indomethacin, tripelennamine and propranolol prior to the antigen challenge. Anaphylactic bronchoconstriction was prevented by ibudilast (1-4 mg/kg i.v. and 5-20 mg/...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236460

    authors: Ohashi M,Uno T,Nishino K

    更新日期:1993-01-01 00:00:00

  • Lack of detectable alterations in immune responses during sublingual immunotherapy in children with seasonal allergic rhinoconjunctivitis to grass pollen.

    abstract:BACKGROUND:Recent work indicates that subcutaneous specific immunotherapy induces specific T-cell anergy, a shift in the TH1/TH2 ratio, and antibody production in favor of IgG4. There are few data on sublingual immunotherapy (SLIT), especially in children. METHODS:We assessed the proliferation of peripheral blood mono...

    journal_title:International archives of allergy and immunology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000083320

    authors: Rolinck-Werninghaus C,Kopp M,Liebke C,Lange J,Wahn U,Niggemann B

    更新日期:2005-02-01 00:00:00

  • Variability of Ole e 9 allergen in olive pollen extracts: relevance of minor allergens in immunotherapy treatments.

    abstract:BACKGROUND:Clustered severe adverse reactions to immunotherapy with olive pollen extracts have been occasionally reported in areas where olive trees are extensively grown. Allergic patients from these areas, in addition to the major olive pollen allergen Ole e 1, frequently recognize a recently described allergen, Ole ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000092532

    authors: Duffort O,Palomares O,Lombardero M,Villalba M,Barber D,Rodríguez R,Polo F

    更新日期:2006-01-01 00:00:00

  • A B cell lymphoma line, BALL-1 stimulates T cells to produce a unique eosinophil chemotactic factor.

    abstract::Human mononuclear leukocytes (MNL), probably OKT4-positive T cells, produced an eosinophil chemotactic factor (ECF) when they were cocultured with irradiated BALL-1, a B cell lymphoma line. Treatment of MNL, with anti-IL-2 antibody failed to suppress BALL-1-induced ECF production. Periodate-lysine-paraformaldehyde-fix...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236736

    authors: Yoshida N,Ueno M,Saita N,Hirashima M

    更新日期:1994-01-01 00:00:00

  • The synthetic PPARgamma agonist troglitazone inhibits eotaxin-enhanced eosinophil adhesion to ICAM-1-coated plates.

    abstract::Accumulation and activation of eosinophils in tissue are critical events in the allergic inflammatory response and adhesion molecules play important roles in this process. We previously demonstrated that human eosinophils expressed a nuclear receptor, peroxisome proliferator-activated receptor gamma (PPARgamma), and t...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000126054

    authors: Hirasawa H,Chiba T,Ueki S,Kamada Y,Ito W,Takeda M,Fujita M,Kato H,Kayaba H,Chihara J

    更新日期:2008-01-01 00:00:00

  • Interest of ImmunoCAP system to recombinant omega-5 gliadin for the diagnosis of exercise-induced wheat allergy.

    abstract:BACKGROUND:omega-5 gliadin is a major allergen in exercise-induced wheat allergy (EIWA), but it is also implicated in immediate-type reactions to wheat. An ImmunoCAP assay to measure omega-5 gliadin-specific IgE has become available. This study aimed to evaluate this new biological test in wheat allergy diagnosis and t...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000176309

    authors: Jacquenet S,Morisset M,Battais F,Denery-Papini S,Croizier A,Baudouin E,Bihain B,Moneret-Vautrin DA

    更新日期:2009-01-01 00:00:00

  • Degranulation from human eosinophils stimulated with C3a and C5a.

    abstract::It is unclear what actually induces eosinophil degranulation in vivo. We examined eosinophil cationic protein (ECP) release from normal human eosinophils (Eos) in response to C3a and C5a. C3a and C5a induced remarkable ECP release when Eos were preincubated with cytochalasin B. ECP release induced by C3a or C5a was gr...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236743

    authors: Takafuji S,Tadokoro K,Ito K,Dahinden CA

    更新日期:1994-01-01 00:00:00

  • Effect of enzymatically modified isoquercitrin, a flavonoid, on symptoms of Japanese cedar pollinosis: a randomized double-blind placebo-controlled trial.

    abstract:BACKGROUND:Flavonoids exert antiallergic and antioxidant effects. We investigated the efficacy of enzymatically modified isoquercitrin (EMIQ), a flavonoid, to relieve symptoms of pollinosis. METHODS:In a parallel-group, double-blind placebo-controlled study design, 20 subjects with Japanese cedar pollinosis took two c...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000205582

    authors: Kawai M,Hirano T,Arimitsu J,Higa S,Kuwahara Y,Hagihara K,Shima Y,Narazaki M,Ogata A,Koyanagi M,Kai T,Shimizu R,Moriwaki M,Suzuki Y,Ogino S,Kawase I,Tanaka T

    更新日期:2009-01-01 00:00:00

  • Steady-State Therapy with Azithromycin or Low-Dose Prednisolone in Paediatric Cystic Fibrosis Patients: Inflammatory Markers and Disease Progression.

    abstract:BACKGROUND:Anti-inflammatory therapy is a logical approach to slowing the inevitable lung function deterioration in cystic fibrosis (CF) patients. This study's aim was to evaluate inflammatory markers and disease progression in paediatric CF patients chronically treated with azithromycin or low-dose prednisolone. METH...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000453451

    authors: Shmarina G,Pukhalsky A,Avakian L,Semykin S,Pukhalskaya D,Alioshkin V

    更新日期:2017-01-01 00:00:00

  • Rheumatic fever: from sore throat to autoimmune heart lesions.

    abstract::Molecular mimicry between streptococci and heart components has been proposed as the triggering factor leading to autoimmunity in rheumatic heart disease (RHD). In this review, we present data from cellular autoimmune responses, focusing on the interactions between HLA class II molecules, streptococcal peptides and he...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000077915

    authors: Guilherme L,Kalil J

    更新日期:2004-05-01 00:00:00

  • Tolerability and clinical outcome of coseasonal treatment with Escherichia coli strain Nissle 1917 in grass pollen-allergic subjects.

    abstract:BACKGROUND:Nonpathogenic Escherichia coli strain Nissle 1917 (EcN) has immunomodulatory properties and can act on different cells which are important for the allergic immune response. Herein, we investigated the efficacy and tolerability of EcN in subjects with grass pollen-dependent allergic rhinoconjunctivitis. METH...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000356328

    authors: Dölle S,Berg J,Rasche C,Worm M

    更新日期:2014-01-01 00:00:00

  • Skin Care and Synbiotics for Prevention of Atopic Dermatitis or Food Allergy in Newborn Infants: A 2 × 2 Factorial, Randomized, Non-Treatment Controlled Trial.

    abstract:BACKGROUND:Atopic dermatitis (AD) and food allergy (FA) are common childhood diseases, which may either be interrelated or be the result of skin barrier disruption and gut mucosal dysbiosis. Although some evidence suggests the efficacy of emollients and synbiotics, there is no conclusive evidence on the use of these in...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000501636

    authors: Dissanayake E,Tani Y,Nagai K,Sahara M,Mitsuishi C,Togawa Y,Suzuki Y,Nakano T,Yamaide F,Ohno H,Shimojo N

    更新日期:2019-01-01 00:00:00

  • Hormones and local immunity.

    abstract::The modulatory role of hormones in the regulation of the immune response has been well documented. Here, we present some thoughts on how sex hormones affect immunity, particularly at mucosal sites. We further discuss the possible pitfalls and difficulties associated with analysis of the data. ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000236631

    authors: Stanisz AM,Kataeva G,Bienenstock J

    更新日期:1994-01-01 00:00:00

  • Responsiveness of peripheral blood mononuclear cells from normal and atopic donors to microbial superantigens.

    abstract::Patients with atopic dermatitis (AD) are frequently colonized with Staphylococcus aureus strains secreting exotoxins such as the staphylococcal enterotoxin B (SEB) and A (SEA). Nonetheless the role of SEB and SEA in AD is yet unknown. We analyzed the responsiveness of peripheral blood mononuclear cells (PBMCs) and iso...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236832

    authors: König B,Neuber K,König W

    更新日期:1995-02-01 00:00:00

  • Enhancement of interleukin-4 production in activated CD4+ T cells by diphthalate plasticizers via increased NF-AT binding activity.

    abstract:BACKGROUND:Diethylhexyl phthalate (DEHP) and diisononyl phthalate (DINP), two commonly used plasticizers in flexible polyvinylchloride formulations, have potentially adverse effects on human health. However, the influence of these diphthalates on allergic responses remains unclear. In this study we examined the effects...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000078768

    authors: Lee MH,Park J,Chung SW,Kang BY,Kim SH,Kim TS

    更新日期:2004-07-01 00:00:00

  • Studies on avian spinal cord chimeras. II. Immune response of the chicken host to the graft of quail tissue.

    abstract::A previous study described clinical and pathological manifestations observed in 49 chimeras produced by replacing a small fragment of the neural tube of a chicken embryo by a similar fragment from a Japanese quail embryo. Predominant antibodies in sera of these birds were directed against xenogeneic antigens which are...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236097

    authors: Yang G,Albini B,Milgrom F

    更新日期:1992-01-01 00:00:00

  • Purification and N-terminal sequence analysis of Streptomyces chromofuscus phospholipase D.

    abstract::Partially purified commercial phospholipase D (PLD) was fractionated by dye-ligand affinity chromatography and nondenaturing polyacrylamide gel electrophoresis (PAGE). Active material migrated as three bands on SDS-PAGE. The two higher-abundance species were shown to have identical N-terminal sequences, while the thir...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236934

    authors: Dinh TT,McClure GD,Kennerly DA

    更新日期:1995-05-01 00:00:00

  • Specific antibodies in oral immunotherapy for cow's milk allergy: kinetics and prediction of clinical outcome.

    abstract:BACKGROUND:METHODS for predicting the clinical outcome of specific oral immunotherapy (OIT) would improve the safety of the therapy. METHODS:We investigated 40 children aged 6-17 years with IgE-mediated cow's milk allergy (CMA) who either successfully completed OIT (n = 32) or discontinued the therapy due to adverse r...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000361023

    authors: Savilahti EM,Kuitunen M,Savilahti E,Mäkelä MJ

    更新日期:2014-01-01 00:00:00

  • Correlations between complaints, inflammatory cells and mediator concentrations in nasal secretions after nasal allergen challenge and during natural allergen exposure.

    abstract::A quantitative determination of the inflammatory mediators was performed and correlated with complaints and the measurement of the inflammatory cells in nasal secretions of 18 seasonal allergic rhinitis patients (group 1) outside the pollen season and 40 symptomatic patients (group 2) with seasonal allergic rhinitis d...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236855

    authors: Wang D,Clement P,Smitz J,De Waele M,Derde MP

    更新日期:1995-03-01 00:00:00

  • Predictors of Persistent Milk Allergy in Children: A Retrospective Cohort Study.

    abstract:BACKGROUND:Cow's milk (CM) allergy is the second most common food allergy developed during infancy in Japan. To identify predictors of persistent CM allergy, we investigated the tolerance acquisition rate based on an oral food challenge in children under 6 years of age, diagnosed with immediate-type CM allergy. METHOD...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000486311

    authors: Koike Y,Sato S,Yanagida N,Asaumi T,Ogura K,Ohtani K,Imai T,Ebisawa M

    更新日期:2018-01-01 00:00:00

  • Inhibition of IgE antibody formation by plasmid DNA immunization is mediated by both CD4+ and CD8+ T cells.

    abstract:BACKGROUND:We previously showed that immunization of mice with plasmid DNA (pDNA) encoding the Escherichia coli beta-galactosidase gene (pCMV-LacZ) induces a Th1 response, whereas beta-galactosidase (beta-gal) in saline or alum induces a Th2 response. Furthermore, the Th1 response dominates over the Th2 response and do...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237554

    authors: Lee DJ,Tighe H,Corr M,Roman M,Carson DA,Spiegelberg HL,Raz E

    更新日期:1997-05-01 00:00:00

  • Identification of alpha-amylase inhibitor as a major allergen of wheat flour.

    abstract::We isolated a major wheat flour allergen with a molecular weight of 15-kD. The 15-kD allergen was purified from an extract of wheat flour by ammonium sulfate precipitation followed by gel filtration. Using the immunoblot technique, IgE, specifically directed towards the single isolated allergen, was detectable in 50% ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236726

    authors: Fränken J,Stephan U,Meyer HE,König W

    更新日期:1994-01-01 00:00:00

  • Specific activation of human mast cells by the ligand for c-kit: comparison between lung, uterus and heart mast cells.

    abstract::Recent data suggest that stem cell factor (SCF or c-kit ligand, KL) is a major regulator of human mast cells (MCs). In the present study, MCs derived from the lung (n = 8), uterus (n = 14) and heart (n = 4) were analyzed for expression of c-kit receptor and for responses to recombinant SCF. MCs of all organs tested we...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236568

    authors: Sperr WR,Czerwenka K,Mundigler G,Müller MR,Semper H,Klappacher G,Glogar HD,Lechner K,Valent P

    更新日期:1993-01-01 00:00:00