The Th1/Th2 paradigm and experimental murine leishmaniasis.

Abstract:

:In recent years, the Th1/Th2 concept has become of prime importance in the understanding of heterogeneous responses of the immune system and implications thereof for infectious and autoimmune diseases. Originally established on the basis of different cytokines produced by T cell clones, it is now known that the Th1/Th2 concept really defines totally different immune pathways that affect most if not all cells of the immune system. Murine experimental leishmaniasis was the first model to confirm the relevance of the Th1/Th2 concept in vivo. Herein, we summarize the current knowledge on the characteristics and generation of Th1 and Th2 cells, as well as on recent advances of the application of this concept to murine cutaneous leishmaniasis.

authors

Lohoff M,Gessner A,Bogdan C,Röllinghoff M

doi

10.1159/000023900

subject

Has Abstract

pub_date

1998-03-01 00:00:00

pages

191-202

issue

3

eissn

1018-2438

issn

1423-0097

pii

iaa15191

journal_volume

115

pub_type

杂志文章,评审
  • Low-allergenic hydrolyzed egg induces oral tolerance in mice.

    abstract:BACKGROUND:Egg allergy is one of the most common food allergies in children. The standard therapy for egg allergy is strict avoidance. Yet, there is considerable clinical and scientific interest in primary or secondary prevention. A major drawback of oral tolerance (OT) induction protocols, however, is the possibility ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000363110

    authors: Hacini-Rachinel F,Vissers YM,Doucet-Ladevéze R,Blanchard C,Demont A,Perrot M,Panchaud A,Prioult G,Mercenier A,Nutten S

    更新日期:2014-01-01 00:00:00

  • Baked Tolerance in Cow's Milk Allergy: Quite Frequent, Hard to Predict!

    abstract:INTRODUCTION:Cow's milk protein allergy (CMA) is the most common type of food allergy in childhood and exclusion diet is a challenge for patients. OBJECTIVE:The study aim was to investigate the frequency of tolerance to baked foods containing milk and evaluate immediate skin prick test (SPT) and specific IgEs for diff...

    journal_title:International archives of allergy and immunology

    pub_type: 新闻

    doi:10.1159/000511148

    authors: Vilar LK,Araújo FA,Santos TP,Menezes TT,Cheik MF,Segundo GRS

    更新日期:2020-10-14 00:00:00

  • Food-dependent exercise-induced anaphylaxis: clinical and laboratory findings in 54 subjects.

    abstract:BACKGROUND:In some subjects, specific foods trigger anaphylaxis when exercise follows ingestion (specific food-dependent exercise-induced anaphylaxis, FDEIAn). Skin test and/or RAST positivity to foods suggest an IgE-mediated pathogenic mechanism. Others suffer from anaphylaxis after all meals followed by exercise, reg...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000053825

    authors: Romano A,Di Fonso M,Giuffreda F,Papa G,Artesani MC,Viola M,Venuti A,Palmieri V,Zeppilli P

    更新日期:2001-07-01 00:00:00

  • Sequence analysis of BIRC4/XIAP in male patients with common variable immunodeficiency.

    abstract:BACKGROUND:Common variable immunodeficiency (CVID) is the most common primary antibody deficiency syndrome in humans, but it remains a diagnosis of exclusion in most cases. Several genetically defined primary immunodeficiencies mimic CVID. Among them is the X-linked lymphoproliferative syndrome (XLP) which was shown to...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000135702

    authors: Salzer U,Hagena T,Webster DB,Grimbacher B

    更新日期:2008-01-01 00:00:00

  • Modifications of Phleum pratense grass pollen allergens following artificial exposure to gaseous air pollutants (O(3), NO(2), SO(2)).

    abstract:BACKGROUND:Air pollution is frequently proposed as a potential cause of the increased incidence of allergy in industrialised countries. Our objective was to investigate the impact of the major gaseous air pollutants on grass pollen allergens. METHODS:Timothy grass pollen was exposed to ozone (O(3)), nitrogen dioxide (...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000099079

    authors: Rogerieux F,Godfrin D,Sénéchal H,Motta AC,Marlière M,Peltre G,Lacroix G

    更新日期:2007-01-01 00:00:00

  • Inhibitory effects of human neutrophil functions by the 45-kD glycoprotein derived from the parasitic nematode Trichinella spiralis.

    abstract:AIM:We evaluated the effect of the 45-kD protein of Trichinella spiralis (gp45), purified by affinity chromatography, on random migration and chemotaxis, the oxidative metabolism of human neutrophils and on the CD11b upregulation induced by formyl-methionyl-leucyl-phenylalanine (f-MLP). METHODS:Donor neutrophils incub...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000024359

    authors: Bruschi F,Carulli G,Azzarà A,Homan W,Minnucci S,Rizzuti-Gullaci A,Sbrana S,Angiolini C

    更新日期:2000-05-01 00:00:00

  • The pathophysiological roles of PI3Ks and therapeutic potential of selective inhibitors in allergic inflammation.

    abstract::Phosphoinositide 3-kinases (PI3Ks) are known to be involved in a variety of cellular responses such as cell survival, proliferation, differentiation and cell migration. Recently, PI3Ks have been associated with the pathogenesis of asthma because various immune cells regulate allergic responses. Among the three classes...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000312132

    authors: Takeda M,Ito W,Tanabe M,Ueki S,Kihara J,Kato H,Tanigai T,Kayaba H,Sasaki T,Chihara J

    更新日期:2010-01-01 00:00:00

  • Suppression of specific IgE antibody responses by liposome-conjugated ovalbumin in mice sensitized with ovalbumin via the respiratory tract.

    abstract:BACKGROUND:Previously we have shown that intranasal administration of ovalbumin (OVA) together with cholera toxin (CT) abrogates nasal tolerance to OVA, resulting in the induction of specific IgE antibody (Ab) responses, and that intraperitoneal injection of OVA coupled with liposomes (OVA-liposomes) induces a selectiv...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000024305

    authors: Yoshikawa T,Uchida T,Naito S,Horino A,Taneichi M,Kato H,Komuro K,Nakano Y,Mori M,Nishinohara S,Chiba J,Kurata T,Tamura S

    更新日期:2000-02-01 00:00:00

  • The Role of Der p 23 Sensitization: An Analysis of 474 Patients Sensitized to Mite.

    abstract:INTRODUCTION:House dust mite contains several allergen components and causes perennial allergy. Lately, a new major allergen, Der p 23, was described with relatively high sensitization rates in different European Countries. In addition, Der p 23 is supposed to cause asthmatic disease. OBJECTIVE:We would like to questi...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000508522

    authors: Eder K,Becker S,Gellrich D,Zieglmayer P,Gröger M

    更新日期:2020-01-01 00:00:00

  • Profilins: mimickers of allergy or relevant allergens?

    abstract::Profilins are ubiquitous proteins, present in all eukaryotic cells and identified as allergens in pollen, latex and plant foods. The highly conserved structure justifies the cross-reactive nature of IgE antibodies against plant profilins and their designation as pan-allergens. Primary sensitization to profilin seems t...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000321178

    authors: Santos A,Van Ree R

    更新日期:2011-01-01 00:00:00

  • Predictors of Persistent Milk Allergy in Children: A Retrospective Cohort Study.

    abstract:BACKGROUND:Cow's milk (CM) allergy is the second most common food allergy developed during infancy in Japan. To identify predictors of persistent CM allergy, we investigated the tolerance acquisition rate based on an oral food challenge in children under 6 years of age, diagnosed with immediate-type CM allergy. METHOD...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000486311

    authors: Koike Y,Sato S,Yanagida N,Asaumi T,Ogura K,Ohtani K,Imai T,Ebisawa M

    更新日期:2018-01-01 00:00:00

  • Observational study of the safety of an ultra-rush sublingual immunotherapy regimen to treat rhinitis due to house dust mites.

    abstract:BACKGROUND:Ultra-rush regimens for administering sublingual immunotherapy to patients with allergies are becoming more widespread. We aimed to assess treatment safety for patients with allergic rhinitis with or without asthma caused by Dermatophagoides house dust mites. METHODS:This observational study at 5 Spanish ce...

    journal_title:International archives of allergy and immunology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1159/000319211

    authors: Roger A,Justicia JL,Navarro LÁ,Eseverri JL,Ferrès J,Malet A,Alvà V

    更新日期:2011-01-01 00:00:00

  • A B cell lymphoma line, BALL-1 stimulates T cells to produce a unique eosinophil chemotactic factor.

    abstract::Human mononuclear leukocytes (MNL), probably OKT4-positive T cells, produced an eosinophil chemotactic factor (ECF) when they were cocultured with irradiated BALL-1, a B cell lymphoma line. Treatment of MNL, with anti-IL-2 antibody failed to suppress BALL-1-induced ECF production. Periodate-lysine-paraformaldehyde-fix...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236736

    authors: Yoshida N,Ueno M,Saita N,Hirashima M

    更新日期:1994-01-01 00:00:00

  • High-Sensitivity C-Reactive Protein and Allergic Endpoints in German Adolescents.

    abstract:BACKGROUND:Assessing high-sensitivity C-reactive protein (hs-CRP) in relation to allergic endpoints can shed light on both the mechanisms of allergic disease development and early non-communicable disease prevention. However, only a few epidemiological studies so far have investigated the relationship in children and a...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000497320

    authors: Yang BY,Markevych I,Harris C,Standl M,Schikowski T,Koletzko S,Herberth G,Bauer CP,von Berg A,Berdel D,Dong GH,Heinrich J

    更新日期:2019-01-01 00:00:00

  • IL-4 gene transcription in human T cells is suppressed by T-bet.

    abstract:UNLABELLED:T-bet is crucially implicated in Th1 differentiation due to its strong promoting activity for IFN-gamma gene transcription. However, the regulatory role of T-bet in Th2 cytokines is not fully delineated. METHODS:The effect of T-bet on mRNA expression as well as the promoter activity of IL-4 in human T cells...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000101408

    authors: Kitamura N,Kitamura F,Kaminuma O,Miyatake S,Tatsumi H,Nemoto S,Mori A

    更新日期:2007-01-01 00:00:00

  • Effect of enzymatically modified isoquercitrin, a flavonoid, on symptoms of Japanese cedar pollinosis: a randomized double-blind placebo-controlled trial.

    abstract:BACKGROUND:Flavonoids exert antiallergic and antioxidant effects. We investigated the efficacy of enzymatically modified isoquercitrin (EMIQ), a flavonoid, to relieve symptoms of pollinosis. METHODS:In a parallel-group, double-blind placebo-controlled study design, 20 subjects with Japanese cedar pollinosis took two c...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000205582

    authors: Kawai M,Hirano T,Arimitsu J,Higa S,Kuwahara Y,Hagihara K,Shima Y,Narazaki M,Ogata A,Koyanagi M,Kai T,Shimizu R,Moriwaki M,Suzuki Y,Ogino S,Kawase I,Tanaka T

    更新日期:2009-01-01 00:00:00

  • Lipopolysaccharide contamination of beta-lactoglobulin affects the immune response against intraperitoneally and orally administered antigen.

    abstract:BACKGROUND:Microbial components in the environment are potent activators of the immune system with capacity to shift the active immune response towards priming of Th1 and/or Th2 cells. Lipopolysaccharide (LPS), a cell-wall component of Gram-negative bacteria, is extensively present in food products like cow's milk. It ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000081306

    authors: Brix S,Kjaer TM,Barkholt V,Frøkiaer H

    更新日期:2004-11-01 00:00:00

  • Soluble CD23 levels are inversely associated with atopy and parasite-specific IgE levels but not with polyclonal IgE levels in people exposed to helminth infection.

    abstract:BACKGROUND:Protective acquired immunity against helminths and allergic sensitisation are both characterised by high IgE antibody levels. Levels of IgE antibodies are naturally tightly regulated by several mechanisms including binding of the CD23 receptor. Following observations that helminth infections and allergic sen...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000346545

    authors: Rujeni N,Nausch N,Midzi N,Gwisai R,Mduluza T,Taylor DW,Mutapi F

    更新日期:2013-01-01 00:00:00

  • Specific activation of human mast cells by the ligand for c-kit: comparison between lung, uterus and heart mast cells.

    abstract::Recent data suggest that stem cell factor (SCF or c-kit ligand, KL) is a major regulator of human mast cells (MCs). In the present study, MCs derived from the lung (n = 8), uterus (n = 14) and heart (n = 4) were analyzed for expression of c-kit receptor and for responses to recombinant SCF. MCs of all organs tested we...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236568

    authors: Sperr WR,Czerwenka K,Mundigler G,Müller MR,Semper H,Klappacher G,Glogar HD,Lechner K,Valent P

    更新日期:1993-01-01 00:00:00

  • Human keratinocytes release mast cell differentiation factors other than stem cell factor.

    abstract::Besides stem cell factor (SCF), additional fibroblast-derived mast cell growth factors have previously been described. Since keratinocytes have also been shown to produce SCF, we have studied the ability of culture supernatants from the human HaCaT keratinocyte cell line to induce SCF-independent mast cell differentia...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236956

    authors: Welker P,Grabbe J,Czarnetzki BM

    更新日期:1995-05-01 00:00:00

  • House dust mite allergen characterisation: implications for T-cell responses and immunotherapy.

    abstract::T cells are central regulators and mediators of allergic sensitisation and disease. The house dust mite allergens are a biochemically diverse group of proteins which are present in extracts and the environment in a wide range of concentrations. Here the importance of ascertaining the contribution of the different alle...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章,评审

    doi:10.1159/000023824

    authors: Thomas WR,Smith W,Hales BJ

    更新日期:1998-01-01 00:00:00

  • Enhancement of Tissue Factor Expression in Monocyte-Derived Dendritic Cells by Pentraxin 3 and Its Modulation by C1 Esterase Inhibitor.

    abstract:BACKGROUND:We have previously shown that human monocyte-derived dendritic cells (moDCs) may participate in immune system-mediated hypercoagulable state through enhanced tissue factor (TF) expression and that the complement system may be involved in this process. OBJECTIVES:The aim of this study was to explore the role...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000496744

    authors: Kasuda S,Sakurai Y,Tatsumi K,Takeda T,Kudo R,Yuui K,Hatake K

    更新日期:2019-01-01 00:00:00

  • GM-CSF downregulates expression of tryptase, Fc epsilon RI and histamine in HMC-1 mast cells.

    abstract::Fibroblast-derived growth factors like SCF are able to upregulate the expression of mast cell characteristics in human multilineage hematopoietic progenitor cells. Other factors, like GM-CSF, have been reported to inhibit this process, probably by the competitive recruitment of cells not belonging to the mast cell lin...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237574

    authors: Welker P,Grabbe J,Zuberbier T,Henz BM

    更新日期:1997-05-01 00:00:00

  • Clinical features and immunological markers of atopic dermatitis in elderly patients.

    abstract:BACKGROUND:Atopic dermatitis (AD) is increasing among the elderly. Staphylococcus aureus colonization is one of the most important aggravating factors in AD. OBJECTIVE:This study analyses the clinical features of AD in elderly patients and determines the pathogenic roles of staphylococcal superantigens in AD with low ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000329150

    authors: Bozek A,Fisher A,Filipowska B,Mazur B,Jarzab J

    更新日期:2012-01-01 00:00:00

  • Clinical and laboratory examinations in the subgroups of chronic urticaria.

    abstract:BACKGROUND:The aetiology of chronic urticaria is heterogeneous. Physical urticaria (PU) is estimated at around 35%, autoimmune urticaria (AIU) at 25% and chronic idiopathic urticaria (CIU) at 35% of all chronic urticaria cases. METHODS:Differences in clinical and laboratory parameters among AIU, PU and CIU groups were...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000103995

    authors: Irinyi B,Széles G,Gyimesi E,Tumpek J,Herédi E,Dimitrios G,Adány R,Hunyadi J,Szegedi A

    更新日期:2007-01-01 00:00:00

  • Inhibitory effect of NZ-107 on anaphylactic bronchoconstriction in guinea pigs and rats.

    abstract::We studied the effect of NZ-107 in a number of animal models of anaphylactic bronchoconstriction. In conscious guinea pigs, pretreated with indomethacin, pyrilamine and propranolol, passively sensitized with heterologous anti serum, NZ-107 in doses of 10-30 mg/kg per os inhibited the aerosolized antigen-induced cough ...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000236103

    authors: Iwama T,Shikada K,Yamamoto A,Sakashita M,Hibi M,Tanaka S

    更新日期:1992-01-01 00:00:00

  • Serum total immunoglobulin E is a surrogate of atopy in adult-onset asthma: a longitudinal study.

    abstract:BACKGROUND:Studies have shown that serum total immunoglobulin E (IgE) levels are higher in asthmatics. However, the role of the serum total IgE level, independently from atopy, in adult asthma is not understood. We studied the associations between serum total IgE, the number of sensitizations and the sum of specific Ig...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000342464

    authors: Carsin AE,Zock JP,Jarvis D,Basagaña X,Heinrich J,Toren K,Janson C,Anto JM,Sunyer J

    更新日期:2013-01-01 00:00:00

  • IgE binding to raw and boiled shrimp proteins in atopic and nonatopic patients with adverse reactions to shrimp.

    abstract:BACKGROUND:Characterization of seafood allergens is important to understand the immune response to these allergens. Moreover, a detailed comparison between atopic and nonatopic patients with adverse reactions to shrimp has never been reported. METHODS:Raw and boiled shrimp extracts were analyzed by immunoblotting usin...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000076828

    authors: Samson KT,Chen FH,Miura K,Odajima Y,Iikura Y,Naval Rivas M,Minoguchi K,Adachi M

    更新日期:2004-03-01 00:00:00

  • Lipopolysaccharides modulate allergen-specific immune regulation in a murine model of mucosal tolerance induction.

    abstract:BACKGROUND:Farming has been widely reported to be associated with decreased risk of developing atopic disorders, but underlying immunomodulatory mechanisms are still not fully defined. We delineated T-cell functions after induction of mucosal tolerance in the context of intranasally delivered organic dust compounds, li...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000128583

    authors: Gerhold K,Avagyan A,Reichert E,Blumchen K,Wahn U,Hamelmann E

    更新日期:2008-01-01 00:00:00

  • Characterization of Fc epsilonRI expressing human monocytic cell lines. 1. The role of CD45 on signal transduction in primary monocytes and cell lines.

    abstract:BACKGROUND:Recently, the high affinity receptor for IgE (Fc epsilonRI), which plays a major role in allergies, has been identified on a number of different antigen-presenting cell types, including human monocytes from atopic and nonatopic donors. In this report human monocytic cell lines were used to test for the expre...

    journal_title:International archives of allergy and immunology

    pub_type: 杂志文章

    doi:10.1159/000237621

    authors: Reischl IG,Corvaïa N,Unger J,Woisetschläger M,Mudde GC

    更新日期:1997-08-01 00:00:00