当前位置： SCI文献检索 > INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY期刊下所有文献 > Interferon-gamma inhibits in vitro mobilization of eosinophils by interleukin-5.

Interferon-gamma inhibits in vitro mobilization of eosinophils by interleukin-5.

Abstract：

BACKGROUND:Th2 cytokines play pivotal roles in allergic inflammation, including eosinophilia, and their actions are antagonized by Th1 cytokines, conferring them therapeutic potential. METHODS:In this study, we examined the ability of a number of cytokines to suppress the activation of eosinophils that function as effector cells for allergic airway diseases. RESULTS:Interleukin (IL)-5, IL-6, and tumor necrosis factor (TNF) induced an eosinophil shape change, whereas interferon (IFN)-gamma significantly inhibited the shape change. Other cytokines, including IL-1beta, IL-4, IL-10 and IL-13, had little or only slightly enhancing or reducing effects on the shape change. We further analyzed the IFN-gamma effect, showing that pretreatment with IFN-gamma strongly suppressed IL-5-induced eosinophil shape change, and cycloheximide (CHX) abrogated the suppression by IFN-gamma, suggesting that new protein synthesis is required for the inhibitory effect by this cytokine. In agreement with these results, IFN-gamma blocked the eosinophil migration and ERK phophorylation induced by IL-5, and the addition of CHX restored eosinophil chemotaxis. CONCLUSIONS:Collectively, IFN-gamma may attenuate eosinophilic inflammation by directly negating eosinophil mobilization.

journal_name

Int Arch Allergy Immunol

journal_title

International archives of allergy and immunology

authors

Park CS,Choi EN,Kim JS,Choi YS,Rhim TY,Chang HS,Chung IY

doi

10.1159/000083957

keywords:

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

295-302

issue

3

eissn

1018-2438

issn

1423-0097

pii

83957

journal_volume

136

pub_type

杂志文章

相关文献

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY文献大全
  • Higher frequencies of CD161+ circulating T lymphocytes in allergic rhinitis patients compared to healthy donors.

    abstract：BACKGROUND:Th17 is a subset of T-helper lymphocytes that produce proinflammatory cytokines, mainly IL-17. Serum IL-17 is increased in allergic patients and relates to clinical severity. Recently, it has been reported that CD161 is a highly upregulated gene in Th17 clones and all IL-17-producing cells are contained in C...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000330903

    authors： Poggi A,Canevali P,Contatore M,Ciprandi G

    更新日期：2012-01-01 00:00:00

  • Direct expression of Der f2, a major house dust mite allergen, in Escherichia coli.

    abstract：:Der f2 protein in a highly antigenic form was directly expressed in bacteria. Plasmid pFLU11 derived from pKK233-2 was designed to express methionyl-Der f2 under the control of the trc promoter and it has the replication origin of pUC118 instead of its original to increase the copy number. This expression plasmid dire...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237263

    authors： Iwamoto N,Nishiyama C,Yasuhara T,Saito A,Yuuki T,Okumura Y,Okudaira H

    更新日期：1996-04-01 00:00:00

  • House dust mite allergen characterisation: implications for T-cell responses and immunotherapy.

    abstract：:T cells are central regulators and mediators of allergic sensitisation and disease. The house dust mite allergens are a biochemically diverse group of proteins which are present in extracts and the environment in a wide range of concentrations. Here the importance of ascertaining the contribution of the different alle...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,评审

    doi：10.1159/000023824

    authors： Thomas WR,Smith W,Hales BJ

    更新日期：1998-01-01 00:00:00

  • Antigen-induced reduction in mast cell and basophil functional responses due to reduced Syk protein levels.

    abstract：BACKGROUND:The high-affinity IgE receptor, FcepsilonRI, is unresponsive on mast cells and basophils from people in several populations through an unknown mechanism. Similarly, FcepsilonRI-positive basophils from 'nonreleasers' are IgE-unresponsive and are deficient in the tyrosine kinase Syk. OBJECTIVE:To test the hyp...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000087355

    authors： Kepley CL

    更新日期：2005-09-01 00:00:00

  • Orange germin-like glycoprotein Cit s 1: an equivocal allergen.

    abstract：BACKGROUND:Orange allergens are virtually unknown, in spite of the large consumption of this fruit. Germin-like proteins, together with vicilins and legumins, form the cupin superfamily of plant proteins, which includes many seed allergens. METHODS:Twenty-nine patients with allergy to oranges were studied. A major IgE...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000090384

    authors： Ahrazem O,Ibáñez MD,López-Torrejón G,Sánchez-Monge R,Sastre J,Lombardero M,Barber D,Salcedo G

    更新日期：2006-01-01 00:00:00

  • Alkaline serine proteinase from Aspergillus fumigatus has synergistic effects on Asp-f-2-induced immune response in mice.

    abstract：BACKGROUND:Exposure to Aspergillus fumigatus allergens results in the sensitization and the development of allergic bronchopulmonary aspergillosis in susceptible individuals. Aspergillus antigen consists of a number of chemically diverse components and their cumulative or synergistic effect may result in disease. When ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000065882

    authors： Kurup VP,Xia JQ,Shen HD,Rickaby DA,Henderson JD Jr,Fink JN,Chou H,Kelly KJ,Dawson CA

    更新日期：2002-10-01 00:00:00

  • Greater Real-Life Diagnostic Efficacy of Allergen Molecule-Based Diagnosis for Prescription of Immunotherapy in an Area with Multiple Pollen Exposure.

    abstract：BACKGROUND:Allergen molecule-based diagnosis has been suggested to facilitate the identification of disease-causing allergen sources and the prescription of allergen-specific immunotherapy (AIT). The aim of the current study was to compare allergen molecule-based IgE serology with allergen extract-based skin testing fo...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000477442

    authors： Saltabayeva U,Garib V,Morenko M,Rosenson R,Ispayeva Z,Gatauova M,Zulus L,Karaulov A,Gastager F,Valenta R

    更新日期：2017-01-01 00:00:00

  • Cytokine production by highly purified human CD8+ T cells.

    abstract：:We have systematically investigated the capacity of highly purified human peripheral CD8+ T cells to produce interleukin (IL)-4 and interferon (IFN)-gamma when triggered by different stimuli. CD8+ T cells were isolated from peripheral blood by positive selection to > 99% purity and stimulated with one of three differe...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237030

    authors： Li Y,Richards D,Noble A,Kemeny DM

    更新日期：1995-05-01 00:00:00

  • Thrombin affects eosinophil migration via protease-activated receptor-1.

    abstract：BACKGROUND:Protease-activated receptors (PARs) are a unique class of G-protein-coupled receptors, which are activated by proteolytic cleavage of the amino terminus of the receptor itself. Although expression of the PAR1, which is typically activated by thrombin, on human eosinophils has been demonstrated, no effect of ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000080037

    authors： Feistritzer C,Mosheimer BA,Kaneider NC,Riewald M,Patsch JR,Wiedermann CJ

    更新日期：2004-09-01 00:00:00

  • Exposure to indoor allergens in homes of patients with asthma and/or rhinitis in southeast Brazil: effect of mattress and pillow covers on mite allergen levels.

    abstract：BACKGROUND:Exposure and sensitization to indoor allergens have been associated with the development of asthma and other allergic diseases in many parts of the world. It is important to establish the degree of exposure, and to evaluate whether allergen control measures are effective in a particular area. METHODS:Concen...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000077356

    authors： Tobias KR,Ferriani VP,Chapman MD,Arruda LK

    更新日期：2004-04-01 00:00:00

  • An odorant-binding protein as a new allergen from Siberian hamster (Phodopus sungorus).

    abstract：:A case of anaphylaxis following a bite from a Siberian hamster (SH; Phodopus sungorus) is described. Skin prick tests with hair, urine and salivary gland extracts from SH were positive, while the tests were negative for hair extracts from other rodents. IgE immunoblotting with the patient serum revealed 3 IgE-binding ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000324956

    authors： Torres JA,Pastor-Vargas C,de las Heras M,Vivanco F,Cuesta J,Sastre J

    更新日期：2012-01-01 00:00:00

  • Probiotics have a different immunomodulatory potential in vitro versus ex vivo upon oral administration in children with food allergy.

    abstract：BACKGROUND:Previous studies suggest that administration of probiotics in vitro can stimulate regulatory and Th1 immune responses. We studied both the in vitro immunological effects of probiotics and the ex vivo immunological effects after oral administration of probiotics in children with food allergy, a Th2-mediated d...

    journal_title：International archives of allergy and immunology

    pub_type： 临床试验,杂志文章

    doi：10.1159/000099467

    authors： Flinterman AE,Knol EF,van Ieperen-van Dijk AG,Timmerman HM,Knulst AC,Bruijnzeel-Koomen CA,Pasmans SG,van Hoffen E

    更新日期：2007-01-01 00:00:00

  • Patients' satisfaction with diagnostic drug provocation tests and perception of its usefulness.

    abstract：BACKGROUND AND AIM:Although still controversial, drug provocation tests (DPTs) are considered by many as the gold standard for diagnosis of drug hypersensitivity. No studies have addressed the opinion of patients submitted to DPT. We aimed to determine patient satisfaction with diagnostic DPT and their perception of it...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,多中心研究

    doi：10.1159/000323898

    authors： Gomes ER,Kvedariene V,Demoly P,Bousquet PJ

    更新日期：2011-01-01 00:00:00

  • Successful pregnancy in a Churg-Strauss syndrome patient with a history of intrauterine fetal death.

    abstract：:Allergic granulomatosis and angiitis was first reported as a disease entity separate from polyarteritis nodosa in 1951 by Churg and Strauss. It is characterized by bronchial asthma, eosinophilia, and vasculitis and is especially rare in women of reproductive age, though, when present, may be associated with fetal mort...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237140

    authors： Ogasawara M,Kajiura S,Inagaki H,Sasa H,Aoki K,Yagami Y

    更新日期：1995-10-01 00:00:00

  • Characterization of Fc epsilonRI expressing human monocytic cell lines. 1. The role of CD45 on signal transduction in primary monocytes and cell lines.

    abstract：BACKGROUND:Recently, the high affinity receptor for IgE (Fc epsilonRI), which plays a major role in allergies, has been identified on a number of different antigen-presenting cell types, including human monocytes from atopic and nonatopic donors. In this report human monocytic cell lines were used to test for the expre...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237621

    authors： Reischl IG,Corvaïa N,Unger J,Woisetschläger M,Mudde GC

    更新日期：1997-08-01 00:00:00

  • DP2 (CRTh2) antagonism reduces ocular inflammation induced by allergen challenge and respiratory syncytial virus.

    abstract：BACKGROUND:Allergic conjunctivitis is characterized by itchy, watery and swollen eyes which occur in response to exposure to seasonal or environmental allergens. The early phase reaction of allergic conjunctivitis is primarily mediated by mast cell degranulation while the late phase reaction is driven by Th2 cells and ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000328769

    authors： Stebbins KJ,Broadhead AR,Musiyenko A,Barik S,Scott JM,Truong YP,Stearns BA,Hutchinson JH,Prasit P,Evans JF,Lorrain DS

    更新日期：2012-01-01 00:00:00

  • Immediate Wheal Reactivity to Autologous Sweat in Atopic Dermatitis Is Associated with Clinical Severity, Serum Total and Specific IgE and Sweat Tryptase Activity.

    abstract：BACKGROUND:Sweating can worsen atopic dermatitis (AD). The purpose of this work was to study the associations between reactivity to autologous sweat and the clinical severity of AD as well as investigate the possible wheal-inducing factors of sweat. METHODS:Intracutaneous skin tests with autologous sweat were performe...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000447638

    authors： Ilves T,Virolainen A,Harvima IT

    更新日期：2016-01-01 00:00:00

  • Respiratory responses of asthmatics to ozone.

    abstract：:Asthmatic individuals in the general population appear to be susceptible to disease exacerbation during summertime 'smog' episodes (ambient air pollution containing other pollutants in addition to ozone). Although controlled exposure to ozone causes acute decrements in lung function, asthmatic subjects are only margin...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,评审

    doi：10.1159/000236989

    authors： Koren HS,Bromberg PA

    更新日期：1995-05-01 00:00:00

  • Mite-Induced Asthma and IgE Levels to Shrimp, Mite, Tropomyosin, Arginine Kinase, and Der p 10 Are the Most Relevant Risk Factors for Challenge-Proven Shrimp Allergy.

    abstract：BACKGROUND:Shrimp sensitization is common in the general population, but the presence of symptoms is only moderately related to sensitization. A point still at issue is which in vivo and/or in vitro tests (food challenge, component-resolved diagnosis, house dust mite [HDM] sensitization) can help in distinguishing shri...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000481985

    authors： Farioli L,Losappio LM,Giuffrida MG,Pravettoni V,Micarelli G,Nichelatti M,Scibilia J,Mirone C,Cavallarin L,Lamberti C,Balossi LG,Pastorello EA

    更新日期：2017-01-01 00:00:00

  • Responsiveness of peripheral blood mononuclear cells from normal and atopic donors to microbial superantigens.

    abstract：:Patients with atopic dermatitis (AD) are frequently colonized with Staphylococcus aureus strains secreting exotoxins such as the staphylococcal enterotoxin B (SEB) and A (SEA). Nonetheless the role of SEB and SEA in AD is yet unknown. We analyzed the responsiveness of peripheral blood mononuclear cells (PBMCs) and iso...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000236832

    authors： König B,Neuber K,König W

    更新日期：1995-02-01 00:00:00

  • Lack of cross-reactivity between casein and gliadin in sera from coeliac disease patients.

    abstract：BACKGROUND:While searching for antigliadin and anticasein antibodies in sera from coeliac patients we investigated more than 20 persons suffering from this enteropathy. In some of sera, we registered antibodies against gliadin and in parallel the appearance of anticasein antibodies. A high percentage of glutamic acid h...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000024003

    authors： Paranos S,Nikolic G

    更新日期：1998-10-01 00:00:00

  • Iris protein antibodies in serum of patients with juvenile rheumatoid arthritis and uveitis.

    abstract：:Homogenates of bovine iris were fractionated by gel filtration chromatography, and the column-eluted proteins were probed with pooled sera obtained from patients with pauciarticular juvenile rheumatoid arthritis (JRA). The serum pool prepared from patients with pauciarticular JRA and a history of anterior uveitis, but...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000236431

    authors： Hunt DW,Petty RE,Millar F

    更新日期：1993-01-01 00:00:00

  • The importance of serine proteinases as aeroallergens associated with asthma.

    abstract：:Penicillium and Aspergillus species have been identified as prevalent indoor airborne fungi that are associated with extrinsic bronchial asthma. We have recently analyzed the IgE-binding components in 8 prevalent Penicillium and Aspergillus species (P. citrinum, P. notatum, P. oxalicum, P. brevicompactum, A. fumigatus...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章,评审

    doi：10.1159/000024202

    authors： Shen HD,Tam MF,Chou H,Han SH

    更新日期：1999-08-01 00:00:00

  • cDNA cloning, biological and immunological characterization of the alkaline serine protease major allergen from Penicillium chrysogenum.

    abstract：BACKGROUND:Penicillium chrysogenum (Penicillium notatum) is a prevalent airborne Penicillium species. A 34-kD major IgE-reacting component from P. chrysogenum has been identified as an alkaline serine protease (Pen ch 13, also known as Pen n 13 before) by immunoblot and N-terminal amino acid sequence analysis. METHODS...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000048165

    authors： Chou H,Lai HY,Tam MF,Chou MY,Wang SR,Han SH,Shen HD

    更新日期：2002-01-01 00:00:00

  • A rapid and simple photometric assay for quantification of eosinophil chemotaxis.

    abstract：:Various methods have been devised to assay eosinophil chemotaxis. In this review, we introduced a rapid and sensitive eosinophil chemotactic assay system based on eosinophil peroxidase (EPO) determination. Eosinophils were semipurified by dextran sedimentation followed by Percoll gradient centrifugation. Eosinophil mi...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000053624

    authors： Nagase H,Yamaguchi M,Jibiki S,Yamada H,Ohta K,Kawasaki H,Yoshie O,Yamamoto K,Morita Y,Hirai K

    更新日期：2000-05-01 00:00:00

  • Accelerated Dose Escalation with 3 Injections of an Aluminum Hydroxide-Adsorbed Allergoid Preparation of 6 Grasses Is Safe for Children and Adolescents with Moderate to Severe Allergic Rhinitis.

    abstract：:A high-dose, accelerated escalation schedule during subcutaneous allergen-specific immunotherapy (AIT) is safe and well-tolerated in adults. However, there are no data in children and adolescents. The aim of the present trial was to assess safety and tolerability of an accelerated dose escalation schedule of an AIT wi...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000512561

    authors： Bovermann X,Ricklefs I,Vogelberg C,Klimek L,Kopp MV

    更新日期：2021-01-27 00:00:00

  • Oral administration of bacterial lysates attenuates experimental food allergy.

    abstract：BACKGROUND:Modulating early immune response by application of bacteria and their by-products has been suggested as a preventive strategy against the development of allergic diseases. In light of this, the aim of the study was to test the effects of oral administration of bacterial lysates (BL) in a rat model of food al...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000322352

    authors： Ahrens B,Quarcoo D,Buhner S,Matricardi PM,Hamelmann E

    更新日期：2011-01-01 00:00:00

  • Histamine augments VCAM-1 expression on IL-4- and TNF-alpha-stimulated human umbilical vein endothelial cells.

    abstract：:Interaction between vascular cell adhesion molecule-1 (VCAM-1) on endothelial cells and CD49d molecules on eosinophils is thought to mediate the selective infiltration of eosinophils into inflamed tissues in allergic disease. IL-4 and TNF-alpha are associated with allergic conditions, and they have been shown to selec...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000237357

    authors： Saito H,Shimizu H,Mita H,Maeda Y,Akiyama K

    更新日期：1996-10-01 00:00:00

  • Exclusive Bee Venom Allergy: Risk Factors and Outcome of Immunotherapy.

    abstract：INTRODUCTION:Venom immunotherapy (VIT) is considered to be the gold-standard treatment for patients with Hymenoptera venom allergy. Data regarding VIT in bee venom (BV) allergic patients are scarce. AIM:The aim of this study was to evaluate the outcome of VIT in patients with exclusive BV allergy and to try to define ...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000500957

    authors： Rosman Y,Nashef F,Cohen-Engler A,Meir-Shafrir K,Lachover-Roth I,Confino-Cohen R

    更新日期：2019-01-01 00:00:00

  • Optimizing the use of a skin prick test device on children.

    abstract：BACKGROUND:Studies comparing skin prick test (SPT) devices have revealed varying results in performance and there is little known about their use on children. METHODS:We performed 2 complementary studies to test the sensitivity, reproducibility and acceptability of commercially available SPT devices (Stallerpoint, Ant...

    journal_title：International archives of allergy and immunology

    pub_type： 杂志文章

    doi：10.1159/000350788

    authors： Buyuktiryaki B,Sahiner UM,Karabulut E,Cavkaytar O,Tuncer A,Sekerel BE

    更新日期：2013-01-01 00:00:00